PL1663197T3 - Zastosowanie pochodnych kwasu fumarowego do leczenia niewydolności serca oraz astmy - Google Patents
Zastosowanie pochodnych kwasu fumarowego do leczenia niewydolności serca oraz astmyInfo
- Publication number
- PL1663197T3 PL1663197T3 PL04764790T PL04764790T PL1663197T3 PL 1663197 T3 PL1663197 T3 PL 1663197T3 PL 04764790 T PL04764790 T PL 04764790T PL 04764790 T PL04764790 T PL 04764790T PL 1663197 T3 PL1663197 T3 PL 1663197T3
- Authority
- PL
- Poland
- Prior art keywords
- fumaric acid
- asthma
- fumarates
- monoalkyl
- monoamido
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10341530 | 2003-09-09 | ||
| DE10360869A DE10360869A1 (de) | 2003-09-09 | 2003-12-23 | Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma |
| EP04764790A EP1663197B1 (en) | 2003-09-09 | 2004-09-03 | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
| PCT/EP2004/009835 WO2005023241A1 (en) | 2003-09-09 | 2004-09-03 | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1663197T3 true PL1663197T3 (pl) | 2008-09-30 |
Family
ID=34276548
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL04764790T PL1663197T3 (pl) | 2003-09-09 | 2004-09-03 | Zastosowanie pochodnych kwasu fumarowego do leczenia niewydolności serca oraz astmy |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US20070027076A1 (pl) |
| EP (2) | EP1913942B1 (pl) |
| AT (1) | ATE380027T1 (pl) |
| AU (1) | AU2004269903B2 (pl) |
| BR (1) | BRPI0410805A (pl) |
| CA (1) | CA2526586C (pl) |
| DE (1) | DE602004010531T2 (pl) |
| DK (1) | DK1663197T3 (pl) |
| ES (1) | ES2297461T3 (pl) |
| MX (1) | MXPA06002657A (pl) |
| NO (1) | NO335991B1 (pl) |
| PL (1) | PL1663197T3 (pl) |
| RU (1) | RU2313339C2 (pl) |
| SI (1) | SI1663197T1 (pl) |
| WO (1) | WO2005023241A1 (pl) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| AU2002219236B2 (en) | 2001-01-12 | 2006-02-09 | Biogen International Gmbh | Fumaric acid amides |
| ATE380027T1 (de) | 2003-09-09 | 2007-12-15 | Fumapharm Ag | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
| DE14172396T1 (de) * | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
| TWI405756B (zh) | 2005-12-21 | 2013-08-21 | Array Biopharma Inc | 新穎硫酸氫鹽 |
| WO2008096271A2 (en) * | 2007-02-08 | 2008-08-14 | Ralf Gold | Neuroprotection in demyelinating diseases |
| PT2137537E (pt) | 2007-02-08 | 2013-08-22 | Biogen Idec Inc | Composições e respectivas utilizações para o tratamento da esclerose múltipla |
| DE102008030023A1 (de) | 2008-06-16 | 2009-12-17 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Arzneimittel zur Behandlung einer durch Parasiten verursachten Krankheit |
| RU2383345C1 (ru) * | 2008-08-07 | 2010-03-10 | Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Росздрава" (ГОУ ВПО "НИЖГМА РОСЗДРАВА") | Способ лечения больных бронхиальной астмой |
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| CN109044985A (zh) | 2009-01-09 | 2018-12-21 | 前进制药知识产权有限公司 | 包含溶蚀骨架中的一种或多种富马酸酯的药物制剂 |
| CA2824391A1 (en) * | 2011-01-10 | 2012-07-19 | Sorbent Therapeutics, Inc. | Compositions comprising crosslinked cation-binding polymers and a base, uses thereof |
| MX355421B (es) | 2011-06-08 | 2018-04-18 | Biogen Ma Inc | Proceso para preparar fumarato de dimetilo cristalino y de alta pureza. |
| US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| CN104169261A (zh) | 2012-02-07 | 2014-11-26 | 什诺波特有限公司 | 富马酸吗啉代烃基酯化合物、药物组合物和使用方法 |
| AU2013203445C1 (en) * | 2012-02-07 | 2017-04-20 | Biogen Ma Inc. | Pharmaceutical compositions containing dimethyl fumarate |
