FR14C0050I1 - Compositions et leurs utilisations pour le traitement de la sclerose en plaques - Google Patents
Compositions et leurs utilisations pour le traitement de la sclerose en plaquesInfo
- Publication number
- FR14C0050I1 FR14C0050I1 FR14C0050C FR14C0050C FR14C0050I1 FR 14C0050 I1 FR14C0050 I1 FR 14C0050I1 FR 14C0050 C FR14C0050 C FR 14C0050C FR 14C0050 C FR14C0050 C FR 14C0050C FR 14C0050 I1 FR14C0050 I1 FR 14C0050I1
- Authority
- FR
- France
- Prior art keywords
- compositions
- treatment
- multiple sclerosis
- sclerosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000203 mixture Substances 0.000 title 1
- 201000006417 multiple sclerosis Diseases 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/217—IFN-gamma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/902—Oxidoreductases (1.)
- G01N2333/90209—Oxidoreductases (1.) acting on NADH or NADPH (1.6), e.g. those with a heme protein as acceptor (1.6.2) (general), Cytochrome-b5 reductase (1.6.2.2) or NADPH-cytochrome P450 reductase (1.6.2.4)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/285—Demyelinating diseases; Multipel sclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88892107P | 2007-02-08 | 2007-02-08 | |
PCT/US2008/001602 WO2008097596A2 (fr) | 2007-02-08 | 2008-02-07 | Essais de criblage de nrf2 et procédés et compositions correspondants |
Publications (1)
Publication Number | Publication Date |
---|---|
FR14C0050I1 true FR14C0050I1 (fr) | 2014-08-08 |
Family
ID=39682314
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR14C0050C Active FR14C0050I1 (fr) | 2007-02-08 | 2014-06-25 | Compositions et leurs utilisations pour le traitement de la sclerose en plaques |
FR23C1003C Active FR23C1003I2 (fr) | 2007-02-08 | 2023-01-12 | Compositions et leurs utilisations pour le traitement de la Sclérose en plaques |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR23C1003C Active FR23C1003I2 (fr) | 2007-02-08 | 2023-01-12 | Compositions et leurs utilisations pour le traitement de la Sclérose en plaques |
Country Status (19)
Country | Link |
---|---|
US (8) | US20110112196A1 (fr) |
EP (10) | EP2680006A1 (fr) |
CY (2) | CY1114340T1 (fr) |
DE (2) | DE13169139T1 (fr) |
DK (3) | DK2137537T3 (fr) |
ES (3) | ES2916649T3 (fr) |
FI (2) | FI2629097T1 (fr) |
FR (2) | FR14C0050I1 (fr) |
HK (1) | HK1139204A1 (fr) |
HR (2) | HRP20220902T3 (fr) |
HU (1) | HUS2300001I1 (fr) |
LT (2) | LT2653873T (fr) |
LU (1) | LU92487I2 (fr) |
NO (1) | NO2023001I1 (fr) |
PL (2) | PL2137537T3 (fr) |
PT (2) | PT2137537E (fr) |
RS (2) | RS63489B1 (fr) |
SI (2) | SI2137537T1 (fr) |
WO (1) | WO2008097596A2 (fr) |
Families Citing this family (87)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
BRPI0410805A (pt) | 2003-09-09 | 2006-06-27 | Fumapharm Ag | uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma |
DE14172398T1 (de) | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
EP3135282A1 (fr) * | 2007-02-08 | 2017-03-01 | Biogen MA Inc. | Neuroprotection dans des maladies démyélinisantes |
HRP20220902T3 (hr) | 2007-02-08 | 2022-10-14 | Biogen Ma Inc. | Pripravci i njihova upotreba u liječenju multiple skleroze |
WO2009089545A1 (fr) | 2008-01-11 | 2009-07-16 | Reata Pharmaceuticals, Inc. | Triterpénoïdes synthétiques et procédés d'utilisation dans le traitement de maladies |
CA2721838C (fr) | 2008-04-18 | 2017-05-23 | Reata Pharmaceuticals, Inc. | Modulateurs d'inflammation antioxydants: derives d'acide oleanolique presentant une modification du groupe amino et d'autres modifications en c-17 |
CN102164941B (zh) | 2008-04-18 | 2015-05-27 | 里亚塔医药公司 | 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物 |
MX2010011435A (es) | 2008-04-18 | 2011-01-25 | Reata Pharmaceuticals Inc | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. |
BRPI0911422B8 (pt) | 2008-04-18 | 2021-05-25 | Reata Pharmaceuticals Inc | compostos moduladores inflamatórios antioxidantes, composição farmacêutica e usos dos mesmos |
