DK3166968T3 - Sammensætninger og fremgangsmåder til kimæriske autoantistofreceptor-T-celler - Google Patents
Sammensætninger og fremgangsmåder til kimæriske autoantistofreceptor-T-celler Download PDFInfo
- Publication number
- DK3166968T3 DK3166968T3 DK15786710.2T DK15786710T DK3166968T3 DK 3166968 T3 DK3166968 T3 DK 3166968T3 DK 15786710 T DK15786710 T DK 15786710T DK 3166968 T3 DK3166968 T3 DK 3166968T3
- Authority
- DK
- Denmark
- Prior art keywords
- compositions
- cells
- methods
- chimeric autoantibody
- autoantibody receptor
- Prior art date
Links
- 210000001744 T-lymphocyte Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4621—Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4631—Chimeric Antigen Receptors [CAR]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/46433—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464402—Receptors, cell surface antigens or cell surface determinants
- A61K39/464411—Immunoglobulin superfamily
- A61K39/464412—CD19 or B4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
- A61K39/464468—Mesothelin [MSLN]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the structure of the chimeric antigen receptor [CAR]
- A61K2239/11—Antigen recognition domain
- A61K2239/15—Non-antibody based
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461987989P | 2014-05-02 | 2014-05-02 | |
| PCT/US2015/028872 WO2015168613A2 (en) | 2014-05-02 | 2015-05-01 | Compositions and methods of chimeric autoantibody receptor t cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3166968T3 true DK3166968T3 (da) | 2021-12-06 |
Family
ID=54359505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15786710.2T DK3166968T3 (da) | 2014-05-02 | 2015-05-01 | Sammensætninger og fremgangsmåder til kimæriske autoantistofreceptor-T-celler |
Country Status (7)
| Country | Link |
|---|---|
| US (6) | US10301370B2 (da) |
| EP (2) | EP4008725A1 (da) |
| CN (2) | CN107074929B (da) |
| CA (1) | CA2984484C (da) |
| DK (1) | DK3166968T3 (da) |
| ES (1) | ES2900327T3 (da) |
| WO (1) | WO2015168613A2 (da) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2984484C (en) * | 2014-05-02 | 2024-01-23 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor t cells |
| CA2975384A1 (en) | 2015-01-29 | 2016-08-04 | Regents Of The University Of Minnesota | Chimeric antigen receptors, compositions, and methods |
| SG11201706774WA (en) | 2015-02-27 | 2017-09-28 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars) targeting hematologic malignancies, compositions and methods of use thereof |
| CN114634943A (zh) | 2015-05-18 | 2022-06-17 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| US11173179B2 (en) | 2015-06-25 | 2021-11-16 | Icell Gene Therapeutics Llc | Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof |
| TWI833684B (zh) | 2015-06-25 | 2024-03-01 | 美商生物細胞基因治療有限公司 | 嵌合抗原受體（ｃａｒ）、組合物及其使用方法 |
| WO2017222593A1 (en) | 2016-06-24 | 2017-12-28 | Icell Gene Therapeutics Llc | Chimeric antigen receptors (cars), compositions and methods thereof |
| EA201890782A1 (ru) * | 2015-09-22 | 2018-09-28 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Способ перенацеливания t-клеток для лечения инфекции hiv |
| DK3443096T5 (da) * | 2016-04-15 | 2024-09-09 | Novartis Ag | Sammensætninger og fremgangsmåder til selektiv ekspression af kimære antigenreceptorer |
| AU2017248817A1 (en) * | 2016-04-15 | 2018-11-15 | The Children's Hospital Of Philadelphia | Compositions and methods of chimeric alloantigen receptor T cells |
| EP3494138A1 (en) | 2016-08-02 | 2019-06-12 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
