MA43859A - Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion - Google Patents

Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion

Info

Publication number
MA43859A
MA43859A MA043859A MA43859A MA43859A MA 43859 A MA43859 A MA 43859A MA 043859 A MA043859 A MA 043859A MA 43859 A MA43859 A MA 43859A MA 43859 A MA43859 A MA 43859A
Authority
MA
Morocco
Prior art keywords
immunostimulants
monoclonal antibodies
fusion proteins
directed against
against human
Prior art date
Application number
MA043859A
Other languages
English (en)
Inventor
Natalia Arenas-Ramirez
Iwan Beuvink
Onur Boyman
Barbara Brannetti
Andreas Katopodis
Simone Popp
Catherine Regnier
Chao Zou
Original Assignee
Novartis Ag
Univ Zuerich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag, Univ Zuerich filed Critical Novartis Ag
Publication of MA43859A publication Critical patent/MA43859A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/246—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
MA043859A 2016-01-11 2017-01-11 Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion MA43859A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662277113P 2016-01-11 2016-01-11

Publications (1)

Publication Number Publication Date
MA43859A true MA43859A (fr) 2018-11-21

Family

ID=57882113

Family Applications (1)

Application Number Title Priority Date Filing Date
MA043859A MA43859A (fr) 2016-01-11 2017-01-11 Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion

Country Status (14)