US9085527B2 (en) | 2008-07-08 | 2015-07-21 | Catabasis Pharmaceuticals, Inc. | Fatty acid acylated salicylates and their uses |
JP5758801B2 (ja) | 2008-07-22 | 2015-08-05 | トラスティーズ・オブ・ダートマス・カレッジTrustees of Dartmouth College | 単環式シアノエノンおよびその使用方法説明 |
DK2334378T3 (da) | 2008-08-19 | 2014-07-07 | Xenoport Inc | Prodrugs af methylhydrogenfumarat, farmaceutiske sammensætninger deraf og fremgangsmåder til anvendelse |
PT2564839T (pt) | 2009-01-09 | 2016-07-14 | Forward Pharma As | Formulação farmacêutica compreendendo um ou mais ésteres de ácido fumárico numa matriz de erosão |
EP3466420A1 (fr) * | 2009-04-29 | 2019-04-10 | Biogen MA Inc. | Fumarate de diméthyle pour le traitement de l'ataxie de friedreich |
US20110172240A1 (en) | 2010-01-08 | 2011-07-14 | Milne Jill C | Fatty acid fumarate derivatives and their uses |
US8759535B2 (en) | 2010-02-18 | 2014-06-24 | High Point Pharmaceuticals, Llc | Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof |
SG10201509831XA (en) * | 2010-12-07 | 2015-12-30 | Teva Pharma | Use of laquinimod for reducing fatigue, improving functional status, and improving quality of life in multiple sclerosis patients |
US8513436B2 (en) | 2010-12-17 | 2013-08-20 | Reata Pharmaceuticals, Inc. | Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators |
MX348862B (es) | 2011-03-11 | 2017-07-03 | Reata Pharmaceuticals Inc | Derivados c4-monometil triterpenoides y sus metodos de uso. |
WO2012145420A1 (fr) * | 2011-04-18 | 2012-10-26 | Rutgers, The State University Of New Jersey | Composition, procédé de synthèse et utilisation de nouveaux modulateurs d'inflammation antioxydants |
CA2865316A1 (fr) * | 2011-04-28 | 2012-11-01 | Gino Cortopassi | Agents utiles pour le traitement de l'ataxie de friedreich et autres maladies neurodegeneratives |
EA201391578A1 (ru) * | 2011-05-26 | 2014-05-30 | Байоджен Айдек Ма Инк. | Способы лечения рассеянного склероза и сохранения и/или увеличения содержания миелина |
HUE036085T2 (hu) | 2011-06-08 | 2018-06-28 | Biogen Ma Inc | Nagy tisztaságú és kristályos dimetil-fumarát elõállítására szolgáló eljárás |
WO2013067036A1 (fr) * | 2011-10-31 | 2013-05-10 | Rutgers, The State University Of New Jersey | Inhibiteurs directs de l'interaction keap1-nrf2 en tant que modulateurs de l'inflammation par anti-oxydant |
WO2013090799A1 (fr) | 2011-12-16 | 2013-06-20 | Biogen Idec Ma Inc. | Esters de l'acide fumarique contenant du silicium |
US9504679B2 (en) | 2011-12-19 | 2016-11-29 | Bjoern Colin Kahrs | Pharmaceutical compositions comprising glitazones and Nrf2 activators |
US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
US20130259856A1 (en) * | 2012-03-27 | 2013-10-03 | Teva Pharmaceutical Industries, Ltd. | Treatment of multiple sclerosis with combination of laquinimod and dimethyl fumarate |
EP2830611B1 (fr) * | 2012-03-30 | 2016-04-27 | Nestec S.A. | Acide 4-oxo-2-penténoïque et santé du cerveau |
WO2013163344A1 (fr) | 2012-04-27 | 2013-10-31 | Reata Pharmaceuticals, Inc. | Dérivés 2,2-difluoropropionamide de bardoxolone méthyle, leurs formes polymorphes et leurs procédés d'utilisation |
US9556222B2 (en) | 2012-06-15 | 2017-01-31 | Reata Pharmaceuticals, Inc. | A-ring epoxidized triterpenoid-based anti-inflammation modulators and methods of use thereof |
US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
US9512094B2 (en) | 2012-09-10 | 2016-12-06 | Reata Pharmaceuticals, Inc. | C17-heteroaryl derivatives of oleanolic acid and methods of use thereof |
US9278912B2 (en) | 2012-09-10 | 2016-03-08 | Reata Pharmaceuticals, Inc. | C13-hydroxy derivatives of oleanolic acid and methods of use thereof |
DK2892912T3 (da) | 2012-09-10 | 2019-06-24 | Reata Pharmaceuticals Inc | C17-alkandiyl og alkenediylderivater af oleanolsyre og fremgangsmåder til anvendelse deraf |