| EP2887934A1 (en) | 2012-08-22 | 2015-07-01 | XenoPort, Inc. | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| WO2014071371A1 (en) | 2012-11-05 | 2014-05-08 | Xenoport, Inc. | Cocrystals of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate |
| EP3566701A1 (en) | 2012-12-21 | 2019-11-13 | Biogen MA Inc. | Deuterium substituted fumarate derivatives |
| UA116648C2 (uk) | 2013-03-14 | 2018-04-25 | Алкермес Фарма Айерленд Лімітед | Фумарати як проліки та їх застосування при лікуванні різних захворювань |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| WO2014160633A1 (en) * | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) * | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| WO2015035184A1 (en) | 2013-09-06 | 2015-03-12 | Xenoport, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| WO2015042294A1 (en) | 2013-09-18 | 2015-03-26 | Xenoport, Inc. | Nanoparticle compositions of dimethyl fumarate |
| US9604922B2 (en) | 2014-02-24 | 2017-03-28 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| EP3501510B1 (en) | 2014-02-28 | 2020-07-01 | Banner Life Sciences LLC | Controlled release enteric soft capsules of fumarate esters |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016061393A1 (en) | 2014-10-15 | 2016-04-21 | Xenoport, Inc. | Fumarate compounds, pharmaceutical compositions, and methods of use |
| WO2016074684A1 (en) * | 2014-11-11 | 2016-05-19 | Syddansk Universitet | Fumaric acid derivatives for medical use |
| JP2018503651A (ja) | 2015-02-08 | 2018-02-08 | アルカーメス ファーマ アイルランド リミテッド | フマル酸モノメチルプロドラッグ組成物 |
| MA41785A (fr) * | 2015-03-20 | 2018-01-23 | Biogen Ma Inc | Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques |
| ES2826825T3 (es) | 2015-03-27 | 2021-05-19 | Symbionyx Pharmaceuticals Inc | Composiciones y métodos para el tratamiento de la psoriasis |
| CA2987895A1 (en) * | 2015-06-01 | 2016-12-08 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical compositions of dimethyl fumarate |
| US10213411B2 (en) | 2015-08-27 | 2019-02-26 | Vijaykumar Rajasekhar | Use of prodrugs of fumarates in treating heart failure diseases |
| WO2017060420A1 (en) | 2015-10-07 | 2017-04-13 | Neurovive Pharmaceutical Ab | Protected fumaric acid-based metabolites for the treatment of autoimmune diseases |
| DE102015117882A1 (de) * | 2015-10-21 | 2017-04-27 | Mehrdad Ghashghaeinia | Pharmazeutische Zusammensetzung |
| US9993265B2 (en) * | 2015-12-01 | 2018-06-12 | Lsi Solutions, Inc. | Percuscopic access device and cleaning obturator |
| US10463642B2 (en) | 2016-02-01 | 2019-11-05 | Vijaykumar Rajasekhar | Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate |
| WO2021142062A1 (en) | 2020-01-10 | 2021-07-15 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| CN118903149A (zh) * | 2024-07-19 | 2024-11-08 | 文韬创新药物研究(北京)股份有限公司 | 含泼尼松的药物组合物及其制备方法和应用 |
Family Cites Families (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1153927A (en) | 1966-08-25 | 1969-06-04 | Wilhelm Hoerrmann | Medicinal Composition Suitable For Treating Diseases Of The Retina |
| GB1357813A (en) * | 1970-09-07 | 1974-06-26 | Siphar Sa | Effervescent composition for the treatment of heart diseases |
| DE2530372A1 (de) | 1975-07-08 | 1977-01-13 | Walter Dr Schweckendiek | Pharmazeutische zubereitungen zur behandlung von psoriasis |
| JPS5283957A (en) | 1975-12-01 | 1977-07-13 | Henkel & Cie Gmbh | Medicine for treating metabolic obstruction of calcium |
