ES2916604T1 - Ensayos de detección de nrf2 y métodos y composiciones relacionados - Google Patents
Ensayos de detección de nrf2 y métodos y composiciones relacionados Download PDFInfo
- Publication number
- ES2916604T1 ES2916604T1 ES13156663T ES13156663T ES2916604T1 ES 2916604 T1 ES2916604 T1 ES 2916604T1 ES 13156663 T ES13156663 T ES 13156663T ES 13156663 T ES13156663 T ES 13156663T ES 2916604 T1 ES2916604 T1 ES 2916604T1
- Authority
- ES
- Spain
- Prior art keywords
- fumarate
- administered
- use according
- monomethyl
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000203 mixture Substances 0.000 title claims abstract 10
- 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 title 1
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 title 1
- 238000003556 assay Methods 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- LDCRTTXIJACKKU-ONEGZZNKSA-N dimethyl fumarate Chemical compound COC(=O)\C=C\C(=O)OC LDCRTTXIJACKKU-ONEGZZNKSA-N 0.000 claims abstract 24
- 229960004419 dimethyl fumarate Drugs 0.000 claims abstract 24
- NKHAVTQWNUWKEO-UHFFFAOYSA-N fumaric acid monomethyl ester Natural products COC(=O)C=CC(O)=O NKHAVTQWNUWKEO-UHFFFAOYSA-N 0.000 claims abstract 24
- NKHAVTQWNUWKEO-NSCUHMNNSA-N monomethyl fumarate Chemical compound COC(=O)\C=C\C(O)=O NKHAVTQWNUWKEO-NSCUHMNNSA-N 0.000 claims abstract 24
- 229940005650 monomethyl fumarate Drugs 0.000 claims abstract 24
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 11
- 201000006417 multiple sclerosis Diseases 0.000 claims abstract 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000000324 neuroprotective effect Effects 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- OSNIIMCBVLBNGS-UHFFFAOYSA-N 1-(1,3-benzodioxol-5-yl)-2-(dimethylamino)propan-1-one Chemical compound CN(C)C(C)C(=O)C1=CC=C2OCOC2=C1 OSNIIMCBVLBNGS-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90209—Oxidoreductases (1.) acting on NADH or NADPH (1.6), e.g. those with a heme protein as acceptor (1.6.2) (general), Cytochrome-b5 reductase (1.6.2.2) or NADPH-cytochrome P450 reductase (1.6.2.4)
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/285—Demyelinating diseases; Multipel sclerosis
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- General Health & Medical Sciences (AREA)
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Abstract
Una composición farmacéutica para usarse en el tratamiento de la esclerosis múltiple, la composición que consiste en: (a) fumarato de dimetilo y/o fumarato de monometilo, y (b) uno o más excipientes farmacéuticamente aceptables, donde la composición se va a administrar por vía oral a un sujeto que necesita tratamiento para la esclerosis múltiple, y donde la dosis de fumarato de dimetilo o fumarato de monometilo que se va a administrar es de aproximadamente 480 mg a aproximadamente 720 mg por día.
Claims (20)
1. Una composición farmacéutica para usarse en el tratamiento de la esclerosis múltiple, la composición que consiste en:
(a) fumarato de dimetilo y/o fumarato de monometilo, y
(b) uno o más excipientes farmacéuticamente aceptables,
donde la composición se va a administrar por vía oral a un sujeto que necesita tratamiento para la esclerosis múltiple, y donde la dosis de fumarato de dimetilo o fumarato de monometilo que se va a administrar es de aproximadamente 480 mg a aproximadamente 720 mg por día.
2. La composición farmacéutica para usarse según la reivindicación 1, donde la composición consiste en fumarato de dimetilo y uno o más excipientes farmacéuticamente aceptables.
3. La composición farmacéutica para usarse según la reivindicación 1, donde la composición consiste en fumarato de monometilo y uno o más excipientes farmacéuticamente aceptables.
4. La composición farmacéutica para usarse según cualquiera de las reivindicaciones 1 a 3, donde la dosis de fumarato de dimetilo o fumarato de monometilo a administrar es de aproximadamente 480 mg por día.