US10054583B2 (en) * | 2012-10-10 | 2018-08-21 | Temple University Of The Commonwealth System Of Higher Education | Nuclear factor-erythroid 2 related factor 2 (NRF2) biosensors and modulators of NRF2 |
US20140171504A1 (en) | 2012-12-14 | 2014-06-19 | Georgia Regents Research Institute, Inc. | Methods of Treating Sickle Cell Disease and Related Disorders Using Fumaric Acid Esters |
US20140179779A1 (en) | 2012-12-21 | 2014-06-26 | Biogen Idec Ma Inc. | Deuterium Substituted Fumarate Derivatives |
WO2014138298A1 (fr) * | 2013-03-05 | 2014-09-12 | University Of Chicago | Traitement de troubles de démyélinisation |
HUE040044T2 (hu) | 2013-03-14 | 2019-02-28 | Alkermes Pharma Ireland Ltd | Fumarátok prodrugjai, és azok alkalmazása különbözõ betegségek kezelésében |
US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
WO2014160633A1 (fr) * | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Compositions pharmaceutiques de fumarate de diméthyle |
US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
WO2014205392A1 (fr) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Co-cristaux de diméthyl fumarate |
ES2526979B1 (es) * | 2013-07-17 | 2015-10-28 | Fundación Para La Investigación Biomédica Del Hospital Universitario De La Princesa | Uso del 3-(2-isotiocianatoetil)-5-metoxi-1H-indol para el tratamiento de enfermedades neurodegenerativas |
TW201516020A (zh) | 2013-09-06 | 2015-05-01 | Xenoport Inc | (n,n-二乙基胺甲醯基)甲基(2e)丁-2-烯-1,4-二酸甲酯之晶形、合成方法及用途 |
WO2015066190A1 (fr) | 2013-10-29 | 2015-05-07 | President And Fellows Of Harvard College | Procédés et compositions pour inhiber le stress oxydatif |
CN103768045B (zh) * | 2013-10-30 | 2015-10-07 | 苏州大学附属第一医院 | 富马酸二甲酯在制备治疗蛛网膜下腔出血后早期脑损伤药物的应用 |
GB201401465D0 (en) | 2014-01-29 | 2014-03-12 | Roach Arthur H | Use of cladribine for treating autoimmune inflammatory disease |
US9604922B2 (en) | 2014-02-24 | 2017-03-28 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
DK3110408T3 (en) | 2014-02-28 | 2019-04-29 | Banner Life Sciences Llc | ENTERY SOFT CAPS OF CONTROLLED RELEASE FUMAR TESTERS |
US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
EP2924127A1 (fr) | 2014-03-27 | 2015-09-30 | Université Paul Sabatier Toulouse III | Procédé et kit pour le pronostic des maladies induites par une défaillance du gène OPA1, telle que l'atrophie optique |
CA2945978A1 (fr) | 2014-04-29 | 2015-11-05 | Teva Pharmaceutical Industries Ltd. | Laquinimod pour le traitement de patients atteints de sclerose en plaques recurrente remittente (sep-rr) chez ayant un degre d'incapacite eleve |
DE102014010832A1 (de) | 2014-07-24 | 2016-01-28 | Peter Krause | Verwendung von medikamentösen Ingredienzien zur Behandlung von Multiple Sklerose |
WO2016089648A1 (fr) | 2014-12-01 | 2016-06-09 | Vtv Therapeutics Llc | Inhibiteurs de bach1 en combinaison avec des activateurs de nrf2 et compositions pharmaceutiques les contenant |
MA41139A (fr) * | 2014-12-11 | 2017-10-17 | Actelion Pharmaceuticals Ltd | Combinaison pharmaceutique comportant un agoniste sélectif du récepteur sip1 |
MA41785A (fr) | 2015-03-20 | 2018-01-23 | Biogen Ma Inc | Procédés et compositions pour l'administration intraveineuse de fumarates pour le traitement de maladies neurologiques |
ES2826825T3 (es) | 2015-03-27 | 2021-05-19 | Symbionyx Pharmaceuticals Inc | Composiciones y métodos para el tratamiento de la psoriasis |
AU2016273068A1 (en) | 2015-06-01 | 2017-12-21 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical compositions of dimethyl fumarate |
CN105087644A (zh) * | 2015-07-23 | 2015-11-25 | 山东大学 | 一种高通量筛选具有Nrf2激活活性的化合物的方法 |
US10213411B2 (en) | 2015-08-27 | 2019-02-26 | Vijaykumar Rajasekhar | Use of prodrugs of fumarates in treating heart failure diseases |
KR20180061251A (ko) | 2015-09-23 | 2018-06-07 | 리아타 파마슈티컬즈, 아이엔씨. | Il-17의 저해를 위한 c4-변형된 올레아놀산 유도체 및 다른 용도 |