| SE7612534L (sv) * | 1975-12-01 | 1977-06-02 | Henkel & Cie Gmbh | Forfarande for framstellning av farmaceutiska preparat for behandling av storningar i kalciumemnesomsettning |
| DE2621214C3 (de) | 1976-05-13 | 1981-11-12 | Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen | Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen |
| JPS5824104B2 (ja) | 1977-12-06 | 1983-05-19 | 博衛 小川 | フマル酸製剤 |
| DE2840498C2 (de) | 1978-09-18 | 1980-04-10 | Walter Dr. 6700 Ludwigshafen Schweckendiek | Pharmazeutische Zubereitungen zur Behandlung von Psoriasis |
| DE3127432A1 (de) * | 1981-07-11 | 1983-02-03 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von fumarsaeuremonoester |
| DE3233830A1 (de) | 1982-09-11 | 1984-03-15 | Hoechst Ag, 6230 Frankfurt | Perfluoralkyl-malein- und -fumarsaeureamide, verfahren zu deren herstellung und ihre verwendung als schmutzabweisendes mittel |
| US5149695A (en) * | 1985-01-15 | 1992-09-22 | Speiser Peter P | Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same |
| CH664150A5 (de) | 1985-01-15 | 1988-02-15 | Peter Paul Prof Dr Speiser | Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen. |
| JPS61194020A (ja) * | 1985-02-22 | 1986-08-28 | Dai Ichi Seiyaku Co Ltd | 網膜症治療剤 |
| GB2176999B (en) | 1985-06-22 | 1989-07-12 | Stanley Stewart Davis | Sustained release medicament |
| US4855305A (en) | 1987-03-23 | 1989-08-08 | Applied Medical Research | Compositions and methods of effecting contraception utilizing melatonin |
| IL83775A (en) | 1987-09-04 | 1991-12-15 | Dexter Chemical Corp | Amino acid esters and amides of fumaric acid and pharmaceutical compositions containing them for use in the treatment of psoriasis |
| US5242905A (en) * | 1987-09-04 | 1993-09-07 | Dexter Chemical Corporation | Pharmaceutical compositions for the treatment of psoriasis |
| US5214196A (en) * | 1987-09-04 | 1993-05-25 | Dexter Chemical Corporation | Diethyl ester of di-glycyl fumaramide |
| US5424332A (en) * | 1987-10-19 | 1995-06-13 | Speiser; Peter P. | Pharmaceutical composition and process for the production thereof |
| US4959389A (en) | 1987-10-19 | 1990-09-25 | Speiser Peter P | Pharmaceutical preparation for the treatment of psoriatic arthritis |
| DE3834794A1 (de) | 1988-10-12 | 1990-04-19 | F Schielein | Oral zu verabreichendes mittel zur behandlung von psoriasis |
| AU634655B2 (en) * | 1990-04-25 | 1993-02-25 | Nissan Chemical Industries Ltd. | Pyridazinone derivative |
| DE4014252A1 (de) | 1990-05-04 | 1991-11-07 | Boehringer Ingelheim Vetmed | Enantiomerentrennung von cimaterol, (-)-cimaterol und dessen verwendung als arzneimittel oder als leistungsfoerderer |
| US5484610A (en) * | 1991-01-02 | 1996-01-16 | Macromed, Inc. | pH and temperature sensitive terpolymers for oral drug delivery |
| AU1271592A (en) * | 1991-01-18 | 1992-08-27 | Dexter Chemical Corporation | Malic acid derivatives and compositions for the treatment of psoriasis |
| IT1251166B (it) | 1991-08-09 | 1995-05-04 | Chiesi Farma Spa | Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono |
| FR2694693B1 (fr) | 1992-07-28 | 1994-10-28 | Abrax Bio Labs Sa | Composition pharmaceutique à base de flavopéréirine et son utilisation dans un traitement contre le virus VIH. |
| US5434185A (en) | 1993-05-17 | 1995-07-18 | The University Of Kentucky Research Foundation | Method for inhibiting angiogenesis with aurintricarboxylic acid, its analogues or salts |
| WO1994028883A1 (en) | 1993-06-08 | 1994-12-22 | Brown Raymond K | Therapeutic compositions and methods of use |
| JPH06345644A (ja) | 1993-06-10 | 1994-12-20 | Unitika Ltd | 自己免疫性疾患治療剤 |
