MX2020002942A - Variantes de anticuerpos. - Google Patents
Variantes de anticuerpos.Info
- Publication number
- MX2020002942A MX2020002942A MX2020002942A MX2020002942A MX2020002942A MX 2020002942 A MX2020002942 A MX 2020002942A MX 2020002942 A MX2020002942 A MX 2020002942A MX 2020002942 A MX2020002942 A MX 2020002942A MX 2020002942 A MX2020002942 A MX 2020002942A
- Authority
- MX
- Mexico
- Prior art keywords
- antibody variants
- antibodies
- tnfî
- bind
- binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
La presente invención se refiere a anticuerpos que se unen a TNFa y exhiben una unión a FcRn modificada. Los anticuerpos de la invención tienen buenas funciones efectoras o propiedades farmacocinéticas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17191988.9A EP3456737B1 (en) | 2017-09-19 | 2017-09-19 | Antibody variants |
PCT/EP2018/074523 WO2019057565A1 (en) | 2017-09-19 | 2018-09-11 | ANTIBODY VARIANTS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020002942A true MX2020002942A (es) | 2020-07-22 |
Family
ID=59923274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020002942A MX2020002942A (es) | 2017-09-19 | 2018-09-11 | Variantes de anticuerpos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US20200255511A1 (es) |
EP (2) | EP3456737B1 (es) |
JP (2) | JP7341127B2 (es) |
KR (1) | KR20200052307A (es) |
CN (1) | CN111108122A (es) |
AR (1) | AR113069A1 (es) |
AU (1) | AU2018335083A1 (es) |
BR (1) | BR112020005398A2 (es) |
CA (1) | CA3074249A1 (es) |
EA (1) | EA202090727A1 (es) |
IL (1) | IL272951A (es) |
MX (1) | MX2020002942A (es) |
SG (1) | SG11202001465WA (es) |
TW (1) | TWI818923B (es) |
WO (1) | WO2019057565A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020114616A1 (en) | 2018-12-07 | 2020-06-11 | Tillotts Pharma Ag | Topical treatment of immune checkpoint inhibitor induced diarrhoea, colitis or enterocolitis using antibodies and fragments thereof |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998023289A1 (en) | 1996-11-27 | 1998-06-04 | The General Hospital Corporation | MODULATION OF IgG BINDING TO FcRn |
KR101077001B1 (ko) | 1999-01-15 | 2011-10-26 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
BRPI0518994A2 (pt) | 2004-12-31 | 2008-12-02 | Biogen Idec Inc | anticorpos ou polipeptÍdeos que se ligam a br3, seus usos e formulaÇÕes lÍquidas |
EP2233500A1 (en) | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Optimized Fc variants |
EP2943506B1 (en) | 2013-01-10 | 2024-03-13 | Genmab B.V. | Human igg1 fc region variants and uses thereof |
ES2836349T3 (es) * | 2016-03-17 | 2021-06-24 | Tillotts Pharma Ag | Anticuerpos anti-TNF-alfa y fragmentos funcionales de los mismos |
-
2017
- 2017-09-19 EP EP17191988.9A patent/EP3456737B1/en active Active
-
2018
- 2018-09-11 AU AU2018335083A patent/AU2018335083A1/en active Pending
- 2018-09-11 EP EP18762891.2A patent/EP3684808A1/en active Pending
- 2018-09-11 WO PCT/EP2018/074523 patent/WO2019057565A1/en active Application Filing
- 2018-09-11 EA EA202090727A patent/EA202090727A1/ru unknown
- 2018-09-11 CN CN201880060827.8A patent/CN111108122A/zh active Pending
- 2018-09-11 CA CA3074249A patent/CA3074249A1/en active Pending
- 2018-09-11 KR KR1020207008432A patent/KR20200052307A/ko not_active Application Discontinuation
- 2018-09-11 SG SG11202001465WA patent/SG11202001465WA/en unknown
- 2018-09-11 MX MX2020002942A patent/MX2020002942A/es unknown
- 2018-09-11 BR BR112020005398-8A patent/BR112020005398A2/pt unknown
- 2018-09-11 JP JP2020515974A patent/JP7341127B2/ja active Active
- 2018-09-11 US US16/648,185 patent/US20200255511A1/en active Pending
- 2018-09-17 TW TW107132674A patent/TWI818923B/zh active
- 2018-09-19 AR ARP180102666A patent/AR113069A1/es unknown
-
2020
- 2020-02-27 IL IL272951A patent/IL272951A/en unknown
-
2023
- 2023-05-26 JP JP2023086763A patent/JP2023109960A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
AR113069A1 (es) | 2020-01-22 |
EP3684808A1 (en) | 2020-07-29 |
WO2019057565A1 (en) | 2019-03-28 |
TW201915019A (zh) | 2019-04-16 |
CA3074249A1 (en) | 2019-03-28 |
US20200255511A1 (en) | 2020-08-13 |
CN111108122A (zh) | 2020-05-05 |
EA202090727A1 (ru) | 2020-06-15 |
EP3456737A1 (en) | 2019-03-20 |
KR20200052307A (ko) | 2020-05-14 |
AU2018335083A1 (en) | 2020-04-02 |
IL272951A (en) | 2020-04-30 |
BR112020005398A2 (pt) | 2020-09-29 |
SG11202001465WA (en) | 2020-04-29 |
JP2020534000A (ja) | 2020-11-26 |
JP7341127B2 (ja) | 2023-09-08 |
JP2023109960A (ja) | 2023-08-08 |
EP3456737B1 (en) | 2024-02-14 |
TWI818923B (zh) | 2023-10-21 |
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