US10463642B2 (en) | 2016-02-01 | 2019-11-05 | Vijaykumar Rajasekhar | Methods of treating heart failure diseases using prodrugs of methyl hydrogen fumarate |
EP3534940A1 (fr) | 2016-11-03 | 2019-09-11 | Juno Therapeutics, Inc. | Polythérapie de thérapie cellulaire et d'inhibiteur de la microglie |
CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
JP7379164B2 (ja) | 2017-06-02 | 2023-11-14 | ジュノー セラピューティクス インコーポレイテッド | 細胞療法に関連する毒性に関する製造物品および方法 |
WO2019046832A1 (fr) | 2017-09-01 | 2019-03-07 | Juno Therapeutics, Inc. | Expression génique et évaluation d'un risque de développement d'une toxicité suite à une thérapie cellulaire |
WO2019079242A1 (fr) | 2017-10-16 | 2019-04-25 | Voyager Therapeutics, Inc. | Traitement de la sclérose latérale amyotrophique (sla) |
EP4124658A3 (fr) | 2017-10-16 | 2023-04-19 | Voyager Therapeutics, Inc. | Traitement de la sclérose latérale amyotrophique (sla) |
WO2019089848A1 (fr) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Procédés associés à une charge tumorale pour évaluer une réponse à une thérapie cellulaire |
US20210361318A1 (en) | 2018-07-02 | 2021-11-25 | Voyager Therapeutics, Inc. | Cannula system and use thereof |
JP2021529513A (ja) | 2018-07-02 | 2021-11-04 | ボイジャー セラピューティクス インコーポレイテッドVoyager Therapeutics,Inc. | 筋萎縮性側索硬化症および脊髄に関連する障害の治療 |
US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
KR20210117260A (ko) | 2018-11-30 | 2021-09-28 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법을 사용한 치료방법 |
MX2021006244A (es) | 2018-11-30 | 2021-09-10 | Juno Therapeutics Inc | Metodos de dosificacion y tratamiento de canceres de celulas b en terapia celular adoptiva. |
EP4070097A1 (fr) | 2019-12-06 | 2022-10-12 | Juno Therapeutics, Inc. | Procédés liés à la toxicité et à la réponse associées à une thérapie cellulaire pour le traitement de tumeurs malignes des lymphocytes b |
US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
EP4117785A4 (fr) * | 2020-03-13 | 2024-04-17 | Marc J. Simard | Méthodes de traitement de la sclérose en plaques |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2530372A1 (de) | 1975-07-08 | 1977-01-13 | Walter Dr Schweckendiek | Pharmazeutische zubereitungen zur behandlung von psoriasis |
DE2621214C3 (de) | 1976-05-13 | 1981-11-12 | Koronis Gmbh Chemisch-Pharmazeutische Praeparate, 5441 Sassen | Verwendung von Stabilisatoren in Arzneimitteln mit Fumarsäuremonoäthylester und desen Mineralsalzen |
JPS5824104B2 (ja) | 1977-12-06 | 1983-05-19 | 博衛 小川 | フマル酸製剤 |
DE2840498C2 (de) | 1978-09-18 | 1980-04-10 | Walter Dr. 6700 Ludwigshafen Schweckendiek | Pharmazeutische Zubereitungen zur Behandlung von Psoriasis |
DE3127432A1 (de) | 1981-07-11 | 1983-02-03 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von fumarsaeuremonoester |
CH664150A5 (de) | 1985-01-15 | 1988-02-15 | Peter Paul Prof Dr Speiser | Fumarsaeureprodrug, verfahren zu seiner herstellung und dieses enthaltende darreichungsformen. |
US5149695A (en) | 1985-01-15 | 1992-09-22 | Speiser Peter P | Fumaric acid derivatives, process for the production thereof and pharmaceutical compositions containing same |
JPS61194020A (ja) | 1985-02-22 | 1986-08-28 | Dai Ichi Seiyaku Co Ltd | 網膜症治療剤 |
US4855305A (en) | 1987-03-23 | 1989-08-08 | Applied Medical Research | Compositions and methods of effecting contraception utilizing melatonin |
IL83775A (en) | 1987-09-04 | 1991-12-15 | Dexter Chemical Corp | Amino acid esters and amides of fumaric acid and pharmaceutical compositions containing them for use in the treatment of psoriasis |
US5242905A (en) | 1987-09-04 | 1993-09-07 | Dexter Chemical Corporation | Pharmaceutical compositions for the treatment of psoriasis |
US5214196A (en) | 1987-09-04 | 1993-05-25 | Dexter Chemical Corporation | Diethyl ester of di-glycyl fumaramide |
US4959389A (en) | 1987-10-19 | 1990-09-25 | Speiser Peter P | Pharmaceutical preparation for the treatment of psoriatic arthritis |
