CL2018002034A1 - Proteínas de unión a antígeno que se unen a pd-l1. - Google Patents

Proteínas de unión a antígeno que se unen a pd-l1.

Info

Publication number
CL2018002034A1
CL2018002034A1 CL2018002034A CL2018002034A CL2018002034A1 CL 2018002034 A1 CL2018002034 A1 CL 2018002034A1 CL 2018002034 A CL2018002034 A CL 2018002034A CL 2018002034 A CL2018002034 A CL 2018002034A CL 2018002034 A1 CL2018002034 A1 CL 2018002034A1
Authority
CL
Chile
Prior art keywords
bind
antigen binding
binding proteins
disclosed
antibodies
Prior art date
Application number
CL2018002034A
Other languages
English (en)
Inventor
Heyue Zhou
Original Assignee
Sorrento Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sorrento Therapeutics Inc filed Critical Sorrento Therapeutics Inc
Publication of CL2018002034A1 publication Critical patent/CL2018002034A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

SE DIVULGAN ANTICUERPOS ANTI-PD-L1 DE CLASE IGG QUE TIENEN UNA MEJOR CAPACIDAD PARA ELABORARSE CON ALTOS RENDIMIENTO. MÁS ESPECÍFICAMENTE, SE DIVULGAN ANTICUERPOS HUMANOS QUE SE UNEN A PD-L1, FRAGMENTOS DE UNIÓN A PD-L1 QUE SE PUEDEN ELABORAR CON ALTOS NIVELES.
CL2018002034A 2016-01-29 2018-07-27 Proteínas de unión a antígeno que se unen a pd-l1. CL2018002034A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662288912P 2016-01-29 2016-01-29

Publications (1)

Publication Number Publication Date
CL2018002034A1 true CL2018002034A1 (es) 2019-03-15

Family

ID=59386438

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018002034A CL2018002034A1 (es) 2016-01-29 2018-07-27 Proteínas de unión a antígeno que se unen a pd-l1.

Country Status (16)

Country Link
US (3) US10118963B2 (es)
EP (1) EP3408400A4 (es)
JP (3) JP6883590B2 (es)
KR (1) KR20190026642A (es)
CN (2) CN116333124A (es)
AU (1) AU2017212717B2 (es)
BR (1) BR112018015480A2 (es)
CA (1) CA3013051A1 (es)
CL (1) CL2018002034A1 (es)
EA (1) EA037855B1 (es)
IL (1) IL260846B2 (es)
MX (2) MX2018009228A (es)
PH (1) PH12018501611A1 (es)
SG (1) SG11201806496SA (es)
TW (1) TWI760323B (es)
WO (1) WO2017132562A1 (es)

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EA037855B1 (ru) 2016-01-29 2021-05-27 Сорренто Терапьютикс, Инк. Полностью человеческое антитело класса igg, связывающееся с эпитопом pd-l1
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US20230416369A1 (en) 2020-11-16 2023-12-28 Immuneoncia Therapeutics, Inc. Biomarker for predicting therapeutic responsiveness to cancer immunotherapeutic agent and use thereof
CA3219221A1 (en) 2021-05-07 2022-11-10 Immuneoncia Therapeutics, Inc. Bispecific antibody specifically binding to cd47 and pd-l1
EP4352100A1 (en) 2021-06-09 2024-04-17 Sorrento Therapeutics, Inc. Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device

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Also Published As

Publication number Publication date
AU2017212717B2 (en) 2023-11-16
SG11201806496SA (en) 2018-08-30
EA037855B1 (ru) 2021-05-27
PH12018501611A1 (en) 2019-04-08
KR20190026642A (ko) 2019-03-13
US20170218066A1 (en) 2017-08-03
TW201736400A (zh) 2017-10-16
US10919964B2 (en) 2021-02-16
BR112018015480A2 (pt) 2019-05-21
MX2022011659A (es) 2022-10-13
EA201891709A1 (ru) 2019-01-31
CN109715821A (zh) 2019-05-03
US20210147539A1 (en) 2021-05-20
JP2022095910A (ja) 2022-06-28
US20190092861A1 (en) 2019-03-28
IL260846B (en) 2022-10-01
CN116333124A (zh) 2023-06-27
EP3408400A4 (en) 2019-11-27
AU2017212717A1 (en) 2018-09-06
US10118963B2 (en) 2018-11-06
IL260846B2 (en) 2023-02-01
JP6883590B2 (ja) 2021-06-09
JP7140867B2 (ja) 2022-09-21
MX2018009228A (es) 2019-07-08
JP2019507183A (ja) 2019-03-14
JP2021102633A (ja) 2021-07-15
TWI760323B (zh) 2022-04-11
CA3013051A1 (en) 2017-08-03
WO2017132562A1 (en) 2017-08-03
WO2017132562A8 (en) 2017-09-08
US11919952B2 (en) 2024-03-05
EP3408400A1 (en) 2018-12-05
CN109715821B (zh) 2022-09-06
IL260846A (es) 2018-09-20

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