Country Link
US (2) US10889643B2 (fr)
EP (1) EP3402819A1 (fr)
JP (1) JP6993699B2 (fr)
KR (1) KR20180100224A (fr)
CN (2) CN108473569B (fr)
AU (1) AU2017208133B2 (fr)
BR (1) BR112018014150A2 (fr)
CA (1) CA3009001A1 (fr)
EA (1) EA039865B1 (fr)
HK (1) HK1257518A1 (fr)
IL (1) IL260218B2 (fr)
MA (1) MA43859A (fr)
MX (1) MX2018008592A (fr)
WO (1) WO2017122130A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
BR112016018408A2 (pt) * 2014-03-14 2017-12-26 Immutep Sas moléculas de anticorpo à lag-3 e usos das mesmas
EP3370769A4 (fr) 2015-11-03 2019-05-22 Janssen Biotech, Inc. Anticorps se liant spécifiquement à tim-3 et leurs utilisations
CN108601833B (zh) * 2016-02-01 2022-11-15 伊莱利利公司 甲状旁腺激素-抗rankl抗体融合化合物
CN110087681A (zh) * 2016-09-28 2019-08-02 佐马美国有限公司 结合白细胞介素-2的抗体和其用途
US10961310B2 (en) 2017-03-15 2021-03-30 Pandion Operations, Inc. Targeted immunotolerance
BR112019024127A2 (pt) 2017-05-24 2020-06-23 Pandion Therapeutics, Inc. Imunotolerância alvejada
US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US20190225689A1 (en) * 2018-01-22 2019-07-25 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-pd-1 antibodies
WO2019168791A2 (fr) * 2018-02-28 2019-09-06 The Board Of Trustees Of The Leland Stanford Junior University Fusions d'anticorps/il-2 à chaîne unique qui activent sélectivement des lymphocytes t régulateurs
US20210238558A1 (en) * 2018-06-01 2021-08-05 Medicenna Therapeutics, Inc. Uses and methods for oncolytic virus targeting of il-4/il-13 and fusions thereof
CN114679909A (zh) 2019-05-20 2022-06-28 潘迪恩运营公司 MAdCAM靶向的免疫耐受
JP7292526B2 (ja) * 2020-02-16 2023-06-16 アウロス バイオサイエンス インコーポレイテッド 操作された抗ｉｌ－２抗体
CN111825763B (zh) * 2020-07-15 2022-04-19 扬州大学 流感病毒ha蛋白茎部特异性单克隆抗体及其制备方法和应用
CA3207652A1 (fr) 2021-03-26 2022-09-29 Stephanie Cornen Proteines multi-specifiques comprenant un site de liaison a nkp46, un site de liaison a un antigene tumoral fusionne a une cytokine pour la liaison a des cellules nk
WO2022258678A1 (fr) 2021-06-09 2022-12-15 Innate Pharma Protéines multispécifiques se liant à nkp30, un récepteur de cytokine, un antigène tumoral et cd16a
WO2022258691A1 (fr) 2021-06-09 2022-12-15 Innate Pharma Protéines multispécifiques se liant à nkg2d, récepteur de cytokine, antigène tumoral et cd16a
EP4352098A1 (fr) 2021-06-09 2024-04-17 Innate Pharma Protéines multispécifiques se liant à nkp46, récepteur de cytokine, antigène tumoral et cd16a
US11773160B1 (en) * 2022-08-05 2023-10-03 Anaveon AG Immune-stimulating IL-2 fusion proteins
CN117700535B (zh) * 2024-02-05 2024-04-26 北京纳百生物科技有限公司 一种猫泛白细胞减少症病毒vp2蛋白单克隆抗体及其应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE434680B (sv) 1983-01-21 1984-08-06 Karl Arne Lundblad Anvendning av en saltlosning av monoklonala antikroppar med relativt hog salthalt vid blodgruppsbestemning
EP0138854B1 (fr) 1983-03-08 1992-11-04 Chiron Mimotopes Pty. Ltd. Sequences d'acides amines antigeniquement actives
NZ210634A (en) 1983-12-23 1989-05-29 Hoffmann La Roche Purification of recombinant human interleukin - 2; pharmaceutical compositions
EP0154316B1 (fr) 1984-03-06 1989-09-13 Takeda Chemical Industries, Ltd. Lymphokine chimiquement modifiée et son procédé de préparation
DE68925966T2 (de) 1988-12-22 1996-08-29 Kirin Amgen Inc Chemisch modifizierte granulocytenkolonie erregender faktor
FR2650598B1 (fr) 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
FR2686901A1 (fr) 1992-01-31 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US6121022A (en) 1995-04-14 2000-09-19 Genentech, Inc. Altered polypeptides with increased half-life
US5869046A (en) 1995-04-14 1999-02-09 Genentech, Inc. Altered polypeptides with increased half-life
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
DE69731289D1 (de) 1996-03-18 2004-11-25 Univ Texas Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
DK0920505T3 (da) 1996-08-16 2008-09-08 Schering Corp Pattedyrcelleoverfladeantigener og tilhörende reagenser
US6111090A (en) 1996-08-16 2000-08-29 Schering Corporation Mammalian cell surface antigens; related reagents
WO1998023289A1 (fr) 1996-11-27 1998-06-04 The General Hospital Corporation Modulation de la fixation de l'igg au fcrn
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
AU729035B2 (en) 1997-06-12 2001-01-25 Novartis Ag Artificial antibody polypeptides
US6171586B1 (en) 1997-06-13 2001-01-09 Genentech, Inc. Antibody formulation
EP1025228A4 (fr) 1997-10-21 2002-09-18 Human Genome Sciences Inc Proteines tr11, tr11sv1 et tr11sv2 de type recepteur du facteur de necrose tumorale humain
US6689607B2 (en) 1997-10-21 2004-02-10 Human Genome Sciences, Inc. Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2
EP1053321A1 (fr) 1998-02-09 2000-11-22 Genentech, Inc. Nouveaux homologues recepteurs du facteur necrosant des tumeurs et acides nucleiques codant ceux-ci
IL147442A0 (en) 1999-07-12 2002-08-14 Genentech Inc Promotion or inhibition of angiogenesis and cardiovscularization by tumor necrosis factor ligand/receptor homologs
WO2001079442A2 (fr) 2000-04-12 2001-10-25 Human Genome Sciences, Inc. Proteines fusionnees a de l'albumine
