MX2022011659A - Proteinas de union a antigeno que se unen a pd-l1. - Google Patents

Proteinas de union a antigeno que se unen a pd-l1.

Info

Publication number
MX2022011659A
MX2022011659A MX2022011659A MX2022011659A MX2022011659A MX 2022011659 A MX2022011659 A MX 2022011659A MX 2022011659 A MX2022011659 A MX 2022011659A MX 2022011659 A MX2022011659 A MX 2022011659A MX 2022011659 A MX2022011659 A MX 2022011659A
Authority
MX
Mexico
Prior art keywords
bind
antigen
binding proteins
manufactured
higher yields
Prior art date
Application number
MX2022011659A
Other languages
English (en)
Inventor
Heyue Zhou
Original Assignee
Sorrento Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sorrento Therapeutics Inc filed Critical Sorrento Therapeutics Inc
Publication of MX2022011659A publication Critical patent/MX2022011659A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Se divulgan anticuerpos anti-PD-L1 de clase IgG que tienen una mejor capacidad para elaborarse con altos rendimiento. Más específicamente, se divulgan anticuerpos humanos que se unen a PD-L1, fragmentos de unión a PD-L1 que se pueden elaborar con altos niveles.
MX2022011659A 2016-01-29 2018-07-27 Proteinas de union a antigeno que se unen a pd-l1. MX2022011659A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662288912P 2016-01-29 2016-01-29

Publications (1)

Publication Number Publication Date
MX2022011659A true MX2022011659A (es) 2022-10-13

Family

ID=59386438

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018009228A MX2018009228A (es) 2016-01-29 2017-01-27 Proteínas de unión a antigeno que se unen a pd-l1.
MX2022011659A MX2022011659A (es) 2016-01-29 2018-07-27 Proteinas de union a antigeno que se unen a pd-l1.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018009228A MX2018009228A (es) 2016-01-29 2017-01-27 Proteínas de unión a antigeno que se unen a pd-l1.

Country Status (17)

Country Link
US (4) US10118963B2 (es)
EP (1) EP3408400B1 (es)
JP (3) JP6883590B2 (es)
KR (1) KR102927822B1 (es)
CN (2) CN109715821B (es)
AU (1) AU2017212717B2 (es)
BR (1) BR112018015480A2 (es)
CA (1) CA3013051A1 (es)
CL (1) CL2018002034A1 (es)
EA (1) EA037855B1 (es)
ES (1) ES2986360T3 (es)
IL (1) IL260846B2 (es)
MX (2) MX2018009228A (es)
PH (1) PH12018501611A1 (es)
SG (1) SG11201806496SA (es)
TW (1) TWI760323B (es)
WO (1) WO2017132562A1 (es)

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CN104736168B (zh) 2012-05-31 2018-09-21 索伦托治疗有限公司 与pd-l1结合的抗原结合蛋白
GB201403775D0 (en) 2014-03-04 2014-04-16 Kymab Ltd Antibodies, uses & methods
CA3013051A1 (en) 2016-01-29 2017-08-03 Heyue Zhou Antigen binding proteins that bind pd-l1
US9567399B1 (en) 2016-06-20 2017-02-14 Kymab Limited Antibodies and immunocytokines
TWI640536B (zh) 2016-06-20 2018-11-11 克馬伯有限公司 抗體
US11779604B2 (en) 2016-11-03 2023-10-10 Kymab Limited Antibodies, combinations comprising antibodies, biomarkers, uses and methods
KR20200135447A (ko) * 2018-03-22 2020-12-02 카이레스 아게 길항성 pd-1, pd-l1 및 lag-3 결합 단백질
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EP4245865A4 (en) 2020-11-16 2025-07-23 Immuneoncia Therapeutics Inc BIOMARKER FOR PREDICTING THERAPEUTIC RESPONSE TO A CANCER IMMUNOTHERAPY AGENT AND RELATED USE
TW202305006A (zh) 2021-05-07 2023-02-01 南韓商益免安協公司 與ｃｄ４７及ｐｄ—ｌ１特異性結合的雙特異性抗體
CN117916264A (zh) 2021-06-09 2024-04-19 索伦托药业有限公司 通过经由淋巴微针递送装置施用抗pd-1或抗pd-l1治疗剂来治疗癌症的方法
CN119866227A (zh) * 2022-09-19 2025-04-22 索诺玛生物治疗公司 用于靶向调节性t细胞以治疗化脓性汗腺炎的瓜氨酸化抗原特异性嵌合抗原受体
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Also Published As

Publication number Publication date
JP2019507183A (ja) 2019-03-14
IL260846A (es) 2018-09-20
CN116333124A (zh) 2023-06-27
EP3408400B1 (en) 2024-06-26
US20240190959A1 (en) 2024-06-13
US11919952B2 (en) 2024-03-05
CN109715821B (zh) 2022-09-06
US20170218066A1 (en) 2017-08-03
CL2018002034A1 (es) 2019-03-15
EA201891709A1 (ru) 2019-01-31
US10118963B2 (en) 2018-11-06
TW201736400A (zh) 2017-10-16
JP2022095910A (ja) 2022-06-28
CN109715821A (zh) 2019-05-03
EA037855B1 (ru) 2021-05-27
WO2017132562A8 (en) 2017-09-08
EP3408400A4 (en) 2019-11-27
KR102927822B1 (ko) 2026-02-13
US20190092861A1 (en) 2019-03-28
PH12018501611A1 (en) 2019-04-08
AU2017212717A1 (en) 2018-09-06
CA3013051A1 (en) 2017-08-03
JP2021102633A (ja) 2021-07-15
IL260846B (en) 2022-10-01
KR20190026642A (ko) 2019-03-13
BR112018015480A2 (pt) 2019-05-21
US20210147539A1 (en) 2021-05-20
JP7140867B2 (ja) 2022-09-21
EP3408400A1 (en) 2018-12-05
IL260846B2 (en) 2023-02-01
EP3408400C0 (en) 2024-06-26
ES2986360T3 (es) 2024-11-11
MX2018009228A (es) 2019-07-08
WO2017132562A1 (en) 2017-08-03
NZ745357A (en) 2025-08-29
JP6883590B2 (ja) 2021-06-09
AU2017212717B2 (en) 2023-11-16
TWI760323B (zh) 2022-04-11
US10919964B2 (en) 2021-02-16
SG11201806496SA (en) 2018-08-30

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