MX2022003671A - Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades. - Google Patents
Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades.Info
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- MX2022003671A MX2022003671A MX2022003671A MX2022003671A MX2022003671A MX 2022003671 A MX2022003671 A MX 2022003671A MX 2022003671 A MX2022003671 A MX 2022003671A MX 2022003671 A MX2022003671 A MX 2022003671A MX 2022003671 A MX2022003671 A MX 2022003671A
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- Prior art keywords
- treatment
- inhibitors
- disease
- protein kinase
- interacting protein
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- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
En este documento se dan a conocer compuestos que inhiben a RIPK1, composiciones farmacéuticas y métodos de tratamiento de enfermedades mediadas por RIPK1, tales como trastornos neurodegenerativos, trastornos inflamatorios y cáncer.
Applications Claiming Priority (2)
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US201962907146P | 2019-09-27 | 2019-09-27 | |
PCT/US2020/052789 WO2021062199A1 (en) | 2019-09-27 | 2020-09-25 | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
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MX2022003671A true MX2022003671A (es) | 2022-04-25 |
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MX2022003671A MX2022003671A (es) | 2019-09-27 | 2020-09-25 | Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades. |
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US (1) | US11753381B2 (es) |
EP (1) | EP4034530A4 (es) |
JP (1) | JP2022550099A (es) |
KR (1) | KR20220072857A (es) |
CN (1) | CN115605463A (es) |
AU (1) | AU2020353663A1 (es) |
BR (1) | BR112022005627A2 (es) |
CA (1) | CA3155259A1 (es) |
IL (1) | IL291665A (es) |
MX (1) | MX2022003671A (es) |
WO (1) | WO2021062199A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11718612B2 (en) | 2019-09-06 | 2023-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase I for the treatment of disease |
MX2022003671A (es) | 2019-09-27 | 2022-04-25 | Univ Texas | Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades. |
JP2023502514A (ja) | 2019-11-26 | 2023-01-24 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | 疾患の処置のための受容体相互作用プロテインキナーゼiの阻害剤 |
BR112023016539A2 (pt) * | 2021-02-19 | 2023-11-14 | Kalvista Pharmaceuticals Ltd | Inibidores do fator xiia |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291476B1 (en) | 1999-05-12 | 2001-09-18 | Ortho-Mcneil Pharmaceutical, Inc. | Pyrazole carboxamides useful for the treatment of obesity and other disorders |
US20120122889A1 (en) | 2008-12-23 | 2012-05-17 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
JP2012524754A (ja) | 2009-04-24 | 2012-10-18 | グラクソ グループ リミテッド | Cracチャネル阻害剤としてのピラゾールおよびトリアゾ−ルカルボキサミド |
EP2547661A2 (en) | 2010-03-16 | 2013-01-23 | Dana-Farber Cancer Institute, Inc. | Indazole compounds and their uses |
US9643977B2 (en) | 2011-03-11 | 2017-05-09 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
EP2739143B1 (en) | 2011-08-05 | 2018-07-11 | Gary A. Flynn | Preparation and methods of use for ortho-aryl 5- membered heteroaryl-carboxamide containing multi-targeted kinase inhibitors |
CN102643268B (zh) | 2011-12-30 | 2014-05-21 | 沈阳药科大学 | 喹啉类及噌啉类化合物及其应用 |
PT2810937T (pt) | 2012-01-31 | 2017-03-03 | Daiichi Sankyo Co Ltd | Derivado de piridona |
TWI637951B (zh) | 2013-02-15 | 2018-10-11 | 英商葛蘭素史克智慧財產發展有限公司 | 作為激酶抑制劑之雜環醯胺類 |
RU2015140066A (ru) | 2013-02-22 | 2017-03-30 | Мерк Шарп И Доум Корп. | Противодиабетические бициклические соединения |
WO2015038660A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Pyridazinone compounds and uses thereof |
CN106573006A (zh) | 2014-08-21 | 2017-04-19 | 葛兰素史密斯克莱知识产权发展有限公司 | 作为药物的rip1激酶抑制剂杂环酰胺 |
US10308609B2 (en) * | 2014-09-17 | 2019-06-04 | Zeno Royalties & Milestones, LLC | Bicyclic compounds |
CA2972294C (en) | 2014-12-24 | 2018-09-25 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
