BR112022005627A2 - Composto de fórmula estrutural i ou um sal do mesmo, composição farmacêutica e uso de um composto - Google Patents
Composto de fórmula estrutural i ou um sal do mesmo, composição farmacêutica e uso de um compostoInfo
- Publication number
- BR112022005627A2 BR112022005627A2 BR112022005627A BR112022005627A BR112022005627A2 BR 112022005627 A2 BR112022005627 A2 BR 112022005627A2 BR 112022005627 A BR112022005627 A BR 112022005627A BR 112022005627 A BR112022005627 A BR 112022005627A BR 112022005627 A2 BR112022005627 A2 BR 112022005627A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- salt
- pharmaceutical composition
- structural formula
- ripk1
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
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- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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- A61K31/4192—1,2,3-Triazoles
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- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4965—Non-condensed pyrazines
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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Abstract
Trata-se de compostos que inibem RIPK1, composições farmacêuticas e métodos de tratamento de doenças mediadas por RIPK1, tais como distúrbios neurodegenerativos, distúrbios inflamatórios e câncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201962907146P | 2019-09-27 | 2019-09-27 | |
PCT/US2020/052789 WO2021062199A1 (en) | 2019-09-27 | 2020-09-25 | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
Publications (1)
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BR112022005627A2 true BR112022005627A2 (pt) | 2022-07-12 |
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EP (1) | EP4034530A4 (pt) |
JP (1) | JP2022550099A (pt) |
KR (1) | KR20220072857A (pt) |
CN (1) | CN115605463A (pt) |
AU (1) | AU2020353663A1 (pt) |
BR (1) | BR112022005627A2 (pt) |
CA (1) | CA3155259A1 (pt) |
IL (1) | IL291665A (pt) |
MX (1) | MX2022003671A (pt) |
WO (1) | WO2021062199A1 (pt) |
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WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
EP4034530A4 (en) | 2019-09-27 | 2023-09-06 | Board of Regents, The University of Texas System | PROTEIN KINASE I INHIBITORS INTERACTING WITH RECEPTORS FOR THE TREATMENT OF DISEASE |
CA3162605A1 (en) | 2019-11-26 | 2021-06-03 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
MX2023009677A (es) * | 2021-02-19 | 2023-08-25 | Kalvista Pharmaceuticals Ltd | Inhibidores de enzimas. |
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BRPI0923126A2 (pt) | 2008-12-23 | 2021-09-08 | President And Fellows Of Harvard College | Compostos inibidores de molécula pequena de necroptose, uso e composição compreendendo os mesmos e método de diminuir necroptose |
WO2010122088A1 (en) | 2009-04-24 | 2010-10-28 | Glaxo Group Limited | Pyrazole and triazole carboxamides as crac channel inhibitors |
BR112012023021A2 (pt) | 2010-03-16 | 2016-05-31 | Dana Farber Cancer Inst Inc | compostos de indazol e seus usos |
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EP2739143B1 (en) | 2011-08-05 | 2018-07-11 | Gary A. Flynn | Preparation and methods of use for ortho-aryl 5- membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors |
CN102643268B (zh) | 2011-12-30 | 2014-05-21 | 沈阳药科大学 | 喹啉类及噌啉类化合物及其应用 |
DK2810937T3 (en) | 2012-01-31 | 2017-03-13 | Daiichi Sankyo Co Ltd | PYRIDONE DERIVATIVES |
TWI637951B (zh) | 2013-02-15 | 2018-10-11 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 |
BR112015019836A2 (pt) | 2013-02-22 | 2017-07-18 | Merck Sharp & Dohme | composto, composição farmacêutica, e, uso de um composto |
KR102286860B1 (ko) | 2013-09-12 | 2021-08-05 | 얀센 바이오파마, 인코퍼레이트. | 피리다지논 화합물 및 이의 용도 |
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EP3224245B1 (en) | 2014-12-24 | 2018-09-12 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
EP3271365B1 (en) * | 2015-03-20 | 2019-12-18 | Pfizer Inc | Bifunctional cytotoxic agents containing the cti pharmacophore |
TWI730959B (zh) | 2015-05-19 | 2021-06-21 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺 |
AU2016287581B2 (en) | 2015-07-02 | 2019-06-06 | F. Hoffmann-La Roche Ag | Bicyclic lactams and methods of use thereof |
AU2016340527B2 (en) | 2015-10-23 | 2020-09-17 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN108602809B (zh) * | 2015-12-04 | 2022-09-30 | 戴纳立制药公司 | 异噁唑烷衍生的受体相互作用蛋白激酶1(ripk 1)的抑制剂 |
CR20180413A (es) | 2016-02-05 | 2018-12-04 | Denali Therapeutics Inc | Inhibidores de la proteína quinasa 1 que interactua con el receptor |
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EP3494994A1 (en) | 2017-12-07 | 2019-06-12 | Universität zu Köln | Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases |
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EA202092581A1 (ru) | 2018-05-03 | 2021-04-08 | Ригел Фармасьютикалз, Инк. | Соединения, ингибирующие rip1, а также способы их получения и применения |
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WO2021046515A1 (en) | 2019-09-06 | 2021-03-11 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
EP4034530A4 (en) | 2019-09-27 | 2023-09-06 | Board of Regents, The University of Texas System | PROTEIN KINASE I INHIBITORS INTERACTING WITH RECEPTORS FOR THE TREATMENT OF DISEASE |
US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
CA3162605A1 (en) | 2019-11-26 | 2021-06-03 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
MX2022010693A (es) | 2020-02-28 | 2022-09-26 | Univ Texas | Compuestos, composiciones y metodos para inhibidores de la proteina quinasa que interactua con el receptor i para el tratamiento de enfermedades. |
-
2020
- 2020-09-25 EP EP20867775.7A patent/EP4034530A4/en active Pending
- 2020-09-25 BR BR112022005627A patent/BR112022005627A2/pt unknown
- 2020-09-25 AU AU2020353663A patent/AU2020353663A1/en active Pending
- 2020-09-25 WO PCT/US2020/052789 patent/WO2021062199A1/en active Application Filing
- 2020-09-25 KR KR1020227013817A patent/KR20220072857A/ko unknown
- 2020-09-25 CN CN202080067791.3A patent/CN115605463A/zh active Pending
- 2020-09-25 MX MX2022003671A patent/MX2022003671A/es unknown
- 2020-09-25 CA CA3155259A patent/CA3155259A1/en active Pending
- 2020-09-25 US US17/033,104 patent/US11753381B2/en active Active
- 2020-09-25 JP JP2022519289A patent/JP2022550099A/ja active Pending
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2022
- 2022-03-24 IL IL291665A patent/IL291665A/en unknown
Also Published As
Publication number | Publication date |
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CN115605463A (zh) | 2023-01-13 |
US11753381B2 (en) | 2023-09-12 |
JP2022550099A (ja) | 2022-11-30 |
EP4034530A4 (en) | 2023-09-06 |
WO2021062199A1 (en) | 2021-04-01 |
CA3155259A1 (en) | 2021-04-01 |
IL291665A (en) | 2022-05-01 |
KR20220072857A (ko) | 2022-06-02 |
AU2020353663A1 (en) | 2022-04-07 |
EP4034530A1 (en) | 2022-08-03 |
MX2022003671A (es) | 2022-04-25 |
US20210094921A1 (en) | 2021-04-01 |
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