DE07012625T1 - Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor - Google Patents
Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor Download PDFInfo
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- DE07012625T1 DE07012625T1 DE07012625T DE07012625T DE07012625T1 DE 07012625 T1 DE07012625 T1 DE 07012625T1 DE 07012625 T DE07012625 T DE 07012625T DE 07012625 T DE07012625 T DE 07012625T DE 07012625 T1 DE07012625 T1 DE 07012625T1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Proteomics, Peptides & Aminoacids (AREA)
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Abstract
Immunglobulinmolekül, wobei das Immunglobulinmolekül ausgewählt ist aus einem Antikörper, einer Immunglobulinkette, oder einem Fragment oder einer Region hiervon, wobei das Immunglobulinmolekül eine konstante menschliche Immunglobulinregion und eine variable Immunglobulinregion mit einer Spezifität für ein neutralisierendes Epitop des menschlichen Tumornekrosefaktors-alpha (TNFalpha) umfasst.
Claims (14)
- Immunglobulinmolekül, wobei das Immunglobulinmolekül ausgewählt ist aus einem Antikörper, einer Immunglobulinkette, oder einem Fragment oder einer Region hiervon, wobei das Immunglobulinmolekül eine konstante menschliche Immunglobulinregion und eine variable Immunglobulinregion mit einer Spezifität für ein neutralisierendes Epitop des menschlichen Tumornekrosefaktors-alpha (TNFalpha) umfasst.
- Immunglobulinmolekül gemäß Anspruch 1, umfassend zwei leichte Ketten und zwei schwere Ketten, wobei jede dieser Ketten mindestens einen Teil einer konstanten Region und mindestens einen Teil einer variablen Region umfasst, wobei die variable Region eine Spezifität für menschliches TNFalpha aufweist, wobei das Immunglobulinmolekül mit hoher Affinität an ein neutralisierendes Epitop des menschlichen TNFalpha in vivo bindet.
- Immunglobulinmolekül gemäß Anspruch 1 oder Anspruch 2, wobei: (a) Binden des Immunglobulinmoleküls an TNFalpha eine pathologische Aktivität von TNFalpha hemmt; (b) das Immunglobulinmolekül eine Antigen-Bindungsregion aufweist, die an die Reste 87–108 oder sowohl 59–80 als auch 87–108 von hTNFalpha der SEQ ID NO: 1 bindet.
- Immunglobulinmolekül gemäß Anspruch 1, wobei die Immunglobulinkette eine schwere Kette oder eine leichte Kette ist.
- Immunglobulinmolekül gemäß Anspruch 2, wobei: (a) die Affinität, gemessen als eine Assoziationskonstante (Ka), mindestens 1 × 108 Liter/Mol beträgt, und/oder (b) das Immunglobulinmolekül menschliches TNFalpha mit einer ID50 von mindestens etwa 1 μg/ml neutralisiert.
- Immunglobulinmolekül gemäß einem der Ansprüche 1 bis 5, wobei das Immunglobulinmolekül (a) kompetitiv die Bindung des Antikörpers A2 an TNF hemmt und (b) an ein neutralisierendes Epitop des menschlichen TNFalpha bindet.
- Immunglobulinmolekül gemäß Anspruch 6, wobei: (a) das Molekül eine Antigen-Binderegion aufweist, die an die Reste 87–108 oder sowohl 59–80 als auch 87–108 von hTNFalpha der SEQ ID No: 1 bindet.
- Ein isoliertes TNF-Polynukleotid, umfassend eine Nukleotidsequenz, die ein Immunglobulinmolekül gemäß einem der Ansprüche 1 bis 7 kodiert, wobei die Nukleotidsequenz mindestens eine variable Region in zweckorientierter Verknüpfung mit mindestens einer konstanten Region kodiert.
- Polynukleotid gemäß Anspruch 8, wobei: (a) die Nukleotidsequenz ausgewählt ist aus einer genomischen DNA-Sequenz oder einer cDNA-Sequenz; und/oder (b) das Polynukleotid ein Expressionsvehikel ist.
- Ein Wirt, der mit dem Polynukleotid gemäß Anspruch 6 oder Anspruch 9 transformiert oder transfiziert ist, wobei der Wirt eine eukaryotische Zelle, eine Säugerzelle oder eine Bakterienzelle ist.
- Ein Verfahren zur Herstellung eines Immunglobulinmoleküls gemäß einem der Ansprüche 1 bis 7, aufweisend die Schritte: (a) Kultivieren eines Wirts gemäß Anspruch 10 derart, dass das Immunglobulinmolekül in gewinnbaren Mengen exprimiert wird; und (b) Gewinnen des Immunglobulinmoleküls aus dem Wirt oder der Kultur.