| WO2018067993A1 (en) | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| CA3037387A1 (en) | 2016-10-13 | 2018-04-19 | Juno Therapeutics, Inc. | Immunotherapy methods and compositions involving tryptophan metabolic pathway modulators |
| JP7291396B2 (ja) | 2016-11-22 | 2023-06-15 | ティーシーアール２ セラピューティクス インク． | 融合タンパク質を用いたｔｃｒの再プログラミングのための組成物及び方法 |
| KR20190104528A (ko) | 2016-12-03 | 2019-09-10 | 주노 쎄러퓨티크스 인코퍼레이티드 | Car-t 세포들 투여를 결정하는 방법 |
| EP3548083A1 (en) | 2016-12-03 | 2019-10-09 | Juno Therapeutics, Inc. | Methods for modulation of car-t cells |
| US20190350978A1 (en) | 2016-12-05 | 2019-11-21 | Juno Therapeutics, Inc. | Production of engineered cells for adoptive cell therapy |
| WO2018127585A1 (en) | 2017-01-06 | 2018-07-12 | Txcell | Monospecific regulatory t cell population with cytotoxicity for b cells |
| EP3346001A1 (en) | 2017-01-06 | 2018-07-11 | TXCell | Monospecific regulatory t cell population with cytotoxicity for b cells |
| CN110691792A (zh) | 2017-01-10 | 2020-01-14 | 朱诺治疗学股份有限公司 | 细胞疗法的表观遗传学分析及相关方法 |
| EP3571221A2 (en) | 2017-01-20 | 2019-11-27 | Juno Therapeutics GmbH | Cell surface conjugates and related cell compositions and methods |
| KR20240063204A (ko) | 2017-02-17 | 2024-05-10 | 프레드 허친슨 캔서 센터 | Bcma 관련 암 및 자가면역 장애의 치료를 위한 조합 요법 |
| MX2019012017A (es) | 2017-04-07 | 2020-02-12 | Juno Therapeutics Inc | Celulas modificadas que expresan antigeno de membrana especifico de prostata (psma) o una forma modificada del mismo y metodos relacionados. |
| FI3618842T3 (fi) | 2017-05-01 | 2023-12-15 | Juno Therapeutics Inc | Soluterapian ja immunomodulatorisen yhdisteen yhdistelmä |
| WO2018223101A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| AU2018313950A1 (en) | 2017-08-09 | 2020-02-13 | Juno Therapeutics, Inc. | Methods for producing genetically engineered cell compositions and related compositions |
| MA49981A (fr) | 2017-08-09 | 2020-06-17 | Juno Therapeutics Inc | Procédés et compositions de préparation de cellules génétiquement modifiées |
| AR123115A1 (es) | 2017-10-18 | 2022-11-02 | Novartis Ag | Composiciones y métodos para la degradación selectiva de proteínas |
| US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| US20200289565A1 (en) | 2017-11-06 | 2020-09-17 | Juno Therapeutics, Inc. | Combination of a cell therapy and a gamma secretase inhibitor |
| WO2019109053A1 (en) | 2017-12-01 | 2019-06-06 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| CN112203680A (zh) | 2017-12-08 | 2021-01-08 | 朱诺治疗学股份有限公司 | 用于细胞疗法的表型标记和相关方法 |
| SG11202005228YA (en) | 2017-12-08 | 2020-07-29 | Juno Therapeutics Inc | Serum-free media formulation for culturing cells and methods of use thereof |
| CN112004824B (zh) | 2017-12-08 | 2024-09-13 | 朱诺治疗学股份有限公司 | 生产工程化t细胞组合物的过程 |
| CA3094468A1 (en) | 2018-04-05 | 2019-10-10 | Juno Therapeutics, Inc. | Methods of producing cells expressing a recombinant receptor and related compositions |
| KR20210007998A (ko) * | 2018-05-02 | 2021-01-20 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 포스포리파제 a2 수용체 키메라 자가항체 수용체 t 세포의 조성물 및 방법 |
| EP3801642A4 (en) * | 2018-06-05 | 2022-03-23 | The Trustees of The University of Pennsylvania | COMPOSITIONS AND METHODS FOR CHIMERIC AUTOANTIBODY RECEPTOR CELLS OF MUSCLE-SPECIFIC KINASE |
| AU2019318560A1 (en) | 2018-08-09 | 2021-02-25 | Juno Therapeutics, Inc. | Processes for generating engineered cells and compositions thereof |
| EP3833759A1 (en) | 2018-08-09 | 2021-06-16 | Juno Therapeutics, Inc. | Methods for assessing integrated nucleic acids |
| US20220050114A1 (en) | 2018-09-11 | 2022-02-17 | Juno Therapeutics, Inc. | Methods for mass spectrometry analysis of engineered cell compositions |
