BRPI0410805A - uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma - Google Patents

uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma

Info

Publication number
BRPI0410805A
BRPI0410805A BRPI0410805-1A BRPI0410805A BRPI0410805A BR PI0410805 A BRPI0410805 A BR PI0410805A BR PI0410805 A BRPI0410805 A BR PI0410805A BR PI0410805 A BRPI0410805 A BR PI0410805A
Authority
BR
Brazil
Prior art keywords
fumaric acid
asthma
fumarates
monoalkyl
monoamido
Prior art date
Application number
BRPI0410805-1A
Other languages
English (en)
Inventor
Kumar Rajendra Joshi
Hans-Peter Strebel
Christian Zaugg
Michael Tamm
Original Assignee
Fumapharm Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10360869A external-priority patent/DE10360869A1/de
Application filed by Fumapharm Ag filed Critical Fumapharm Ag
Publication of BRPI0410805A publication Critical patent/BRPI0410805A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

"USO DE DERIVADOS DO áCIDO FUMáRICO PARA TRATAMENTO DA INSUFICIêNCIA CARDìACA E ASMA". De acordo com um primeiro aspecto, a invenção refere-se ao uso de derivados do ácido fumárico selecionados do grupo consistindo em fumaratos de dialquila, hidrogeno fumaratos de monoalquila, sais de éster monoalquílico do ácido fumárico, monoamidas do ácido fumárico, sais monoamido do ácido fumárico, diamidas do ácido fumárico, monoamida de fumarato de monoalquila, oligómeros carbocíclicos e oxacarbocíclicos desses compostos e suas misturas na preparação de uma droga para o tratamento ou prevenção da insuficiência cardíaca, particularmente, insuficiência ventricular esquerda, infarto do miocárdio e angina pectoris. De acordo com um segundo aspecto, a invenção, refere-se ao uso de derivados do ácido fumárico, selecionados do grupo consistindo em fumaratos de dialquila, hidrogeno fumaratos de monoalquila, sais de éster monoalquílico do ácido fumárico, monoamidas do ácido fumárico, sais monoamido do ácido fumárico, diamidas do ácido fumárico, monoamido fumarato de monoalquila, oligómeros carbocíclicos e oxacarbocíclicos desses compostos e suas misturas para preparar uma droga para o tratamento da asma e doenças pulmonares obstrutivas crónicas, especialmente asma ocasionada por alergias, infecções, analgésicos, condições de trabalho ou esforço físico, formas mistas de asma, ou asma cardial.
BRPI0410805-1A 2003-09-09 2004-09-03 uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma BRPI0410805A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10341530 2003-09-09
DE10360869A DE10360869A1 (de) 2003-09-09 2003-12-23 Verwendung von Fumarsäurederivaten zur Therapie der Herzinsuffizienz, der Hyperkeratose und von Asthma
PCT/EP2004/009835 WO2005023241A1 (en) 2003-09-09 2004-09-03 The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma

Publications (1)

Publication Number Publication Date
BRPI0410805A true BRPI0410805A (pt) 2006-06-27

Family

ID=34276548

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410805-1A BRPI0410805A (pt) 2003-09-09 2004-09-03 uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma

Country Status (15)

Country Link
US (3) US20070027076A1 (pt)
EP (2) EP1663197B1 (pt)
AT (1) ATE380027T1 (pt)
AU (1) AU2004269903B2 (pt)
BR (1) BRPI0410805A (pt)
CA (1) CA2526586C (pt)
DE (1) DE602004010531T2 (pt)
DK (1) DK1663197T3 (pt)
ES (1) ES2297461T3 (pt)
MX (1) MXPA06002657A (pt)
NO (1) NO335991B1 (pt)
PL (1) PL1663197T3 (pt)
RU (1) RU2313339C2 (pt)
SI (1) SI1663197T1 (pt)
WO (1) WO2005023241A1 (pt)

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EP1913942A3 (en) 2008-05-21
NO335991B1 (no) 2015-04-13
AU2004269903A1 (en) 2005-03-17
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US20070027076A1 (en) 2007-02-01
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US8980832B2 (en) 2015-03-17
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RU2005141547A (ru) 2006-06-10
DE602004010531T2 (de) 2008-07-03
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US20160030374A1 (en) 2016-02-04
RU2313339C2 (ru) 2007-12-27
CA2526586A1 (en) 2005-03-17
PL1663197T3 (pl) 2008-09-30
DK1663197T3 (da) 2008-01-07
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EP1663197A1 (en) 2006-06-07

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