DE13156663T1 - NRF2-Screening-Assays sowie entsprechende Verfahren und Zusammensetzungen - Google Patents

NRF2-Screening-Assays sowie entsprechende Verfahren und Zusammensetzungen Download PDF

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DE13156663T1
DE13156663T1 DE13156663.0T DE13156663T DE13156663T1 DE 13156663 T1 DE13156663 T1 DE 13156663T1 DE 13156663 T DE13156663 T DE 13156663T DE 13156663 T1 DE13156663 T1 DE 13156663T1
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fumarate
administered
monomethyl
dimethyl fumarate
dimethyl
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Matvey E. Lukashev
Gilmore O'neill
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Biogen MA Inc
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Biogen MA Inc
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • A—HUMAN NECESSITIES
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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Abstract

Pharmazeutische Zusammensetzung zur Verwendung bei der Behandlung Multipler Sklerose, wobei die Zusammensetzung aus Folgendem besteht:(a) Fumarsäuredimethylester oder Fumarsäuremonomethylester und(b) einem oder mehreren pharmazeutisch unbedenklichen Arzneimittelträgern, wobei die Zusammensetzung einem Patienten mit Behandlungsbedarf bei Multipler Sklerose oral zu verabreichen ist und wobei die zu verabreichende Dosis Fumarsäuredimethylester oder Fumarsäuremonomethylester etwa 480 mg bis etwa 720 mg pro Tag beträgt.

Claims (20)

  1. Pharmazeutische Zusammensetzung zur Verwendung bei der Behandlung Multipler Sklerose, wobei die Zusammensetzung aus Folgendem besteht: (a) Fumarsäuredimethylester oder Fumarsäuremonomethylester und (b) einem oder mehreren pharmazeutisch unbedenklichen Arzneimittelträgern, wobei die Zusammensetzung einem Patienten mit Behandlungsbedarf bei Multipler Sklerose oral zu verabreichen ist und wobei die zu verabreichende Dosis Fumarsäuredimethylester oder Fumarsäuremonomethylester etwa 480 mg bis etwa 720 mg pro Tag beträgt.
  2. Pharmazeutische Zusammensetzung zur Verwendung nach Anspruch 1, wobei die Zusammensetzung aus Fumarsäuredimethylester und einem oder mehreren pharmazeutisch unbedenklichen Arzneimittelträgern besteht.
  3. Pharmazeutische Zusammensetzung zur Verwendung nach Anspruch 1, wobei die Zusammensetzung aus Fumarsäuremonomethylester und einem oder mehreren pharmazeutisch unbedenklichen Arzneimittelträgern besteht.
  4. Pharmazeutische Zusammensetzung zur Verwendung nach irgendeinem der Ansprüche 1 bis 3, wobei die zu verabreichende Dosis Fumarsäuredimethylester oder Fumarsäuremonomethylester etwa 480 mg pro Tag beträgt.
  5. Pharmazeutische Zusammensetzung zur Verwendung nach irgendeinem der Ansprüche 1 bis 4, wobei die Zusammensetzung in Form einer Tablette, einer Suspension oder einer Kapsel zu verabreichen ist.
  6. Pharmazeutische Zusammensetzung zur Verwendung nach irgendeinem der Ansprüche 1 bis 5, wobei der Fumarsäuredimethylester und/oder Fumarsäuremonomethylester in getrennten Verabreichungen von 2, 3, 4 oder 6 gleichen Dosen zu verabreichen ist.
  7. Pharmazeutische Zusammensetzung zur Verwendung nach Anspruch 6, wobei die Dosis von Fumarsäuredimethylester oder Fumarsäuremonomethylester in getrennten Verabreichungen von 2 gleichen Dosen zu verabreichen ist.
  8. Pharmazeutische Zusammensetzung zur Verwendung nach Anspruch 6, wobei die Dosis von Fumarsäuredimethylester oder Fumarsäuremonomethylester in getrennten Verabreichungen von 3 gleichen Dosen zu verabreichen ist.
  9. Pharmazeutische Zusammensetzung zur Verwendung nach irgendeinem der Ansprüche 1 bis 8, wobei die Zusammensetzung dem Patienten 5, 10, 12, 20, 40, 52, 100 oder 200 Wochen lang oder länger zu verabreichen ist.
  10. Pharmazeutische Zusammensetzung zur Verwendung nach irgendeinem der Ansprüche 1 bis 9, wobei die Zusammensetzung dem Patienten für mindestens 12 Wochen zu verabreichen ist.
  11. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung bei der Behandlung Multipler Sklerose, wobei der Fumarsäuredimethylester oder Fumarsäuremonomethylester das einzige zu verabreichende Neuroprotektivum ist und wobei der Fumarsäuredimethylester oder Fumarsäuremonomethylester einem Patienten mit Behandlungsbedarf bei Multipler Sklerose mit einer Dosis von etwa 480 mg bis etwa 720 mg pro Tag oral zu verabreichen ist.
  12. Fumarsäuredimethylester zur Verwendung nach Anspruch 11, wobei der Fumarsäuredimethylester das einzige zu verabreichende Neuroprotektivum ist.
  13. Fumarsäuremonomethylester zur Verwendung nach Anspruch 11, wobei der Fumarsäuremonomethylester das einzige zu verabreichende Neuroprotektivum ist.
  14. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung nach irgendeinem der Ansprüche 11 bis 13, wobei die Dosis etwa 480 mg pro Tag beträgt.
  15. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung nach irgendeinem der Ansprüche 11 bis 14, wobei der Fumarsäuredimethylester oder Fumarsäuremonomethylester in Form einer Tablette, einer Suspension oder einer Kapsel zu verabreichen ist.
  16. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung nach irgendeinem der Ansprüche 11 bis 15, wobei die Dosis in getrennten Verabreichungen von 2, 3, 4 oder 6 gleichen Dosen zu verabreichen ist.
  17. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung nach Anspruch 16, wobei die Dosis in getrennten Verabreichungen von 2 gleichen Dosen zu verabreichen ist.
  18. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung nach Anspruch 16, wobei die Dosis in getrennten Verabreichungen von 3 gleichen Dosen zu verabreichen ist.
  19. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung nach irgendeinem der Ansprüche 11 bis 18, wobei der Fumarsäuredimethylester oder Fumarsäuremonomethylester dem Patienten 5, 10, 12, 20, 40, 52, 100 oder 200 Wochen lang oder länger zu verabreichen ist.
  20. Fumarsäuredimethylester oder Fumarsäuremonomethylester zur Verwendung nach irgendeinem der Ansprüche 11 bis 19, wobei der Fumarsäuredimethylester oder Fumarsäuremonomethylester dem Patienten mindestens 12 Wochen lang zu verabreichen ist.
DE13156663.0T 2007-02-08 2008-02-07 NRF2-Screening-Assays sowie entsprechende Verfahren und Zusammensetzungen Pending DE13156663T1 (de)