- Eine pharmazeutische Zusammensetzung, umfassend ein Immunglobulinmolekül gemäß einem der Ansprüche 1 bis 7 und einen pharmazeutisch verträglichen Träger.
- Pharmazeutische Zusammensetzung gemäß Anspruch 12 für die Verwendung in einem Verfahren zur Behandlung eines Individuums mit einer TNFalpha-vermittelten Pathologie; wobei die Pathologie ausgewählt ist aus Sepsissyndrom, Kachexie, Kreislaufkollaps und Schock aufgrund von akuter oder chronischer bakterieller Infektion, einer bakteriellen Infektion, einer viralen Infektion, einer Pilzinfektion, systemischem Lupus Erythematosus, rheumatoider Arthritis, alkoholinduzierter Hepatitis, einer chronisch-entzündlichen Pathologie, einer entzündlichen Gefäßpathologie, einer Transplantat-gegen-Empfänger-Pathologie, Kaisaki-Pathologie und einer malignen Pathologie.
- Pharmazeutische Zusammensetzung gemäß Anspruch 13, wobei die Pathologie ausgewählt ist aus rheumatoider Arthritis, einer chronisch-entzündlichen Pathologie, einer entzündlichen Gefäßpathologie, einer Transplantat-gegen-Empfänger-Pathologie und einer malignen Pathologie.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67082791A | 1991-03-18 | 1991-03-18 | |
US670827 | 1991-03-18 |
Publications (1)
Publication Number | Publication Date |
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DE07012625T1 true DE07012625T1 (de) | 2010-01-21 |
Family
ID=24692048
Family Applications (7)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233701T Expired - Lifetime DE69233701T2 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper spezifisch für menschlichen Tumornekrosefaktor |
DE2001199067 Active DE10199067I2 (de) | 1991-03-18 | 1992-03-18 | Fuer Menschlichen Tumornekrose-Faktor spezifische Monoklonale und Chimaere Antikoerper |
DE07012625T Pending DE07012625T1 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
DE07006112T Pending DE07006112T1 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
DE69231828T Expired - Lifetime DE69231828T3 (de) | 1991-03-18 | 1992-03-18 | Spezifisch gegen menschlichen Tumornekrosefaktor gerichtete monoklonale und chimäre Antikörper |
DE07012626T Pending DE07012626T1 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
DE06001779T Pending DE06001779T1 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233701T Expired - Lifetime DE69233701T2 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper spezifisch für menschlichen Tumornekrosefaktor |
DE2001199067 Active DE10199067I2 (de) | 1991-03-18 | 1992-03-18 | Fuer Menschlichen Tumornekrose-Faktor spezifische Monoklonale und Chimaere Antikoerper |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE07006112T Pending DE07006112T1 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
DE69231828T Expired - Lifetime DE69231828T3 (de) | 1991-03-18 | 1992-03-18 | Spezifisch gegen menschlichen Tumornekrosefaktor gerichtete monoklonale und chimäre Antikörper |
DE07012626T Pending DE07012626T1 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
DE06001779T Pending DE06001779T1 (de) | 1991-03-18 | 1992-03-18 | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
Country Status (13)
Country | Link |
---|---|
EP (6) | EP1681305A3 (de) |
JP (8) | JPH06506120A (de) |
AT (2) | ATE201234T1 (de) |
AU (1) | AU668864B2 (de) |
CA (2) | CA2106299C (de) |
DE (7) | DE69233701T2 (de) |
DK (2) | DK1097945T3 (de) |
ES (2) | ES2156859T5 (de) |
GR (1) | GR3036375T3 (de) |
HK (1) | HK1037923A1 (de) |
LU (1) | LU90854I2 (de) |
NL (1) | NL300069I2 (de) |
WO (1) | WO1992016553A1 (de) |
Families Citing this family (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
US6750325B1 (en) | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
GB9109645D0 (en) * | 1991-05-03 | 1991-06-26 | Celltech Ltd | Recombinant antibodies |
US5994510A (en) * | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
US5919452A (en) * | 1991-03-18 | 1999-07-06 | New York University | Methods of treating TNFα-mediated disease using chimeric anti-TNF antibodies |
US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
