CU22545A1
(es)
|
1994-11-18 |
1999-03-31 |
Centro Inmunologia Molecular |
Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
|
US4554101A
(en)
|
1981-01-09 |
1985-11-19 |
New York Blood Center, Inc. |
Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
|
DE3378250D1
(en)
|
1982-04-22 |
1988-11-24 |
Ici Plc |
Continuous release formulations
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
FR2556739A1
(fr)
|
1983-12-19 |
1985-06-21 |
Pasteur Institut |
Lignees cellulaires secretant des anticorps monoclonaux contre la pg e2, leur preparation, les anticorps obtenus et leur application
|
US4753894A
(en)
|
1984-02-08 |
1988-06-28 |
Cetus Corporation |
Monoclonal anti-human breast cancer antibodies
|
US4943533A
(en)
|
1984-03-01 |
1990-07-24 |
The Regents Of The University Of California |
Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
US6492107B1
(en)
|
1986-11-20 |
2002-12-10 |
Stuart Kauffman |
Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
|
DE229046T1
(de)
|
1985-03-30 |
1987-12-17 |
Marc Genf/Geneve Ballivet |
Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
|
DE3683541D1
(de)
|
1985-06-07 |
1992-03-05 |
Ici America Inc |
Selektionierte difluorverbindungen.
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
US5618920A
(en)
|
1985-11-01 |
1997-04-08 |
Xoma Corporation |
Modular assembly of antibody genes, antibodies prepared thereby and use
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
WO1989006692A1
(en)
|
1988-01-12 |
1989-07-27 |
Genentech, Inc. |
Method of treating tumor cells by inhibiting growth factor receptor function
|
US5006309A
(en)
|
1988-04-22 |
1991-04-09 |
Abbott Laboratories |
Immunoassay device with liquid transfer between wells by washing
|
US5089424A
(en)
|
1988-06-14 |
1992-02-18 |
Abbott Laboratories |
Method and apparatus for heterogeneous chemiluminescence assay
|
DE68927933T2
(de)
|
1988-09-02 |
1997-08-14 |
Dyax Corp |
Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
AU643427B2
(en)
|
1988-10-31 |
1993-11-18 |
Immunex Corporation |
Interleukin-4 receptors
|
WO1990005144A1
(en)
|
1988-11-11 |
1990-05-17 |
Medical Research Council |
Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
|
US5063081A
(en)
|
1988-11-14 |
1991-11-05 |
I-Stat Corporation |
Method of manufacturing a plurality of uniform microfabricated sensing devices having an immobilized ligand receptor
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
AU652539B2
(en)
|
1989-05-16 |
1994-09-01 |
Medical Research Council |
Co-expression of heteromeric receptors
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
CA2016842A1
(en)
|
1989-05-16 |
1990-11-16 |
Richard A. Lerner |
Method for tapping the immunological repertoire
|
AU6430190A
(en)
|
1989-10-10 |
1991-05-16 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
AU642932B2
(en)
|
1989-11-06 |
1993-11-04 |
Alkermes Controlled Therapeutics, Inc. |
Protein microspheres and methods of using them
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
DE69133566T2
(de)
|
1990-01-12 |
2007-12-06 |
Amgen Fremont Inc. |
Bildung von xenogenen Antikörpern
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
AT396939B
(de)
|
1990-05-29 |
1993-12-27 |
Alois Dipl Ing Dr Jungbauer |
Komplexes virales antigen von hiv-1 bindendes rekombinantes protein
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
JPH06508511A
(ja)
|
1990-07-10 |
1994-09-29 |
ケンブリッジ アンティボディー テクノロジー リミティド |
特異的な結合ペアーの構成員の製造方法
|
EP0542810A1
(en)
|
1990-08-02 |
1993-05-26 |
B.R. Centre Limited |
Methods for the production of proteins with a desired function
|
DE69130647T2
(de)
|
1990-08-24 |
1999-05-06 |
Ixsys, Inc., San Diego, Calif. |
Verfahren zur herstellung von oligonukleotiden mit regellosen codonen
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
US5780279A
(en)
|
1990-12-03 |
1998-07-14 |
Genentech, Inc. |
Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech, Inc., South San Francisco, Calif. |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
WO1992011272A1
(en)
|
1990-12-20 |
1992-07-09 |
Ixsys, Inc. |
Optimization of binding proteins
|
EP0575485A1
(en)
|
1991-03-01 |
1993-12-29 |
Dyax Corp. |
Process for the development of binding mini-proteins
|
JP3854306B2
(ja)
|
1991-03-06 |
2006-12-06 |
メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング |
ヒト化及びキメラモノクローナル抗体
|
US6277969B1
(en)
|
1991-03-18 |
2001-08-21 |
New York University |
Anti-TNF antibodies and peptides of human tumor necrosis factor
|
US5656272A
(en)
|
1991-03-18 |
1997-08-12 |
New York University Medical Center |
Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies
|
DE07012625T1
(de)
|
1991-03-18 |
2010-01-21 |
New York University |
Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor
|
JP3672306B2
(ja)
|
1991-04-10 |
2005-07-20 |
ザ スクリップス リサーチ インスティテュート |
ファージミドを使用するヘテロ二量体受容体ライブラリー
|
DE69229482T2
(de)
|
1991-04-25 |
1999-11-18 |
Chugai Seiyaku K.K., Tokio/Tokyo |
Rekombinierte humane antikörper gegen den humanen interleukin 6-rezeptor
|
ES2181673T3
(es)
|
1991-05-01 |
2003-03-01 |
Jackson H M Found Military Med |
Procedimiento de tratamiento de las enfermedades respiratorias infecciosas.
