BR112023016539A2 - Inibidores do fator xiia - Google Patents
Inibidores do fator xiiaInfo
- Publication number
- BR112023016539A2 BR112023016539A2 BR112023016539A BR112023016539A BR112023016539A2 BR 112023016539 A2 BR112023016539 A2 BR 112023016539A2 BR 112023016539 A BR112023016539 A BR 112023016539A BR 112023016539 A BR112023016539 A BR 112023016539A BR 112023016539 A2 BR112023016539 A2 BR 112023016539A2
- Authority
- BR
- Brazil
- Prior art keywords
- factor xiia
- compounds
- xiia inhibitors
- inhibitors
- factor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Abstract
a presente invenção refere-se a compostos da fórmula (i): composições que compreendem tais compostos; o uso de tais compostos na medicina; e métodos de tratamento de pacientes com tais compostos; em que a, w, v, z, u, x, y e b são conforme definidos neste documento.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163151178P | 2021-02-19 | 2021-02-19 | |
GBGB2102384.1A GB202102384D0 (en) | 2021-02-19 | 2021-02-19 | Enzyme inhibitors |
US202163169607P | 2021-04-01 | 2021-04-01 | |
GBGB2104788.1A GB202104788D0 (en) | 2021-04-01 | 2021-04-01 | Enzyme inhibitors |
US202163182283P | 2021-04-30 | 2021-04-30 | |
GBGB2106284.9A GB202106284D0 (en) | 2021-04-30 | 2021-04-30 | Enzyme inhibitors |
PCT/GB2022/050447 WO2022175675A1 (en) | 2021-02-19 | 2022-02-18 | Factor xiia inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023016539A2 true BR112023016539A2 (pt) | 2023-11-14 |
Family
ID=80595374
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023016539A BR112023016539A2 (pt) | 2021-02-19 | 2022-02-18 | Inibidores do fator xiia |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP4294798A1 (pt) |
JP (1) | JP2024507222A (pt) |
KR (1) | KR20230157981A (pt) |
AU (1) | AU2022222458A1 (pt) |
BR (1) | BR112023016539A2 (pt) |
CA (1) | CA3211159A1 (pt) |
CL (1) | CL2023002446A1 (pt) |
CO (1) | CO2023012342A2 (pt) |
IL (1) | IL305307A (pt) |
MX (1) | MX2023009677A (pt) |
TW (1) | TW202302565A (pt) |
WO (1) | WO2022175675A1 (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024038282A1 (en) * | 2022-08-18 | 2024-02-22 | Kalvista Pharmaceuticals Limited | 2-aza- and 2-oxabicyclo[2.1.1]hexane derivatives as factor xiia enzyme inhibitors |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6109081B2 (ja) | 2011-03-09 | 2017-04-05 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 人工表面との接触を含む医学的手技に伴う投与のためのfxii阻害剤 |
TW201348231A (zh) * | 2012-02-29 | 2013-12-01 | Amgen Inc | 雜雙環化合物 |
RS62649B1 (sr) * | 2013-03-12 | 2021-12-31 | Vertex Pharma | Inhibitori dnk-pk |
WO2015199206A1 (ja) * | 2014-06-27 | 2015-12-30 | 塩野義製薬株式会社 | Trpv4阻害活性を有する6員環誘導体 |
MA41253A (fr) * | 2014-12-23 | 2017-10-31 | Proteostasis Therapeutics Inc | Composés, compositions et procédés pour augmenter l'activité du cftr |
WO2017123518A1 (en) | 2016-01-11 | 2017-07-20 | The Rockefeller University | Aminotriazole immunomodulators for treating autoimmune diseases |
AR108326A1 (es) * | 2016-04-27 | 2018-08-08 | Samumed Llc | Isoquinolin-3-il carboxamidas y preparación y uso de las mismas |
CN109475530B (zh) | 2016-05-23 | 2022-03-01 | 洛克菲勒大学 | 用于治疗自身免疫性疾病的氨酰基吲唑免疫调节剂 |
