RS56972B1 - Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata - Google Patents

Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata

Info

Publication number
RS56972B1
RS56972B1 RS20180175A RSP20180175A RS56972B1 RS 56972 B1 RS56972 B1 RS 56972B1 RS 20180175 A RS20180175 A RS 20180175A RS P20180175 A RSP20180175 A RS P20180175A RS 56972 B1 RS56972 B1 RS 56972B1
Authority
RS
Serbia
Prior art keywords
high purity
preparing high
dimethyl fumarate
crystalline dimethyl
crystalline
Prior art date
Application number
RS20180175A
Other languages
English (en)
Inventor
John Guzowski
William KIESMAN
Erwin Irdam
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47296498&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS56972(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of RS56972B1 publication Critical patent/RS56972B1/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
    • C07C69/60—Maleic acid esters; Fumaric acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
RS20180175A 2011-06-08 2012-06-08 Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata RS56972B1 (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161494775P 2011-06-08 2011-06-08
PCT/US2012/041715 WO2012170923A1 (en) 2011-06-08 2012-06-08 Process for preparing high purity and crystalline dimethyl fumarate
EP12796164.7A EP2718257B1 (en) 2011-06-08 2012-06-08 Process for preparing high purity and crystalline dimethyl fumarate

Publications (1)

Publication Number Publication Date
RS56972B1 true RS56972B1 (sr) 2018-05-31

Family

ID=47296498

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20180175A RS56972B1 (sr) 2011-06-08 2012-06-08 Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata

Country Status (30)