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
DE4118120A1
(de)
|
1991-06-03 |
1992-12-10 |
Behringwerke Ag |
Tetravalente bispezifische rezeptoren, ihre herstellung und verwendung
|
CA2069530A1
(en)
|
1991-06-03 |
1992-12-04 |
Cass J. Grandone |
Reagent pack for immunoassays
|
CA2110799A1
(en)
|
1991-06-14 |
1992-12-23 |
Arnold H. Horwitz |
Microbially-produced antibody fragments and their conjugates
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
AU675916B2
(en)
|
1991-06-14 |
1997-02-27 |
Genentech Inc. |
Method for making humanized antibodies
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
DE69229477T2
(de)
|
1991-09-23 |
1999-12-09 |
Cambridge Antibody Technology Ltd., Melbourn |
Methoden zur Herstellung humanisierter Antikörper
|
EP1136556B1
(en)
|
1991-11-25 |
2005-06-08 |
Enzon, Inc. |
Method of producing multivalent antigen-binding proteins
|
ATE408012T1
(de)
|
1991-12-02 |
2008-09-15 |
Medical Res Council |
Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken
|
DE69233204T2
(de)
|
1991-12-13 |
2004-07-15 |
Xoma Corp., Berkeley |
Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
EP0652950B1
(en)
|
1992-07-24 |
2007-12-19 |
Amgen Fremont Inc. |
Generation of xenogeneic antibodies
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
NZ258392A
(en)
|
1992-11-13 |
1997-09-22 |
Idec Pharma Corp |
Chimeric and radiolabelled antibodies to the b lymphocyte cellsurface antigen bp35 (cd-20) and their use in the treatment of b cell lymphona
|
US5736137A
(en)
|
1992-11-13 |
1998-04-07 |
Idec Pharmaceuticals Corporation |
Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
AU6132994A
(en)
|
1993-02-02 |
1994-08-29 |
Scripps Research Institute, The |
Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
|
US6491916B1
(en)
|
1994-06-01 |
2002-12-10 |
Tolerance Therapeutics, Inc. |
Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
|
WO1995001997A1
(en)
|
1993-07-09 |
1995-01-19 |
Smithkline Beecham Corporation |
RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
|
WO1995009917A1
(en)
|
1993-10-07 |
1995-04-13 |
The Regents Of The University Of California |
Genetically engineered bispecific tetravalent antibodies
|
EP0659766A1
(en)
|
1993-11-23 |
1995-06-28 |
Schering-Plough |
Human monoclonal antibodies against human cytokines and methods of making and using such antibodies
|
US5565352A
(en)
|
1993-11-24 |
1996-10-15 |
Arch Development Corporation |
Deubiquitinating enzyme: compositions and methods
|
WO1995015982A2
(en)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Process for generating specific antibodies
|
WO1995016026A1
(en)
|
1993-12-10 |
1995-06-15 |
Abbott Laboratories |
Reagents and methods for the detection of methotrexate
|
GB9401182D0
(en)
|
1994-01-21 |
1994-03-16 |
Inst Of Cancer The Research |
Antibodies to EGF receptor and their antitumour effect
|
DE69534347T2
(de)
|
1994-01-31 |
2006-05-24 |
Trustees Of Boston University, Boston |
Bibliotheken aus Polyklonalen Antikörpern
|
ZA95960B
(en)
|
1994-03-14 |
1995-10-10 |
Genetics Inst |
Use of interleukin-12 antagonists in the treatment of autoimmune diseases
|
EP0699237B1
(en)
|
1994-03-17 |
2003-02-19 |
MERCK PATENT GmbH |
Anti-egfr single-chain fvs and anti-egfr antibodies
|
IL109632A
(en)
|
1994-05-11 |
2007-03-08 |
Yeda Res & Dev |
Modulators of the function of tnf receptors
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
CA2195557C
(en)
|
1994-08-12 |
2006-10-17 |
Shui-On Leung |
Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells
|
ATE252894T1
(de)
|
1995-01-05 |
2003-11-15 |
Univ Michigan |
Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
|
GB9504344D0
(en)
|
1995-03-03 |
1995-04-19 |
Unilever Plc |
Antibody fragment production
|
US6091001A
(en)
|
1995-03-29 |
2000-07-18 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
US6130364A
(en)
|
1995-03-29 |
2000-10-10 |
Abgenix, Inc. |
Production of antibodies using Cre-mediated site-specific recombination
|
US5641870A
(en)
|
1995-04-20 |
1997-06-24 |
Genentech, Inc. |
Low pH hydrophobic interaction chromatography for antibody purification
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
EP0826034A4
(en)
|
1995-04-21 |
2002-06-19 |
Cell Genesys Inc |
PRODUCTION OF LARGE GENOMIC DNA DELETIONS
|
ATE390933T1
(de)
|
1995-04-27 |
2008-04-15 |
Amgen Fremont Inc |
Aus immunisierten xenomäusen stammende menschliche antikörper gegen il-8
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
US7060808B1
(en)
|
1995-06-07 |
2006-06-13 |
Imclone Systems Incorporated |
Humanized anti-EGF receptor monoclonal antibody
|
WO1996040210A1
(en)
|
1995-06-07 |
1996-12-19 |
Imclone Systems Incorporated |
Antibody and antibody fragments for inhibiting the growth of tumors
|
JP2000507912A
(ja)
|
1995-08-31 |
2000-06-27 |
アルカームズ コントロールド セラピューティックス,インコーポレイテッド |
作用剤の徐放性組成物
|
BR9606706A
(pt)
|
1995-10-16 |
1999-04-06 |
Unilever Nv |
Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo
|
US6090382A
(en)
|
1996-02-09 |
2000-07-18 |
Basf Aktiengesellschaft |
Human antibodies that bind human TNFα
|
US6331431B1
(en)
|
1995-11-28 |
2001-12-18 |
Ixsys, Inc. |
Vacuum device and method for isolating periplasmic fraction from cells
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
BRPI9715219B8
(pt)
|
1996-02-09 |
2015-07-07 |
Abbvie Biotechnology Ltd |
Vetor recombinante de expressão, e célula hospedeira procariótica.
|
ES2395214T3
(es)
|
1996-03-04 |
2013-02-11 |
The Penn State Research Foundation |
Materiales y métodos para aumentar la internalización celular
|
US5714352A
(en)
|
1996-03-20 |
1998-02-03 |
Xenotech Incorporated |
Directed switch-mediated DNA recombination
|
US6015884A
(en)
|
1996-03-28 |
2000-01-18 |
The Johns Hopkins University |
Soluble divalent and multivalent heterodimeric analogs of proteins
|
EP0894135B1
(en)
|
1996-04-04 |
2004-08-11 |
Unilever Plc |
Multivalent and multispecific antigen-binding protein
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
US6699658B1
(en)
|
1996-05-31 |
2004-03-02 |
Board Of Trustees Of The University Of Illinois |
Yeast cell surface display of proteins and uses thereof
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
US6986890B1
(en)
|
1996-11-21 |
2006-01-17 |
Kyowa Hakko Kogyo Co., Ltd. |
Anti-human VEGF receptor Flt-1 monoclonal antibody
|
US7258857B2
(en)
|
1996-11-22 |
2007-08-21 |
The Trustees Of Columbia University In The City Of New York |
Rage-related methods for treating inflammation
|
AU5702298A
(en)
|
1996-12-03 |
1998-06-29 |
Abgenix, Inc. |
Transgenic mammals having human Ig loci including plural VH and VK regions nd antibodies produced therefrom
|
WO1998031346A1
(en)
|
1997-01-16 |
1998-07-23 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
CN1238366C
(zh)
|
1997-01-21 |
2006-01-25 |
综合医院公司 |
利用rna-蛋白融合体筛选蛋白
|
US6057098A
(en)
|
1997-04-04 |
2000-05-02 |
Biosite Diagnostics, Inc. |
Polyvalent display libraries
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
DE122007000021I1
(de)
|
1997-04-07 |
2007-05-24 |
Genentech Inc |
Anti-vefg Antibodies
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
WO1999006834A2
(en)
|
1997-08-04 |
1999-02-11 |
Ixsys, Incorporated |
Methods for identifying ligand specific binding molecules
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
EP1027439B1
(en)
|
1997-10-27 |
2010-03-17 |
Bac Ip B.V. |
Multivalent antigen-binding proteins
|
US7179892B2
(en)
|
2000-12-06 |
2007-02-20 |
Neuralab Limited |
Humanized antibodies that recognize beta amyloid peptide
|
AU2978899A
(en)
|
1998-03-03 |
1999-09-20 |
Abgenix, Inc. |
Cd147 binding molecules as therapeutics
|
US20020029391A1
(en)
|
1998-04-15 |
2002-03-07 |
Claude Geoffrey Davis |
Epitope-driven human antibody production and gene expression profiling
|
ES2340112T3
(es)
|
1998-04-20 |
2010-05-28 |
Glycart Biotechnology Ag |
Ingenieria de glicosilacion de anticuerpos para la mejora de la citotoxicidad celular dependiente de anticuerpos.
