PE20141639A1 - Proceso para preparar fumarato de dimetilo de alta pureza y cristalino - Google Patents
Proceso para preparar fumarato de dimetilo de alta pureza y cristalinoInfo
- Publication number
- PE20141639A1 PE20141639A1 PE2013002765A PE2013002765A PE20141639A1 PE 20141639 A1 PE20141639 A1 PE 20141639A1 PE 2013002765 A PE2013002765 A PE 2013002765A PE 2013002765 A PE2013002765 A PE 2013002765A PE 20141639 A1 PE20141639 A1 PE 20141639A1
- Authority
- PE
- Peru
- Prior art keywords
- smoke
- high purity
- preparing crystalline
- crystalline high
- purity dimethyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/62—Use of additives, e.g. for stabilisation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/60—Maleic acid esters; Fumaric acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
SE REFIERE A UN METODO PARA LA PREPARACION DE FUMARATO DE DIMETILO, QUE COMPRENDE: HACER REACCIONAR ACIDO FUMARICO Y METANOL EN PRESENCIA DE ACIDO SULFURICO, EN UNA MEZCLA DE REACCION PARA OBTENER UNA MEZCLA DEL PRODUCTO QUE COMPRENDE UN NIVEL BAJO DE SULFATO DE DIMETILO, DONDE DICHO SULFATO DE DIMETILO ES MENOR QUE 4,0 ppm; ADICIONALMENTE SE REDUCE EL TAMANO DE PARTICULA DEL FUMARATO DE DIMETILO A UN TAMANO QUE VARIA DE 20�m A 250�m. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161494775P | 2011-06-08 | 2011-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20141639A1 true PE20141639A1 (es) | 2014-11-08 |
Family
ID=47296498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2013002765A PE20141639A1 (es) | 2011-06-08 | 2012-06-08 | Proceso para preparar fumarato de dimetilo de alta pureza y cristalino |
Country Status (30)
Country | Link |
---|---|
US (1) | US9422226B2 (es) |
EP (1) | EP2718257B1 (es) |
JP (3) | JP6385273B6 (es) |
KR (2) | KR20150080037A (es) |
CN (1) | CN103649041A (es) |
AU (1) | AU2012267524A1 (es) |
BR (1) | BR112013031616A2 (es) |
CA (1) | CA2838271A1 (es) |
CL (1) | CL2013003483A1 (es) |
CO (1) | CO6821956A2 (es) |
CY (1) | CY1119920T1 (es) |
DK (1) | DK2718257T3 (es) |
EA (1) | EA201391638A1 (es) |
EC (1) | ECSP14013123A (es) |
ES (1) | ES2659771T3 (es) |
HR (1) | HRP20180203T1 (es) |
HU (1) | HUE036085T2 (es) |
IL (1) | IL229656A0 (es) |
LT (1) | LT2718257T (es) |
ME (1) | ME02960B (es) |
MX (1) | MX355421B (es) |
NO (1) | NO2820009T3 (es) |
NZ (1) | NZ618178A (es) |
PE (1) | PE20141639A1 (es) |
PL (1) | PL2718257T3 (es) |
PT (1) | PT2718257T (es) |
RS (1) | RS56972B1 (es) |
SG (1) | SG195227A1 (es) |
SI (1) | SI2718257T1 (es) |
WO (1) | WO2012170923A1 (es) |
Families Citing this family (37)
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EP1663197B1 (en) | 2003-09-09 | 2007-12-05 | Fumapharm AG | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
LT2801354T (lt) | 2004-10-08 | 2017-06-26 | Forward Pharma A/S | Kontroliuojamo atpalaidavimo farmacinės kompozicijos, apimančios fumaro rūgšties esterį |
MX2011001341A (es) | 2008-08-19 | 2011-03-29 | Xenoport Inc | Prodrogas de metil hidrogeno fumarato, sus composiciones farmaceuticas, y metodos de uso. |
US9422226B2 (en) | 2011-06-08 | 2016-08-23 | Biogen Ma Inc. | Process for preparing high purity and crystalline dimethyl fumarate |
JP2015526476A (ja) | 2012-08-22 | 2015-09-10 | ゼノポート,インコーポレイティド | メチル水素フマレートの経口剤形およびそのプロドラッグ |
US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
AR094277A1 (es) | 2012-12-21 | 2015-07-22 | Biogen Idec Inc | Derivados de fumarato sustituidos con deuterio |
US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
PT2970101T (pt) | 2013-03-14 | 2018-10-04 | Alkermes Pharma Ireland Ltd | Pró-fármacos de fumaratos e seu uso no tratamento de várias doenças |
US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
CN104098471A (zh) * | 2013-04-03 | 2014-10-15 | 南京卡文迪许生物工程技术有限公司 | 富马酸二甲酯多晶型物及其制备方法和药物组合物 |
WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
JP2016534133A (ja) | 2013-09-06 | 2016-11-04 | ゼノポート,インコーポレイティド | (n,n−ジエチルカルバモイル)メチル メチル(2e)ブト−2−エン−1,4−ジオエートの結晶形態、その合成方法及び使用 |
IN2013MU03070A (es) * | 2013-09-25 | 2015-07-17 | Glenmark Pharmaceuticals Ltd | |
EP3097075A4 (en) * | 2014-01-24 | 2017-06-21 | Shilpa Medicare Limited | Process for preparation of dimethyl-(e)-butenedioate |
NZ723269A (en) | 2014-02-24 | 2017-04-28 | Alkermes Pharma Ireland Ltd | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
CA2939990C (en) | 2014-02-28 | 2018-07-10 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
EP3119741B1 (en) * | 2014-03-17 | 2019-12-18 | Biophore India Pharmaceuticals Pvt. Ltd. | An improved process for the synthesis of dimethyl fumarate |
US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
WO2016001093A1 (en) * | 2014-07-03 | 2016-01-07 | Synthon B.V. | Process for making microcrystalline dimethyl fumarate |
CN104151165B (zh) * | 2014-08-11 | 2016-08-24 | 广东东阳光药业有限公司 | 制备富马酸二甲酯的方法 |
CN104761453A (zh) * | 2015-04-22 | 2015-07-08 | 河南中帅医药科技股份有限公司 | 一种富马酸二甲酯晶型及其制备方法 |
AU2016273068A1 (en) * | 2015-06-01 | 2017-12-21 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical compositions of dimethyl fumarate |
CN107920997A (zh) * | 2015-06-17 | 2018-04-17 | 比奥根Ma公司 | 富马酸二甲酯颗粒和其药物组合物 |
CN106316841A (zh) * | 2015-06-30 | 2017-01-11 | 深圳翰宇药业股份有限公司 | 一种富马酸二甲酯的制备方法 |
WO2017013672A1 (en) * | 2015-07-23 | 2017-01-26 | Natco Pharma Ltd | Process for the preparation of pharmaceutical grade dimethyl fumarate |
US10011663B2 (en) | 2016-02-04 | 2018-07-03 | Eastman Chemical Company | Vulcanizing composition containing cyclododecasulfur and improved cyclododecasulfur compound |
RU2616605C1 (ru) * | 2016-04-07 | 2017-04-18 | Олег Ростиславович Михайлов | Кристаллическая бета - модификация (Е)-диметилбутендиоата, способ её получения и фармацевтическая композиция на её основе |
CN107285320A (zh) * | 2017-08-02 | 2017-10-24 | 内蒙古新福地科技有限公司 | 一种氟硅酸钠的结晶方法及装置 |
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