BR112018013677A2 - proteínas de fusão de ligação de 41bb multivalentes e multiespecíficas - Google Patents

proteínas de fusão de ligação de 41bb multivalentes e multiespecíficas

Info

Publication number
BR112018013677A2
BR112018013677A2 BR112018013677A BR112018013677A BR112018013677A2 BR 112018013677 A2 BR112018013677 A2 BR 112018013677A2 BR 112018013677 A BR112018013677 A BR 112018013677A BR 112018013677 A BR112018013677 A BR 112018013677A BR 112018013677 A2 BR112018013677 A2 BR 112018013677A2
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BR
Brazil
Prior art keywords
multivalent
multispecific
fusion proteins
binding fusion
bind
Prior art date
Application number
BR112018013677A
Other languages
English (en)
Inventor
Hussain Abrahim
S Razai Amir
P Eckelman Brendan
Becklund Bryan
Hata Chelsie
C Timmer John
S Jones Kyle
Rason Lucas
Kaplan Mike
Deveraux Quinn
Pandit Rajay
Original Assignee
Inhibrx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inhibrx Inc filed Critical Inhibrx Inc
Publication of BR112018013677A2 publication Critical patent/BR112018013677A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Detergent Compositions (AREA)
  • Cosmetics (AREA)

Abstract

esta invenção refere-se geralmente a moléculas que se ligam especificamente a 41bb, um membro da superfamília de receptores de tnf (tnfrsf). mais especificamente, esta invenção refere-se a moléculas multivalentes e multiespecíficas que se ligam a pelo menos 41bb.
BR112018013677A 2016-01-11 2017-01-11 proteínas de fusão de ligação de 41bb multivalentes e multiespecíficas BR112018013677A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277028P 2016-01-11 2016-01-11
PCT/US2017/013040 WO2017123650A2 (en) 2016-01-11 2017-01-11 Multivalent and multispecific 41bb-binding fusion proteins

Publications (1)

Publication Number Publication Date
BR112018013677A2 true BR112018013677A2 (pt) 2019-01-22

Family

ID=59275541

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018013677A BR112018013677A2 (pt) 2016-01-11 2017-01-11 proteínas de fusão de ligação de 41bb multivalentes e multiespecíficas

Country Status (12)

Country Link
US (3) US10501551B2 (pt)
EP (1) EP3402823A4 (pt)
JP (3) JP7022993B2 (pt)
KR (1) KR20180096789A (pt)
CN (1) CN108779176A (pt)
AU (2) AU2017207742B2 (pt)
BR (1) BR112018013677A2 (pt)
CA (1) CA3009661A1 (pt)
IL (2) IL260530B2 (pt)
MX (2) MX2018008308A (pt)
SG (2) SG10201912405TA (pt)
WO (1) WO2017123650A2 (pt)

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US20170198050A1 (en) 2017-07-13
IL304871A (en) 2023-10-01
EP3402823A4 (en) 2019-09-18
IL260530A (pt) 2018-08-30
IL260530B1 (en) 2023-09-01
RU2018128601A (ru) 2020-02-13
IL260530B2 (en) 2024-01-01
RU2018128601A3 (pt) 2020-06-17
US20230416387A1 (en) 2023-12-28
CA3009661A1 (en) 2017-07-20
EP3402823A2 (en) 2018-11-21
US11566078B2 (en) 2023-01-31
JP2019504831A (ja) 2019-02-21
JP2022062146A (ja) 2022-04-19
SG11201805532XA (en) 2018-07-30
AU2017207742A1 (en) 2018-07-12
JP7022993B2 (ja) 2022-02-21
US10501551B2 (en) 2019-12-10
AU2022200918A1 (en) 2022-03-03
WO2017123650A2 (en) 2017-07-20
CN108779176A (zh) 2018-11-09
KR20180096789A (ko) 2018-08-29
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AU2017207742B2 (en) 2022-03-17
JP7510447B2 (ja) 2024-07-03
JP2024123158A (ja) 2024-09-10
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US20200199243A1 (en) 2020-06-25
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