|
ATE370961T1
(de)
|
1998-05-06 |
2007-09-15 |
Genentech Inc |
Reinigung von antikörpern durch ionenaustauschchromatographie
|
ATE238768T1
(de)
|
1998-06-24 |
2003-05-15 |
Advanced Inhalation Res Inc |
Grosse poröse partikel ausgestossen von einem inhalator
|
CA2341029A1
(en)
|
1998-08-17 |
2000-02-24 |
Abgenix, Inc. |
Generation of modified molecules with increased serum half-lives
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
PT2112166T
(pt)
|
1998-12-23 |
2019-01-30 |
Pfizer |
Anticorpos monoclonais humanos contra ctla-4
|
PL209786B1
(pl)
|
1999-01-15 |
2011-10-31 |
Genentech Inc |
Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna
|
US6914128B1
(en)
|
1999-03-25 |
2005-07-05 |
Abbott Gmbh & Co. Kg |
Human antibodies that bind human IL-12 and methods for producing
|
CA2796140A1
(en)
|
1999-03-25 |
2000-09-28 |
Jochen Salfeld |
Human antibodies that bind human il-12 and methods for producing
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Hakko Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
CN1119415C
(zh)
|
1999-06-04 |
2003-08-27 |
长春迈灵生物工程有限公司 |
抗ca125双功能基因工程抗体的克隆与表达
|
US7070959B1
(en)
|
1999-06-08 |
2006-07-04 |
Regeneron Pharmaceuticals, Inc. |
Modified chimeric polypeptides with improved pharmacokinetic properties
|
US6531580B1
(en)
|
1999-06-24 |
2003-03-11 |
Ixsys, Inc. |
Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
|
WO2001000244A2
(en)
|
1999-06-25 |
2001-01-04 |
Genentech, Inc. |
METHODS OF TREATMENT USING ANTI-ErbB ANTIBODY-MAYTANSINOID CONJUGATES
|
EP1230269A2
(en)
|
1999-11-03 |
2002-08-14 |
Maxygen, Inc. |
Antibody diversity generation
|
TWI335336B
(es)
|
2000-02-10 |
2011-01-01 |
Abbott Gmbh & Co Kg |
|
AU783679B2
(en)
|
2000-02-24 |
2005-11-24 |
Genentech Inc. |
Caspase activated prodrugs therapy
|
KR100812658B1
(ko)
|
2000-02-25 |
2008-03-13 |
더 거번먼트 오브 더 유나이티드 스테이츠, 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비스즈 |
향상된 세포독성 및 수율의 항-이지에프알브이 3,에스씨에프브이에스, 이에 기초한 면역독소, 및 이의 이용방법
|
US7094566B2
(en)
|
2000-03-16 |
2006-08-22 |
Amgen Inc., |
IL-17 receptor like molecules and uses thereof
|
HUP0300919A2
(hu)
|
2000-03-24 |
2003-07-28 |
Micromet Ag |
Többfunkciós polipeptidek NKG2D receptor komplex epitóp kötőhellyel
|
KR20020093029A
(ko)
|
2000-04-11 |
2002-12-12 |
제넨테크, 인크. |
다가 항체 및 그의 용도
|
JP2003533187A
(ja)
|
2000-05-03 |
2003-11-11 |
アムジエン・インコーポレーテツド |
治療薬としてのFcドメインを含む修飾ペプチド
|
KR100480985B1
(ko)
|
2000-05-19 |
2005-04-07 |
이수화학 주식회사 |
표피 성장 인자 수용체에 대한 사람화된 항체
|
US7449308B2
(en)
|
2000-06-28 |
2008-11-11 |
Glycofi, Inc. |
Combinatorial DNA library for producing modified N-glycans in lower eukaryotes
|
EP1297172B1
(en)
|
2000-06-28 |
2005-11-09 |
Glycofi, Inc. |
Methods for producing modified glycoproteins
|
SK1152003A3
(en)
|
2000-06-29 |
2003-07-01 |
Abbott Lab |
Dual specificity antibodies and methods of making and using
|
US20040220388A1
(en)
|
2000-06-30 |
2004-11-04 |
Nico Mertens |
Novel heterodimeric fusion proteins
|
US20090081234A1
(en)
|
2000-08-07 |
2009-03-26 |
George Heavner |
Anti-tnf antibodies, compositions, methods and uses for treatment of depression and related conditions
|
UA81743C2
(uk)
|
2000-08-07 |
2008-02-11 |
Центокор, Инк. |
МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
|
GB0020685D0
(en)
|
2000-08-22 |
2000-10-11 |
Novartis Ag |
Organic compounds
|
JP2004529610A
(ja)
|
2000-10-13 |
2004-09-30 |
ユーエイビー リサーチ ファンデーション |
ヒト抗上皮増殖因子受容体一本鎖抗体
|
JP5312721B2
(ja)
|
2000-11-07 |
2013-10-09 |
シティ・オブ・ホープ |
Cd19特異的再指向免疫細胞
|
TWI255272B
(en)
|
2000-12-06 |
2006-05-21 |
Guriq Basi |
Humanized antibodies that recognize beta amyloid peptide
|
US6818392B2
(en)
|
2000-12-06 |
2004-11-16 |
Abbott Laboratories |
Monoclonal antibodies to human immunodeficiency virus and uses thereof
|
CA2433353C
(en)
|
2000-12-28 |
2017-03-21 |
Altus Biologics, Inc. |
Crystals of whole antibodies and fragments thereof and methods for making and using them
|
PE20020801A1
(es)
|
2001-01-05 |
2002-09-06 |
Pfizer |
Anticuerpos contra el receptor del factor de crecimiento similar a insulina
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
US20100056762A1
(en)
|
2001-05-11 |
2010-03-04 |
Old Lloyd J |
Specific binding proteins and uses thereof
|
WO2002097048A2
(en)
|
2001-05-30 |
2002-12-05 |
Centocor, Inc. |
ANTI-p40 IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES
|
US7727527B2
(en)
|
2001-05-30 |
2010-06-01 |
Genentech, Inc. |
Anti-NGF antibodies for the therapeutic treatments
|
CA2450285C
(en)
|
2001-06-13 |
2016-08-02 |
Genmab A/S |
Human monoclonal antibodies to epidermal growth factor receptor (egfr)
|
US20060073141A1
(en)
|
2001-06-28 |
2006-04-06 |
Domantis Limited |
Compositions and methods for treating inflammatory disorders
|
US20040241745A1
(en)
|
2001-07-31 |
2004-12-02 |
Tasuku Honjo |
Substance specific to pd-1
|
WO2003016466A2
(en)
|
2001-08-17 |
2003-02-27 |
Eli Lilly And Company |
ANTI-Aβ ANTIBODIES
|
US7247304B2
(en)
|
2001-08-23 |
2007-07-24 |
Genmab A/S |
Methods of treating using anti-IL-15 antibodies
|
US20030226155A1
(en)
|
2001-08-30 |
2003-12-04 |
Biorexis Pharmaceutical Corporation |
Modified transferrin-antibody fusion proteins
|
EP1431310A4
(en)
|
2001-09-25 |
2005-03-23 |
Immuno Biological Lab Co Ltd |
ANTI-OSTEOPONTIN RECOMBINANT ANTIBODY AND USE THEREOF
|
PT1438400E
(pt)
|
2001-10-01 |
2009-09-10 |
Dyax Corp |
Vectores de apresentação eucarióticos de cadeias múltiplas e suas utilizações
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
MXPA04003798A
(es)
|
2001-10-25 |
2004-07-30 |
Genentech Inc |
Composiciones de glicoproteina.