| EP3874024A1 (en) | 2018-10-31 | 2021-09-08 | Juno Therapeutics GmbH | Methods for selection and stimulation of cells and apparatus for same |
| MX2021005021A (es) | 2018-11-06 | 2021-08-11 | Juno Therapeutics Inc | Proceso para producir celulas t geneticamente modificadas. |
| KR20210111247A (ko) | 2018-11-08 | 2021-09-10 | 주노 쎄러퓨티크스 인코퍼레이티드 | 치료 및 ｔ 세포 조절을 위한 방법 및 조합 |
| US20230043255A1 (en) | 2018-11-14 | 2023-02-09 | Flagship Pioneering Innovations V, Inc. | Fusosome compositions for t cell delivery |
| US20220008465A1 (en) | 2018-11-16 | 2022-01-13 | Juno Therapeutics, Inc. | Methods of dosing engineered t cells for the treatment of b cell malignancies |
| PT3886875T (pt) | 2018-11-30 | 2024-06-27 | Juno Therapeutics Inc | Métodos para tratamento utilizando terapia celular adotiva |
| FI3886894T3 (fi) | 2018-11-30 | 2024-05-24 | Juno Therapeutics Inc | Menetelmiä annosteluun ja b-solumaligniteettien hoitoon adoptiivisessa soluterapiassa |
| WO2020223535A1 (en) | 2019-05-01 | 2020-11-05 | Juno Therapeutics, Inc. | Cells expressing a recombinant receptor from a modified tgfbr2 locus, related polynucleotides and methods |
| JP2022531577A (ja) | 2019-05-01 | 2022-07-07 | ジュノー セラピューティクス インコーポレイテッド | 改変されたｃｄ２４７遺伝子座からキメラ受容体を発現する細胞、関連ポリヌクレオチド、および方法 |
| WO2020231999A1 (en) * | 2019-05-13 | 2020-11-19 | The Trustees Of The University Of Pennsylvania | Compositions and methods of acetylcholine receptor chimeric autoantibody receptor cells |
| EP3980458A1 (en) | 2019-06-05 | 2022-04-13 | Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) | Chimeric autoantibody receptor (caar) that binds autoantibodies targeting the central nervous system in neurological autoimmune disease |
| EP3997129A4 (en) * | 2019-07-11 | 2024-02-21 | Valkyr, Inc. | SYSTEM AND METHODS RELATING TO CHIMERIC AUTOANTIBODY RECEPTORS |
| EP4022091A1 (en) * | 2019-08-30 | 2022-07-06 | Janssen Biotech, Inc. | B-cell maturation complex car t construct and primers |
| WO2021084050A1 (en) | 2019-10-30 | 2021-05-06 | Juno Therapeutics Gmbh | Cell selection and/or stimulation devices and methods of use |
| BR112022010310A2 (pt) | 2019-12-06 | 2022-08-16 | Juno Therapeutics Inc | Métodos relacionados com a toxicidade e resposta associada com terapia celular para tratamento de malignidades de célula b |
| EP4097218A1 (en) | 2020-01-28 | 2022-12-07 | Juno Therapeutics, Inc. | Methods for t cell transduction |
| US20230167429A1 (en) * | 2020-04-28 | 2023-06-01 | The Trustees Of The University Of Pennsylvania | Compositions and methods of adamts13 chimeric autoantibody receptor cells |
| US20230181641A1 (en) | 2020-05-13 | 2023-06-15 | Juno Therapeutics, Inc. | Process for producing donor-batched cells expressing a recombinant receptor |
| JP2023531531A (ja) | 2020-06-26 | 2023-07-24 | ジュノ セラピューティクス ゲーエムベーハー | 組換え受容体を条件付きで発現する操作されたｔ細胞、関連ポリヌクレオチド、および方法 |
| CN116157415A (zh) * | 2020-09-03 | 2023-05-23 | 苏州博腾生物制药有限公司 | 靶向抗rh抗体的组合物和方法 |
| US20240041927A1 (en) | 2020-12-22 | 2024-02-08 | Deutsches Zentrum Für Neurodegenerative Erkrankungen E. V. (Dzne) | Chimeric autoantibody receptor (caar) comprising a nicotinic acetylcholine receptor autoantigen |
| US20220241328A1 (en) | 2021-01-11 | 2022-08-04 | Sana Biotechnology, Inc. | Use of cd8-targeted viral vectors |
| CN117693508A (zh) | 2021-03-03 | 2024-03-12 | 朱诺治疗学股份有限公司 | T细胞疗法和dgk抑制剂的组合 |
| US20240150472A1 (en) * | 2021-03-17 | 2024-05-09 | Daiichi Sankyo Company, Limited | Gene coding for chimeric receptor for anti-acetylcholine receptor autoantibody |
| AU2022241654A1 (en) | 2021-03-22 | 2023-09-28 | Juno Therapeutics, Inc. | Methods of determining potency of a therapeutic cell composition |