Country Link
US (1) US9422226B2 (sr)
EP (1) EP2718257B1 (sr)
JP (3) JP6385273B6 (sr)
KR (2) KR20140035995A (sr)
CN (1) CN103649041A (sr)
AU (1) AU2012267524A1 (sr)
BR (1) BR112013031616A2 (sr)
CA (1) CA2838271A1 (sr)
CL (1) CL2013003483A1 (sr)
CO (1) CO6821956A2 (sr)
CY (1) CY1119920T1 (sr)
DK (1) DK2718257T3 (sr)
EA (1) EA201391638A1 (sr)
EC (1) ECSP14013123A (sr)
ES (1) ES2659771T3 (sr)
HR (1) HRP20180203T1 (sr)
HU (1) HUE036085T2 (sr)
IL (1) IL229656A0 (sr)
LT (1) LT2718257T (sr)
ME (1) ME02960B (sr)
MX (1) MX355421B (sr)
NO (1) NO2820009T3 (sr)
NZ (1) NZ618178A (sr)
PE (1) PE20141639A1 (sr)
PL (1) PL2718257T3 (sr)
PT (1) PT2718257T (sr)
RS (1) RS56972B1 (sr)
SG (1) SG195227A1 (sr)
SI (1) SI2718257T1 (sr)
WO (1) WO2012170923A1 (sr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1663197T1 (sl) 2003-09-09 2008-06-30 Biogen Idec Internat Gmbh Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme
PT2801355E (pt) 2004-10-08 2015-09-18 Forward Pharma As Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico
PL2334378T3 (pl) 2008-08-19 2014-09-30 Xenoport Inc Proleki wodorofumaranu metylu, ich kompozycje farmaceutyczne i sposoby zastosowania
PL2718257T3 (pl) 2011-06-08 2018-04-30 Biogen Ma Inc. Sposób przygotowywania dimetylofumaranu krystalicznego o wysokiej czystości
US10945984B2 (en) 2012-08-22 2021-03-16 Arbor Pharmaceuticals, Llc Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects
JP2015526477A (ja) 2012-08-22 2015-09-10 ゼノポート，インコーポレイティド メチル水素フマレートの経口剤形およびそのプロドラッグ
AR094277A1 (es) 2012-12-21 2015-07-22 Biogen Idec Inc Derivados de fumarato sustituidos con deuterio
SG11201507371RA (en) 2013-03-14 2015-10-29 Alkermes Pharma Ireland Ltd Prodrugs of fumarates and their use in treating various deseases
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
US10179118B2 (en) 2013-03-24 2019-01-15 Arbor Pharmaceuticals, Llc Pharmaceutical compositions of dimethyl fumarate
CN104098471A (zh) * 2013-04-03 2014-10-15 南京卡文迪许生物工程技术有限公司 富马酸二甲酯多晶型物及其制备方法和药物组合物
WO2014197860A1 (en) 2013-06-07 2014-12-11 Xenoport, Inc. Method of making monomethyl fumarate
WO2014205392A1 (en) 2013-06-21 2014-12-24 Xenoport, Inc. Cocrystals of dimethyl fumarate
US9416096B2 (en) 2013-09-06 2016-08-16 Xenoport, Inc. Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use
WO2015044853A2 (en) * 2013-09-25 2015-04-02 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of dimethyl fumarate
IN2014CH00308A (sr) * 2014-01-24 2015-07-31 Shilpa Medicare Ltd
CA2940845C (en) 2014-02-24 2019-09-24 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
EP3110408B1 (en) 2014-02-28 2019-01-16 Banner Life Sciences LLC Controlled release enteric soft capsules of fumarate esters
US9636318B2 (en) 2015-08-31 2017-05-02 Banner Life Sciences Llc Fumarate ester dosage forms
US10098863B2 (en) 2014-02-28 2018-10-16 Banner Life Sciences Llc Fumarate esters
US9326947B1 (en) 2014-02-28 2016-05-03 Banner Life Sciences Llc Controlled release fumarate esters
EP3119741B1 (en) * 2014-03-17 2019-12-18 Biophore India Pharmaceuticals Pvt. Ltd. An improved process for the synthesis of dimethyl fumarate
US9999672B2 (en) 2014-03-24 2018-06-19 Xenoport, Inc. Pharmaceutical compositions of fumaric acid esters
WO2016001093A1 (en) * 2014-07-03 2016-01-07 Synthon B.V. Process for making microcrystalline dimethyl fumarate
CN104151165B (zh) * 2014-08-11 2016-08-24 广东东阳光药业有限公司 制备富马酸二甲酯的方法
CN104761453A (zh) * 2015-04-22 2015-07-08 河南中帅医药科技股份有限公司 一种富马酸二甲酯晶型及其制备方法
AU2016273068A1 (en) * 2015-06-01 2017-12-21 Sun Pharmaceutical Industries Ltd. Pharmaceutical compositions of dimethyl fumarate
CN107920997A (zh) * 2015-06-17 2018-04-17 比奥根Ma公司 富马酸二甲酯颗粒和其药物组合物
CN106316841A (zh) * 2015-06-30 2017-01-11 深圳翰宇药业股份有限公司 一种富马酸二甲酯的制备方法
WO2017013672A1 (en) * 2015-07-23 2017-01-26 Natco Pharma Ltd Process for the preparation of pharmaceutical grade dimethyl fumarate
US10011663B2 (en) 2016-02-04 2018-07-03 Eastman Chemical Company Vulcanizing composition containing cyclododecasulfur and improved cyclododecasulfur compound
RU2616605C1 (ru) * 2016-04-07 2017-04-18 Олег Ростиславович Михайлов Кристаллическая бета - модификация (Е)-диметилбутендиоата, способ её получения и фармацевтическая композиция на её основе
CN107285320A (zh) * 2017-08-02 2017-10-24 内蒙古新福地科技有限公司 一种氟硅酸钠的结晶方法及装置
JP7153069B2 (ja) 2017-10-10 2022-10-13 ファイザー・インク ロルラチニブ遊離塩基水和物の結晶形態
US11903918B2 (en) 2020-01-10 2024-02-20 Banner Life Sciences Llc Fumarate ester dosage forms with enhanced gastrointestinal tolerability
KR102271575B1 (ko) * 2020-09-16 2021-07-01 김갑용 염의 이온교환법을 이용한 친환경 고효율 에스터화반응 기반의 에스터화합물 제조방법 및 이의 화합물
JP6865489B1 (ja) * 2020-10-20 2021-04-28 株式会社エス・ディー・エス バイオテック ２，３，５，６−テトラクロロ−１，４−ベンゼンジカルボン酸ジメチルの製造方法