|
WO2003039486A2
(en)
|
2001-11-09 |
2003-05-15 |
Idec Pharmaceuticals Corporation |
Anti-cd80 antibody having adcc activity for adcc mediated killing of b cell lymphoma cells alone or in combination with other therapies
|
ES2624547T3
(es)
|
2001-11-14 |
2017-07-14 |
Janssen Biotech, Inc. |
Anticuerpos anti il 6, composiciones, métodos y usos
|
US7452539B2
(en)
|
2001-12-19 |
2008-11-18 |
Genentech, Inc. |
Stabilizing polypeptides which have been exposed to urea
|
WO2003066662A2
(en)
|
2002-02-05 |
2003-08-14 |
Genentech, Inc. |
Protein purification
|
WO2003068801A2
(en)
|
2002-02-11 |
2003-08-21 |
Genentech, Inc. |
Antibody variants with faster antigen association rates
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
US7419821B2
(en)
|
2002-03-05 |
2008-09-02 |
I-Stat Corporation |
Apparatus and methods for analyte measurement and immunoassay
|
EP1499352A4
(en)
|
2002-04-12 |
2006-10-11 |
Medimmune Inc |
ANTI-INTERLEUKIN-9 RECOMBINANT ANTIBODIES
|
JP2006512891A
(ja)
|
2002-04-18 |
2006-04-20 |
ジェネンコー・インターナショナル・インク |
糸状菌における機能性抗体の生産
|
WO2003102132A2
(en)
|
2002-04-26 |
2003-12-11 |
Genetech, Inc. |
Non-affinity purification of proteins
|
US20030206898A1
(en)
|
2002-04-26 |
2003-11-06 |
Steven Fischkoff |
Use of anti-TNFalpha antibodies and another drug
|
ATE444972T1
(de)
|
2002-04-30 |
2009-10-15 |
Kyowa Hakko Kirin Co Ltd |
ANTIKÖRPER GEGEN DEN HUMANEN ßINSULIN-LIKEß WACHSTUMSFAKTOR
|
JP4563171B2
(ja)
|
2002-05-24 |
2010-10-13 |
シェーリング コーポレイション |
中和ヒト抗igfr抗体
|
EP1575499A2
(en)
|
2002-06-28 |
2005-09-21 |
Centocor, Inc. |
Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses
|
US9321832B2
(en)
|
2002-06-28 |
2016-04-26 |
Domantis Limited |
Ligand
|
CN1678634A
(zh)
|
2002-06-28 |
2005-10-05 |
多曼蒂斯有限公司 |
免疫球蛋白单个变体抗原结合区及其特异性构建体
|
PT1523496E
(pt)
|
2002-07-18 |
2011-09-29 |
Merus B V |
Produção de misturas de anticorpos de forma recombinante
|
US20040018577A1
(en)
|
2002-07-29 |
2004-01-29 |
Emerson Campbell John Lewis |
Multiple hybrid immunoassay
|
US20040033228A1
(en)
|
2002-08-16 |
2004-02-19 |
Hans-Juergen Krause |
Formulation of human antibodies for treating TNF-alpha associated disorders
|
MEP18108A
(en)
|
2002-08-19 |
2010-06-10 |
Astrazeneca Ab |
Antibodies directed to monocyte chemo-attractant protein-1 (mcp-1) and uses thereof
|
HUE033623T2
(en)
|
2002-09-11 |
2017-12-28 |
Genentech Inc |
protein purification
|
US7820166B2
(en)
|
2002-10-11 |
2010-10-26 |
Micromet Ag |
Potent T cell modulating molecules
|
DE60333228D1
(de)
|
2002-12-02 |
2010-08-12 |
Amgen Fremont Inc |
Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
|
BRPI0316779B1
(pt)
|
2002-12-16 |
2020-04-28 |
Genentech Inc |
anticorpo humanizado que liga cd20 humano, composição, artigo manufaturado, método de indução da apoptose, método de tratamento de câncer cd20 positivo, métodos de tratamento de doenças autoimunes, ácidos nucléicos isolados, vetores de expressão, células hospedeiras, método para a produção de um anticorpo 2h7 humanizado, polipeptídeo isolado, formulação líquida, método de tratamento de artrite reumatóide (ra) e anticorpos de ligação de cd20 humanizados
|
WO2004058184A2
(en)
|
2002-12-24 |
2004-07-15 |
Rinat Neuroscience Corp. |
Anti-ngf antibodies and methods using same
|
US7569364B2
(en)
|
2002-12-24 |
2009-08-04 |
Pfizer Inc. |
Anti-NGF antibodies and methods using same
|
CA2513113A1
(en)
|
2003-01-23 |
2004-08-05 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
JP3803790B2
(ja)
|
2003-02-17 |
2006-08-02 |
株式会社東北テクノアーチ |
新規なダイアボディ型二重特異性抗体
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
ES2335005T5
(es)
|
2003-03-05 |
2013-04-17 |
Halozyme, Inc. |
Glicoproteína hialuronidasa soluble (shasegp), proceso para prepararla, usos y composiciones farmacéuticas que la comprenden
|
JP2007535895A
(ja)
|
2003-05-01 |
2007-12-13 |
イムクローン システムズ インコーポレイティド |
ヒトインシュリン様成長因子−1受容体に対する完全ヒト抗体
|
AU2004242846A1
(en)
|
2003-05-31 |
2004-12-09 |
Micromet Ag |
Pharmaceutical compositions comprising bispecific anti-CD3, anti-CD19 antibody constructs for the treatment of B-cell related disorders
|
NZ544797A
(en)
|
2003-07-18 |
2011-04-29 |
Amgen Fremont Inc |
Specific antibodies that bind HGF and neutralise binding of HGF to met
|
SI1648940T1
(sl)
|
2003-07-28 |
2016-08-31 |
Genentech, Inc. |
Zmanjševanje izluževanja proteina A med afinitetno kromatografijo proteina A
|
US20050026881A1
(en)
|
2003-07-31 |
2005-02-03 |
Robinson Cynthia B. |
Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anti-IgE antibody for treatment of asthma or chronic obstructive pulmonary disease
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
WO2005044853A2
(en)
|
2003-11-01 |
2005-05-19 |
Genentech, Inc. |
Anti-vegf antibodies
|
US7662928B2
(en)
|
2003-08-08 |
2010-02-16 |
The Research Foundation Of State University Of New York |
Anti-FcRn antibodies for treatment of auto/allo immune conditions
|
WO2005018572A2
(en)
|
2003-08-22 |
2005-03-03 |
Biogen Idec Ma Inc. |
Improved antibodies having altered effector function and methods for making the same
|
JP2007528723A
(ja)
|
2003-08-22 |
2007-10-18 |
メディミューン,インコーポレーテッド |
抗体のヒト化
|