US20040033228A1 (en) 2002-08-16 2004-02-19 Hans-Juergen Krause Formulation of human antibodies for treating TNF-alpha associated disorders
WO2004056875A1 (fr) 2002-12-23 2004-07-08 Wyeth Anticorps anti pd-1 et utilisations
EP2572715A1 (fr) 2002-12-30 2013-03-27 3M Innovative Properties Company Combinaisons immunostimulantes
US7618632B2 (en) 2003-05-23 2009-11-17 Wyeth Method of treating or ameliorating an immune cell associated pathology using GITR ligand antibodies
WO2005007190A1 (fr) 2003-07-11 2005-01-27 Schering Corporation Agonistes ou antagonistes du recepteur du facteur de necrose tumorale induit par les glucocorticoides (gitr) ou de son ligand utilises dans le traitement des troubles immuns, des infections et du cancer
EP1692318A4 (fr) 2003-12-02 2008-04-02 Genzyme Corp Compositions et methodes pour le diagnostic et le traitement du cancer du poumon
GB0409799D0 (en) 2004-04-30 2004-06-09 Isis Innovation Method of generating improved immune response
EP1765402A2 (fr) 2004-06-04 2007-03-28 Duke University Methodes et compositions ameliorant l'immunite par depletion in vivo de l'activite cellulaire immunosuppressive
JO3000B1 (ar) 2004-10-20 2016-09-05 Genentech Inc مركبات أجسام مضادة .
DK1866339T3 (da) 2005-03-25 2013-09-02 Gitr Inc GTR-bindende molekyler og anvendelser heraf
CA2607147C (fr) 2005-05-09 2018-07-17 Ono Pharmaceutical Co., Ltd. Anticorps monoclonaux humains pour mort programmee 1 (mp-1) et procedes pour traiter le cancer en utilisant des anticorps anti-mp-1 seuls ou associes a d'autres immunotherapies
CA2609234C (fr) 2005-06-01 2014-04-22 Micromet Ag Anticorps anti-il2
MX2007016306A (es) 2005-06-15 2008-03-07 Schering Corp Formulaciones de anticuerpo anti-igf1r.
CN102875681A (zh) 2005-07-08 2013-01-16 拜奥根Idec马萨诸塞公司 抗-αvβ6抗体及其用途
US20110212086A1 (en) 2006-01-19 2011-09-01 Genzyme Corporation GITR Antibodies For The Treatment of Cancer
CN101495136A (zh) 2006-02-15 2009-07-29 英克隆系统公司 抗体配制品
KR20080112232A (ko) * 2006-02-16 2008-12-24 네이슨트 바이오로직스, 인크. 포유동물 환자의 면역기능의 개선 방법 및 질병의 예방 또는 치료 방법
CN104945508B (zh) 2007-06-18 2019-02-22 默沙东有限责任公司 针对人程序性死亡受体pd-1的抗体
CA2693677C (fr) 2007-07-12 2018-02-13 Tolerx, Inc. Therapies combinees utilisant des molecules de liaison au gitr
CN104548091A (zh) 2008-02-11 2015-04-29 治疗科技公司 用于肿瘤治疗的单克隆抗体
US8168757B2 (en) 2008-03-12 2012-05-01 Merck Sharp & Dohme Corp. PD-1 binding proteins
NZ590667A (en) 2008-07-02 2013-01-25 Emergent Product Dev Seattle Tgf-b antagonist multi-target binding proteins
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
BRPI0917891A2 (pt) 2008-08-25 2015-11-24 Amplimmune Inc antagonistas de pd-1 e métodos de utilização dos mesmos
EP2350129B1 (fr) 2008-08-25 2015-06-10 Amplimmune, Inc. Compositions d'antagonistes de pd-1 et methodes d'utilisation associees
WO2010030002A1 (fr) 2008-09-12 2010-03-18 国立大学法人三重大学 Cellule capable d'exprimer un ligand gitr exogène
CN102574924A (zh) 2009-09-03 2012-07-11 先灵公司 抗-gitr抗体
GB0919054D0 (en) 2009-10-30 2009-12-16 Isis Innovation Treatment of obesity
EP2504028A4 (fr) 2009-11-24 2014-04-09 Amplimmune Inc Inhibition simultanée de pd-l1/pd-l2
WO2011090762A1 (fr) 2009-12-29 2011-07-28 Emergent Product Development Seattle, Llc Protéines de liaison hétérodimères et utilisations de celles-ci
TWI629483B (zh) 2010-06-11 2018-07-11 協和醱酵麒麟有限公司 anti-TIM-3 antibody
ME02352B (fr) 2010-08-12 2016-06-20 Lilly Co Eli ANTICORPS ANTI-PEPTIDE BÊTA-AMYLOÏDE N3pGlu ET LEURS UTILISATIONS
SI3489255T1 (sl) 2011-02-10 2021-11-30 Roche Glycart Ag Mutantni polipeptidi interlevkina-2
US20130108641A1 (en) 2011-09-14 2013-05-02 Sanofi Anti-gitr antibodies
PT2838548T (pt) 2012-04-17 2023-10-13 Univ Washington Through Its Center For Commercialization Células deficientes em hla de classe ii, células deficientes em hla de classe i capazes de expressar proteínas de hla de classe ii, e utilizações das mesmas
WO2013157105A1 (fr) 2012-04-18 2013-10-24 公立大学法人大阪市立大学 Anticorps humain spécifique de mucine 5ac et son utilisation
KR101566538B1 (ko) 2012-06-08 2015-11-05 국립암센터 신규한 Ｔｈ17 세포 전환용 에피토프 및 이의 용도
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
CN112587658A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
ES2754269T3 (es) 2013-05-18 2020-04-16 Aduro Biotech Inc Composiciones y métodos de activación de la señalización dependiente del "estimulador de los genes de interferón
WO2014189806A1 (fr) 2013-05-18 2014-11-27 Aduro Biotech, Inc. Compositions et procédés d'inhibition de la signalisation dépendante du « stimulateur des gènes interférons »
AR097306A1 (es) 2013-08-20 2016-03-02 Merck Sharp & Dohme Modulación de la inmunidad tumoral
WO2015109212A1 (fr) 2014-01-17 2015-07-23 Pfizer Inc. Anticorps anti-il-2 et compositions et utilisations de ceux-ci
JOP20200094A1 (ar) 2014-01-24 2017-06-16 Dana Farber Cancer Inst Inc جزيئات جسم مضاد لـ pd-1 واستخداماتها
JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
BR112016018408A2 (pt) 2014-03-14 2017-12-26 Immutep Sas moléculas de anticorpo à lag-3 e usos das mesmas
US10894828B2 (en) * 2014-07-10 2021-01-19 Universität Zürich Immune-stimulating monoclonal antibodies against human interleukin-2