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EP13156663.0A EP2629097A1 (de) 2007-02-08 2008-02-07 NRF2-Screening-Assays sowie entsprechende Verfahren und Zusammensetzungen

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EP4137819A1 (de) 2023-02-22
FR23C1003I2 (fr) 2024-01-12
US20120196931A1 (en) 2012-08-02
SI2137537T1 (sl) 2013-10-30
WO2008097596A3 (en) 2008-12-11
HRP20220902T3 (hr) 2022-10-14
EP2680010A1 (de) 2014-01-01
US20130317103A1 (en) 2013-11-28
ES2916604T1 (es) 2022-07-04
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CY2014026I2 (el) 2016-10-05
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ES2916649T3 (es) 2022-09-21
EP2680007A1 (de) 2014-01-01
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US20180263906A1 (en) 2018-09-20
PL2653873T1 (pl) 2022-07-04
LU92487I2 (fr) 2015-11-02
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US20150366803A1 (en) 2015-12-24
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HK1139204A1 (en) 2010-09-10
FR23C1003I1 (fr) 2023-03-10
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EP2680008A1 (de) 2014-01-01
FR14C0050I1 (fr) 2014-08-08
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EP2653873A1 (de) 2013-10-23
DK2653873T1 (da) 2022-05-30
EP2137537B1 (de) 2013-05-29
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US20120259012A1 (en) 2012-10-11
PT2137537E (pt) 2013-08-22
EP2680009A1 (de) 2014-01-01
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US8399514B2 (en) 2013-03-19
US20110112196A1 (en) 2011-05-12
US20200016072A1 (en) 2020-01-16
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PL2137537T3 (pl) 2013-10-31
EP2653873B8 (de) 2022-08-24
CY1114340T1 (el) 2016-08-31
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