US7682833B2
(en)
|
2003-09-10 |
2010-03-23 |
Abbott Point Of Care Inc. |
Immunoassay device with improved sample closure
|
US7723099B2
(en)
|
2003-09-10 |
2010-05-25 |
Abbott Point Of Care Inc. |
Immunoassay device with immuno-reference electrode
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
JP2007526022A
(ja)
|
2003-10-24 |
2007-09-13 |
メドトロニック・インコーポレーテッド |
炎症誘発性媒介物質の産生を減弱することによって神経性障害を処置する技法
|
US7968684B2
(en)
|
2003-11-12 |
2011-06-28 |
Abbott Laboratories |
IL-18 binding proteins
|
EP2264191A1
(en)
|
2003-11-21 |
2010-12-22 |
ANP Technologies, Inc. |
Asymmetrically branched polymer conjugates and microarray assays
|
EP1697741A4
(en)
|
2003-12-04 |
2008-02-13 |
Xencor Inc |
PROCESS FOR PRODUCING PROTEIN VARIANTS WITH INCREASED HOST STRUCTURE CONTENT AND COMPOSITIONS THEREOF
|
US7235641B2
(en)
|
2003-12-22 |
2007-06-26 |
Micromet Ag |
Bispecific antibodies
|
ITRM20030601A1
(it)
|
2003-12-24 |
2005-06-25 |
Lay Line Genomics Spa |
Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti.
|
WO2005070965A2
(en)
|
2004-01-21 |
2005-08-04 |
Five Prime Therapeutics, Inc. |
Pharmaceutical compositions containing antagonists to lrp4, lrp8 or megalin for treatment of diseases
|
WO2006107617A2
(en)
|
2005-04-06 |
2006-10-12 |
Ibc Pharmaceuticals, Inc. |
Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses
|
WO2005087812A1
(en)
|
2004-03-05 |
2005-09-22 |
Ludwig Institute For Cancer Research |
Multivalent antibody materials and methods for vegf/pdgf family of growth factors
|
US7794713B2
(en)
|
2004-04-07 |
2010-09-14 |
Lpath, Inc. |
Compositions and methods for the treatment and prevention of hyperproliferative diseases
|
US7691379B2
(en)
|
2004-04-12 |
2010-04-06 |
Medimmune, Llc |
Anti-IL-9 antibody formulations
|
AU2005233387B2
(en)
|
2004-04-15 |
2011-05-26 |
Glycofi, Inc. |
Production of galactosylated glycoproteins in lower eukaryotes
|
JP2008508858A
(ja)
|
2004-05-13 |
2008-03-27 |
イムクローン システムズ インコーポレイティド |
マクロファージ−刺激タンパク質受容体(ron)の阻害
|
WO2006001965A2
(en)
|
2004-05-24 |
2006-01-05 |
Abgenix, Inc. |
Reducing the risk of human anti-human antibodies through v gene manipulation
|
SG188175A1
(en)
|
2004-06-03 |
2013-03-28 |
Novimmune Sa |
Anti-cd3 antibodies and methods of use thereof
|
WO2006020258A2
(en)
|
2004-07-17 |
2006-02-23 |
Imclone Systems Incorporated |
Novel tetravalent bispecific antibody
|
CA2574881C
(en)
|
2004-08-04 |
2013-01-08 |
Amgen Inc. |
Antibodies to dkk-1
|
GB0417487D0
(en)
|
2004-08-05 |
2004-09-08 |
Novartis Ag |
Organic compound
|
DE602005020799D1
(de)
|
2004-08-05 |
2010-06-02 |
Genentech Inc |
Humanisierte anti-cmet-antagonisten
|
AU2005285347A1
(en)
|
2004-08-19 |
2006-03-23 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
GB0419424D0
(en)
|
2004-09-02 |
2004-10-06 |
Viragen Scotland Ltd |
Transgene optimisation
|
ES2377979T3
(es)
|
2004-09-03 |
2012-04-03 |
Genentech, Inc. |
Antagonistas anti-beta7 humanizados y utilizaciones para los mismos
|
CA2582683A1
(en)
|
2004-10-01 |
2006-04-13 |
Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. |
Novel antibodies directed to the mammalian eag1 ion channel protein
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
KR101370253B1
(ko)
|
2004-10-22 |
2014-03-05 |
암젠 인크 |
재조합 항체의 재접힘 방법
|
US20060253100A1
(en)
|
2004-10-22 |
2006-11-09 |
Medtronic, Inc. |
Systems and Methods to Treat Pain Locally
|
US7423128B2
(en)
|
2004-11-03 |
2008-09-09 |
Amgen Fremont Inc. |
Anti-properdin antibodies, and methods for making and using same
|
WO2006063150A2
(en)
|
2004-12-08 |
2006-06-15 |
Immunomedics, Inc. |
Methods and compositions for immunotherapy and detection of inflammatory and immune-dysregulatory disease, infectious disease, pathologic angiogenesis and cancer
|
CA2589017A1
(en)
|
2004-12-15 |
2006-06-22 |
Neuralab Limited |
Amyloid beta antibodies for use in improving cognition
|
EP2284194A1
(en)
|
2004-12-21 |
2011-02-16 |
AstraZeneca AB |
Antibodies directed to angiopoietin-2 and uses thereof
|
WO2006081139A2
(en)
|
2005-01-26 |
2006-08-03 |
Abgenix, Inc. |
Antibodies against interleukin-1 beta
|
AU2006214121B9
(en)
|
2005-02-15 |
2013-02-14 |
Duke University |
Anti-CD19 antibodies and uses in oncology
|
EP1860119B1
(en)
|
2005-02-28 |
2011-08-03 |
Institute for Antibodies Co., Ltd. |
ANTI-IgSF4 ANTIBODY AND UTILIZATION OF THE SAME
|
EP1869085B1
(en)
|
2005-03-24 |
2012-03-14 |
ThromboGenics N.V. |
Novel anti-plgf antibody
|
EA201100642A1
(ru)
|
2005-04-25 |
2011-12-30 |
Пфайзер Инк. |
Антитела к миостатину
|
US7592429B2
(en)
|
2005-05-03 |
2009-09-22 |
Ucb Sa |
Sclerostin-binding antibody
|
EP2221316A1
(en)
|
2005-05-05 |
2010-08-25 |
Duke University |
Anti-CD19 antibody therapy for autoimmune disease
|
EP1885388B1
(en)
|
2005-05-10 |
2013-09-11 |
Biogen Idec MA Inc. |
Treating and evaluating inflammatory disorders
|
WO2006130429A2
(en)
|
2005-05-27 |
2006-12-07 |
Biogen Idec Ma Inc. |
Treatment of cancer
|
NZ583636A
(en)
|
2005-05-27 |
2011-12-22 |
Biogen Idec Inc |
Tweak binding antibodies
|
ITRM20050290A1
(it)
|
2005-06-07 |
2006-12-08 |
Lay Line Genomics Spa |
Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato.
