BR112023020077A2 - Compostos de oxoisoindolina substituída por piridinila - Google Patents
Compostos de oxoisoindolina substituída por piridinilaInfo
- Publication number
- BR112023020077A2 BR112023020077A2 BR112023020077A BR112023020077A BR112023020077A2 BR 112023020077 A2 BR112023020077 A2 BR 112023020077A2 BR 112023020077 A BR112023020077 A BR 112023020077A BR 112023020077 A BR112023020077 A BR 112023020077A BR 112023020077 A2 BR112023020077 A2 BR 112023020077A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- oxoisoindoline
- pyridinyl
- compounds replaced
- replaced
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- FIULGFJIHJJXMT-UHFFFAOYSA-N [C]1[N]C=CC=C1 Chemical class [C]1[N]C=CC=C1 FIULGFJIHJJXMT-UHFFFAOYSA-N 0.000 title 1
- 101000599037 Homo sapiens Zinc finger protein Helios Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000036142 Viral infection Diseases 0.000 abstract 1
- 102100037796 Zinc finger protein Helios Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000009385 viral infection Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
compostos de oxoisoindolina substituída por piridinila. são descritos compostos de fórmula (i) ou um sal dos mesmos, em que r1, r2, r4, r6, m e n são definidos aqui. são também descritos métodos de uso de tais compostos para inibir a proteína helios e composições farmacêuticas compreendendo tais compostos. estes compostos são úteis no tratamento de infecções virais e distúrbios proliferativos, tais como câncer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN202111016193 | 2021-04-06 | ||
IN202111022098 | 2021-05-17 | ||
PCT/US2022/023387 WO2022216644A1 (en) | 2021-04-06 | 2022-04-05 | Pyridinyl substituted oxoisoindoline compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023020077A2 true BR112023020077A2 (pt) | 2023-11-14 |
Family
ID=81385129
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023020077A BR112023020077A2 (pt) | 2021-04-06 | 2022-04-05 | Compostos de oxoisoindolina substituída por piridinila |
Country Status (14)
Country | Link |
---|---|
US (2) | US11718601B2 (pt) |
EP (1) | EP4320112A1 (pt) |
JP (1) | JP2024515243A (pt) |
KR (1) | KR20230165815A (pt) |
AR (1) | AR125298A1 (pt) |
AU (1) | AU2022253242A1 (pt) |
BR (1) | BR112023020077A2 (pt) |
CA (1) | CA3214244A1 (pt) |
CL (1) | CL2023002966A1 (pt) |
CO (1) | CO2023013321A2 (pt) |
IL (1) | IL307343A (pt) |
PE (1) | PE20231941A1 (pt) |
TW (1) | TW202304881A (pt) |
WO (1) | WO2022216644A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW202346277A (zh) | 2022-03-17 | 2023-12-01 | 美商基利科學股份有限公司 | Ikaros鋅指家族降解劑及其用途 |
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-
2022
- 2022-04-05 BR BR112023020077A patent/BR112023020077A2/pt unknown
- 2022-04-05 PE PE2023002812A patent/PE20231941A1/es unknown
- 2022-04-05 IL IL307343A patent/IL307343A/en unknown
- 2022-04-05 JP JP2023561684A patent/JP2024515243A/ja active Pending
- 2022-04-05 EP EP22718513.9A patent/EP4320112A1/en active Pending
- 2022-04-05 US US17/713,598 patent/US11718601B2/en active Active
- 2022-04-05 WO PCT/US2022/023387 patent/WO2022216644A1/en active Application Filing
- 2022-04-05 AR ARP220100840A patent/AR125298A1/es unknown
- 2022-04-05 AU AU2022253242A patent/AU2022253242A1/en active Pending
- 2022-04-05 TW TW111112957A patent/TW202304881A/zh unknown
- 2022-04-05 CA CA3214244A patent/CA3214244A1/en active Pending
- 2022-04-05 KR KR1020237037708A patent/KR20230165815A/ko unknown
-
2023
- 2023-06-08 US US18/331,348 patent/US20230303527A1/en active Pending
- 2023-10-04 CL CL2023002966A patent/CL2023002966A1/es unknown
- 2023-10-05 CO CONC2023/0013321A patent/CO2023013321A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
CO2023013321A2 (es) | 2023-10-19 |
JP2024515243A (ja) | 2024-04-08 |
IL307343A (en) | 2023-11-01 |
US20220324840A1 (en) | 2022-10-13 |
AR125298A1 (es) | 2023-07-05 |
CL2023002966A1 (es) | 2024-02-23 |
TW202304881A (zh) | 2023-02-01 |
CA3214244A1 (en) | 2022-10-13 |
US11718601B2 (en) | 2023-08-08 |
WO2022216644A1 (en) | 2022-10-13 |
AU2022253242A1 (en) | 2023-11-23 |
US20230303527A1 (en) | 2023-09-28 |
PE20231941A1 (es) | 2023-12-05 |
KR20230165815A (ko) | 2023-12-05 |
EP4320112A1 (en) | 2024-02-14 |
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