SI1663197T1 - Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme - Google Patents
Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astmeInfo
- Publication number
- SI1663197T1 SI1663197T1 SI200430558T SI200430558T SI1663197T1 SI 1663197 T1 SI1663197 T1 SI 1663197T1 SI 200430558 T SI200430558 T SI 200430558T SI 200430558 T SI200430558 T SI 200430558T SI 1663197 T1 SI1663197 T1 SI 1663197T1
- Authority
- SI
- Slovenia
- Prior art keywords
- fumaric acid
- asthma
- fumarates
- monoalkyl
- monoamido
- Prior art date
Links
- 150000002237 fumaric acid derivatives Chemical class 0.000 title abstract 3
- 206010019280 Heart failures Diseases 0.000 title abstract 2
- 206010007522 Cardiac asthma Diseases 0.000 title 1
- 208000004327 Paroxysmal Dyspnea Diseases 0.000 title 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical class OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 8
- 208000006673 asthma Diseases 0.000 abstract 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical class [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 abstract 4
- FSQQTNAZHBEJLS-OWOJBTEDSA-N (e)-4-amino-4-oxobut-2-enoic acid Chemical class NC(=O)\C=C\C(O)=O FSQQTNAZHBEJLS-OWOJBTEDSA-N 0.000 abstract 2
- BSSNZUFKXJJCBG-OWOJBTEDSA-N (e)-but-2-enediamide Chemical class NC(=O)\C=C\C(N)=O BSSNZUFKXJJCBG-OWOJBTEDSA-N 0.000 abstract 2
- 125000002837 carbocyclic group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- -1 ester salts Chemical class 0.000 abstract 2
- 239000001530 fumaric acid Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 2
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 206010024119 Left ventricular failure Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10341530 | 2003-09-09 | ||
| DE10360869A DE10360869A1 (de) | 2003-09-09 | 2003-12-23 | Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma |
| PCT/EP2004/009835 WO2005023241A1 (en) | 2003-09-09 | 2004-09-03 | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
| EP04764790A EP1663197B1 (en) | 2003-09-09 | 2004-09-03 | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1663197T1 true SI1663197T1 (sl) | 2008-06-30 |
Family
ID=34276548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200430558T SI1663197T1 (sl) | 2003-09-09 | 2004-09-03 | Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20070027076A1 (sl) |
| EP (2) | EP1913942B1 (sl) |
| AT (1) | ATE380027T1 (sl) |
| AU (1) | AU2004269903B2 (sl) |
| BR (1) | BRPI0410805A (sl) |
| CA (1) | CA2526586C (sl) |
| DE (1) | DE602004010531T2 (sl) |
| DK (1) | DK1663197T3 (sl) |
| ES (1) | ES2297461T3 (sl) |
| MX (1) | MXPA06002657A (sl) |
| NO (1) | NO335991B1 (sl) |
| PL (1) | PL1663197T3 (sl) |
| RU (1) | RU2313339C2 (sl) |
| SI (1) | SI1663197T1 (sl) |
| WO (1) | WO2005023241A1 (sl) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| CZ304198B6 (cs) | 2001-01-12 | 2013-12-27 | Fumapharm Ag | Amidy kyseliny fumarové |
| SI1663197T1 (sl) | 2003-09-09 | 2008-06-30 | Biogen Idec Internat Gmbh | Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme |
| ES2582942T3 (es) | 2004-10-08 | 2016-09-16 | Forward Pharma A/S | Composiciones farmacéuticas de liberación controlada que comprenden un éster de ácido fumárico |
| TWI405756B (zh) | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| US20100130607A1 (en) * | 2007-02-08 | 2010-05-27 | Ralf Gold | Neuroprotection in demyelinating diseases |
| PL2137537T3 (pl) | 2007-02-08 | 2013-10-31 | Biogen Ma Inc | Kompozycje i zastosowania do leczenia stwardnienia rozsianego |
| DE102008030023A1 (de) | 2008-06-16 | 2009-12-17 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung einer durch Parasiten verursachten Krankheit |
| RU2383345C1 (ru) * | 2008-08-07 | 2010-03-10 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Росздрава" (ГОУ ВПО "НИЖГМА РОСЗДРАВА") | Способ лечения больных бронхиальной астмой |