|
AU2006261442A1
(en)
|
2005-06-24 |
2006-12-28 |
Novozymes A/S |
Lipases for pharmaceutical use
|
US7491391B2
(en)
|
2005-06-30 |
2009-02-17 |
Centocor, Inc. |
Anti-IL-23 antibodies, compositions, methods and uses
|
US20070041905A1
(en)
|
2005-08-19 |
2007-02-22 |
Hoffman Rebecca S |
Method of treating depression using a TNF-alpha antibody
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
US20090215992A1
(en)
|
2005-08-19 |
2009-08-27 |
Chengbin Wu |
Dual variable domain immunoglobulin and uses thereof
|
WO2007024715A2
(en)
|
2005-08-19 |
2007-03-01 |
Abbott Laboratories |
Dual variable domain immunoglobin and uses thereof
|
BRPI0615397B1
(pt)
|
2005-08-26 |
2023-10-03 |
Roche Glycart Ag |
Anticorpo anti-cd20, composição farmacêutica que o contém e uso do mesmo
|
US7906116B2
(en)
|
2005-09-01 |
2011-03-15 |
Parkash Gill |
Methods for using and identifying modulators of Delta-like 4
|
CA2862540C
(en)
|
2005-09-21 |
2018-07-31 |
The Regents Of The University Of California |
Systems, compositions, and methods for local imaging and treatment of pain
|
WO2007038392A2
(en)
|
2005-09-23 |
2007-04-05 |
Walter Reed Army Institute Of Research (Wrair) |
Antibodies with simultaneous subsite specificities to protein and lipid epitopes
|
EP1940881B1
(en)
|
2005-10-11 |
2016-11-30 |
Amgen Research (Munich) GmbH |
Compositions comprising cross-species-specific antibodies and uses thereof
|
US20080299137A1
(en)
|
2005-10-28 |
2008-12-04 |
Novo Nordisk A/S |
Fusion Proteins That Bind Effector Lymphocytes And Target Cells
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
AR056806A1
(es)
|
2005-11-14 |
2007-10-24 |
Amgen Inc |
Moleculas quimericas de anticuerpo rankl- pth/ pthrp
|
AU2006318580A1
(en)
|
2005-11-21 |
2007-05-31 |
Merck Serono Sa |
Compositions and methods of producing hybrid antigen binding molecules and uses thereof
|
CN101432302A
(zh)
|
2005-11-30 |
2009-05-13 |
艾博特公司 |
抗-Aβ球聚体抗体,其抗原结合部分,相应的杂交瘤、核酸、载体、宿主细胞,生产所述抗体的方法,包含所述抗体的组合物,所述抗体的应用以及使用所述抗体的方法
|
ES2385054T3
(es)
|
2005-12-13 |
2012-07-17 |
Medimmune Limited |
Proteínas de unión específicas para factores de crecimiento de tipo insulina y usos de las mismas
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
KR101535678B1
(ko)
|
2006-01-23 |
2015-07-09 |
조셉 피. 에리코 |
표적 약물 개발의 방법 및 조성물
|
KR20080099290A
(ko)
|
2006-01-31 |
2008-11-12 |
노파르티스 아게 |
암 치료용 il-17 길항 항체
|
EP1991252A2
(en)
|
2006-02-21 |
2008-11-19 |
Oklahoma Medical Research Foundation |
Treatment of alzheimer's disease with inhibitors of apoe binding to apoe receptor
|
KR101516823B1
(ko)
|
2006-03-17 |
2015-05-07 |
바이오겐 아이덱 엠에이 인코포레이티드 |
안정화된 폴리펩티드 조성물
|
WO2007109749A2
(en)
|
2006-03-21 |
2007-09-27 |
Wyeth |
Methods for preventing and treating amyloidogenic diseases
|
US20070232556A1
(en)
|
2006-03-31 |
2007-10-04 |
Montine Thomas J |
Methods and compositions for the treatment of neurological diseases and disorders
|
EP2010213A4
(en)
|
2006-04-10 |
2010-08-11 |
Abbott Biotech Ltd |
USE AND COMPOSITIONS FOR THE TREATMENT OF JUVENIL RHEUMATOID ARTHRITIS
|
US20100047204A1
(en)
|
2006-04-14 |
2010-02-25 |
Dana Sue Yoo |
Use of organic compounds
|
KR101317235B1
(ko)
|
2006-04-21 |
2013-10-15 |
조마 테크놀로지 리미티드 |
길항제 항-cd40 항체 제약 조성물
|
US20080118978A1
(en)
|
2006-04-28 |
2008-05-22 |
Takashi Sato |
Anti-tumor agent
|
CN101058609B
(zh)
|
2006-05-26 |
2011-04-13 |
神州细胞工程有限公司 |
人源抗体及其表达
|
AR061170A1
(es)
|
2006-06-02 |
2008-08-06 |
Aveo Pharmaceuticals Inc |
Proteinas que se unen con el factor de crecimiento de hepatocitos (hgf)
|
JP2009539384A
(ja)
|
2006-06-06 |
2009-11-19 |
ジェネンテック・インコーポレーテッド |
抗dll4抗体および抗dll4抗体使用の方法
|
EP2029159A2
(en)
|
2006-06-06 |
2009-03-04 |
Genentech, Inc. |
Compositions and methods for modulating vascular development
|
US20090182127A1
(en)
|
2006-06-22 |
2009-07-16 |
Novo Nordisk A/S |
Production of Bispecific Antibodies
|
EP2032989B2
(en)
|
2006-06-30 |
2015-10-28 |
Merck Sharp & Dohme Corp. |
Igfbp2 biomarker
|
EP2046833B9
(en)
|
2006-07-14 |
2014-02-19 |
AC Immune S.A. |
Humanized antibody against amyloid beta
|
AU2007285976B2
(en)
|
2006-08-14 |
2011-08-18 |
Xencor, Inc |
Optimized antibodies that target CD19
|
KR101544108B1
(ko)
|
2006-09-08 |
2015-08-13 |
애브비 바하마스 리미티드 |
인터루킨-13 결합 단백질
|
CA2664738C
(en)
|
2006-09-29 |
2017-03-07 |
Oncomed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
NZ613356A
(en)
|
2006-10-27 |
2015-02-27 |
Abbvie Biotechnology Ltd |
Crystalline anti-htnfalpha antibodies
|
PL2907827T3
(pl)
|
2006-11-02 |
2019-03-29 |
Genentech, Inc. |
Humanizowane przeciwciała przeciw czynnikowi D i ich zastosowanie
|
WO2008079326A2
(en)
|
2006-12-20 |
2008-07-03 |
Vasgene Therapeutics, Inc. |
Methods for using and identifying modulators of delta-like 4
|
WO2008100995A1
(en)
|
2007-02-14 |
2008-08-21 |
Vaccinex, Inc. |
Humanized anti-cd100 antibodies
|
PL2129396T3