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1848724A (en) 1932-03-08 Alphons
US2764609A (en) * 1953-07-24 1956-09-25 Monsanto Chemicals Isomerization of dialkyl maleates to dialkyl fumarates
US3078302A (en) * 1958-09-25 1963-02-19 Monsanto Chemicals Production of dialkyl fumarates
US3993684A (en) 1971-08-20 1976-11-23 Western Litho Plate & Supply Co. Monomeric compounds
US4866187A (en) 1976-09-24 1989-09-12 Exxon Research & Engineering Company Thio-bis(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions
US4568756A (en) 1976-09-24 1986-02-04 Exxon Research & Engineering Co. Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions
US4417062A (en) 1976-09-24 1983-11-22 Exxon Research & Engineering Co. Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions
US4239636A (en) 1978-10-23 1980-12-16 Exxon Research & Engineering Co. Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions
US5118835A (en) 1976-09-24 1992-06-02 Exxon Research & Engineering Co. Thio-bis(alkyl lactone acid esters) and thio-bis (Hydrocarbyl diacid esters) are usefull additives for lubricating compositions
US4965375A (en) 1976-09-24 1990-10-23 Exxon Research And Engineering Co. Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions
JPS60193946U (ja) 1984-03-01 1985-12-24 内山　茂夫 変色炎を有するろうそく
JPS60193946A (ja) * 1984-03-16 1985-10-02 Nippon Oil & Fats Co Ltd ジイソプロピルフマレ−トの製造法
US5149695A (en) 1985-01-15 1992-09-22 Speiser Peter P Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same
CH664150A5 (de) 1985-01-15 1988-02-15 Peter Paul Prof Dr Speiser Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen.
JPS61246147A (ja) 1985-04-22 1986-11-01 Nippon Shokubai Kagaku Kogyo Co Ltd マレイン酸ジアルキルエステルの精製方法
US4866139A (en) 1986-10-07 1989-09-12 Exxon Chemical Patents Inc. Lactone modified, esterified dispersant additives useful in oleaginous compositions
US4954276A (en) 1986-10-07 1990-09-04 Exxon Chemical Patents Inc. Lactone modified adducts or reactants and oleaginous compositions containing same
US4954277A (en) 1986-10-07 1990-09-04 Exxon Chemical Patents Inc. Lactone modified, esterified or aminated additives useful in oleaginous compositions and compositions containing same
US4963275A (en) 1986-10-07 1990-10-16 Exxon Chemical Patents Inc. Dispersant additives derived from lactone modified amido-amine adducts
US4906394A (en) 1986-10-07 1990-03-06 Exxon Chemical Patents Inc. Lactone modified mono-or dicarboxylic acid based adduct dispersant compositions
US5032320A (en) 1986-10-07 1991-07-16 Exxon Chemical Patents Inc. Lactone modified mono- or dicarboxylic acid based adduct dispersant compositions
US4866140A (en) 1986-10-07 1989-09-12 Exxon Chemical Patents Inc. Lactone modified adducts or reactants and oleaginous compositions containing same
DE3711155A1 (de) 1987-04-02 1988-10-13 Bayer Ag Verfahren zur herstellung von maleinsaeuredimethylester
US4820432A (en) 1987-07-24 1989-04-11 Exxon Chemical Patents Inc. Lactone-modified, Mannich base dispersant additives useful in oleaginous compositions
US4971711A (en) 1987-07-24 1990-11-20 Exxon Chemical Patents, Inc. Lactone-modified, mannich base dispersant additives useful in oleaginous compositions
