DK3365364T3 - Kimære antistof/T-celle-receptorkonstruktioner og anvendelser deraf - Google Patents
Kimære antistof/T-celle-receptorkonstruktioner og anvendelser deraf Download PDFInfo
- Publication number
- DK3365364T3 DK3365364T3 DK16858388.8T DK16858388T DK3365364T3 DK 3365364 T3 DK3365364 T3 DK 3365364T3 DK 16858388 T DK16858388 T DK 16858388T DK 3365364 T3 DK3365364 T3 DK 3365364T3
- Authority
- DK
- Denmark
- Prior art keywords
- cell receptor
- chimeric antibody
- receptor constructs
- constructs
- chimeric
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
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- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07—ORGANIC CHEMISTRY
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- C07K2317/622—Single chain antibody (scFv)
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
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- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562245944P | 2015-10-23 | 2015-10-23 | |
US201662304918P | 2016-03-07 | 2016-03-07 | |
US201662345649P | 2016-06-03 | 2016-06-03 | |
US201662369694P | 2016-08-01 | 2016-08-01 | |
PCT/US2016/058305 WO2017070608A1 (en) | 2015-10-23 | 2016-10-21 | Antibody/t-cell receptor chimeric constructs and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3365364T3 true DK3365364T3 (da) | 2024-05-06 |
Family
ID=58558140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK16858388.8T DK3365364T3 (da) | 2015-10-23 | 2016-10-21 | Kimære antistof/T-celle-receptorkonstruktioner og anvendelser deraf |
Country Status (17)
Country | Link |
---|---|
US (6) | US11421013B2 (da) |
EP (2) | EP3842450A1 (da) |
JP (3) | JP7316042B2 (da) |
KR (1) | KR20180063325A (da) |
CN (4) | CN115927191A (da) |
AU (2) | AU2016342041B2 (da) |
CA (1) | CA3001137A1 (da) |
DK (1) | DK3365364T3 (da) |
HK (2) | HK1248243A1 (da) |
IL (2) | IL258405B (da) |
MX (1) | MX2018004721A (da) |
MY (1) | MY194628A (da) |
PH (1) | PH12018500861A1 (da) |
RU (2) | RU2022103665A (da) |
SG (3) | SG11201802895QA (da) |
TW (2) | TWI780031B (da) |
WO (1) | WO2017070608A1 (da) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107206077B (zh) | 2014-12-05 | 2021-06-08 | 纪念斯隆-凯特琳癌症中心 | 靶向g-蛋白偶联受体的抗体和使用方法 |
MY192065A (en) | 2014-12-05 | 2022-07-25 | Memorial Sloan Kettering Cancer Center | Chimeric antigen receptors targeting g-protein coupled receptor and uses thereof |
PL3298033T5 (pl) | 2015-05-18 | 2023-10-30 | TCR2 Therapeutics Inc. | Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych |
CN115927191A (zh) | 2015-10-23 | 2023-04-07 | 优瑞科生物技术公司 | 抗体/t细胞受体嵌合构建体及其用途 |
WO2017189964A2 (en) | 2016-04-29 | 2017-11-02 | Voyager Therapeutics, Inc. | Compositions for the treatment of disease |
US11307205B2 (en) | 2016-09-19 | 2022-04-19 | University Of Southern California | Non-radioactive cytotoxicity assays |
JP2020500530A (ja) * | 2016-12-02 | 2020-01-16 | ユニバーシティ オブ サザン カリフォルニア | 合成免疫受容体およびその使用方法 |
KR102663596B1 (ko) | 2017-04-26 | 2024-05-10 | 유레카 쎄라퓨틱스, 인코포레이티드 | 글리피칸 3을 특이적으로 인식하는 구축물 및 그의 용도 |
IL310182A (en) * | 2017-04-26 | 2024-03-01 | Eureka Therapeutics Inc ׂ A Delaware Corp | Structures of chimeric antibody/T-cell receptor and uses thereof |
AU2018298884A1 (en) * | 2017-07-14 | 2020-02-27 | Immatics Biotechnologies Gmbh | Improved dual specificity polypeptide molecule |
US20190201443A1 (en) * | 2017-09-06 | 2019-07-04 | California Institute Of Technology | Signaling and antigen-presenting bifunctional receptors (sabr) |
SG11202002261VA (en) | 2017-09-22 | 2020-04-29 | Wuxi Biologics Ireland Ltd | Novel bispecific polypeptide complexes |
WO2019057124A1 (en) | 2017-09-22 | 2019-03-28 | Wuxi Biologics (Shanghai) Co., Ltd. | NEW BISPECIFIC CD3 / CD19 POLYPEPTIDE COMPLEXES |
AU2018338647A1 (en) * | 2017-09-27 | 2020-05-07 | University Of Southern California | Novel platforms for co-stimulation, novel car designs and other enhancements for adoptive cellular therapy |
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JP2018525973A (ja) | 2015-06-24 | 2018-09-13 | ユーリカ セラピューティックス, インコーポレイテッド | Ny−eso−1ペプチド/mhc複合体を標的とする構築物およびその使用 |
WO2017004252A1 (en) | 2015-06-30 | 2017-01-05 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Redirected cells with mhc chimeric receptors and methods of use in immunotherapy |
MX2018000839A (es) | 2015-07-22 | 2018-05-04 | Eureka Therapeutics Inc | Construccion dirigida a complejos de peptido de antigeno prostatico especifico (psa)/complejo mayor de histocompatibilidad (mhc) y usos de los mismos. |
MY196631A (en) | 2015-10-13 | 2023-04-24 | Eureka Therapeutics Inc | Antibody Agents Specific for Human Cd19 and uses Thereof |
CN115927191A (zh) | 2015-10-23 | 2023-04-07 | 优瑞科生物技术公司 | 抗体/t细胞受体嵌合构建体及其用途 |
CN105331585A (zh) | 2015-11-13 | 2016-02-17 | 科济生物医药(上海)有限公司 | 携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞 |
MX2018006787A (es) | 2015-12-04 | 2018-11-09 | Memorial Sloan Kettering Cancer Center | Anticuerpos que dirigen al receptor fc similar a 5 y metodos de uso. |
US11505599B2 (en) | 2016-01-14 | 2022-11-22 | Memorial Sloan-Kettering Cancer Center | T cell receptor-like antibodies specific for Foxp3-derived peptides |
WO2018057967A2 (en) | 2016-09-23 | 2018-03-29 | Eureka Therapeutics, Inc. | Constructs targeting hiv peptide/mhc complexes and uses thereof |
KR102663596B1 (ko) | 2017-04-26 | 2024-05-10 | 유레카 쎄라퓨틱스, 인코포레이티드 | 글리피칸 3을 특이적으로 인식하는 구축물 및 그의 용도 |
WO2019191704A1 (en) | 2018-03-30 | 2019-10-03 | Eureka Therapeutics, Inc. | Constructs targeting cd22 and uses thereof |
US11993661B2 (en) | 2018-06-18 | 2024-05-28 | Eureka Therapeutics, Inc. | Constructs targeting prostate-specific membrane antigen (PSMA) and uses thereof |
KR20210101235A (ko) | 2018-11-16 | 2021-08-18 | 메모리얼 슬로안 케터링 캔서 센터 | 뮤신-16에 대한 항체 및 이의 사용 방법 |
US20220235143A1 (en) | 2019-05-08 | 2022-07-28 | Memorial Sloan Kettering Cancer Center | Humanized antibodies to mucin-16 and methods of use thereof |
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