(pl)
|
2007-02-16 |
2014-02-28 |
Merrimack Pharmaceuticals Inc |
Przeciwciała przeciw ERBB3 i ich zastosowania
|
BRPI0809042B1
(pt)
|
2007-03-22 |
2021-08-31 |
Biogen Ma Inc. |
Proteína de ligação a cd154 isolada, seu uso, e composição
|
US20090068195A1
(en)
|
2007-04-23 |
2009-03-12 |
Wyeth |
Methods and compositions for treating and monitoring treatment of il-13-associated disorders
|
GB0708002D0
(en)
|
2007-04-25 |
2007-06-06 |
Univ Sheffield |
Antibodies
|
EP1997832A1
(en)
|
2007-05-29 |
2008-12-03 |
Ganymed Pharmaceuticals AG |
Monoclonal antibodies against Claudin-18 for treatment of cancer
|
AU2008260135A1
(en)
|
2007-05-30 |
2008-12-11 |
Lpath, Inc. |
Compositions and methods for binding lysophosphatidic acid
|
US8227201B2
(en)
|
2007-06-27 |
2012-07-24 |
Board Of Trustees Of The Leland Stanford Junior University |
BETA2-microglobulin and C reactive protein (CRP) as biomarkers for peripheral artery disease
|
EP2626371A1
(en)
|
2007-07-31 |
2013-08-14 |
MedImmune, LLC |
Multispecific epitope binding proteins and uses thereof
|
CN101980722A
(zh)
|
2007-08-08 |
2011-02-23 |
雅培制药有限公司 |
结晶抗体的组合物和方法
|
EP2178914A2
(en)
|
2007-08-15 |
2010-04-28 |
Bayer Schering Pharma Aktiengesellschaft |
Monospecific and multispecific antibodies and method of use
|
EP2050764A1
(en)
|
2007-10-15 |
2009-04-22 |
sanofi-aventis |
Novel polyvalent bispecific antibody format and uses thereof
|
EP2235053A1
(en)
|
2007-10-19 |
2010-10-06 |
Abbott Laboratories |
Glycosylated mammalian ngal and use thereof
|
KR101499278B1
(ko)
|
2007-12-17 |
2015-03-06 |
화이자 리미티드 |
간질성 방광염의 치료
|
EP2235064B1
(en)
|
2008-01-07 |
2015-11-25 |
Amgen Inc. |
Method for making antibody fc-heterodimeric molecules using electrostatic steering effects
|
WO2009091912A2
(en)
|
2008-01-15 |
2009-07-23 |
Abbott Laboratories |
Improved mammalian expression vectors and uses thereof
|
US8962803B2
(en)
|
2008-02-29 |
2015-02-24 |
AbbVie Deutschland GmbH & Co. KG |
Antibodies against the RGM A protein and uses thereof
|
KR20110014607A
(ko)
|
2008-04-29 |
2011-02-11 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
US20100260668A1
(en)
|
2008-04-29 |
2010-10-14 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
WO2009136382A2
(en)
|
2008-05-09 |
2009-11-12 |
Abbott Gmbh & Co. Kg |
Antibodies to receptor of advanced glycation end products (rage) and uses thereof
|
MX2010013239A
(es)
|
2008-06-03 |
2011-02-24 |
Abbott Lab |
Inmunoglobulinas de dominio variable doble y usos de las mismas.
|
UY31861A
(es)
|
2008-06-03 |
2010-01-05 |
Abbott Lab |
Inmunoglobulina con dominio variable dual y usos de la misma
|
US8741287B2
(en)
|
2008-06-18 |
2014-06-03 |
Abbott Laboratories |
PlGF-1 assay and kits and components thereof
|
RU2559525C2
(ru)
|
2008-07-08 |
2015-08-10 |
Эббви Инк |
Белки, связывающие простагландин е2, и их применение
|
MX2010014574A
(es)
|
2008-07-08 |
2011-04-27 |
Abbott Lab |
Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas.
|
WO2010017103A2
(en)
|
2008-08-04 |
2010-02-11 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic |
Fully human anti-human nkg2d monoclonal antibodies
|
WO2010039850A1
(en)
|
2008-09-30 |
2010-04-08 |
Abbott Laboratories |
Improved method of rna display
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
SG171812A1
(en)
|
2008-12-04 |
2011-07-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
WO2010093771A1
(en)
|
2009-02-11 |
2010-08-19 |
Bristol-Myers Squibb Company |
Combination vegfr2 therapy with temozolomide
|
NZ611324A
(en)
|
2009-03-05 |
2015-02-27 |
Abbvie Inc |
Il-17 binding proteins
|
KR20120044294A
(ko)
|
2009-05-01 |
2012-05-07 |
아보트 러보러터리즈 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
BRPI1012195A2
(pt)
|
2009-05-01 |
2018-04-24 |
Abbott Lab |
imunoglobulinas de domínio variável duplo e usos das mesmas
|
UY32808A
(es)
|
2009-07-29 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas como dominio variable dual y usos de las mismas
|
PE20121647A1
(es)
|
2009-08-29 |
2012-12-31 |
Abbvie Inc |
Proteinas terapeuticas de union a dll4
|
UY32870A
(es)
|
2009-09-01 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
UY32920A
(es)
|
2009-10-02 |
2011-04-29 |
Boehringer Ingelheim Int |
Moleculas de unión biespecíficas para la terapia anti-angiogénesis
|
CA2775402A1
(en)
|
2009-10-15 |
2011-04-21 |
Abbott Laboratories |
Il-1 binding proteins
|
RU2012119756A
(ru)
|
2009-10-15 |
2013-11-20 |
Эбботт Лэборетриз |
Иммуноглобулины с двумя вариабельными доменами и их применение
|
UY32979A
(es)
|
2009-10-28 |
2011-02-28 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
WO2011084714A2
(en)
|
2009-12-17 |
2011-07-14 |
Biogen Idec Ma Inc. |
STABILIZED ANTI-TNF-ALPHA scFv MOLECULES OR ANTI-TWEAK scFv MOLECULES AND USES THEREOF
|
WO2011091304A1
(en)
|
2010-01-22 |
2011-07-28 |
Genentech, Inc. |
