BR112018014150A2 - anticorpos monoclonais humanizados imunoestimulantes contra interleucina-2 humana, e proteínas de fusão dos mesmos - Google Patents

anticorpos monoclonais humanizados imunoestimulantes contra interleucina-2 humana, e proteínas de fusão dos mesmos

Info

Publication number
BR112018014150A2
BR112018014150A2 BR112018014150A BR112018014150A BR112018014150A2 BR 112018014150 A2 BR112018014150 A2 BR 112018014150A2 BR 112018014150 A BR112018014150 A BR 112018014150A BR 112018014150 A BR112018014150 A BR 112018014150A BR 112018014150 A2 BR112018014150 A2 BR 112018014150A2
Authority
BR
Brazil
Prior art keywords
immunostimulating
human interleukin
monoclonal antibodies
fusion proteins
humanized monoclonal
Prior art date
Application number
BR112018014150A
Other languages
English (en)
Inventor
Katopodis Andreas
Brannetti Barbara
Regnier Catherine
Zou Chao
Beuvink Iwan
ARENAS-RAMIREZ Natalia
Boyman Onur
POPP Simone
Original Assignee
Novartis Ag
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Zuerich filed Critical Novartis Ag
Publication of BR112018014150A2 publication Critical patent/BR112018014150A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

a presente invenção se refere a anticorpos que se ligam à interleucina-2 humana (hil-2). a invenção se refere, mais especificamente, a anticorpos humanizados que se ligam especificamente a um epítopo particular de hil-2 e, quando ligados a esse epítopo, exibem uma capacidade exclusiva de inibir a ligação de hil-2 a cd25.
BR112018014150A 2016-01-11 2017-01-11 anticorpos monoclonais humanizados imunoestimulantes contra interleucina-2 humana, e proteínas de fusão dos mesmos BR112018014150A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662277113P 2016-01-11 2016-01-11
PCT/IB2017/050127 WO2017122130A1 (en) 2016-01-11 2017-01-11 Immune-stimulating humanized monoclonal antibodies against human interleukin-2, and fusion proteins thereof

Publications (1)

Publication Number Publication Date
BR112018014150A2 true BR112018014150A2 (pt) 2018-12-11

Family

ID=57882113

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018014150A BR112018014150A2 (pt) 2016-01-11 2017-01-11 anticorpos monoclonais humanizados imunoestimulantes contra interleucina-2 humana, e proteínas de fusão dos mesmos

Country Status (14)

Country Link
US (2) US10889643B2 (pt)
EP (1) EP3402819A1 (pt)
JP (1) JP6993699B2 (pt)
KR (1) KR20180100224A (pt)
CN (2) CN116003593A (pt)
AU (1) AU2017208133B2 (pt)
BR (1) BR112018014150A2 (pt)
CA (1) CA3009001A1 (pt)
EA (1) EA039865B1 (pt)
HK (1) HK1257518A1 (pt)
IL (1) IL260218B2 (pt)
MA (1) MA43859A (pt)
MX (1) MX2018008592A (pt)
WO (1) WO2017122130A1 (pt)

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Also Published As

Publication number Publication date
IL260218A (en) 2018-07-31
KR20180100224A (ko) 2018-09-07
IL260218B2 (en) 2023-04-01
US11851484B2 (en) 2023-12-26
JP6993699B2 (ja) 2022-02-03
EP3402819A1 (en) 2018-11-21
IL260218B (en) 2022-12-01
CN108473569A (zh) 2018-08-31
US10889643B2 (en) 2021-01-12
HK1257518A1 (zh) 2019-10-25
US20210246200A1 (en) 2021-08-12
EA201891582A1 (ru) 2018-12-28
CA3009001A1 (en) 2017-07-20
MX2018008592A (es) 2018-12-10
WO2017122130A1 (en) 2017-07-20
CN116003593A (zh) 2023-04-25
CN108473569B (zh) 2022-11-22
AU2017208133A1 (en) 2018-07-05
US20190016797A1 (en) 2019-01-17
JP2019511200A (ja) 2019-04-25
MA43859A (fr) 2018-11-21
AU2017208133B2 (en) 2023-12-21
WO2017122130A9 (en) 2018-02-01
EA039865B1 (ru) 2022-03-22

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