RU2013111077A - Дипептидное пролекарство, его применение и лекарственное средство - Google Patents

Дипептидное пролекарство, его применение и лекарственное средство Download PDF

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RU2013111077A
RU2013111077A RU2013111077/04A RU2013111077A RU2013111077A RU 2013111077 A RU2013111077 A RU 2013111077A RU 2013111077/04 A RU2013111077/04 A RU 2013111077/04A RU 2013111077 A RU2013111077 A RU 2013111077A RU 2013111077 A RU2013111077 A RU 2013111077A
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Ханс-Георг Лерхен
Урсула КРЕНЦ
Йорг Кельдених
Николь ДИДРИХС
Томас КРАН
Клаудиа Хирт-Дитрих
Барбара Альбрехт-Кюппер
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Байер Фарма Акциенгезельшафт
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid

Abstract

1. Дипептидное пролекарство формулы (I):,в которойRозначает группуиRозначает группу,илиRозначает группуиRозначает группу,илиRозначает группуиRозначает,илиRозначает группуииRозначает группу,илиRозначает группуиRозначает группу,илиRозначает группуиRозначает группу,илиRозначает группуиRозначает группу,а * означает место присоединения к атому кислорода.2. Применение соединения по п.1 для изготовления лекарственного средства, предназначенного для лечения и/или профилактики сердечно-сосудистых заболеваний.3. Лекарственное средство для лечения и/или профилактики сердечно-сосудистых заболеваний, содержащее соединение формулы (I) по п.1, при необходимости, в комбинации с одним или несколькими инертными, нетоксичными, фармацевтически пригодными вспомогательными веществами.

Claims (3)

1. Дипептидное пролекарство формулы (I):
Figure 00000001
,
в которой
RA означает группу
Figure 00000002
и
RB означает группу
Figure 00000003
,
или
RA означает группу
Figure 00000002
и
RB означает группу
Figure 00000004
,
или
RA означает группу
Figure 00000005
и
RB означает
Figure 00000003
,
или
RA означает группу
и
Figure 00000006
и
RB означает группу
Figure 00000003
,
или
RA означает группу
Figure 00000002
и
RB означает группу
Figure 00000003
,
или
RA означает группу
Figure 00000005
и
RB означает группу
Figure 00000004
,
или
RA означает группу
Figure 00000007
и
RB означает группу
Figure 00000003
,
а * означает место присоединения к атому кислорода.
2. Применение соединения по п.1 для изготовления лекарственного средства, предназначенного для лечения и/или профилактики сердечно-сосудистых заболеваний.
3. Лекарственное средство для лечения и/или профилактики сердечно-сосудистых заболеваний, содержащее соединение формулы (I) по п.1, при необходимости, в комбинации с одним или несколькими инертными, нетоксичными, фармацевтически пригодными вспомогательными веществами.
RU2013111077A 2007-08-01 2013-03-13 Дипептидное пролекарство, его применение и лекарственное средство RU2629558C2 (ru)

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US20150133364A1 (en) 2015-05-14
RU2010106877A (ru) 2011-09-10
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TW200920365A (en) 2009-05-16
DE102007036076A1 (de) 2009-02-05
JP5486492B2 (ja) 2014-05-07
TWI436766B (zh) 2014-05-11
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CA2695036C (en) 2015-11-24
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