Delivery system for diagnostic and therapeutic agents
|
WO2011109298A2
(en)
|
2010-03-02 |
2011-09-09 |
Abbott Laboratories |
Therapeutic dll4 binding proteins
|
UY33386A
(es)
|
2010-05-14 |
2011-12-30 |
Abbott Laboratoires |
Proteínas de unión a il-1
|
KR20130043168A
(ko)
|
2010-06-24 |
2013-04-29 |
아비에 인코포레이티드 |
이원 가변 도메인 면역글로불린 및 이의 용도
|
UY33492A
(es)
|
2010-07-09 |
2012-01-31 |
Abbott Lab |
Inmunoglobulinas con dominio variable dual y usos de las mismas
|
TW201206473A
(en)
|
2010-08-03 |
2012-02-16 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
JP2013539364A
(ja)
|
2010-08-26 |
2013-10-24 |
アッヴィ・インコーポレイテッド |
二重可変ドメイン免疫グロブリンおよびその使用
|
WO2012061374A2
(en)
|
2010-11-02 |
2012-05-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
US20120263722A1
(en)
|
2010-11-04 |
2012-10-18 |
Abbott Laboratories |
Dual Variable Domain Immunoglobulins and Uses Thereof
|
CA2818173C
(en)
|
2010-11-30 |
2022-05-03 |
Genentech, Inc. |
Low affinity blood brain barrier receptor antibodies and uses therefor
|
JP6009455B2
(ja)
|
2010-12-21 |
2016-10-19 |
アッヴィ・インコーポレイテッド |
Il−1アルファおよびベータ二重特異的二重可変ドメイン免疫グロブリンおよびその使用
|
EP2654792A4
(en)
|
2010-12-22 |
2016-05-11 |
Abbvie Inc |
HALF IMMUNOGLOBULIN BINDING PROTEINS AND USES THEREOF
|
RU2015134562A
(ru)
|
2011-02-08 |
2018-12-24 |
Эббви Инк. |
Лечение остеоартрита и боли
|
BR112013026306A2
(pt)
|
2011-04-20 |
2017-09-05 |
Roche Glycart Ag |
MÉTODO E CONSTRUTOS PARA A PASSAGEM DE PENDENTE DO pH DA BARREIRA SANGUE-CÉREBRO
|
ES2707580T3
(es)
|
2011-09-23 |
2019-04-04 |
Oncomed Pharm Inc |
Agentes de unión a VEGF/DLL4 y usos de los mismos
|
EP2771360A1
(en)
|
2011-10-24 |
2014-09-03 |
AbbVie Inc. |
Immunobinders directed against sclerostin
|
RS20140202A1
(en)
|
2011-10-24 |
2014-10-31 |
Abbvie Inc. |
BIOSPECIFIC IMMUNOVELING PROTEINS DIRECTED AGAINST TNF AND IL-17
|
AU2012328921B2
(en)
|
2011-10-24 |
2017-05-11 |
Abbvie Inc. |
Immunobinders directed against TNF
|
AU2012340878A1
(en)
|
2011-11-21 |
2014-06-12 |
Abbvie Inc. |
IL-1 binding proteins
|
WO2013081612A1
(en)
|
2011-11-30 |
2013-06-06 |
Abbvie Biotherapeutics Inc. |
Vectors and host cells comprising a modified sv40 promoter for protein expression
|
EP2797954A2
(en)
|
2011-12-30 |
2014-11-05 |
AbbVie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
MX2014008101A
(es)
|
2011-12-30 |
2014-09-25 |
Abbvie Inc |
Proteinas de union especificas duales dirigidas contra il-13 y/o il-17.
|
EP2797956A2
(en)
|
2011-12-30 |
2014-11-05 |
Abbvie Inc. |
Dual variable domain immunoglobulins against receptors
|
NZ714482A
(en)
|
2012-01-27 |
2017-08-25 |
Abbvie Inc |
Composition and method for diagnosis and treatment of diseases associated with neurite degeneration
|
KR102293061B1
(ko)
|
2012-05-21 |
2021-08-23 |
제넨테크, 인크. |
혈액-뇌 장벽 수송의 안전성을 개선하는 방법
|
EP3315514A1
(en)
|
2012-08-29 |
2018-05-02 |
F. Hoffmann-La Roche AG |
Blood brain barrier shuttle
|
US20140161817A1
(en)
|
2012-11-01 |
2014-06-12 |
Michael Siedler |
Stable dual variable domain immunoglobulin protein formulations
|
TW201811825A
(zh)
|
2012-11-01 |
2018-04-01 |
美商艾伯維有限公司 |
抗-vegf/dll4雙重可變區域免疫球蛋白及其用途
|
JP2016501881A
(ja)
|
2012-12-04 |
2016-01-21 |
アッヴィ・インコーポレイテッド |
血液脳関門(bbb)を透過する二重特異性結合タンパク質
|
US20140213771A1
(en)
|
2012-12-28 |
2014-07-31 |
Abbvie, Inc. |
Multi-specific binding proteins
|
US20140213772A1
(en)
|
2012-12-28 |
2014-07-31 |
Abbvie, Inc. |
Cross-over dual variable domain immunoglobulin constructs
|
WO2014106001A2
(en)
|
2012-12-28 |
2014-07-03 |
Abbvie, Inc. |
Dual specific binding proteins having a receptor sequence
|
US9915665B2
(en)
|
2012-12-28 |
2018-03-13 |
Abbvie Inc. |
High-throughput system and method for identifying antibodies having specific antigen binding activities
|
US9458244B2
(en)
|
2012-12-28 |
2016-10-04 |
Abbvie Inc. |
Single chain multivalent binding protein compositions and methods
|
US9856319B2
(en)
|
2012-12-28 |
2018-01-02 |
Abbvie Inc. |
Monovalent binding proteins
|
US20140235476A1
(en)
|
2012-12-28 |
2014-08-21 |
Abbvie, Inc. |
Multivalent binding protein compositions and methods for identifying variants of same
|
TW201512219A
(zh)
|
2013-03-15 |
2015-04-01 |
Abbvie Inc |
針對IL-1β及/或IL-17之雙特異性結合蛋白
|
EP2970457A2
(en)
|
2013-03-15 |
2016-01-20 |
AbbVie Inc. |
Dual specific binding proteins directed against tnf
|
AU2014236769B2
(en)
|
2013-03-15 |
2018-09-27 |
Amgen Inc. |
Heterodimeric bispecific antibodies
|
MX2016001145A
(es)
|
2013-08-02 |
2016-04-29 |
Hoffmann La Roche |
Proteina de fusion terapeutica.
|
WO2015138337A1
(en)
|
2014-03-09 |
2015-09-17 |
Abbvie, Inc. |
Compositions and methods for treating rheumatoid arthritis
|
WO2015191934A2
(en)
|
2014-06-11 |
2015-12-17 |
Abbvie Inc. |
Blood-brain barrier (bbb) penetrating dual specific binding proteins for treating brain and neurological diseases
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|