Also Published As

Publication number Publication date
CN108473569B (zh) 2022-11-22
IL260218A (en) 2018-07-31
JP2019511200A (ja) 2019-04-25
US11851484B2 (en) 2023-12-26
US20190016797A1 (en) 2019-01-17
EA201891582A1 (ru) 2018-12-28
IL260218B2 (en) 2023-04-01
CA3009001A1 (fr) 2017-07-20
US10889643B2 (en) 2021-01-12
BR112018014150A2 (pt) 2018-12-11
JP6993699B2 (ja) 2022-02-03
CN116003593A (zh) 2023-04-25
EA039865B1 (ru) 2022-03-22
US20210246200A1 (en) 2021-08-12
EP3402819A1 (fr) 2018-11-21
HK1257518A1 (zh) 2019-10-25
WO2017122130A1 (fr) 2017-07-20
CN108473569A (zh) 2018-08-31
AU2017208133A1 (en) 2018-07-05
AU2017208133B2 (en) 2023-12-21
KR20180100224A (ko) 2018-09-07
IL260218B (en) 2022-12-01
WO2017122130A9 (fr) 2018-02-01
MX2018008592A (es) 2018-12-10

Similar Documents

Publication Publication Date Title
MA43859A (fr) Anticorps monoclonaux humainisés immunostimulants dirigés contre l'interleukine -2 humaine, et leurs protéines de fusion
ZA202001285B (en) Antigen-binding proteins targeting shared antigens
IL275547A (en) Antigen-binding proteins target co-antigens
EP3621642A4 (fr) Anticorps monoclonaux humains contre lag3 et leurs utilisations
MA44077A (fr) Anticorps neutralisants le virus de l'immunodéficience humaine
MA41867A (fr) Anticorps dirigés contre l'immunoglobuline de cellule t et protéine 3 de mucine (tim-3)
CL2017003261A1 (es) Factor xi anticuerpos y métodos de uso
NZ738008A (en) Tigit-binding agents and uses thereof
IL279455A (en) ANTI-PD-1 antibodies and their uses
BR112016021717A2 (pt) anticorpos anti-egfr e conjugados anticorpo-fármaco
IL268704B (en) Formulations of antibodies against human rankl, and methods of using them
MA49727A (fr) Anticorps et polypeptides dirigés contre cd127
MA41375A (fr) Anticorps igg bispécifiques et leurs procédés de préparation
MA43738A (fr) Anticorps anti-tnfalpha et leurs fragments fonctionnels
MA50908A (fr) Formulations de protéines de fusion vegfr-fc
EP3518971A4 (fr) Formulations thérapeutiques d'anticorps et de protéines et leurs utilisations
DK3380122T3 (da) Anti-5t4 antistoffer og antistoflægemiddel konjugater
MY194084A (en) Interferon beta antibodies and uses thereof
BR112018002382A2 (pt) novos anticorpos anti-gvpi humano e usos dos mesmos
IL280890A (en) An antigen-binding protein that targets co-antigens
IL276675A (en) Anti-PD-1 antibodies and uses thereof
UY36262A (es) Anticuerpos anti proteína similar a angiopoyetina 4 y métodos de uso
EP4011919A3 (fr) Protéines de fusion d'immunoglobuline de relaxine et procédés d'utilisation
IL283180A (en) Anti-PD-1 antibodies and their uses
IL281397B (en) Human pd–l1 antibodies