HUE036085T2 - Nagy tisztaságú és kristályos dimetil-fumarát elõállítására szolgáló eljárás - Google Patents

Nagy tisztaságú és kristályos dimetil-fumarát elõállítására szolgáló eljárás

Info

Publication number
HUE036085T2
HUE036085T2 HUE12796164A HUE12796164A HUE036085T2 HU E036085 T2 HUE036085 T2 HU E036085T2 HU E12796164 A HUE12796164 A HU E12796164A HU E12796164 A HUE12796164 A HU E12796164A HU E036085 T2 HUE036085 T2 HU E036085T2
Authority
HU
Hungary
Prior art keywords
high purity
preparing high
dimethyl fumarate
crystalline dimethyl
crystalline
Prior art date
Application number
HUE12796164A
Other languages
English (en)
Inventor
John Guzowski
William KIESMAN
Erwin Irdam
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47296498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUE036085(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of HUE036085T2 publication Critical patent/HUE036085T2/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
HUE12796164A 2011-06-08 2012-06-08 Nagy tisztaságú és kristályos dimetil-fumarát elõállítására szolgáló eljárás HUE036085T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161494775P 2011-06-08 2011-06-08

Publications (1)

Publication Number Publication Date
HUE036085T2 true HUE036085T2 (hu) 2018-06-28

Family

ID=47296498

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE12796164A HUE036085T2 (hu) 2011-06-08 2012-06-08 Nagy tisztaságú és kristályos dimetil-fumarát elõállítására szolgáló eljárás

Country Status (30)

Country Link
US (1) US9422226B2 (hu)
EP (1) EP2718257B1 (hu)
JP (3) JP6385273B6 (hu)
KR (2) KR20140035995A (hu)
CN (1) CN103649041A (hu)
AU (1) AU2012267524A1 (hu)
BR (1) BR112013031616A2 (hu)
CA (1) CA2838271A1 (hu)
CL (1) CL2013003483A1 (hu)
CO (1) CO6821956A2 (hu)
CY (1) CY1119920T1 (hu)
DK (1) DK2718257T3 (hu)
EA (1) EA201391638A1 (hu)
EC (1) ECSP14013123A (hu)
ES (1) ES2659771T3 (hu)
HR (1) HRP20180203T1 (hu)
HU (1) HUE036085T2 (hu)
IL (1) IL229656A0 (hu)
LT (1) LT2718257T (hu)
ME (1) ME02960B (hu)
MX (1) MX355421B (hu)
NO (1) NO2820009T3 (hu)
NZ (1) NZ618178A (hu)
PE (1) PE20141639A1 (hu)
PL (1) PL2718257T3 (hu)
PT (1) PT2718257T (hu)
RS (1) RS56972B1 (hu)
SG (1) SG195227A1 (hu)
SI (1) SI2718257T1 (hu)
WO (1) WO2012170923A1 (hu)

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AU2012267524A1 (en) 2013-12-12
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