US4959389A (en) 1987-10-19 1990-09-25 Speiser Peter P Pharmaceutical preparation for the treatment of psoriatic arthritis
US5424332A (en) 1987-10-19 1995-06-13 Speiser; Peter P. Pharmaceutical composition and process for the production thereof
US4943382A (en) 1988-04-06 1990-07-24 Exxon Chemical Patents Inc. Lactone modified dispersant additives useful in oleaginous compositions
US5153352A (en) 1988-10-25 1992-10-06 Bristol-Myers Squibb Company Process for preparation of intermediates of carbocyclic nucleoside analogs
ES2103536T3 (es) 1993-01-21 1997-09-16 Akzo Nobel Nv Dispersiones polimeras acuosas de secado al aire.
CN1103398A (zh) * 1993-11-30 1995-06-07 张治明 一种由顺酐生产富马酸二甲酯的工艺方法
US6100339A (en) 1994-11-21 2000-08-08 Asahi Kasei Kogyo Kabushiki Kaisha Curable resin and resin composition comprising the same
EP0923559A1 (en) 1996-06-24 1999-06-23 Cytec Technology Corp. Polymerizable urea/ureido functional monomers
US6239189B1 (en) 1997-04-01 2001-05-29 Henkel Corporation Radiation-polymerizable composition and printing inks containing same
DE19721099C2 (de) 1997-05-20 1999-12-02 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten
US6376702B1 (en) 1997-07-11 2002-04-23 Showa Denko K.K. Ether compound, production thereof and curable compositions
JP4050330B2 (ja) 1997-07-11 2008-02-20 昭和電工株式会社 新規なエーテル化合物およびその製造法
GB9724004D0 (en) 1997-11-13 1998-10-21 Kvaerner Process Tech Ltd Process
DE19814358C2 (de) 1998-03-31 2002-01-17 Fumapharm Ag Muri Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn
DE19839566C2 (de) 1998-08-31 2002-01-17 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten in der Transplantationsmedizin
DE19848260C2 (de) 1998-10-20 2002-01-17 Fumapharm Ag Muri Fumarsäure-Mikrotabletten
DE19853487A1 (de) 1998-11-19 2000-05-25 Fumapharm Ag Muri Verwendung von Dialkylfumaraten
US7056965B2 (en) 1999-12-27 2006-06-06 Asahi Kasei Kabushiki Kaisha Polyoxymethylene resin composition
DE10000577A1 (de) 2000-01-10 2001-07-26 Fumapharm Ag Muri Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten
KR20010112941A (ko) 2000-02-15 2001-12-22 오하시 미츠오 푸마르산에스테르류의 제조방법
JP2001281800A (ja) 2000-03-31 2001-10-10 Konica Corp 熱現像写真感光材料
US6586452B1 (en) 2000-07-14 2003-07-01 Merck & Co., Inc. C1 to C4 side chain modified nodulisporic acid analogs
US20020098451A1 (en) 2000-09-07 2002-07-25 Tadashi Arimoto Photothermographic material
DE10101307A1 (de) 2001-01-12 2002-08-01 Fumapharm Ag Muri Fumarsäurederivate als NF-kappaB-Inhibitor
ATE447945T1 (de) 2001-01-12 2009-11-15 Biogen Idec Internat Gmbh Verwendung von fumarsäureamiden
JP2003160535A (ja) 2001-11-28 2003-06-03 Nof Corp 不飽和二塩基酸ジエステルの製造方法
CN100509751C (zh) 2002-02-28 2009-07-08 住友化学株式会社 苯并吡喃酮化合物的制备方法
DE10217314A1 (de) 2002-04-18 2003-11-13 Fumapharm Ag Muri Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere
JP2003315960A (ja) 2002-04-25 2003-11-06 Konica Minolta Holdings Inc 銀塩光熱写真ドライイメージング材料
JP4259815B2 (ja) 2002-06-06 2009-04-30 ダイセル化学工業株式会社 高純度酢酸ブチルの製造方法
SI1663197T1 (sl) 2003-09-09 2008-06-30 Biogen Idec Internat Gmbh Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme
JP4163653B2 (ja) 2004-02-27 2008-10-08 株式会社日本触媒 光学部品用硬化性組成物
US7557241B2 (en) 2004-08-30 2009-07-07 Sanyo Chemical Industries, Ltd. Method for producing α,β-unsaturated carboxylic acid ester, α,β-unsaturated carboxylic acid ester, and lubricating oil additive
PT2801355E (pt) 2004-10-08 2015-09-18 Forward Pharma As Composições farmacêuticas de libertação controlada compreendendo um éster de ácido fumárico
TWI279403B (en) * 2004-10-20 2007-04-21 Eternal Chemical Co Ltd Cyclobutanetetracarboxylate compound and preparation method thereof
EP1812374A1 (en) 2004-11-10 2007-08-01 Aditech Pharma AB Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
EP2199304A1 (en) 2004-12-17 2010-06-23 Metanomics GmbH Process for the control of production of fine chemicals
EP1875312B1 (en) 2005-04-22 2009-12-02 Canon Kabushiki Kaisha Magnetic toner
DE102005022845A1 (de) 2005-05-18 2006-11-23 Fumapharm Ag Thiobernsteinsäurederivate und deren Verwendung
WO2007006307A2 (en) 2005-07-07 2007-01-18 Aditech Pharma Ab Novel salts of fumaric acid monoalkylesters and their pharmaceutical use
TW200707103A (en) 2005-08-12 2007-02-16 Lion Corp Photoresist polymer having nanosmoothness and etching resistance and resist composition
WO2007042034A1 (en) 2005-10-07 2007-04-19 Aditech Pharma Ab Controlled release pharmaceutical compositions comprising a fumaric acid ester
WO2007042035A2 (en) 2005-10-07 2007-04-19 Aditech Pharma Ab Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders
JP2009539386A (ja) 2006-06-16 2009-11-19 ガムリンク エー／エス 疎水性酵素配合物を含むチューインガム
ES2599227T3 (es) 2007-02-08 2017-01-31 Biogen Ma Inc. Neuroprotección en enfermedades desmielinizantes
ES2916604T1 (es) 2007-02-08 2022-07-04 Biogen Ma Inc Ensayos de detección de nrf2 y métodos y composiciones relacionados
TWI525195B (zh) 2007-08-10 2016-03-11 奇諾麥提卡公司 合成烯酸及其衍生物之方法
EP2219783B1 (en) 2007-10-26 2017-10-11 Purolite International, Ltd. Controlled catalysis
WO2009075303A1 (ja) 2007-12-12 2009-06-18 Mitsubishi Chemical Corporation 脂肪族ポリエステル樹脂及びその製造方法
EP2564839B1 (en) 2009-01-09 2016-05-11 Forward Pharma A/S Pharmaceutical formulation comprising one or more fumaric acid esters in an erosion matrix
JP2012525385A (ja) 2009-04-29 2012-10-22 バイオジェン・アイデック・エムエイ・インコーポレイテッド 神経変性および神経炎症の治療
JP5615920B2 (ja) 2009-08-07 2014-10-29 インヴィスタ テクノロジーズ エスアエルエル ジエステルを形成するための水素化およびエステル化
RS54551B1 (sr) 2010-02-12 2016-06-30 Biogen Ma Inc. Neuroprotekcija kod demijelinizujućih bolesti
CN102757346A (zh) 2011-04-26 2012-10-31 中国科学院兰州化学物理研究所 一种富马酸二甲酯的制备方法
JP2014515373A (ja) 2011-05-26 2014-06-30 バイオジェン・アイデック・エムエイ・インコーポレイテッド 多発性硬化症の治療方法およびミエリン量を保存および／または増加させる方法
PL2718257T3 (pl) 2011-06-08 2018-04-30 Biogen Ma Inc. Sposób przygotowywania dimetylofumaranu krystalicznego o wysokiej czystości
CN102432464A (zh) 2011-12-14 2012-05-02 费近峰 一种富马酸二甲酯的连续生产工艺
CN114146079A (zh) 2012-02-07 2022-03-08 比奥根玛公司 含有富马酸二甲酯的药物组合物
CN102766050A (zh) 2012-08-10 2012-11-07 太仓市运通化工厂 一种富马酸二甲酯的合成方法
AR094277A1 (es) 2012-12-21 2015-07-22 Biogen Idec Inc Derivados de fumarato sustituidos con deuterio
CN103848739A (zh) 2014-03-20 2014-06-11 徐晓宁 一种高纯度富马酸二甲酯的生产方法