| CA2125763C (en) * | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | P40 homodimer of interleukin-12 |
| WO1995012572A1 (en) | 1993-11-04 | 1995-05-11 | Abbott Laboratories | Cyclobutane derivatives as inhibitors of squalene synthetase and protein farnesyltransferase |
| US5407772A (en) * | 1993-11-30 | 1995-04-18 | Xerox Corporation | Unsaturated polyesters |
| JPH09510222A (ja) | 1994-03-16 | 1997-10-14 | ノボ ノルディスク アクティーゼルスカブ | 2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピン化合物の酸付加塩 |
| US6576236B1 (en) | 1994-07-01 | 2003-06-10 | Dana Farber Cancer Institute | Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain |
| GB2291422A (en) | 1994-07-18 | 1996-01-24 | Fujisawa Pharmaceutical Co | 4-phenyl-pyrido[2,3-b]pyrazin-4-ones |
| US5763190A (en) | 1994-09-21 | 1998-06-09 | The Trustees Of The University Of Pennsylvania | Methods for the identification of compounds capable of inducing the nuclear translocation of a receptor complex comprising the glucocoticoid receptor type II and viral protein R interacting protein |
| CN1125141A (zh) | 1994-12-22 | 1996-06-26 | 杭州中美华东制药有限公司 | 一种含环孢菌素a的固体分散物及其外用剂型上的用途 |
| JP2535141B2 (ja) | 1995-01-17 | 1996-09-18 | 中外製薬株式会社 | フマル酸含有徐放性製剤 |
| US6011000A (en) * | 1995-03-03 | 2000-01-04 | Perrine; Susan P. | Compositions for the treatment of blood disorders |
| HUP9900169A2 (hu) | 1995-09-13 | 2000-03-28 | Takeda Chemical Industries, Ltd. | Immunoszuppresszáns hatású kinolin- vagy kinozalinszármazékok és ezeket tartalmazó gyógyászati készítmények |
| EP0852233A4 (en) | 1995-09-21 | 1999-09-15 | Nippon Shinyaku Co Ltd | CYCLOSPORIN PHOSPHATE DERIVATIVES AND MEDICINAL COMPOSITION |
| HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
| JP4004567B2 (ja) | 1996-02-14 | 2007-11-07 | アステラス製薬株式会社 | Wb2663b物質を含有する免疫抑制剤 |
| KR970064620A (ko) | 1996-03-05 | 1997-10-13 | 임성기 | 사이클로스포린-함유 외용약제 조성물 |
| WO1997044054A2 (en) | 1996-05-22 | 1997-11-27 | University Of Alberta | Type-2 chemokine binding proteins and methods of use therefor |
| AU7003096A (en) | 1996-06-21 | 1998-01-07 | Jury Evgenievich Belyaev | Semi-finished product for producing drug bases, bases obtained using the same and variants, and drugs obtained using these bases and variants |
| EP2298350A3 (en) | 1996-07-26 | 2011-06-08 | Susan P. Perrine | Composition comprising an inducing agent and an anti-viral agent for the treatment of viral disorders |
| WO1998027970A2 (en) | 1996-12-24 | 1998-07-02 | National Research Council Of Canada | Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals |
| US5972363A (en) * | 1997-04-11 | 1999-10-26 | Rohm And Haas Company | Use of an encapsulated bioactive composition |
| DE19721099C2 (de) | 1997-05-20 | 1999-12-02 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten |
| US20050245612A1 (en) | 2004-05-03 | 2005-11-03 | Blass John P | Pharmaceutical compositions for metabolic insufficiencies |
| US6537969B1 (en) | 1997-10-24 | 2003-03-25 | John P. Blass | Nutritional supplement for cerebral metabolic insufficiencies |
| EP1051159B1 (en) | 1998-01-22 | 2002-04-10 | Zentaris AG | Solid pharmaceutical compositions containing miltefosine for oral administration in the treatment of leishmaniasis |
| DE19814358C2 (de) * | 1998-03-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn |
| DE19839566C2 (de) | 1998-08-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten in der Transplantationsmedizin |
| DE19848260C2 (de) * | 1998-10-20 | 2002-01-17 | Fumapharm Ag Muri | Fumarsäure-Mikrotabletten |
| DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
| US6537584B1 (en) * | 1999-11-12 | 2003-03-25 | Macromed, Inc. | Polymer blends that swell in an acidic environment and deswell in a basic environment |
| DE10000577A1 (de) * | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
| ATE370225T1 (de) | 2000-02-11 | 2007-09-15 | Philadelphia Health & Educatio | Differenzierung von knochenmarkzellen in neuronale zellen und deren verwendungen |
| WO2002002190A2 (en) | 2000-07-05 | 2002-01-10 | Johns Hopkins School Of Medicine | Prevention and treatment of neurodegenerative diseases by glutathione and phase ii detoxification enzymes |
| AU2001292818A1 (en) * | 2000-09-20 | 2002-04-02 | Beth Israel Deaconness Medical Center | Use of transcription factors for treating inflammation and other diseases |
| JP2002148784A (ja) * | 2000-11-07 | 2002-05-22 | Tokyo Ohka Kogyo Co Ltd | 化学増幅型ポジ型レジスト塗布液及びそれを用いたレジストパターン形成方法 |
| AU2002230423A1 (en) | 2000-11-08 | 2002-05-21 | Massachusetts Institute Of Technology | Serotonergic compositions and methods for treatment of mild cognitive impairment |
| DE10101307A1 (de) * | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
| AU2002219236B2 (en) * | 2001-01-12 | 2006-02-09 | Biogen International Gmbh | Fumaric acid amides |
| EE200200585A (et) * | 2001-02-14 | 2004-04-15 | Rath Matthias | Biokeemiliste ühendite kompositsioon ja selle raviotstarbeline kasutamine rakulise energiavahetuse parendamiseks |
| RU2189813C1 (ru) | 2001-06-01 | 2002-09-27 | Российский научно-исследовательский институт гематологии и трансфузиологии | Лекарственное средство антигипоксического действия |
| BR0210867A (pt) | 2001-07-06 | 2004-06-29 | Lifecycle Pharma As | Processo para a preparação de um material particulado, métodos para aglomeração controlada de um material sólido finamente disperso, para melhorar a biodisponibilidade de uma substância terapêutica e/ou profilaticamente ativa, e para melhorar a vida em prateleira de uma composição farmacêutica, material articulado, composição farmacêutica, uso de um veìculo, material particulado farmacêutico, e, uso de aluminossilicato de magnésio e/ou de aluminometassilicato de magnésio |
| US20030104997A1 (en) * | 2001-09-05 | 2003-06-05 | Black Ira B. | Multi-lineage directed induction of bone marrow stromal cell differentiation |
| WO2003032969A2 (en) | 2001-10-15 | 2003-04-24 | National Research Council Of Canada | Anti-glycation agents for preventing age-, diabetes-, and smoking-related complications |
| PL223471B1 (pl) | 2002-03-15 | 2016-10-31 | Cypress Bioscience Inc | Kompozycja farmaceutyczna zawierająca milnacypran do stosowania w leczeniu zespołu nadwrażliwości jelita grubego |
| DE10214031A1 (de) | 2002-03-27 | 2004-02-19 | Pharmatech Gmbh | Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation |
| DE10217314A1 (de) * | 2002-04-18 | 2003-11-13 | Fumapharm Ag Muri | Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere |
| MXPA04009352A (es) | 2002-04-18 | 2005-01-25 | Pharmacia Corp | Terapia de combinacion para el tratamiento de la enfermedad de parkinson con inhibidores de ciclooxigenasa-2 (cox2). |
| US6830759B2 (en) * | 2002-06-28 | 2004-12-14 | Ajinomoto Co., Inc. | Antidiabetic preparation for oral administration |
| EP1575565B1 (en) | 2003-08-08 | 2010-01-06 | Biovail Laboratories International Srl | Modified-release tablet of bupropion hydrochloride |