| KR20230158573A (ko) | 2021-03-22 | 2023-11-20 | 주노 쎄러퓨티크스 인코퍼레이티드 | 바이러스 벡터 입자의 효력을 평가하는 방법 |
| WO2022234009A2 (en) | 2021-05-06 | 2022-11-10 | Juno Therapeutics Gmbh | Methods for stimulating and transducing t cells |
| RU2770444C1 (ru) * | 2021-05-27 | 2022-04-18 | Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) | Рекомбинантные белки-антигены и способ определения эпитопной специфичности аутореактивных антител к отдельным фрагментам экстрацеллюлярного домена десмоглеина 3-го типа человека у больных обыкновенной пузырчаткой, тест-система на их основе |
| WO2023015217A1 (en) | 2021-08-04 | 2023-02-09 | Sana Biotechnology, Inc. | Use of cd4-targeted viral vectors |
| EP4380963A1 (en) * | 2021-08-05 | 2024-06-12 | The Trustees of The University of Pennsylvania | Compositions and methods of chimeric autoantibody receptor cells expressing extended phospholipase a2 receptor fragments |
| CN114152753B (zh) * | 2021-11-12 | 2024-03-05 | 钱华 | 一种用于检测人Dsg3 IgG抗体的ELISA试剂盒及其应用 |
| CN114152754B (zh) * | 2021-11-26 | 2024-03-05 | 钱华 | 一种用于检测人Dsg1 IgG抗体的ELISA试剂盒及其应用 |
| WO2023150518A1 (en) | 2022-02-01 | 2023-08-10 | Sana Biotechnology, Inc. | Cd3-targeted lentiviral vectors and uses thereof |
| CN114656572B (zh) * | 2022-02-25 | 2024-07-19 | 北京大学第一医院 | 一种bp180抗体快速检测试剂盒及其制备方法 |
| WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
| WO2023213969A1 (en) | 2022-05-05 | 2023-11-09 | Juno Therapeutics Gmbh | Viral-binding protein and related reagents, articles, and methods of use |
| WO2024054944A1 (en) | 2022-09-08 | 2024-03-14 | Juno Therapeutics, Inc. | Combination of a t cell therapy and continuous or intermittent dgk inhibitor dosing |
| WO2024081820A1 (en) | 2022-10-13 | 2024-04-18 | Sana Biotechnology, Inc. | Viral particles targeting hematopoietic stem cells |
| WO2024100604A1 (en) | 2022-11-09 | 2024-05-16 | Juno Therapeutics Gmbh | Methods for manufacturing engineered immune cells |
| WO2024161021A1 (en) | 2023-02-03 | 2024-08-08 | Juno Therapeutics Gmbh | Methods for non-viral manufacturing of engineered immune cells |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US6352694B1 (en) | 1994-06-03 | 2002-03-05 | Genetics Institute, Inc. | Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells |
| US6905680B2 (en) | 1988-11-23 | 2005-06-14 | Genetics Institute, Inc. | Methods of treating HIV infected subjects |
| US6534055B1 (en) | 1988-11-23 | 2003-03-18 | Genetics Institute, Inc. | Methods for selectively stimulating proliferation of T cells |
| US5858358A (en) | 1992-04-07 | 1999-01-12 | The United States Of America As Represented By The Secretary Of The Navy | Methods for selectively stimulating proliferation of T cells |
| US5585362A (en) | 1989-08-22 | 1996-12-17 | The Regents Of The University Of Michigan | Adenovirus vectors for gene therapy |
| US6004811A (en) | 1991-03-07 | 1999-12-21 | The Massachussetts General Hospital | Redirection of cellular immunity by protein tyrosine kinase chimeras |
| US5199942A (en) | 1991-06-07 | 1993-04-06 | Immunex Corporation | Method for improving autologous transplantation |
| GB9125768D0 (en) | 1991-12-04 | 1992-02-05 | Hale Geoffrey | Therapeutic method |
| US5350674A (en) | 1992-09-04 | 1994-09-27 | Becton, Dickinson And Company | Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof |
| US7175843B2 (en) | 1994-06-03 | 2007-02-13 | Genetics Institute, Llc | Methods for selectively stimulating proliferation of T cells |
| US5738847A (en) | 1994-09-19 | 1998-04-14 | The Regents Of The University Of California | Anti-VH3-15 reagents and methods for their use |