US5424332A (en) | 1987-10-19 | 1995-06-13 | Speiser; Peter P. | Pharmaceutical composition and process for the production thereof |
DE3834794A1 (de) | 1988-10-12 | 1990-04-19 | F Schielein | Oral zu verabreichendes mittel zur behandlung von psoriasis |
WO1992012952A1 (fr) | 1991-01-18 | 1992-08-06 | Dexter Chemical Corporation | Derives d'acide malique et compositions pour le traitement du psoriasis |
IT1251166B (it) | 1991-08-09 | 1995-05-04 | Chiesi Farma Spa | Derivati di geneserina,loro preparazione e composizioni farmaceutiche che li contengono |
US5459667A (en) | 1993-01-22 | 1995-10-17 | Sumitomo Electric Industries, Ltd. | Navigation apparatus for informing vehicle driver of information regarding travel route |
WO1994028883A1 (fr) | 1993-06-08 | 1994-12-22 | Brown Raymond K | Compositions therapeutiques et procedes d'utilisation |
JPH06345644A (ja) | 1993-06-10 | 1994-12-20 | Unitika Ltd | 自己免疫性疾患治療剤 |
US5407772A (en) | 1993-11-30 | 1995-04-18 | Xerox Corporation | Unsaturated polyesters |
JPH09510222A (ja) | 1994-03-16 | 1997-10-14 | ノボ ノルディスク アクティーゼルスカブ | 2,3,4,5−テトラヒドロ−1h−3−ベンゾアゼピン化合物の酸付加塩 |
WO1997011092A1 (fr) | 1994-04-07 | 1997-03-27 | Nippon Shinyaku Co., Ltd. | Derives de phosphates de cyclosporine et composition medicinale |
US6649143B1 (en) | 1994-07-01 | 2003-11-18 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
US5650135A (en) | 1994-07-01 | 1997-07-22 | The Board Of Trustees Of The Leland Stanford Junior University | Non-invasive localization of a light-emitting conjugate in a mammal |
US6576236B1 (en) | 1994-07-01 | 2003-06-10 | Dana Farber Cancer Institute | Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain |
GB2291422A (en) | 1994-07-18 | 1996-01-24 | Fujisawa Pharmaceutical Co | 4-phenyl-pyrido[2,3-b]pyrazin-4-ones |
US5763190A (en) | 1994-09-21 | 1998-06-09 | The Trustees Of The University Of Pennsylvania | Methods for the identification of compounds capable of inducing the nuclear translocation of a receptor complex comprising the glucocoticoid receptor type II and viral protein R interacting protein |
CN1125141A (zh) | 1994-12-22 | 1996-06-26 | 杭州中美华东制药有限公司 | 一种含环孢菌素a的固体分散物及其外用剂型上的用途 |
JP2535141B2 (ja) | 1995-01-17 | 1996-09-18 | 中外製薬株式会社 | フマル酸含有徐放性製剤 |
HUP9900169A2 (hu) | 1995-09-13 | 2000-03-28 | Takeda Chemical Industries, Ltd. | Immunoszuppresszáns hatású kinolin- vagy kinozalinszármazékok és ezeket tartalmazó gyógyászati készítmények |
HU9502843D0 (en) | 1995-09-29 | 1995-11-28 | Livigene Ltd | Pharmaceutical composition |
JP4004567B2 (ja) | 1996-02-14 | 2007-11-07 | アステラス製薬株式会社 | Wb2663b物質を含有する免疫抑制剤 |
KR970064620A (ko) | 1996-03-05 | 1997-10-13 | 임성기 | 사이클로스포린-함유 외용약제 조성물 |
EP0901379B1 (fr) | 1996-05-22 | 2000-09-06 | University Of Alberta | Proteines de fixation de la chimiokine de type 2 et leurs procedes d'utilisation |
AU7003096A (en) | 1996-06-21 | 1998-01-07 | Jury Evgenievich Belyaev | Semi-finished product for producing drug bases, bases obtained using the same and variants, and drugs obtained using these bases and variants |
EP2298350A3 (fr) | 1996-07-26 | 2011-06-08 | Susan P. Perrine | Compositions contenant un agent inducteur ainsi qu'un agent antiviral et destinees au traitement de troubles viraux |
AU5474198A (en) | 1996-12-24 | 1998-07-17 | National Research Council Of Canada | Treatment of diseases or prevention of cellular damage caused by oxygen-containing free radicals |
US5972363A (en) | 1997-04-11 | 1999-10-26 | Rohm And Haas Company | Use of an encapsulated bioactive composition |
DE19721099C2 (de) | 1997-05-20 | 1999-12-02 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten |
US20050245612A1 (en) | 2004-05-03 | 2005-11-03 | Blass John P | Pharmaceutical compositions for metabolic insufficiencies |
EP1032403B1 (fr) | 1997-10-24 | 2012-05-02 | John P. Blass | Supplement nutritionnel pour personnes atteintes d'insuffisances du metabolisme cerebral |
