MX2021006238A - Metodos para tratamiento que usan terapia celular adoptiva. - Google Patents

Metodos para tratamiento que usan terapia celular adoptiva.

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Publication number
MX2021006238A
MX2021006238A MX2021006238A MX2021006238A MX2021006238A MX 2021006238 A MX2021006238 A MX 2021006238A MX 2021006238 A MX2021006238 A MX 2021006238A MX 2021006238 A MX2021006238 A MX 2021006238A MX 2021006238 A MX2021006238 A MX 2021006238A
Authority
MX
Mexico
Prior art keywords
methods
cell therapy
treatment
cell
adoptive cell
Prior art date
Application number
MX2021006238A
Other languages
English (en)
Inventor
Tina Albertson
Mark Gilbert
Nikolaus Sebastian Trede
Claire Sutherland
Jacob Randolph Garcia
He Li
Original Assignee
Juno Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juno Therapeutics Inc filed Critical Juno Therapeutics Inc
Publication of MX2021006238A publication Critical patent/MX2021006238A/es

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/804—Blood cells [leukemia, lymphoma]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2319/00—Fusion polypeptide
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    • C12Q2600/00—Oligonucleotides characterized by their use
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Abstract

En la presente se proporciona terapia celular adoptiva que implica la administración de dosis de células para tratar sujetos con enfermedad y condiciones tal como ciertas malignidades de células B y métodos, composiciones, usos y artículos de fabricación relacionados. Las células expresan en general receptores recombinantes, tal como receptores de antígeno quimérico (CAR). En algunas modalidades, la enfermedad o condición es un linfoma de células B grandes, tal como un linfoma difuso de células B grandes (DLBCL). También se proporcionan métodos para valorar el riesgo de desarrollar una toxicidad relacionada con una terapia celular, y métodos para identificar sujetos y métodos para tratar sujetos con base en la valoración de riesgos.
MX2021006238A 2018-11-30 2019-11-29 Metodos para tratamiento que usan terapia celular adoptiva. MX2021006238A (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862774164P 2018-11-30 2018-11-30
US201862776415P 2018-12-06 2018-12-06
US201962847926P 2019-05-14 2019-05-14
US201962854945P 2019-05-30 2019-05-30
US201962890600P 2019-08-22 2019-08-22
US201962931204P 2019-11-05 2019-11-05
PCT/US2019/063889 WO2020113194A2 (en) 2018-11-30 2019-11-29 Methods for treatment using adoptive cell therapy

Publications (1)

Publication Number Publication Date
MX2021006238A true MX2021006238A (es) 2021-10-01

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MX2021006238A MX2021006238A (es) 2018-11-30 2019-11-29 Metodos para tratamiento que usan terapia celular adoptiva.

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US (1) US20220088070A1 (es)
EP (1) EP3886875B1 (es)
JP (1) JP2022513685A (es)
KR (1) KR20210117260A (es)
CN (1) CN113710256A (es)
AU (1) AU2019387497A1 (es)
BR (1) BR112021010354A2 (es)
CA (1) CA3120869A1 (es)
IL (1) IL283325A (es)
MX (1) MX2021006238A (es)
SG (1) SG11202105502RA (es)
WO (1) WO2020113194A2 (es)

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MX2023002544A (es) 2020-09-10 2023-03-14 Genmab As Anticuerpo biespecifico contra cumulo de diferenciacion 3 (cd3) y cumulo de diferenciacion 20 (cd20) en terapia de combinacion para tratar linfoma folicular.
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WO2023250400A1 (en) * 2022-06-22 2023-12-28 Juno Therapeutics, Inc. Treatment methods for second line therapy of cd19-targeted car t cells
CN117153252A (zh) * 2023-08-31 2023-12-01 山东第一医科大学附属省立医院(山东省立医院) 一种用于弥漫大b细胞淋巴瘤患者预后生物标志物及其系统和应用

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