SG11202002261VA - Novel bispecific polypeptide complexes - Google Patents
Novel bispecific polypeptide complexesInfo
- Publication number
- SG11202002261VA SG11202002261VA SG11202002261VA SG11202002261VA SG11202002261VA SG 11202002261V A SG11202002261V A SG 11202002261VA SG 11202002261V A SG11202002261V A SG 11202002261VA SG 11202002261V A SG11202002261V A SG 11202002261VA SG 11202002261V A SG11202002261V A SG 11202002261VA
- Authority
- SG
- Singapore
- Prior art keywords
- polypeptide complexes
- bispecific polypeptide
- novel bispecific
- novel
- complexes
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
- A61K39/001112—CD19 or B4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/66—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a swap of domains, e.g. CH3-CH2, VH-CL or VL-CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017103030 | 2017-09-22 | ||
| PCT/CN2018/106766 WO2019057122A1 (en) | 2017-09-22 | 2018-09-20 | Novel bispecific polypeptide complexes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202002261VA true SG11202002261VA (en) | 2020-04-29 |
Family
ID=65810646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202002261VA SG11202002261VA (en) | 2017-09-22 | 2018-09-20 | Novel bispecific polypeptide complexes |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11845796B2 (en) |
| EP (1) | EP3684805A4 (en) |
| JP (2) | JP7387611B2 (en) |
| KR (1) | KR20200055729A (en) |
| CN (2) | CN111133003B (en) |
| AU (1) | AU2018334886A1 (en) |
| BR (1) | BR112020005676A2 (en) |
| CA (1) | CA3075693A1 (en) |
| EA (1) | EA202090812A1 (en) |
| IL (2) | IL310960A (en) |
| MA (1) | MA50188A (en) |
| MX (1) | MX2020003145A (en) |
| SG (1) | SG11202002261VA (en) |
| TW (1) | TWI786188B (en) |
| WO (1) | WO2019057122A1 (en) |
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| ES2906639T3 (en) | 2016-03-25 | 2022-04-19 | Biomunex Pharmaceuticals | CD38 and PD-L1 binding molecules |
| SG11201908825TA (en) | 2017-03-27 | 2019-10-30 | Biomunex Pharmaceuticals | Stable multispecific antibodies |
| BR112020005675A2 (en) | 2017-09-22 | 2020-10-20 | WuXi Biologics Ireland Limited | new bispecific cd3 / cd19 polypeptide complexes |
| JP7387611B2 (en) | 2017-09-22 | 2023-11-28 | ウーシー バイオロジクス アイルランド リミテッド | Novel bispecific polypeptide complex |
| CN113286808A (en) * | 2018-10-23 | 2021-08-20 | 蜻蜓疗法股份有限公司 | Heterodimeric Fc fusion proteins |
| EP3902825A1 (en) * | 2018-12-24 | 2021-11-03 | Sanofi | Pseudofab-based multispecific binding proteins |
| TWI754211B (en) * | 2019-01-28 | 2022-02-01 | 大陸商上海藥明生物技術有限公司 | Novel bispecific cd3/cd20 polypeptide complexes |
| CN114144429B (en) * | 2019-07-16 | 2023-10-13 | 上海药明生物技术有限公司 | Bispecific antibodies against PD-1 and LAG-3 |
| CA3149939A1 (en) * | 2019-09-06 | 2021-03-11 | Stephen J. Demarest | Proteins comprising t-cell receptor constant domains |
| US20230067182A1 (en) * | 2019-11-29 | 2023-03-02 | Boe Technology Group Co., Ltd. | Data Processing Device and Method, and Computer Readable Storage Medium |
| WO2021110995A1 (en) | 2019-12-04 | 2021-06-10 | Ac Immune Sa | Novel molecules for therapy and diagnosis |
| CN113135996A (en) * | 2019-12-09 | 2021-07-20 | 启愈生物技术(上海)有限公司 | Bispecific antibody and application thereof |
| KR20220131253A (en) * | 2019-12-30 | 2022-09-27 | 차이나 이뮤노테크 (베이징) 바이오테크놀로지 컴퍼니 리미티드 | Improved T-cell receptor STAR and its application |
| AU2021205561A1 (en) | 2020-01-09 | 2022-08-11 | Jiangsu Hengrui Medicine Co., Ltd. | New polypeptide complex |
| CN115698057A (en) | 2020-02-03 | 2023-02-03 | 维尔生物科技有限公司 | Antibodies against SARS-COV-2 and methods of use thereof |
| BR112022017048A2 (en) | 2020-02-26 | 2022-11-16 | Vir Biotechnology Inc | ANTIBODIES AGAINST SARS-COV-2 AND METHODS FOR USING THEM |
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| CN115734969A (en) * | 2020-04-13 | 2023-03-03 | 上海药明生物技术有限公司 | Purification of bispecific antibodies |
| WO2021211775A1 (en) | 2020-04-14 | 2021-10-21 | Vir Biotechnology, Inc. | Antibodies against sars-cov-2 and methods of using the same |
| CN113563473A (en) | 2020-04-29 | 2021-10-29 | 三生国健药业（上海）股份有限公司 | Tetravalent bispecific antibody, preparation method and application thereof |
| MX2022013886A (en) | 2020-05-08 | 2022-11-30 | Vir Biotechnology Inc | Antibodies against sars-cov-2. |
| WO2021247925A1 (en) | 2020-06-03 | 2021-12-09 | Vir Biotechnology, Inc. | Structure-guided immunotherapy against sars-cov-2 |