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
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| EA201391638A1 (ru) | 2011-06-08 | 2014-05-30 | Байоджен Айдек Ма Инк. | Способ получения высокочистого и кристаллического диметилфумарата |
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| EP2887933A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| WO2014071371A1 (en) | 2012-11-05 | 2014-05-08 | Xenoport, Inc. | Cocrystals of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate |
| EP3566701A1 (en) | 2012-12-21 | 2019-11-13 | Biogen MA Inc. | Deuterium substituted fumarate derivatives |
| JP6373353B2 (ja) | 2013-03-14 | 2018-08-15 | アルカーメス ファーマ アイルランド リミテッド | フマル酸エステルのプロドラッグおよび種々の疾患の治療におけるその使用 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| WO2015035184A1 (en) | 2013-09-06 | 2015-03-12 | Xenoport, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
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| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| AU2015222880B2 (en) | 2014-02-28 | 2016-11-24 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016061393A1 (en) | 2014-10-15 | 2016-04-21 | Xenoport, Inc. | Fumarate compounds, pharmaceutical compositions, and methods of use |
| WO2016074684A1 (en) * | 2014-11-11 | 2016-05-19 | Syddansk Universitet | Fumaric acid derivatives for medical use |
| UA121323C2 (uk) | 2015-02-08 | 2020-05-12 | Алкермес Фарма Айрленд Лімітед | Композиції на основі проліків монометилфумарату |
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-
2004
- 2004-09-03 SI SI200430558T patent/SI1663197T1/sl unknown
- 2004-09-03 DE DE602004010531T patent/DE602004010531T2/de not_active Expired - Lifetime
- 2004-09-03 MX MXPA06002657A patent/MXPA06002657A/es active IP Right Grant
- 2004-09-03 DK DK04764790T patent/DK1663197T3/da active
- 2004-09-03 US US10/571,241 patent/US20070027076A1/en not_active Abandoned
- 2004-09-03 EP EP07121903A patent/EP1913942B1/en not_active Expired - Lifetime
- 2004-09-03 PL PL04764790T patent/PL1663197T3/pl unknown
- 2004-09-03 WO PCT/EP2004/009835 patent/WO2005023241A1/en not_active Ceased
- 2004-09-03 EP EP04764790A patent/EP1663197B1/en not_active Expired - Lifetime
- 2004-09-03 ES ES04764790T patent/ES2297461T3/es not_active Expired - Lifetime
- 2004-09-03 AU AU2004269903A patent/AU2004269903B2/en not_active Ceased
- 2004-09-03 RU RU2005141547/15A patent/RU2313339C2/ru not_active IP Right Cessation
- 2004-09-03 BR BRPI0410805-1A patent/BRPI0410805A/pt not_active IP Right Cessation
- 2004-09-03 AT AT04764790T patent/ATE380027T1/de active
- 2004-09-03 CA CA2526586A patent/CA2526586C/en not_active Expired - Fee Related
-
2006
- 2006-03-24 NO NO20061340A patent/NO335991B1/no not_active IP Right Cessation
-
2010
- 2010-09-17 US US12/884,573 patent/US8980832B2/en not_active Expired - Lifetime
-
2015
- 2015-03-12 US US14/656,505 patent/US20160030374A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK1663197T3 (da) | 2008-01-07 |
| NO335991B1 (no) | 2015-04-13 |
| RU2313339C2 (ru) | 2007-12-27 |
| PL1663197T3 (pl) | 2008-09-30 |
| EP1913942A2 (en) | 2008-04-23 |
| AU2004269903B2 (en) | 2010-09-02 |
| NO20061340L (no) | 2006-03-24 |
| MXPA06002657A (es) | 2006-06-05 |
| EP1913942B1 (en) | 2009-11-11 |
| EP1913942A3 (en) | 2008-05-21 |
| BRPI0410805A (pt) | 2006-06-27 |
| WO2005023241A1 (en) | 2005-03-17 |
| ATE380027T1 (de) | 2007-12-15 |
| US20110124615A1 (en) | 2011-05-26 |
| AU2004269903A1 (en) | 2005-03-17 |
| EP1663197A1 (en) | 2006-06-07 |
| US20160030374A1 (en) | 2016-02-04 |
| ES2297461T3 (es) | 2008-05-01 |
| DE602004010531T2 (de) | 2008-07-03 |
| CA2526586A1 (en) | 2005-03-17 |
| CA2526586C (en) | 2010-03-16 |
| DE602004010531D1 (de) | 2008-01-17 |
| EP1663197B1 (en) | 2007-12-05 |
| US8980832B2 (en) | 2015-03-17 |
| RU2005141547A (ru) | 2006-06-10 |
| US20070027076A1 (en) | 2007-02-01 |
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