AR056806A1 - Moleculas quimericas de anticuerpo rankl- pth/ pthrp - Google Patents
Moleculas quimericas de anticuerpo rankl- pth/ pthrpInfo
- Publication number
- AR056806A1 AR056806A1 ARP060104942A ARP060104942A AR056806A1 AR 056806 A1 AR056806 A1 AR 056806A1 AR P060104942 A ARP060104942 A AR P060104942A AR P060104942 A ARP060104942 A AR P060104942A AR 056806 A1 AR056806 A1 AR 056806A1
- Authority
- AR
- Argentina
- Prior art keywords
- agent
- rankl
- pth
- chemical molecules
- bone
- Prior art date
Links
- 101150071808 PTHLH gene Proteins 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 3
- 108700020797 Parathyroid Hormone-Related Proteins 0.000 abstract 2
- 108090000445 Parathyroid hormone Proteins 0.000 abstract 2
- 102000043299 Parathyroid hormone-related Human genes 0.000 abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 2
- 208000020084 Bone disease Diseases 0.000 abstract 1
- 102000003945 NF-kappa B Human genes 0.000 abstract 1
- 108010057466 NF-kappa B Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000003982 Parathyroid hormone Human genes 0.000 abstract 1
- 102100036893 Parathyroid hormone Human genes 0.000 abstract 1
- 102000014128 RANK Ligand Human genes 0.000 abstract 1
- 108010025832 RANK Ligand Proteins 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000036039 immunity Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000199 parathyroid hormone Substances 0.000 abstract 1
- 229960001319 parathyroid hormone Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Environmental Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Se describen moléculas quiméricas que comprenden el receptor activador de anticuerpos del ligando NF-kB (RANKL) y péptidos de la hormona paratiroides / proteína relacionada con la hormona paratiroides (PTH/PTHrP). También se describen las composiciones y métodos para el tratamiento de enfermedades oseas. Reivindicacion 90: La composicion farmacéutica de la reivindicacion 89, que comprende además por lo menos un agente terapéutico seleccionado entre un agente anti-resortivo oseo, un agente anabolico oseo, un agente anti-inflamatorio, un agente supresor de inmunidad y un agente para terapia de cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73666405P | 2005-11-14 | 2005-11-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR056806A1 true AR056806A1 (es) | 2007-10-24 |
Family
ID=38017054
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060104942A AR056806A1 (es) | 2005-11-14 | 2006-11-10 | Moleculas quimericas de anticuerpo rankl- pth/ pthrp |
Country Status (15)
Country | Link |
---|---|
US (2) | US8992925B2 (es) |
EP (3) | EP2366715A3 (es) |
JP (2) | JP5443761B2 (es) |
AR (1) | AR056806A1 (es) |
AU (1) | AU2006315542C1 (es) |
CA (1) | CA2628628A1 (es) |
DK (1) | DK1948692T3 (es) |
ES (1) | ES2453365T3 (es) |
HK (1) | HK1123562A1 (es) |
PE (1) | PE20070684A1 (es) |
PL (1) | PL1948692T3 (es) |
PT (1) | PT1948692E (es) |
SI (1) | SI1948692T1 (es) |
TW (1) | TW200736277A (es) |
WO (1) | WO2007059136A2 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI256473B (en) * | 2003-08-27 | 2006-06-11 | Ind Tech Res Inst | Biosensor and method for bone mineral density measurement |
NZ581097A (en) | 2007-05-24 | 2012-03-30 | Ablynx Nv | Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders |
KR20110014607A (ko) | 2008-04-29 | 2011-02-11 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
RU2010153578A (ru) | 2008-06-03 | 2012-07-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойными вариабельными доменами и их применение |
US20100004175A1 (en) * | 2008-06-09 | 2010-01-07 | Tanya Shang | Novel bmp-12-related proteins and methods of their manufacture |
SG192489A1 (en) | 2008-07-08 | 2013-08-30 | Abbott Lab | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
PE20131412A1 (es) | 2010-08-03 | 2014-01-19 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
CA2809433A1 (en) | 2010-08-26 | 2012-03-01 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
KR102072250B1 (ko) | 2011-05-27 | 2020-03-02 | 아블린쓰 엔.브이. | Rankl 결합 펩티드를 이용한 골 재흡수 억제 |
CA2854372A1 (en) | 2011-11-07 | 2013-05-16 | Universite Laval | Use of rank/rankl antagonists for treating neuromuscular disorders, genetic myopathies and/or non genetic myopathies and/or for regulating skeletal and cardiac muscle disuse, diseases and aging |