| CA3180477A1 (en) | 2020-06-12 | 2021-12-16 | Elizabeth Alexander | Antibody therapies for sars-cov-2 infection |
| CN113939533B (en) * | 2020-06-18 | 2022-12-06 | 武汉全景生物技术有限公司 | Anti-soluble CD14 subtype antibody, kit and application thereof |
| WO2022067269A2 (en) | 2020-09-28 | 2022-03-31 | Humabs Biomed Sa | Antibodies against sars-cov-2 |
| JP2023546071A (en) | 2020-10-13 | 2023-11-01 | アルミラル・ソシエダッド・アノニマ | Bispecific molecules and treatment methods using them |
| IL302938A (en) | 2020-11-23 | 2023-07-01 | Vir Biotechnology Inc | Antibodies against influenza a viruses |
| JP2023551668A (en) | 2020-11-23 | 2023-12-12 | ヴィア・バイオテクノロジー・インコーポレイテッド | Broadly neutralizing antibody against influenza neuraminidase |
| CA3199429A1 (en) | 2020-11-23 | 2022-05-27 | Davide Corti | Anti-influenza antibodies and combinations thereof |
| TW202235107A (en) | 2020-11-25 | 2022-09-16 | 美商維爾生物科技股份有限公司 | Antibodies that bind to multiple betacoronaviruses |
| WO2022152289A1 (en) * | 2021-01-18 | 2022-07-21 | Wuxi Biologics (Shanghai) Co., Ltd. | An engineered antibody and antibody-drug conjugates comprisign same |
| TWI830124B (en) * | 2021-01-19 | 2024-01-21 | 大陸商上海藥明生物技術有限公司 | Peptide complexes with improved stability and performance |
| KR20230133878A (en) * | 2021-01-19 | 2023-09-19 | 우시 바이올로직스 아일랜드 리미티드 | Polypeptide complex with improved stability and expression |
| CN112961245B (en) * | 2021-02-24 | 2023-07-25 | 重庆精准生物技术有限公司 | Bispecific antibody targeting CD96 and preparation method and application thereof |
| WO2022204202A1 (en) | 2021-03-23 | 2022-09-29 | Vir Biotechnology, Inc. | Antibodies that bind to multiple sarbecoviruses |
| CA3217520A1 (en) * | 2021-04-22 | 2022-10-27 | Guangdong Fapon Biopharma Inc. | Bispecific multifunctional fusion polypeptide |
| US20220372165A1 (en) | 2021-05-05 | 2022-11-24 | Immatics Biotechnologies Gmbh | Antigen binding proteins specifically binding prame |
| EP4339213A1 (en) | 2021-05-14 | 2024-03-20 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Antigen-binding molecule |
| IL308509A (en) | 2021-05-24 | 2024-01-01 | Vir Biotechnology Inc | Engineered polypeptides |
| AU2022317127A1 (en) * | 2021-07-29 | 2024-01-04 | Nantcell, Inc. | Modified t cell receptors for the prevention and treatment of viral infections and cancer |
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| CN117295526A (en) * | 2021-09-10 | 2023-12-26 | 上海药明合联生物技术有限公司 | Method for preparing highly homogeneous antibody-drug conjugates of engineered antibodies |
| TW202313701A (en) * | 2021-09-24 | 2023-04-01 | 大陸商廣東菲鵬製藥股份有限公司 | Bispecific polypeptide complex |
| WO2023064856A1 (en) * | 2021-10-13 | 2023-04-20 | The Wistar Institute Of Anatomy And Biology | In vivo interacting protein domains and methods of use thereof |
| WO2023072159A1 (en) | 2021-10-27 | 2023-05-04 | Virtuoso Binco, Inc. | Multispecific antibodies for treating cd47-associated diseases |
| WO2023179370A1 (en) * | 2022-03-21 | 2023-09-28 | The Hong Kong Polytechnic University | Peptidic bispecific antibody, methods for preparation and uses thereof |
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| WO2023219120A1 (en) * | 2022-05-12 | 2023-11-16 | アステラス製薬株式会社 | Anti-cd37/anti-cd3 bispecific antibody |
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| WO2023245078A1 (en) | 2022-06-15 | 2023-12-21 | Humabs Biomed Sa | Anti-parvovirus antibodies and uses thereof |
| WO2023246911A1 (en) * | 2022-06-24 | 2023-12-28 | 北京可瑞生物科技有限公司 | T cell receptor-based bispecific polypeptide molecule and use thereof |
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2018
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| WO2019057122A1 (en) | 2019-03-28 |
| CN111133003B (en) | 2024-01-12 |
| US11845796B2 (en) | 2023-12-19 |
| KR20200055729A (en) | 2020-05-21 |
| BR112020005676A2 (en) | 2020-10-20 |
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| JP2024012612A (en) | 2024-01-30 |
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| JP7387611B2 (en) | 2023-11-28 |
| TW201915025A (en) | 2019-04-16 |
| IL273217A (en) | 2020-04-30 |
| MA50188A (en) | 2021-06-02 |
| EP3684805A1 (en) | 2020-07-29 |
| TWI786188B (en) | 2022-12-11 |
| EP3684805A4 (en) | 2021-06-09 |
| US20200283524A1 (en) | 2020-09-10 |
| AU2018334886A1 (en) | 2020-04-09 |
| CA3075693A1 (en) | 2019-03-28 |
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