| ATE380027T1 (de) | 2003-09-09 | 2007-12-15 | Fumapharm Ag | Verwendung von fumarsäure-derivaten zur behandlung von herzinsuffizienz und asthma |
| DE10342423A1 (de) | 2003-09-13 | 2005-04-14 | Heidland, August, Prof. Dr.med. Dr.h.c. | Verwendung von Fumarsäurederivaten zur Prophylaxe und zur Behandlung von Genomschäden |
| CA2555114C (en) | 2004-03-31 | 2012-05-29 | Bpsi Holdings, Inc. | Enteric coatings for orally ingestible substrates |
| DE14172396T1 (de) * | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
| EP1812374A1 (en) | 2004-11-10 | 2007-08-01 | Aditech Pharma AB | Novel salts of fumaric acid monoalkylesters and their pharmaceutical use |
| JP2008520717A (ja) | 2004-11-19 | 2008-06-19 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 多発性硬化症についての処置 |
| US7638119B2 (en) | 2004-12-02 | 2009-12-29 | Wisconsin Alumni Research Foundation | Method of diminishing the symptoms of neurodegenerative disease |
| EP1674082A1 (de) | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| JP4873352B2 (ja) | 2005-02-16 | 2012-02-08 | シェーリング コーポレイション | Cxcr3アンタゴニスト活性を有する、複素環で置換されたピペラジン |
| CN101203509B (zh) | 2005-02-16 | 2013-05-08 | 默沙东公司 | 具有cxcr3拮抗剂活性的胺-连接的吡啶基和苯基取代的哌嗪-哌啶 |
| WO2006088919A2 (en) | 2005-02-16 | 2006-08-24 | Schering Corporation | Pyridyl and phenyl substituted piperazine-piperidines with cxcr3 antagonist activity |
| AU2006216941B2 (en) | 2005-02-16 | 2009-12-03 | Pharmacopeia, Llc | Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity |
| BRPI0607946A2 (pt) | 2005-02-16 | 2009-10-20 | Schering Corp | piperazina-piperidinas substituìdas por pirazinila com atividade de antagonista cxcr3 |
| MX2007010068A (es) | 2005-02-16 | 2007-10-10 | Schering Corp | Piperazino-piperidinas con actividad antagonista de cxcr3. |
| EP1853587B1 (en) * | 2005-02-16 | 2011-08-03 | Schering Corporation | Novel heterocyclic substituted pyridine or phenyl compounds with cxcr3 antagonist activity |
| DE102005022845A1 (de) * | 2005-05-18 | 2006-11-23 | Fumapharm Ag | Thiobernsteinsäurederivate und deren Verwendung |
| AU2006265113A1 (en) | 2005-07-01 | 2007-01-11 | The Johns Hopkins University | Compositions and methods for the treatment or prevention of disorders relating to oxidative stress |
| DE602006011910D1 (de) | 2005-07-07 | 2010-03-11 | Aditech Pharma Ag | Neue glucopyranoseester und glucofuranoseester von fumarsäurealkylestern und deren pharmazeutische verwendung |
| US20080227847A1 (en) | 2005-07-07 | 2008-09-18 | Aditech Pharma Ab | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use |
| EP1951206A1 (en) | 2005-10-07 | 2008-08-06 | Aditech Pharma AB | Controlled release pharmaceutical compositions comprising a fumaric acid ester |
| WO2007042035A2 (en) | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Combination therapy with fumaric acid esters for the treatment of autoimmune and/or inflammatory disorders |
| US20080089861A1 (en) | 2006-07-10 | 2008-04-17 | Went Gregory T | Combination therapy for treatment of demyelinating conditions |
| JP2010502649A (ja) | 2006-09-01 | 2010-01-28 | シーブイ・セラピューティクス・インコーポレイテッド | 心筋層画像化法中の患者の耐性を増加させるための方法および組成物 |
| WO2008096271A2 (en) | 2007-02-08 | 2008-08-14 | Ralf Gold | Neuroprotection in demyelinating diseases |
| PT2137537E (pt) * | 2007-02-08 | 2013-08-22 | Biogen Idec Inc | Composições e respectivas utilizações para o tratamento da esclerose múltipla |
| US20080274182A1 (en) | 2007-05-03 | 2008-11-06 | Regina Helena Alida Boekema | Tablet coatings made from modified carboxymethylcellulose materials |