DE19814358C2 (de) | 1998-03-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Alkylhydrogenfumaraten zur Behandlung von Psoriasis, psoriatischer Arthritis, Neurodermitis und Enteritis regionalis Crohn |
DE19839566C2 (de) | 1998-08-31 | 2002-01-17 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten in der Transplantationsmedizin |
DE19848260C2 (de) | 1998-10-20 | 2002-01-17 | Fumapharm Ag Muri | Fumarsäure-Mikrotabletten |
DE19853487A1 (de) | 1998-11-19 | 2000-05-25 | Fumapharm Ag Muri | Verwendung von Dialkylfumaraten |
DE10000577A1 (de) | 2000-01-10 | 2001-07-26 | Fumapharm Ag Muri | Verwendung von Fumarsäurederivaten zur Behandlung mitochondrialer Krankheiten |
ATE370225T1 (de) | 2000-02-11 | 2007-09-15 | Philadelphia Health & Educatio | Differenzierung von knochenmarkzellen in neuronale zellen und deren verwendungen |
US6812248B2 (en) | 2000-07-05 | 2004-11-02 | John Hopkins University School Of Medicine | Prevention and treatment of degenerative diseases by glutathione and phase II detoxification enzymes |
US20020173511A1 (en) | 2000-11-08 | 2002-11-21 | Wurtman Richard J. | Serotonergic compositions and methods for treatment of mild cognitive impairment |
US6451667B1 (en) | 2000-12-21 | 2002-09-17 | Infineon Technologies Ag | Self-aligned double-sided vertical MIMcap |
JP2004523511A (ja) | 2001-01-12 | 2004-08-05 | フーマファーム アーゲー | フマル酸アミド類 |
DE10101307A1 (de) | 2001-01-12 | 2002-08-01 | Fumapharm Ag Muri | Fumarsäurederivate als NF-kappaB-Inhibitor |
CN1457255A (zh) | 2001-02-14 | 2003-11-19 | 马蒂亚斯·拉特 | 参与细胞生物能代谢的生物化学化合物的组合物和其使用方法 |
RU2189813C1 (ru) | 2001-06-01 | 2002-09-27 | Российский научно-исследовательский институт гематологии и трансфузиологии | Лекарственное средство антигипоксического действия |
US20030104997A1 (en) | 2001-09-05 | 2003-06-05 | Black Ira B. | Multi-lineage directed induction of bone marrow stromal cell differentiation |
US20050043408A1 (en) | 2001-10-15 | 2005-02-24 | Faustinus Yeboah | Anti-glycation agents for preventing age- diabetes- and smoking-related complications |
DE10217314A1 (de) | 2002-04-18 | 2003-11-13 | Fumapharm Ag Muri | Carbocyclische und Oxacarboncyclische Fumarsäure-Oligomere |
BRPI0410805A (pt) | 2003-09-09 | 2006-06-27 | Fumapharm Ag | uso de derivados do ácido fumárico para tratamento da insuficiência cardìaca e asma |
DE10342423A1 (de) | 2003-09-13 | 2005-04-14 | Heidland, August, Prof. Dr.med. Dr.h.c. | Verwendung von Fumarsäurederivaten zur Prophylaxe und zur Behandlung von Genomschäden |
DE14172398T1 (de) | 2004-10-08 | 2015-01-08 | Forward Pharma A/S | Gesteuerte Freisetzung von pharmazeutischen Zusammensetzungen mit Fumarinsäureester |
EP1812374A1 (fr) | 2004-11-10 | 2007-08-01 | Aditech Pharma AB | Nouveaux sels de monoalkylesters d'acide fumarique et leur utilisation pharmaceutique |
EP2808033A1 (fr) | 2004-11-19 | 2014-12-03 | Biogen Idec MA Inc. | Traitement de la sclérose en plaques |
US7638119B2 (en) | 2004-12-02 | 2009-12-29 | Wisconsin Alumni Research Foundation | Method of diminishing the symptoms of neurodegenerative disease |
EP1674082A1 (fr) | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Procédé pour la manufacture des suspensions ou lyophilisates steriles des complexes mal-soluble de peptides basic, des formulations pharmaceutiques avec ces complexes et leur utilisation comme medicament |
AU2006214480A1 (en) | 2005-02-16 | 2006-08-24 | Pharmacopeia, Inc. | Novel heterocyclic substituted pyridine or phenyl compounds with CXCR3 antagonist activity |
CN101142209A (zh) | 2005-02-16 | 2008-03-12 | 先灵公司 | 具有cxcr3拮抗剂活性的吡嗪基取代的哌嗪-哌啶 |
AU2006214378A1 (en) | 2005-02-16 | 2006-08-24 | Pharmacopeia, Inc. | Pyridyl and phenyl substituted piperazine-piperidines with CXCR3 antagonist activity |
