AR123115A1 - Composiciones y métodos para la degradación selectiva de proteínas - Google Patents

Composiciones y métodos para la degradación selectiva de proteínas

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Publication number
AR123115A1
AR123115A1 ARP180103055A ARP180103055A AR123115A1 AR 123115 A1 AR123115 A1 AR 123115A1 AR P180103055 A ARP180103055 A AR P180103055A AR P180103055 A ARP180103055 A AR P180103055A AR 123115 A1 AR123115 A1 AR 123115A1
Authority
AR
Argentina
Prior art keywords
methods
compositions
proteins
selective degradation
polypeptide
Prior art date
Application number
ARP180103055A
Other languages
English (en)
Inventor
James E Bradner
Andrei Golosov
Carleton Proctor Goold
Guimaraes Carla Patricia Pinto
Marc Horst Peter Hild
Gregory Motz
Nathan Thomas Ross
Rohan Eric John Beckwith
Jonathan M Solomon
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR123115A1 publication Critical patent/AR123115A1/es

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Abstract

La invención proporciona composiciones que incluyen un polipéptido de fusión y métodos para fabricar un polipéptido de fusión que incluye un polipéptido de unión a COF1 / CRBN, un polipéptido de unión a COF2 / CRBN, o un polipéptido de unión a COF3 / CRBN y un polipéptido heterólogo de interés.
ARP180103055A 2017-10-18 2018-10-18 Composiciones y métodos para la degradación selectiva de proteínas AR123115A1 (es)

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KR20200086278A (ko) 2020-07-16
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BR112020007576A2 (pt) 2020-09-24

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