RU2016134843A - Антитела к ceacam1 и способы их использования - Google Patents
Антитела к ceacam1 и способы их использования Download PDFInfo
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- RU2016134843A RU2016134843A RU2016134843A RU2016134843A RU2016134843A RU 2016134843 A RU2016134843 A RU 2016134843A RU 2016134843 A RU2016134843 A RU 2016134843A RU 2016134843 A RU2016134843 A RU 2016134843A RU 2016134843 A RU2016134843 A RU 2016134843A
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- Prior art keywords
- cancer
- antibody
- ceacam1
- fragment
- lymphocytes
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- 108010062802 CD66 antigens Proteins 0.000 title claims 12
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 title claims 12
- 238000000034 method Methods 0.000 claims 23
- 210000004698 lymphocyte Anatomy 0.000 claims 15
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 201000011510 cancer Diseases 0.000 claims 9
- 239000012634 fragment Substances 0.000 claims 8
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 210000004881 tumor cell Anatomy 0.000 claims 5
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 4
- 201000001441 melanoma Diseases 0.000 claims 4
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 238000011394 anticancer treatment Methods 0.000 claims 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 2
- 239000012636 effector Substances 0.000 claims 2
- 230000005012 migration Effects 0.000 claims 2
- 238000013508 migration Methods 0.000 claims 2
- 210000000822 natural killer cell Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000035755 proliferation Effects 0.000 claims 2
- 230000004850 protein–protein interaction Effects 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010039491 Sarcoma Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000002519 immonomodulatory effect Effects 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 238000011282 treatment Methods 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 206010046766 uterine cancer Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57473—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving carcinoembryonic antigen, i.e. CEA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (23)
1. Выделенное антитело, распознающее CEACAM1, или его фрагмент, содержащее домен распознавания антигена, где антитело содержит такие же последовательности вариабельных областей CDR1, CDR2 и CDR3 тяжелой цепи, такие же последовательности вариабельных областей CDR1, CDR2 и CDR3 легкой цепи, и такую же ори
ентацию, как CDR антитела, полученного из клетки гибридомы, депонированной под номером доступа ATCC PTA-9974.
2. Выделенное антитело или его фрагмент по п. 1, где антителом является гуманизированное антитело.
3. Способ иммуномодуляции, включающий контактирование CEACAM1-экспрессирующего лимфоцита с антителом или его фрагментом по п. 1 или 2.
4. Способ ингибирования миграции или пролиферации CEACAM1-экспрессирующей опухолевой клетки, где способ включает контактирование CEACAM1-экспрессирующей опухолевой клетки с антителом или его фрагментом по п. 1 или 2, которое ингибирует миграцию или пролиферацию CEACAM1-экспрессирующей опухолевой клетки.
5. Способ лечения или ингибирования рака, где способ включает введение субъекту, нуждающемуся в этом, терапевтического количества антитела или его фрагмента по п. 1 или 2, которое приводит к лечению рака у субъекта.
6. Способ ингибирования CEACAM1 гомотипического или гетеротипического белок-белкового взаимодействия, где способ включает контакирование CEACAM1-экспрессирующего лимфоцита с антителом или его фрагментом по п. 1 или 2, которое ингибирует CEACAM1 гомотипическое или гетеротипическое белок-белковое взаимодействие.
7. Способ по п. 3 или 6, где указанный CEACAM1-экспрессирующий лимфоцит представляет собой противоопухолевый эффекторный лимфоцит, NK клетка или цитотоксическая T клетка.
8. Способ по п. 4, где указанная опухолевая клетка включает опухолевую клетку меланомы.
9. Способ по п. 5, где указанным раком является меланома.
10. Фармацевтическая композиция для лечения или ингибирования рака, включающая в качестве активного компонента терапевтически эффективное количество антитела или его фрагмента по п. 1 или 2 и фармацевтически приемлемый носитель или эксципиент.
11. Фармацевтическая композиция по п.10, дополнительно включающая лимфоциты.
12. Способ лечения или ингибирования рака, где способ включает введение субъекту, нуждающемуся в этом, терапевтического количества антитела или его фрагмента по п. 1 или 2; и дополнительное введение лимфоцитов.
13. Способ по п. 12, где лимфоцитами являются CEACAM1-экспрессирующие лимфоциты.
14. Способ по п. 13, где CEACAM1-экспрессирующие лимфоциты представляют собой противоопухолевые эффекторные лимфоциты, NK клетки или цитотоксические T клетки.
15. Способ по п. 12, где лимфоциты вводят субъекту до введения антитела или фрагмента антитела.
16. Способ по п. 12, где лимфоциты вводят субъекту одновременно с введением антитела или фрагмента антитела.
17. Способ по п. 12, где лимфоциты вводят субъекту после введения антитела или фрагмента антитела.
18. Способ по п. 12, где лимфоциты получают из субъектов и обрабатывают способами размножения ex vivo.