EP3271365B1 (en) * | 2015-03-20 | 2019-12-18 | Pfizer Inc | Bifunctional cytotoxic agents containing the cti pharmacophore |
UY36680A (es) | 2015-05-19 | 2016-12-30 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas como inhibidores de quinasa |
TWI763630B (zh) | 2015-07-02 | 2022-05-11 | 瑞士商赫孚孟拉羅股份公司 | 雙環內醯胺及其使用方法 |
US10787462B2 (en) | 2015-10-23 | 2020-09-29 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US10709692B2 (en) | 2015-12-04 | 2020-07-14 | Denali Therapeutics Inc. | Isoxazolidine derived inhibitors of receptor interacting protein kinase 1 (RIPK1) |
MY196648A (en) | 2016-02-05 | 2023-04-27 | Denali Therapeutics Inc | Inhibitors of Receptor-Interacting Protein Kinase 1 |
EP3429986B1 (en) * | 2016-03-14 | 2022-01-05 | Spirochem AG | Method of preparing substituted bicyclo[1.1.1]pentanes |
CN105785659B (zh) * | 2016-05-20 | 2018-07-10 | 深圳市华星光电技术有限公司 | 含功能化石墨烯层的液晶面板结构及功能化石墨烯膜的制备方法 |
EP3526219B1 (en) | 2016-10-17 | 2021-12-15 | F. Hoffmann-La Roche AG | Bicyclic pyridone lactams and methods of use thereof |
JP6890179B2 (ja) | 2016-12-02 | 2021-06-18 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 二環式アミド化合物及びその使用方法 |
PT3552017T (pt) | 2016-12-09 | 2022-05-04 | Denali Therapeutics Inc | Compostos úteis como inibidores de ripk1 |
US11072607B2 (en) | 2016-12-16 | 2021-07-27 | Genentech, Inc. | Inhibitors of RIP1 kinase and methods of use thereof |
US20200062735A1 (en) | 2017-02-27 | 2020-02-27 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
CN109180681B (zh) * | 2017-08-18 | 2021-08-20 | 四川百利药业有限责任公司 | 一种dna毒性二聚体化合物 |
CA3074073A1 (en) | 2017-09-11 | 2019-03-14 | Recurium Ip Holdings, Llc | Continuous flow processes for making bicyclic compounds |
EP3494994A1 (en) | 2017-12-07 | 2019-06-12 | Universität zu Köln | Combinations of ripk1- and ikk-inhibitors for the prevention or treatment of immune diseases |
EP3781571B1 (en) | 2018-04-20 | 2024-01-17 | F. Hoffmann-La Roche AG | N-[4-oxo-2,3-dihydro-pyrido[3,2-b][1,4]oxazepin-3-yl]-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole-2-carboxamide derivatives and related compounds as rip1 kinase inhibitors for treating e.g. irritable bowel syndrome (ibs) |
AU2019262142A1 (en) | 2018-05-03 | 2020-11-26 | Rigel Pharmaceuticals, Inc. | RIP1 inhibitory compounds and methods for making and using the same |
MD3788044T2 (ro) | 2018-05-03 | 2023-12-31 | Rigel Pharmaceuticals Inc | Compuși inhibitori ai RIP1 și procedee de obţinere și utilizare a acestora |
WO2019224773A1 (en) * | 2018-05-23 | 2019-11-28 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as rip1 kinase inhibitors |
US11718612B2 (en) | 2019-09-06 | 2023-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase I for the treatment of disease |
MX2022003671A (es) | 2019-09-27 | 2022-04-25 | Univ Texas | Inhibidores de proteina cinasa i de interaccion con receptores para el tratamiento de enfermedades. |
US11560366B2 (en) * | 2019-10-21 | 2023-01-24 | Board Of Regents, The University Of Texas System | Bicyclo[1.1.1]pentane inhibitors of dual leucine zipper (DLK) kinase for the treatment of disease |
JP2023502514A (ja) | 2019-11-26 | 2023-01-24 | ボード オブ レジェンツ,ザ ユニバーシティ オブ テキサス システム | 疾患の処置のための受容体相互作用プロテインキナーゼiの阻害剤 |
EP4110765A4 (en) | 2020-02-28 | 2024-03-06 | Univ Texas | INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE I FOR THE TREATMENT OF DISEASES |
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2020
- 2020-09-25 MX MX2022003671A patent/MX2022003671A/es unknown
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WO2021062199A1 (en) | 2021-04-01 |
CA3155259A1 (en) | 2021-04-01 |
EP4034530A1 (en) | 2022-08-03 |
IL291665A (en) | 2022-05-01 |
EP4034530A4 (en) | 2023-09-06 |
JP2022550099A (ja) | 2022-11-30 |
KR20220072857A (ko) | 2022-06-02 |
US20210094921A1 (en) | 2021-04-01 |
BR112022005627A2 (pt) | 2022-07-12 |
AU2020353663A1 (en) | 2022-04-07 |
US11753381B2 (en) | 2023-09-12 |
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