Also Published As

Publication number Publication date
WO2012170923A1 (en) 2012-12-13
EP2718257A4 (en) 2015-08-12
JP2016155868A (ja) 2016-09-01
MX355421B (es) 2018-04-18
HRP20180203T1 (hr) 2018-04-06
KR20140035995A (ko) 2014-03-24
ECSP14013123A (es) 2014-06-30
SG195227A1 (en) 2013-12-30
JP6385273B6 (ja) 2023-12-15
SI2718257T1 (en) 2018-04-30
CY1119920T1 (el) 2018-06-27
CL2013003483A1 (es) 2014-05-09
EP2718257B1 (en) 2017-11-15
CN103649041A (zh) 2014-03-19
AU2012267524A1 (en) 2013-12-12
JP2018162266A (ja) 2018-10-18
JP2014522413A (ja) 2014-09-04
HUE036085T2 (hu) 2018-06-28
US20140200363A1 (en) 2014-07-17
MX2013014320A (es) 2014-01-31
NZ618178A (en) 2016-03-31
LT2718257T (lt) 2018-03-12
CO6821956A2 (es) 2013-12-31
KR20150080037A (ko) 2015-07-08
EA201391638A1 (ru) 2014-05-30
US9422226B2 (en) 2016-08-23
NO2820009T3 (sr) 2018-06-30
CA2838271A1 (en) 2012-12-13
PE20141639A1 (es) 2014-11-08
PT2718257T (pt) 2018-02-26
BR112013031616A2 (pt) 2016-12-06
EP2718257A1 (en) 2014-04-16
PL2718257T3 (pl) 2018-04-30
JP6385273B2 (ja) 2018-09-05
ES2659771T3 (es) 2018-03-19
IL229656A0 (en) 2014-01-30
DK2718257T3 (en) 2018-02-12
ME02960B (me) 2018-07-20

Similar Documents

Publication Publication Date Title
IL229656A0 (en) A process for the preparation of crystalline dimethyl fumarate with a high level of purity
HK1260896A1 (zh) 天然水晶著色劑及其生產方法
EP2743336A4 (en) PROCESS FOR THE PRODUCTION OF HIGH-PURITY BIODIESEL
HK1202709A1 (en) Process for preparing crystalline electrode materials and materials obtained therefrom
EP2801645A4 (en) METHOD FOR THE DEVELOPMENT OF A Beta-Ga2O3 MONOCRYSTAL
PL2785701T3 (pl) Krystaliczna postać kabazytakselu i sposób jej otrzymywania
IL227872A0 (en) A process for the preparation of n-converted phenylhydroxylamines
ZA201207386B (en) Process for preparing benzoxaboroles
HUE038800T2 (hu) Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
EP2690204A4 (en) METHOD FOR PRODUCING A NITRIDE CRYSTAL
PL2753620T3 (pl) Nowy sposób otrzymywania fosamilu ceftaroliny
EP2792640A4 (en) METHOD FOR THE PRODUCTION OF HIGH-PURITY CHLOROPOLYSILANE
HK1205047A1 (en) Reactor and process for producing high-purity silicon
EP2585436A4 (en) PROCESS FOR THE PREPARATION OF 4-HYDROXYPYRIDINES
PL2897903T3 (pl) Sposób wytwarzania produktu w postaci krystalicznego siarczanu amonu
IL223145A0 (en) Process for preparing dithiine-tetracarboxy-diimides
EP2662376A4 (en) PROCESS FOR THE PRODUCTION OF TORISEL
EP2666459A4 (en) METHOD FOR PRODUCING A VESICLE COMPOSITION
HUP1400301A2 (en) Method for producing high-purity crystalline carbamide
HRP20160767T1 (hr) Postupak za pripremu kristalnog oblika i agomelatina
HUP1100071A2 (en) Novel process for producing dronic acids
GB2504444B (en) Process for preparing vaccine composition