| WO2008144011A1 (en) | 2007-05-16 | 2008-11-27 | Avalon Pharmaceuticals | Compounds and methods for treating or preventing autoimmune diseases |
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| CN109044985A (zh) | 2009-01-09 | 2018-12-21 | 前进制药知识产权有限公司 | 包含溶蚀骨架中的一种或多种富马酸酯的药物制剂 |
| NZ617130A (en) | 2009-04-29 | 2015-06-26 | Biogen Ma Inc | Treatment of neurodegeneration and neuroinflammation |
| ME02317B (me) | 2010-02-12 | 2016-06-20 | Biogen Ma Inc | Neuroprotekcija kod demijelinizacijskih bolesti |
| CN103732062A (zh) | 2011-05-26 | 2014-04-16 | 比奥根艾迪克Ma公司 | 治疗多发性硬化以及保持和/或增加髓磷脂含量的方法 |
| MX355421B (es) | 2011-06-08 | 2018-04-18 | Biogen Ma Inc | Proceso para preparar fumarato de dimetilo cristalino y de alta pureza. |
| EP2791181A4 (en) | 2011-12-16 | 2015-08-05 | Biogen Ma Inc | SILICONE-CONTAINING FUMIC ACID ESTERS |
| AU2013203445C1 (en) | 2012-02-07 | 2017-04-20 | Biogen Ma Inc. | Pharmaceutical compositions containing dimethyl fumarate |
| GB201208850D0 (en) | 2012-05-18 | 2012-07-04 | Alphaptose Gmbh | Tri-subsituted glycerol compounds for use in the treatment of clinically isolated syndrome and/or multiple sclerosis |
-
2004
- 2004-09-03 AT AT04764790T patent/ATE380027T1/de active
- 2004-09-03 BR BRPI0410805-1A patent/BRPI0410805A/pt not_active IP Right Cessation
- 2004-09-03 DK DK04764790T patent/DK1663197T3/da active
- 2004-09-03 US US10/571,241 patent/US20070027076A1/en not_active Abandoned
- 2004-09-03 DE DE602004010531T patent/DE602004010531T2/de not_active Expired - Lifetime
- 2004-09-03 MX MXPA06002657A patent/MXPA06002657A/es active IP Right Grant
- 2004-09-03 EP EP07121903A patent/EP1913942B1/en not_active Expired - Lifetime
- 2004-09-03 EP EP04764790A patent/EP1663197B1/en not_active Expired - Lifetime
- 2004-09-03 PL PL04764790T patent/PL1663197T3/pl unknown
- 2004-09-03 CA CA2526586A patent/CA2526586C/en not_active Expired - Fee Related
- 2004-09-03 AU AU2004269903A patent/AU2004269903B2/en not_active Ceased
- 2004-09-03 SI SI200430558T patent/SI1663197T1/sl unknown
- 2004-09-03 WO PCT/EP2004/009835 patent/WO2005023241A1/en not_active Ceased
- 2004-09-03 RU RU2005141547/15A patent/RU2313339C2/ru not_active IP Right Cessation
- 2004-09-03 ES ES04764790T patent/ES2297461T3/es not_active Expired - Lifetime
-
2006
- 2006-03-24 NO NO20061340A patent/NO335991B1/no not_active IP Right Cessation
-
2010
- 2010-09-17 US US12/884,573 patent/US8980832B2/en not_active Expired - Lifetime
-
2015
- 2015-03-12 US US14/656,505 patent/US20160030374A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005023241A1 (en) | 2005-03-17 |
| EP1913942B1 (en) | 2009-11-11 |
| CA2526586C (en) | 2010-03-16 |
| US8980832B2 (en) | 2015-03-17 |
| US20070027076A1 (en) | 2007-02-01 |
| ES2297461T3 (es) | 2008-05-01 |
| RU2313339C2 (ru) | 2007-12-27 |
| BRPI0410805A (pt) | 2006-06-27 |
| MXPA06002657A (es) | 2006-06-05 |
| DE602004010531D1 (de) | 2008-01-17 |
| DE602004010531T2 (de) | 2008-07-03 |
| US20160030374A1 (en) | 2016-02-04 |
| EP1913942A2 (en) | 2008-04-23 |
| EP1663197A1 (en) | 2006-06-07 |
| CA2526586A1 (en) | 2005-03-17 |
| US20110124615A1 (en) | 2011-05-26 |
| SI1663197T1 (sl) | 2008-06-30 |
| EP1663197B1 (en) | 2007-12-05 |
| ATE380027T1 (de) | 2007-12-15 |
| EP1913942A3 (en) | 2008-05-21 |
| DK1663197T3 (da) | 2008-01-07 |
| RU2005141547A (ru) | 2006-06-10 |
| NO20061340L (no) | 2006-03-24 |
| AU2004269903A1 (en) | 2005-03-17 |
| AU2004269903B2 (en) | 2010-09-02 |
| NO335991B1 (no) | 2015-04-13 |
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