| US7067318B2 (en) | 1995-06-07 | 2006-06-27 | The Regents Of The University Of Michigan | Methods for transfecting T cells |
| US6692964B1 (en) | 1995-05-04 | 2004-02-17 | The United States Of America As Represented By The Secretary Of The Navy | Methods for transfecting T cells |
| US7060868B1 (en) * | 1999-03-31 | 2006-06-13 | Keio University | Autoimmune disease model animal |
| WO2001029058A1 (en) | 1999-10-15 | 2001-04-26 | University Of Massachusetts | Rna interference pathway genes as tools for targeted genetic interference |
| US6326193B1 (en) | 1999-11-05 | 2001-12-04 | Cambria Biosciences, Llc | Insect control agent |
| EP2392596A3 (en) * | 1999-12-28 | 2013-11-27 | ESBATech, an Alcon Biomedical Research Unit LLC | Intrabodies with defined framework that is stable in a reducing environment and applications thereof |
| US6797514B2 (en) | 2000-02-24 | 2004-09-28 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| US6867041B2 (en) | 2000-02-24 | 2005-03-15 | Xcyte Therapies, Inc. | Simultaneous stimulation and concentration of cells |
| IL151287A0 (en) | 2000-02-24 | 2003-04-10 | Xcyte Therapies Inc | A method for stimulation and concentrating cells |
| US7572631B2 (en) | 2000-02-24 | 2009-08-11 | Invitrogen Corporation | Activation and expansion of T cells |
| AU2001275474A1 (en) | 2000-06-12 | 2001-12-24 | Akkadix Corporation | Materials and methods for the control of nematodes |
| US7332168B2 (en) * | 2000-08-22 | 2008-02-19 | Micromet Ag | Composition for the elimination of autoreactive B-cells |
| GB0025307D0 (en) * | 2000-10-16 | 2000-11-29 | Celltech Chiroscience Ltd | Biological products |
| US7550562B2 (en) | 2001-09-04 | 2009-06-23 | Keio University | Pemphigus monoclonal antibody |
| US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
| US20060257420A1 (en) * | 2002-04-26 | 2006-11-16 | Cel-Sci Corporation | Methods of preparation and composition of peptide constructs useful for treatment of autoimmune and transplant related host versus graft conditions |
| JP2006520604A (ja) * | 2003-03-19 | 2006-09-14 | アイソジェニス・インコーポレイテッド | ＣＤ８α鎖に基づき免疫原性が減少した遺伝子治療ベクター |
| US20050118185A1 (en) * | 2003-06-18 | 2005-06-02 | Cell Center Cologne Gmbh | Recombinant immunoreceptors |
| US7084247B2 (en) * | 2004-03-11 | 2006-08-01 | Peptimmune, Inc. | Identification of self and non-self antigens implicated in autoimmune diseases |
| US7754482B2 (en) | 2004-05-27 | 2010-07-13 | The Trustees Of The University Of Pennsylvania | Artificial antigen presenting cells and uses therefor |
| CN101505791A (zh) * | 2006-08-14 | 2009-08-12 | 株式会社未来创药研究所 | 使用抗桥粒芯蛋白3抗体的癌症的诊断和治疗 |
| WO2008097439A2 (en) * | 2007-02-07 | 2008-08-14 | The Trustees Of The University Of Pennsylvania | Anti-autoimmune antibodies for treatment of pemphigus |
| WO2009002380A2 (en) * | 2007-06-26 | 2008-12-31 | The Trustees Of The University Of Pennsylvania | Isolation of anti-desmoglein 1 antibodies by phage display of pemphigus foliaceus autoantibodies |
| SG190997A1 (en) * | 2010-12-09 | 2013-07-31 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9402865B2 (en) * | 2011-01-18 | 2016-08-02 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treating cancer |
| CN104379179A (zh) | 2012-04-11 | 2015-02-25 | 美国卫生和人力服务部 | 靶向b-细胞成熟抗原的嵌合抗原受体 |
| CA2984484C (en) * | 2014-05-02 | 2024-01-23 | The Trustees Of The University Of Pennsylvania | Compositions and methods of chimeric autoantibody receptor t cells |
-
2015
- 2015-05-01 CA CA2984484A patent/CA2984484C/en active Active
- 2015-05-01 EP EP21196321.0A patent/EP4008725A1/en active Pending
