AU6132994A - Methods for producing antibody libraries using universal or randomized immunoglobulin light chains - Google Patents

Methods for producing antibody libraries using universal or randomized immunoglobulin light chains

Info

Publication number
AU6132994A
AU6132994A AU61329/94A AU6132994A AU6132994A AU 6132994 A AU6132994 A AU 6132994A AU 61329/94 A AU61329/94 A AU 61329/94A AU 6132994 A AU6132994 A AU 6132994A AU 6132994 A AU6132994 A AU 6132994A
Authority
AU
Australia
Prior art keywords
universal
methods
light chains
immunoglobulin light
antibody libraries
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU61329/94A
Inventor
Carlos F. Barbas Iii
Dennis R Burton
Richard A. Lerner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US1256693A priority Critical
Priority to US012566 priority
Priority to US17467493A priority
Priority to US174674 priority
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Priority to PCT/US1994/001234 priority patent/WO1994018219A1/en
Publication of AU6132994A publication Critical patent/AU6132994A/en
Application status is Abandoned legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/02Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
AU61329/94A 1993-02-02 1994-02-02 Methods for producing antibody libraries using universal or randomized immunoglobulin light chains Abandoned AU6132994A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US1256693A true 1993-02-02 1993-02-02
US012566 1993-02-02
US17467493A true 1993-12-28 1993-12-28
US174674 1993-12-28
PCT/US1994/001234 WO1994018219A1 (en) 1993-02-02 1994-02-02 Methods for producing antibody libraries using universal or randomized immunoglobulin light chains

Publications (1)

Publication Number Publication Date
AU6132994A true AU6132994A (en) 1994-08-29

Family

ID=26683719

Family Applications (1)

Application Number Title Priority Date Filing Date
AU61329/94A Abandoned AU6132994A (en) 1993-02-02 1994-02-02 Methods for producing antibody libraries using universal or randomized immunoglobulin light chains

Country Status (2)

Country Link
AU (1) AU6132994A (en)
WO (1) WO1994018219A1 (en)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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US7067284B1 (en) 1992-01-27 2006-06-27 The Scripps Research Institute Methods for producing antibody libraries using universal or randomized immunoglobulin light chains
US6010861A (en) * 1994-08-03 2000-01-04 Dgi Biotechnologies, Llc Target specific screens and their use for discovering small organic molecular pharmacophores
AU747323B2 (en) * 1994-08-03 2002-05-16 Dgi Biotechnologies Inc. Target specific screens and their use for discovering small organic molecular pharmacophores
US5702892A (en) * 1995-05-09 1997-12-30 The United States Of America As Represented By The Department Of Health And Human Services Phage-display of immunoglobulin heavy chain libraries
DE69610310T2 (en) * 1995-06-02 2001-03-15 M & E Biotech As Horsholm A method for identification of biologically active peptides and nucleic acids
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US20100184021A1 (en) 2006-01-16 2010-07-22 Compugen Ltd. Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
WO2008127271A2 (en) 2006-09-08 2008-10-23 Abbott Laboratories Interleukin -13 binding proteins
US8663980B2 (en) 2007-10-26 2014-03-04 Janssen Biotech, Inc. Vectors, host cells, and methods of production and uses
CN102076355B (en) 2008-04-29 2014-05-07 Abbvie公司 Dual varistructure domain immunoglobulins and uses thereof
WO2009136382A2 (en) 2008-05-09 2009-11-12 Abbott Gmbh & Co. Kg Antibodies to receptor of advanced glycation end products (rage) and uses thereof
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SG191625A1 (en) 2008-06-03 2013-07-31 Abbott Lab Dual variable domain immunoglobulins and uses thereof
CA2729949A1 (en) 2008-07-08 2010-01-14 Abbott Laboratories Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
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BR112012004710A2 (en) 2009-09-01 2016-08-16 Abbott Lab double variable domain immunoglobulins and their use
TW201119676A (en) 2009-10-15 2011-06-16 Abbott Lab Dual variable domain immunoglobulins and uses thereof
UY32979A (en) 2009-10-28 2011-02-28 Abbott Lab Immunoglobulins Dual variable domain and uses thereof
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ES2635594T3 (en) 2010-05-14 2017-10-04 Abbvie Inc. IL-1 binding proteins
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ES2665954T3 (en) 2010-08-19 2018-04-30 Zoetis Belgium S.A. Anti-NGF antibodies and their use
CN103260639A (en) 2010-08-26 2013-08-21 Abbvie 公司 Dual variable domain immunoglobulins and uses thereof
TW201307388A (en) 2010-12-21 2013-02-16 Abbott Lab IL-1 binding proteins
AR088513A1 (en) 2011-10-24 2014-06-18 Abbvie Inc Inmunoenlazantes directed against sclerostin
TW201333035A (en) 2011-12-30 2013-08-16 Abbvie Inc Dual specific binding proteins directed against IL-13 and/or IL-17
CA2875783C (en) 2012-06-06 2018-12-11 Zoetis Llc Caninized anti-ngf antibodies and methods thereof
US9670276B2 (en) 2012-07-12 2017-06-06 Abbvie Inc. IL-1 binding proteins
NZ726258A (en) 2012-08-31 2019-07-26 Immunogen Inc Antibodies and uses thereof to detect folate receptor 1
UY35110A (en) 2012-11-01 2014-05-30 Abbvie Inc Dual variable domain immunoglobulins anti-vegf / Dll4 and uses thereof
US9550986B2 (en) 2012-12-21 2017-01-24 Abbvie Inc. High-throughput antibody humanization
CA2906417A1 (en) 2013-03-14 2014-09-18 Robert Ziemann Hcv core lipid binding domain monoclonal antibodies
WO2014143342A1 (en) 2013-03-14 2014-09-18 Abbott Laboratories Hcv ns3 recombinant antigens and mutants thereof for improved antibody detection
US9194873B2 (en) 2013-03-14 2015-11-24 Abbott Laboratories HCV antigen-antibody combination assay and methods and compositions for use therein
MX2015013166A (en) 2013-03-15 2015-12-11 Abbvie Inc Dual specific binding proteins directed against il-1 beta and il-17.
GB201406767D0 (en) 2014-04-15 2014-05-28 Cancer Rec Tech Ltd Humanized anti-Tn-MUC1 antibodies anf their conjugates
WO2016094881A2 (en) 2014-12-11 2016-06-16 Abbvie Inc. Lrp-8 binding proteins
WO2016102588A1 (en) * 2014-12-22 2016-06-30 Genmab A/S Method for the production of antibodies
TW201710286A (en) 2015-06-15 2017-03-16 艾伯維有限公司 Binding proteins against VEGF, PDGF, and/or their receptors
WO2019025299A1 (en) 2017-07-31 2019-02-07 F. Hoffmann-La Roche Ag Three-dimensional structure-based humanization method

Also Published As

Publication number Publication date
WO1994018219A1 (en) 1994-08-18

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