US7868006B2 (en) | 2005-02-16 | 2011-01-11 | Schering Corporation | Heterocyclic substituted piperazines with CXCR3 antagonist activity |
EP1853583B1 (fr) | 2005-02-16 | 2011-09-07 | Schering Corporation | Pyridyle a liaison amine et piperazine-piperidines substituees a activite agoniste cxcr3 |
CN101189238A (zh) | 2005-02-16 | 2008-05-28 | 先灵公司 | 具有cxcr3拮抗剂活性的哌嗪-哌啶 |
AU2006216941B2 (en) | 2005-02-16 | 2009-12-03 | Pharmacopeia, Llc | Heteroaryl substituted pyrazinyl-piperazine-piperidines with CXCR3 antagonist activity |
DE102005022845A1 (de) | 2005-05-18 | 2006-11-23 | Fumapharm Ag | Thiobernsteinsäurederivate und deren Verwendung |
EP1959969A2 (fr) * | 2005-07-01 | 2008-08-27 | The Johns Hopkins University | Compositions et procedes pour traiter ou prevenir des troubles associes au stress oxydatif |
EP1915387B1 (fr) | 2005-07-07 | 2010-01-20 | Aditech Pharma AG | Nouveaux esters de glucopyranose et esters de glucofuranose d'alkyl-fumarates et leur utilisation pharmaceutique |
US20080227847A1 (en) | 2005-07-07 | 2008-09-18 | Aditech Pharma Ab | Novel Salts of Fumaric Acid Monoalkylesters and Their Pharmaceutical Use |
WO2007042035A2 (fr) | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Therapie de combinaison pour le traitement d'un trouble auto-immun et/ou inflammatoire et de conditions associees |
WO2007042034A1 (fr) | 2005-10-07 | 2007-04-19 | Aditech Pharma Ab | Compositions pharmaceutiques a liberation controlee comportant un ester de l'acide fumarique |
US20080089861A1 (en) | 2006-07-10 | 2008-04-17 | Went Gregory T | Combination therapy for treatment of demyelinating conditions |
HRP20220902T3 (hr) | 2007-02-08 | 2022-10-14 | Biogen Ma Inc. | Pripravci i njihova upotreba u liječenju multiple skleroze |
EP3135282A1 (fr) | 2007-02-08 | 2017-03-01 | Biogen MA Inc. | Neuroprotection dans des maladies démyélinisantes |
EP3466420A1 (fr) | 2009-04-29 | 2019-04-10 | Biogen MA Inc. | Fumarate de diméthyle pour le traitement de l'ataxie de friedreich |
DK2533634T3 (en) | 2010-02-12 | 2016-01-25 | Biogen Ma Inc | NEURO PROTECTIVE demyelinating diseases |
JP2013221921A (ja) | 2012-04-19 | 2013-10-28 | Heidenhain Kk | ロータリーエンコーダ |
-
2008
- 2008-02-07 HR HRP20220902TT patent/HRP20220902T3/hr unknown
- 2008-02-07 ES ES13169139T patent/ES2916649T3/es active Active
- 2008-02-07 EP EP13179016.4A patent/EP2680006A1/fr not_active Withdrawn
- 2008-02-07 PT PT87252565T patent/PT2137537E/pt unknown
- 2008-02-07 EP EP13179023.0A patent/EP2680008A1/fr not_active Withdrawn
- 2008-02-07 EP EP13179021.4A patent/EP2680007A1/fr not_active Withdrawn
- 2008-02-07 EP EP13156663.0A patent/EP2629097A1/fr not_active Withdrawn
- 2008-02-07 ES ES08725256T patent/ES2424022T3/es active Active
- 2008-02-07 EP EP22185834.3A patent/EP4137819A1/fr active Pending
- 2008-02-07 PL PL08725256T patent/PL2137537T3/pl unknown
- 2008-02-07 RS RS20220688A patent/RS63489B1/sr unknown
- 2008-02-07 PT PT131691396T patent/PT2653873T/pt unknown
- 2008-02-07 SI SI200831007T patent/SI2137537T1/sl unknown
- 2008-02-07 DK DK08725256.5T patent/DK2137537T3/da active
- 2008-02-07 DK DK13156663.0T patent/DK2629097T1/da unknown
- 2008-02-07 US US12/526,296 patent/US20110112196A1/en not_active Abandoned
- 2008-02-07 DK DK13169139.6T patent/DK2653873T3/da active
- 2008-02-07 RS RS20130362A patent/RS52922B/en unknown
- 2008-02-07 EP EP13179024.8A patent/EP2680009A1/fr not_active Withdrawn
- 2008-02-07 EP EP12169644A patent/EP2518511A1/fr not_active Withdrawn
- 2008-02-07 WO PCT/US2008/001602 patent/WO2008097596A2/fr active Application Filing
- 2008-02-07 SI SI200832197T patent/SI2653873T1/sl unknown
- 2008-02-07 EP EP13169139.6A patent/EP2653873B8/fr active Active
- 2008-02-07 PL PL13169139.6T patent/PL2653873T3/pl unknown
- 2008-02-07 EP EP13179025.5A patent/EP2680010A1/fr not_active Withdrawn
- 2008-02-07 EP EP08725256.5A patent/EP2137537B8/fr not_active Revoked