MX2014008101A (es) | 2011-12-30 | 2014-09-25 | Abbvie Inc | Proteinas de union especificas duales dirigidas contra il-13 y/o il-17. |
WO2014033540A2 (en) * | 2012-08-28 | 2014-03-06 | The Governors Of The University Of Alberta | Parathyroid hormone, insulin, and related peptides conjugated to bone targeting moieties and methods of making and using thereof |
WO2014071074A2 (en) | 2012-11-01 | 2014-05-08 | Abbvie Inc. | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof |
JOP20140087B1 (ar) | 2013-03-13 | 2021-08-17 | Amgen Inc | بروتينات مخصصة ل baff و b7rp1 وإستخداماتها |
US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
EP2970459A2 (en) | 2013-03-15 | 2016-01-20 | AbbVie Inc. | Dual specific binding proteins directed against il-1beta and il-17 |
US20150017162A1 (en) * | 2013-03-15 | 2015-01-15 | Omeros Corporation | Methods of Generating Bioactive Peptide-bearing Antibodies and Compositions Comprising the Same |
CN104004093B (zh) * | 2014-06-03 | 2017-01-18 | 大连理工大学 | 一种抗人甲状旁腺激素的纳米抗体及其筛选方法和应用 |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
AU2017214277B2 (en) * | 2016-02-01 | 2020-02-27 | Eli Lilly And Company | Parathyroid hormone – anti-RANKL antibody fusion compounds |
CA3038850A1 (en) | 2016-10-28 | 2018-05-03 | Eli Lilly And Company | Anti-rankl antibodies and uses thereof |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
JOP20190255A1 (ar) | 2017-04-28 | 2019-10-27 | Amgen Inc | صيغ أجسام مضادة لـ rankl بشري، وطرق لاستخدامها |
US11878063B2 (en) * | 2019-03-05 | 2024-01-23 | Children's Medical Center Corporation | Engineered ligands and uses thereof |
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-
2006
- 2006-11-10 PE PE2006001412A patent/PE20070684A1/es not_active Application Discontinuation
- 2006-11-10 AR ARP060104942A patent/AR056806A1/es not_active Application Discontinuation
- 2006-11-10 TW TW095141718A patent/TW200736277A/zh unknown
- 2006-11-13 SI SI200631764T patent/SI1948692T1/sl unknown
- 2006-11-13 AU AU2006315542A patent/AU2006315542C1/en active Active
- 2006-11-13 DK DK06837570.8T patent/DK1948692T3/da active
- 2006-11-13 ES ES06837570.8T patent/ES2453365T3/es active Active
- 2006-11-13 CA CA002628628A patent/CA2628628A1/en not_active Abandoned
- 2006-11-13 EP EP11156478A patent/EP2366715A3/en not_active Withdrawn
- 2006-11-13 EP EP06837570.8A patent/EP1948692B1/en active Active
- 2006-11-13 WO PCT/US2006/044199 patent/WO2007059136A2/en active Application Filing
- 2006-11-13 PT PT68375708T patent/PT1948692E/pt unknown
- 2006-11-13 EP EP14166902.8A patent/EP2816060A1/en not_active Withdrawn
- 2006-11-13 US US11/599,629 patent/US8992925B2/en active Active
- 2006-11-13 PL PL06837570T patent/PL1948692T3/pl unknown
- 2006-11-13 JP JP2008540279A patent/JP5443761B2/ja active Active
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2009
- 2009-01-29 HK HK09100851.9A patent/HK1123562A1/xx unknown
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2012
- 2012-10-16 JP JP2012229099A patent/JP2013055942A/ja active Pending
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2013
- 2013-03-15 US US13/843,987 patent/US20140099670A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
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ES2453365T3 (es) | 2014-04-07 |
EP2366715A3 (en) | 2011-11-02 |
JP5443761B2 (ja) | 2014-03-19 |
US20070134245A1 (en) | 2007-06-14 |
PT1948692E (pt) | 2014-02-11 |
WO2007059136A3 (en) | 2007-08-23 |
US8992925B2 (en) | 2015-03-31 |
PL1948692T3 (pl) | 2014-07-31 |
US20140099670A1 (en) | 2014-04-10 |
WO2007059136A2 (en) | 2007-05-24 |
PE20070684A1 (es) | 2007-08-06 |
SI1948692T1 (sl) | 2014-05-30 |
TW200736277A (en) | 2007-10-01 |
AU2006315542C1 (en) | 2013-06-06 |
AU2006315542A1 (en) | 2007-05-24 |
JP2009515903A (ja) | 2009-04-16 |
DK1948692T3 (da) | 2014-03-31 |
HK1123562A1 (en) | 2009-06-19 |
EP2366715A2 (en) | 2011-09-21 |
AU2006315542B2 (en) | 2012-10-04 |
EP2816060A1 (en) | 2014-12-24 |
CA2628628A1 (en) | 2007-05-24 |
EP1948692B1 (en) | 2014-01-08 |
EP1948692A2 (en) | 2008-07-30 |
JP2013055942A (ja) | 2013-03-28 |
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