5. La composición farmacéutica para usarse según cualquiera de las reivindicaciones 1 a 4, donde la composición se administra en forma de tableta, suspensión o cápsula.
6. La composición farmacéutica para usarse según cualquiera de las reivindicaciones 1 a 5, donde el fumarato de dimetilo y/o fumarato de monometilo es para ser administrado en administraciones separadas de 2, 3, 4 o 6 dosis iguales.
7. La composición farmacéutica para usarse según la reivindicación 6, donde la dosis de fumarato de dimetilo o fumarato de monometilo es para ser administrada en administraciones separadas de 2 dosis iguales.
8. La composición farmacéutica para usarse según la reivindicación 6, donde la dosis de fumarato de dimetilo o fumarato de monometilo es para ser administrada en administraciones separadas de 3 dosis iguales.
9. La composición farmacéutica para usarse según una cualquiera de las reivindicaciones 1 a 8, donde la composición es para ser administrada al sujeto durante 5, 10, 12, 20, 40, 52, 100 o 200 semanas o más.
10. La composición farmacéutica para usarse según cualquiera de las reivindicaciones 1 a 9, donde la composición es para ser administrada al sujeto durante al menos 12 semanas.
11. Fumarato de dimetilo o fumarato de monometilo para usarse en el tratamiento de la esclerosis múltiple, donde el fumarato de dimetilo o fumarato de monometilo es el único compuesto neuroprotector a administrar, y donde el fumarato de dimetilo o fumarato de monometilo se administra por vía oral a un sujeto que necesita tratamiento para esclerosis múltiple a una dosis de aproximadamente 480 mg a aproximadamente 720 mg por día.
12. Fumarato de dimetilo para usarse como en la reivindicación 11, donde el fumarato de dimetilo es el único compuesto neuroprotector a administrar.
13. Fumarato de monometilo para usarse como en la reivindicación 11, donde el fumarato de monometilo es el único compuesto neuroprotector a administrar.
14. Fumarato de dimetilo o fumarato de monometilo para usarse según cualquiera de las reivindicaciones 11 a 13, donde la dosis es de aproximadamente 480 mg por día.
15. El fumarato de dimetilo o fumarato de monometilo para usarse según cualquiera de las reivindicaciones 11 a 14, donde el fumarato de dimetilo o fumarato de monometilo se administra en forma de tableta, suspensión o cápsula.
16. Fumarato de dimetilo o fumarato de monometilo para usarse según cualquiera de las reivindicaciones 11 a 15, donde la dosis debe administrarse en administraciones separadas de 2, 3, 4 o 6 dosis iguales.
17. Fumarato de dimetilo o fumarato de monometilo para usarse según la reivindicación 16, donde la dosis se administra en administraciones separadas de 2 dosis iguales.
18. Fumarato de dimetilo o fumarato de monometilo para usarse según la reivindicación 16, donde la dosis se administra en administraciones separadas de 3 dosis iguales.
19. El fumarato de dimetilo o fumarato de monometilo para usarse como en cualquiera de las reivindicaciones 11 a 18,
donde el fumarato de dimetilo o fumarato de monometilo se va a administrar al sujeto durante 5, 10, 12, 20, 40, 52, 100 o 200 semanas o más.