- 2008-02-07 DE DE13169139.6T patent/DE13169139T1/de active Pending
- 2008-02-07 FI FIEP13156663.0T patent/FI2629097T1/fi unknown
- 2008-02-07 ES ES13156663T patent/ES2916604T1/es active Pending
- 2008-02-07 DE DE13156663.0T patent/DE13156663T1/de active Pending
- 2008-02-07 LT LTEP13169139.6T patent/LT2653873T/lt unknown
-
2010
- 2010-05-14 HK HK10104764.4A patent/HK1139204A1/xx unknown
-
2012
- 2012-02-13 US US13/372,426 patent/US8399514B2/en active Active
- 2012-05-07 US US13/465,740 patent/US20120259012A1/en not_active Abandoned
-
2013
- 2013-02-14 US US13/767,014 patent/US20130317103A1/en not_active Abandoned
- 2013-03-14 US US13/804,283 patent/US20130303613A1/en not_active Abandoned
- 2013-07-25 CY CY20131100634T patent/CY1114340T1/el unknown
- 2013-07-25 HR HRP20130707AT patent/HRP20130707T1/hr unknown
-
2014
- 2014-06-25 FR FR14C0050C patent/FR14C0050I1/fr active Active
- 2014-06-27 LU LU92487C patent/LU92487I2/fr unknown
- 2014-07-16 CY CY2014026C patent/CY2014026I1/el unknown
-
2015
- 2015-05-21 US US14/718,962 patent/US20150366803A1/en not_active Abandoned
-
2018
- 2018-05-24 US US15/988,578 patent/US20180263906A1/en not_active Abandoned
-
2019
- 2019-09-26 US US16/583,491 patent/US20200016072A1/en not_active Abandoned
-
2023
- 2023-01-02 NO NO2023001C patent/NO2023001I1/no unknown
- 2023-01-10 HU HUS2300001C patent/HUS2300001I1/hu unknown
- 2023-01-12 FR FR23C1003C patent/FR23C1003I2/fr active Active
- 2023-01-16 FI FIC20230002C patent/FIC20230002I1/fi unknown
- 2023-01-18 LT LTPA2023503C patent/LTPA2023503I1/lt unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR23C1003I2 (fr) | Compositions et leurs utilisations pour le traitement de la Sclérose en plaques | |
HK1256861A1 (zh) | 用於治療胃腸道炎症的組合物 | |
FR2948016B1 (fr) | Orthese pour le traitement de la rhizarthrose | |
FR2932478B1 (fr) | Composes utiles pour le traitement des cancers. | |
BRPI0921237A2 (pt) | métodos e composições para o tratamento de distúrbios associados ao complemento | |
FR2907011B1 (fr) | Utilisation de la citrulline pour le traitement des etats de denutrition | |
BRPI0911612A2 (pt) | composições e métodos para o tratamento da esclerose múltipla. | |
FR18C1008I2 (fr) | Regime posologique de cladribine pour le traitement de la sclerose en plaques | |
EP2249789A4 (fr) | Compositions et méthodes pour le traitement de la xérostomie | |
SMT201400165B (it) | Composizioni e metodi per il trattamento di sclerosi multipla | |
HK1151304A1 (en) | Compositions and methods for the therapy and diagnosis of cytomegalovirus infections | |
FR2897533B1 (fr) | Agent oxydant pour le traitement des cheveux | |
IT1397446B1 (it) | Compositions comprising amino acids for prevention and/or treatment of renal disorders. | |
FR2917947B1 (fr) | Composition phytosanitaire pour le traitement preventif et curatif du mildiou | |
FR2886153B1 (fr) | Composition destinee au traitement de la sclerose en plaques | |
BRPI0914139A2 (pt) | composições pediátricas para o tratamento de esclerose múltipla | |
FR2905868B1 (fr) | Composition destinee au traitement de la sclerose laterale amyotrophique | |
EP2249843A4 (fr) | Utilisation de compositions immunogènes pour le traitement ou la prévention d infections pathogènes | |
EP2271328A4 (fr) | Compositions antiseptiques pour le traitement d infections | |
FR2928153B1 (fr) | Nouvel additif pour le traitement des aciers resulfures | |
FR2910813B1 (fr) | Nouvelle utilisation therapeutique pour le traitement des leucemies | |
FR2931072B1 (fr) | Composition emolliente pour le traitement preventif de la dermatite atopique | |
FR2901703B1 (fr) | Utilisation de zatosetron pour le traitement de la rosacee, et compositions pharmaceutiques | |
FR2962041B1 (fr) | Inhibiteurs de la calpaine 3 pour le traitement de dystrophies musculaires et de cardiomyopathies | |
ZA201100468B (en) | The treatment of helminthic infections |