WO1992016553A1 (en) | 1991-03-18 | 1992-10-01 | New York University | Monoclonal and chimeric antibodies specific for human tumor necrosis factor |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US5656272A (en) * | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
IT1254315B (it) * | 1992-03-27 | 1995-09-14 | Mini Ricerca Scient Tecnolog | Anticorpi monoclonali anti-idiotipici diretti contro anticorpi anti-tnf. |
EP0585705B1 (de) * | 1992-08-28 | 1998-11-04 | Bayer Corporation | Verwendung von monoklonalen Anti-TNF-Antikörpern für die Behandlung von bakteriellen Meningitiden |
US6270766B1 (en) | 1992-10-08 | 2001-08-07 | The Kennedy Institute Of Rheumatology | Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease |
US6863890B1 (en) | 1993-02-26 | 2005-03-08 | Advanced Biotherapy, Inc. | Treatment of AIDS with antibodies to gamma interferon, alpha interferon and TNF-alpha |
US5888511A (en) * | 1993-02-26 | 1999-03-30 | Advanced Biotherapy Concepts, Inc. | Treatment of autoimmune diseases, including AIDS |
NZ266838A (en) | 1993-06-03 | 1997-02-24 | Therapeutic Antibodies Inc | Treatment of patients with anti-tnfalpha antibody, antibody fragment |
CA2097952C (en) * | 1993-06-08 | 2006-03-14 | Alex D. Romaschin | Early diagnosis of sepsis utilizing antigen-antibody interactions amplified by whole blood chemiluminescence |
NZ278607A (en) * | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
US5804370A (en) * | 1994-06-08 | 1998-09-08 | Critichem Medical Products Limited | Early diagnosis of sepsis utilizing antigen-antibody interactions amplified by whole blood chemiluminescence |
US6203997B1 (en) | 1994-06-08 | 2001-03-20 | Sepsis, Inc. | Quantitation of analytes in whole blood |
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
US20140212413A1 (en) * | 1995-12-11 | 2014-07-31 | New York University | Methods of Treating TNF-alpha-Mediated Diseases Using Chimeric TNF-alpha Antibodies |
NZ512006A (en) | 1996-02-09 | 2005-05-27 | Abbott Biotech Ltd | Medical treatment with human TNF-alpha antibodies |
US7608262B2 (en) * | 1996-02-16 | 2009-10-27 | The Kennedy Institute Of Rheumatology | Methods of preventing or treating thrombosis with tumor necrosis factor antagonists |
WO1998011917A1 (en) * | 1996-09-19 | 1998-03-26 | Centocor, Inc. | Hiv-1 therapy with il-2 and anti-tnf antibody |
DK0936923T3 (da) * | 1996-11-15 | 2004-04-26 | Kennedy Inst Of Rheumatology | Undertrykkelse af TNFalpha og IL-12 ved terapi |
CA2282501A1 (en) * | 1997-02-19 | 1998-08-27 | Centocor, Inc. | Sustained drug delivery and compositions useful therefor |
AU7345798A (en) * | 1997-05-12 | 1998-12-08 | Kennedy Institute Of Rheumatology, The | Suppression of tumor necrosis factor alpha and vascular endothelial growth factor in therapy |
US6159683A (en) * | 1997-12-16 | 2000-12-12 | Spectral Diagnostics, Inc. | Method of determining stage of sepsis |
EP1022027A1 (de) * | 1999-01-22 | 2000-07-26 | Applied Research Systems ARS Holding N.V. | Antagonisten von Tumornecrosefaktor und ihre Verwendungen gegen Endometriose |
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- 1992-03-18 EP EP07012625A patent/EP1905782A1/de not_active Withdrawn
- 1992-03-18 EP EP92910625A patent/EP0610201B2/de not_active Expired - Lifetime
- 1992-03-18 EP EP07012626A patent/EP1857554A1/de not_active Withdrawn
-
2001
- 2001-08-10 GR GR20010401231T patent/GR3036375T3/el unknown
- 2001-11-09 HK HK01107917A patent/HK1037923A1/xx not_active IP Right Cessation
- 2001-11-13 LU LU90854C patent/LU90854I2/fr unknown
- 2001-11-14 NL NL300069C patent/NL300069I2/nl unknown
-
2003
- 2003-12-10 JP JP2003436484A patent/JP2004180686A/ja active Pending
-
2007
- 2007-04-12 JP JP2007105234A patent/JP2007254477A/ja not_active Withdrawn
- 2007-04-12 JP JP2007105224A patent/JP2007197457A/ja not_active Withdrawn
-
2008
- 2008-03-11 JP JP2008061505A patent/JP2008195724A/ja not_active Withdrawn
- 2008-03-11 JP JP2008061497A patent/JP2008156371A/ja not_active Withdrawn
-
2011
- 2011-05-25 JP JP2011117072A patent/JP2011155992A/ja not_active Withdrawn
-
2012
- 2012-01-12 JP JP2012004156A patent/JP2012087144A/ja active Pending
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