20. El fumarato de dimetilo o el fumarato de monometilo para usarse según cualquiera de las reivindicaciones 11 a 19, donde el fumarato de dimetilo o el fumarato de monometilo se va a administrar al sujeto durante al menos 12 semanas.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88892107P | 2007-02-08 | 2007-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2916604T1 true ES2916604T1 (es) | 2022-07-04 |
Family
ID=39682314
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES13156663T Pending ES2916604T1 (es) | 2007-02-08 | 2008-02-07 | Ensayos de detección de nrf2 y métodos y composiciones relacionados |
ES13169139T Active ES2916649T3 (es) | 2007-02-08 | 2008-02-07 | Composiciones y usos para el tratamiento de la esclerosis múltiple |
ES08725256T Active ES2424022T3 (es) | 2007-02-08 | 2008-02-07 | Composiciones y usos para tratar la esclerosis múltiple |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES13169139T Active ES2916649T3 (es) | 2007-02-08 | 2008-02-07 | Composiciones y usos para el tratamiento de la esclerosis múltiple |
ES08725256T Active ES2424022T3 (es) | 2007-02-08 | 2008-02-07 | Composiciones y usos para tratar la esclerosis múltiple |
Country Status (19)
Country | Link |
---|---|
US (8) | US20110112196A1 (es) |
EP (10) | EP2518511A1 (es) |
CY (4) | CY1114340T1 (es) |
DE (2) | DE13156663T1 (es) |
DK (3) | DK2653873T3 (es) |
ES (3) | ES2916604T1 (es) |
FI (2) | FI2629097T1 (es) |
FR (2) | FR14C0050I1 (es) |
HK (1) | HK1139204A1 (es) |
HR (2) | HRP20220902T3 (es) |
HU (1) | HUS2300001I1 (es) |
LT (2) | LT2653873T (es) |
LU (1) | LU92487I2 (es) |
NO (2) | NO2014015I1 (es) |
PL (2) | PL2137537T3 (es) |
PT (2) | PT2653873T (es) |
RS (2) | RS63489B1 (es) |
SI (2) | SI2653873T1 (es) |
WO (1) | WO2008097596A2 (es) |
Families Citing this family (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
BRPI0410805A (pt) | 2003-09-09 | 2006-06-27 | Fumapharm Ag | uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma |
DK2801354T3 (en) | 2004-10-08 | 2017-05-15 | Forward Pharma As | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
SI2653873T1 (sl) | 2007-02-08 | 2022-09-30 | Biogen Ma Inc. | Sestave in načini uporabe za zdravljenje multiple skleroze |
US20100130607A1 (en) * | 2007-02-08 | 2010-05-27 | Ralf Gold | Neuroprotection in demyelinating diseases |
CN104739841B (zh) | 2008-01-11 | 2018-06-01 | 里亚塔医药公司 | 合成三萜类化合物及用以治病之方法 |
LT2276493T (lt) | 2008-04-18 | 2019-01-10 | Reata Pharmaceuticals, Inc. | Antioksidaciniai uždegimo moduliatoriai: oleanolio rūgšties dariniai su amino ir kitomis modifikacijomis c-17 |
TWI442925B (zh) | 2008-04-18 | 2014-07-01 | Reata Pharmaceuticals Inc | 抗氧化性發炎調節劑:c-環飽和之齊墩果酸衍生物 |
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WO2007006307A2 (en) | 2005-07-07 | 2007-01-18 | Aditech Pharma Ab | Novel salts of fumaric acid monoalkylesters and their pharmaceutical use |
EP2186819A1 (en) | 2005-07-07 | 2010-05-19 | Aditech Pharma AG | Novel glucopyranose esters and glucofuranose esters of alkyl- fumarates and their pharmaceutical use |
JP2009510137A (ja) | 2005-10-07 | 2009-03-12 | アディテック・ファルマ・アクチボラゲット | フマル酸エステルを含む制御放出医薬組成物 |
EP1940382A2 (en) | 2005-10-07 | 2008-07-09 | Aditech Pharma AB | Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders |
US20080089861A1 (en) | 2006-07-10 | 2008-04-17 | Went Gregory T | Combination therapy for treatment of demyelinating conditions |
SI2653873T1 (sl) | 2007-02-08 | 2022-09-30 | Biogen Ma Inc. | Sestave in načini uporabe za zdravljenje multiple skleroze |
US20100130607A1 (en) | 2007-02-08 | 2010-05-27 | Ralf Gold | Neuroprotection in demyelinating diseases |
EP3466420A1 (en) | 2009-04-29 | 2019-04-10 | Biogen MA Inc. | Dimethyl fumarate for the treatment of friedreich ataxia |
PL2533634T3 (pl) | 2010-02-12 | 2016-04-29 | Biogen Ma Inc | Neuroprotekcja w chorobach demielinizacyjnych |
JP2013221921A (ja) | 2012-04-19 | 2013-10-28 | Heidenhain Kk | ロータリーエンコーダ |
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