19. Способ по п. 12, где субъект проходит курс другого противоракового лечения до введения антитела или фрагмента антитела или до введения лимфоцитов.
20. Способ по п. 19, где другое противораковое лечение представляет собой химиотерапию или лучевую терапию.
21. Способ по п. 12, где рак выбран из группы, состоящей из меланомы, саркомы, рака легких, рака щитовидной железы, рака груди, рака толстой кишки, рака простаты, рака печени, рака мочевого пузыря, рака почек, цервикального рака, рака поджелудочной железы, лейкемии, лимфомы, рака клеток костного мозга, рака яичников, рака матки, рака желчных протоков или внутриматочного рака.
22. Способ по п. 12, где раком является меланома.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21304009P | 2009-04-30 | 2009-04-30 | |
US61/213,040 | 2009-04-30 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011148598/10A Division RU2598710C2 (ru) | 2009-04-30 | 2010-04-29 | Антитела к сеасам1 и способы их использования |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2016134843A true RU2016134843A (ru) | 2018-12-11 |
RU2016134843A3 RU2016134843A3 (ru) | 2020-02-21 |
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ID=42313044
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2016134843A RU2016134843A (ru) | 2009-04-30 | 2010-04-29 | Антитела к ceacam1 и способы их использования |
RU2011148598/10A RU2598710C2 (ru) | 2009-04-30 | 2010-04-29 | Антитела к сеасам1 и способы их использования |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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RU2011148598/10A RU2598710C2 (ru) | 2009-04-30 | 2010-04-29 | Антитела к сеасам1 и способы их использования |
Country Status (19)
Country | Link |
---|---|
US (4) | US8598322B2 (ru) |
EP (2) | EP2990421B1 (ru) |
JP (1) | JP5726170B2 (ru) |
KR (2) | KR101875227B1 (ru) |
CN (1) | CN102482354B (ru) |
AU (1) | AU2010243211B2 (ru) |
BR (1) | BRPI1015350B1 (ru) |
CA (1) | CA2760385C (ru) |
DK (1) | DK2424896T3 (ru) |
ES (2) | ES2668874T3 (ru) |
HK (2) | HK1167264A1 (ru) |
HR (1) | HRP20151099T8 (ru) |
HU (1) | HUE028294T2 (ru) |
LT (1) | LT2990421T (ru) |
PL (2) | PL2990421T3 (ru) |
PT (1) | PT2424896E (ru) |
RU (2) | RU2016134843A (ru) |
SI (1) | SI2424896T1 (ru) |
WO (1) | WO2010125571A1 (ru) |
Families Citing this family (81)
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US8735157B2 (en) * | 2005-06-09 | 2014-05-27 | Gal Markel | CEACAM1 mediated protective immunity |
EP2990421B1 (en) * | 2009-04-30 | 2018-02-21 | Tel HaShomer Medical Research Infrastructure and Services Ltd. | Anti ceacam1 antibodies and methods of using same |
WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
CA2892371C (en) * | 2011-12-01 | 2021-01-19 | The Brigham And Women's Hospital, Inc. | Anti-ceacam1 recombinant antibodies for cancer therapy |
CA2916638C (en) * | 2012-07-31 | 2021-01-12 | The Brigham And Women's Hospital, Inc. | Modulation of the immune response |
CN105744955B (zh) | 2013-11-25 | 2020-03-20 | 希凯姆生物治疗有限公司 | 用于癌症治疗的包含抗ceacam1抗体和抗pd抗体的组合物 |
WO2015090230A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
JOP20200094A1 (ar) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | جزيئات جسم مضاد لـ pd-1 واستخداماتها |
JOP20200096A1 (ar) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | جزيئات جسم مضاد لـ tim-3 واستخداماتها |
ME03558B (me) | 2014-03-14 | 2020-07-20 | Novartis Ag | Molekuli anti-lag-3 antiтela i njihove upotrebe |
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IL293603B2 (en) | 2014-04-07 | 2024-03-01 | Novartis Ag | Cancer treatment using chimeric antigen receptor (CAR) against CD19 |
MX366359B (es) * | 2014-04-27 | 2019-07-05 | Ccam Biotherapeutics Ltd | Anticuerpos humanizados contra la molecula de adhesion celular relacionada al antigeno carcinoembrionico 1 (ceacam1). |
US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
US9777061B2 (en) | 2014-07-21 | 2017-10-03 | Novartis Ag | Treatment of cancer using a CD33 chimeric antigen receptor |
WO2016014553A1 (en) | 2014-07-21 | 2016-01-28 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
JP2017528433A (ja) | 2014-07-21 | 2017-09-28 | ノバルティス アーゲー | 低い免疫増強用量のmTOR阻害剤とCARの組み合わせ |
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AU2015301460B2 (en) | 2014-08-14 | 2021-04-08 | Novartis Ag | Treatment of cancer using GFR alpha-4 chimeric antigen receptor |
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