EP3541375B1 (en) | 2016-11-18 | 2023-08-23 | Merck Sharp & Dohme LLC | Factor xiia inhibitors |
US11014920B2 (en) | 2016-11-18 | 2021-05-25 | Merck Sharp & Dohme Corp. | Factor XIIa inhibitors |
IL270648B2 (en) * | 2017-05-17 | 2024-03-01 | Denali Therapeutics Inc | Kinase inhibitors and their uses |
AU2018375308A1 (en) | 2017-11-29 | 2020-06-25 | The Rockefeller University | Pyranopyrazole and pyrazolopyridine immunomodulators for treatment of autoimmune diseases |
CN111601807B (zh) * | 2017-12-20 | 2023-03-31 | 詹森药业有限公司 | Menin-mll相互作用的外型-氮杂螺抑制剂 |
GB201805174D0 (en) | 2018-03-29 | 2018-05-16 | Univ Leeds Innovations Ltd | Compounds |
GB201807014D0 (en) | 2018-04-30 | 2018-06-13 | Univ Leeds Innovations Ltd | Factor xlla inhibitors |
WO2019241131A1 (en) * | 2018-06-11 | 2019-12-19 | Pipeline Therapeutics, Inc. | Muscarinic acetylcholine m1 receptor antagonists |
BR112021005914A2 (pt) * | 2018-10-01 | 2021-06-29 | Genzyme Corporation | derivados de tieno[3,2-b]piridina como inibidores de udp glicosiltransferase e métodos de uso |
US20220185816A1 (en) * | 2019-03-14 | 2022-06-16 | Shanghai Synergy Pharmaceutical Sciences Co., Ltd | Jak kinase inhibitor, preparation method for same, and applications thereof in field of medicine |
CN112174951A (zh) * | 2019-07-02 | 2021-01-05 | 深圳美莹基因科技有限公司 | 作为詹纳斯激酶1选择抑制剂的吡咯并[2,3-b]吡啶衍生物 |
WO2021022178A1 (en) * | 2019-07-31 | 2021-02-04 | Aclaris Therapeutics, Inc. | Substituted sulfonamide pyrrolopyridines as jak inhibitors |
TW202122382A (zh) * | 2019-09-06 | 2021-06-16 | 日商小野藥品工業股份有限公司 | 乙內醯脲衍生物 |
AU2020353663A1 (en) * | 2019-09-27 | 2022-04-07 | Board Of Regents, The University Of Texas System | Inhibitors of Receptor Interacting Protein Kinase I for the treatment of disease |
CA3191607A1 (en) * | 2020-09-08 | 2022-03-17 | Gilles Ouvry | Novel jak inhibitor compounds, method for synthesizing same and use thereof |
-
2022
- 2022-02-18 TW TW111106094A patent/TW202302565A/zh unknown
- 2022-02-18 AU AU2022222458A patent/AU2022222458A1/en active Pending
- 2022-02-18 CA CA3211159A patent/CA3211159A1/en active Pending
- 2022-02-18 JP JP2023550048A patent/JP2024507222A/ja active Pending
- 2022-02-18 MX MX2023009677A patent/MX2023009677A/es unknown
- 2022-02-18 KR KR1020237032029A patent/KR20230157981A/ko unknown
- 2022-02-18 WO PCT/GB2022/050447 patent/WO2022175675A1/en active Application Filing
- 2022-02-18 EP EP22706887.1A patent/EP4294798A1/en active Pending
- 2022-02-18 BR BR112023016539A patent/BR112023016539A2/pt unknown
- 2022-02-18 IL IL305307A patent/IL305307A/en unknown
-
2023
- 2023-08-17 CL CL2023002446A patent/CL2023002446A1/es unknown
- 2023-09-18 CO CONC2023/0012342A patent/CO2023012342A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL305307A (en) | 2023-10-01 |
TW202302565A (zh) | 2023-01-16 |
CO2023012342A2 (es) | 2023-09-29 |
KR20230157981A (ko) | 2023-11-17 |
CL2023002446A1 (es) | 2024-01-12 |
JP2024507222A (ja) | 2024-02-16 |
CA3211159A1 (en) | 2022-08-25 |
MX2023009677A (es) | 2023-08-25 |
EP4294798A1 (en) | 2023-12-27 |
WO2022175675A1 (en) | 2022-08-25 |
AU2022222458A1 (en) | 2023-08-24 |
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