- 2015-05-01 WO PCT/US2015/028872 patent/WO2015168613A2/en active Application Filing
- 2015-05-01 US US15/307,644 patent/US10301370B2/en active Active
- 2015-05-01 ES ES15786710T patent/ES2900327T3/es active Active
- 2015-05-01 CN CN201580036310.1A patent/CN107074929B/zh active Active
- 2015-05-01 EP EP15786710.2A patent/EP3166968B1/en active Active
- 2015-05-01 DK DK15786710.2T patent/DK3166968T3/da active
- 2015-05-01 CN CN202110940799.2A patent/CN113604491A/zh active Pending
-
2019
- 2019-04-19 US US16/389,423 patent/US11407802B2/en active Active
- 2019-04-22 US US16/390,685 patent/US11407804B2/en active Active
- 2019-04-22 US US16/390,763 patent/US11578113B2/en active Active
- 2019-04-22 US US16/390,638 patent/US11407803B2/en active Active
-
2023
- 2023-01-19 US US18/156,442 patent/US20230303653A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20230303653A1 (en) | 2023-09-28 |
| CA2984484C (en) | 2024-01-23 |
| US11407803B2 (en) | 2022-08-09 |
| CN113604491A (zh) | 2021-11-05 |
| WO2015168613A2 (en) | 2015-11-05 |
| US11578113B2 (en) | 2023-02-14 |
| CN107074929A (zh) | 2017-08-18 |
| EP3166968B1 (en) | 2021-09-22 |
| CN107074929B (zh) | 2021-09-03 |
| US10301370B2 (en) | 2019-05-28 |
| ES2900327T3 (es) | 2022-03-16 |
| US20190315831A1 (en) | 2019-10-17 |
| WO2015168613A3 (en) | 2015-12-23 |
| US20190315830A1 (en) | 2019-10-17 |
| US11407802B2 (en) | 2022-08-09 |
| CA2984484A1 (en) | 2015-11-05 |
| EP4008725A1 (en) | 2022-06-08 |
| EP3166968A4 (en) | 2018-05-23 |
| US20170051035A1 (en) | 2017-02-23 |
| US20190315829A1 (en) | 2019-10-17 |
| US11407804B2 (en) | 2022-08-09 |
| EP3166968A2 (en) | 2017-05-17 |
| US20190309041A1 (en) | 2019-10-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK3166968T3 (da) | Sammensætninger og fremgangsmåder til kimæriske autoantistofreceptor-T-celler | |
| HK1243333A1 (zh) | 用於修飾的t細胞的方法和組合物 | |
| ZA201901336B (en) | Improved t cell compositions | |
| DK3365364T3 (da) | Kimære antistof/T-celle-receptorkonstruktioner og anvendelser deraf | |
| IL253149A0 (en) | Methods for preparing cells expressing a chimeric receptor antigen | |
| PT3443075T (pt) | Células t transgénicas e composições de células t que expressam um recetor antigénico quimérico e métodos relacionados | |
| IL251524B (en) | t cell receptors | |
| CL2016002196A1 (es) | Receptor antigénico quimérico | |
| DK3215601T3 (da) | Fremgangsmåder til transduktion og celleforarbejdning | |
| IL249373A0 (en) | Polypeptide formulations of related detector and method | |
| DK3227336T3 (da) | Anti-CD79b-antistoffer og fremgangsmåder til anvendelse | |
| DK3092256T3 (da) | Forbindelser og sammensætninger til immunterapi | |
| DK3125927T3 (da) | Fremgangsmåder og sammensætninger til immunmodulering | |
| DK3137605T3 (da) | Sammensætninger og fremgangsmåder til modulering af angiopoietin-lignende-3-ekspression | |
| DK3169703T4 (da) | Kimær antigenreceptor og anvendelse deraf | |
| DK3116911T3 (da) | Anti-mcam-antistoffer og tilhørende fremgangsmåder til anvendelse | |
| DK3172233T3 (da) | Anti-cd74-antistoffer, sammensætninger omfattende anti-cd74- antistoffer og fremgangsmåder til anvendelse af anti-cd74-antistoffer | |
| DK3125898T3 (da) | Farmakofor til trail-induktion | |
| SG11201708313QA (en) | T cell receptor | |
| IL266111A (en) | Methods for inducing a t-cell response | |
| ES2914082T8 (es) | Procedimiento de generación de progenitores de células T | |
| DK3190875T3 (da) | Fremgangsmåder og systemer til udklækning af æg | |
| DK3107554T3 (da) | Antistof til påvirkning af kønsforholdet og metoder til anvendelse deraf | |
| DK3142666T3 (da) | 5-HT4-receptoragonist til gastroparese |