CY1119920T1 - Μεθοδος για την παρασκευη υψηλης καθαροτητας και κρυσταλλικου φουμαρικου διμεθυλεστερα - Google Patents

Μεθοδος για την παρασκευη υψηλης καθαροτητας και κρυσταλλικου φουμαρικου διμεθυλεστερα

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Publication number
CY1119920T1
CY1119920T1 CY20181100183T CY181100183T CY1119920T1 CY 1119920 T1 CY1119920 T1 CY 1119920T1 CY 20181100183 T CY20181100183 T CY 20181100183T CY 181100183 T CY181100183 T CY 181100183T CY 1119920 T1 CY1119920 T1 CY 1119920T1
Authority
CY
Cyprus
Prior art keywords
fumar
crystal
preparing high
high pure
dimethyl fumarate
Prior art date
Application number
CY20181100183T
Other languages
English (en)
Inventor
John Guzowski
William Kiesman
Erwin IRDAM
Original Assignee
Biogen Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47296498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119920(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Ma Inc. filed Critical Biogen Ma Inc.
Publication of CY1119920T1 publication Critical patent/CY1119920T1/el

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/48Separation; Purification; Stabilisation; Use of additives
    • C07C67/62Use of additives, e.g. for stabilisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/08Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/28Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/297Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/48Separation; Purification; Stabilisation; Use of additives
    • C07C67/52Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60Maleic acid esters; Fumaric acid esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/604Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα εφεύρεση περιγράφει μία μέθοδο για την παρασκευή φουμαρικού διμεθυλεστέρα. Η μέθοδος περιλαμβάνει την εστεροποίηση φουμαρικού οξέος και μεθανόλης παρουσία θειικού οξέος ως ενός καταλύτη οξέος. Ο υψηλής καθαρότητας φουμαρικός διμεθυλεστέρας δεν περιέχει περισσότερο από ποσότητες ιχνών θειικού διμεθυλεστέρα. Η παρούσα εφεύρεση παρέχει επίσης μία μέθοδο για την παρασκευή φουμαρικού διμεθυλεστέρα υψηλής καθαρότητας με ένα μέγεθος σωματιδίων από 20 έως 250 μm.
CY20181100183T 2011-06-08 2018-02-14 Μεθοδος για την παρασκευη υψηλης καθαροτητας και κρυσταλλικου φουμαρικου διμεθυλεστερα CY1119920T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161494775P 2011-06-08 2011-06-08
PCT/US2012/041715 WO2012170923A1 (en) 2011-06-08 2012-06-08 Process for preparing high purity and crystalline dimethyl fumarate

Publications (1)

Publication Number Publication Date
CY1119920T1 true CY1119920T1 (el) 2018-06-27

Family

ID=47296498

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100183T CY1119920T1 (el) 2011-06-08 2018-02-14 Μεθοδος για την παρασκευη υψηλης καθαροτητας και κρυσταλλικου φουμαρικου διμεθυλεστερα

Country Status (30)

Country Link
US (1) US9422226B2 (el)
EP (1) EP2718257B1 (el)
JP (3) JP6385273B6 (el)
KR (2) KR20140035995A (el)
CN (1) CN103649041A (el)
AU (1) AU2012267524A1 (el)
BR (1) BR112013031616A2 (el)
CA (1) CA2838271A1 (el)
CL (1) CL2013003483A1 (el)
CO (1) CO6821956A2 (el)
CY (1) CY1119920T1 (el)
DK (1) DK2718257T3 (el)
EA (1) EA201391638A1 (el)
EC (1) ECSP14013123A (el)
ES (1) ES2659771T3 (el)
HR (1) HRP20180203T1 (el)
HU (1) HUE036085T2 (el)
IL (1) IL229656A0 (el)
LT (1) LT2718257T (el)
ME (1) ME02960B (el)
MX (1) MX355421B (el)
NO (1) NO2820009T3 (el)
NZ (1) NZ618178A (el)
PE (1) PE20141639A1 (el)
PL (1) PL2718257T3 (el)
PT (1) PT2718257T (el)
RS (1) RS56972B1 (el)
SG (1) SG195227A1 (el)
SI (1) SI2718257T1 (el)
WO (1) WO2012170923A1 (el)

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