BR112022004777A2 - Composição de micela de estimulação imunológica - Google Patents

Composição de micela de estimulação imunológica

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Publication number
BR112022004777A2
BR112022004777A2 BR112022004777A BR112022004777A BR112022004777A2 BR 112022004777 A2 BR112022004777 A2 BR 112022004777A2 BR 112022004777 A BR112022004777 A BR 112022004777A BR 112022004777 A BR112022004777 A BR 112022004777A BR 112022004777 A2 BR112022004777 A2 BR 112022004777A2
Authority
BR
Brazil
Prior art keywords
stimulating
immune
micelle
composition
relates
Prior art date
Application number
BR112022004777A
Other languages
English (en)
Inventor
elias hansen Anders
Camilla Stavnsbjerg
Esben Christensen
Rosager Henriksen Jonas
Ladan Parhamifar
Münter Dithmar Rasmus
Skjøde Jensen Simon
Lars Andresen Thomas
Original Assignee
Univ Danmarks Tekniske
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Danmarks Tekniske filed Critical Univ Danmarks Tekniske
Publication of BR112022004777A2 publication Critical patent/BR112022004777A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K39/00117—Mucins, e.g. MUC-1
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    • A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
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    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
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Abstract

composição de micela de estimulação imunológica. a presente invenção se refere a composições de micela de estimulação imunológica e seu uso no tratamento de doenças e distúrbios, tais como câncer. em particular, a presente invenção se refere a composições de micela que compreendem um agonista de tlr7, tal como 1v270.
BR112022004777A 2019-09-19 2020-09-18 Composição de micela de estimulação imunológica BR112022004777A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP19198424 2019-09-19
EP19207727 2019-11-07
EP20167952 2020-04-03
PCT/EP2020/076136 WO2021053163A1 (en) 2019-09-19 2020-09-18 Immune stimulating micelle composition

Publications (1)

Publication Number Publication Date
BR112022004777A2 true BR112022004777A2 (pt) 2022-06-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022004777A BR112022004777A2 (pt) 2019-09-19 2020-09-18 Composição de micela de estimulação imunológica

Country Status (11)

Country Link
US (1) US20220354789A1 (pt)
EP (1) EP4031142A1 (pt)
JP (1) JP2022548733A (pt)
KR (1) KR20220066887A (pt)
CN (1) CN114514015A (pt)
AU (1) AU2020349613A1 (pt)
BR (1) BR112022004777A2 (pt)
CA (1) CA3150972A1 (pt)
IL (1) IL291361A (pt)
MX (1) MX2022003398A (pt)
WO (1) WO2021053163A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022200553A2 (en) * 2021-03-25 2022-09-29 Danmarks Tekniske Universitet Immune stimulating nanoparticle composition
WO2024083959A1 (en) * 2022-10-20 2024-04-25 Monta Biosciences Aps Pre-medication and improved treatment regimen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE025555T2 (en) 2007-02-07 2016-02-29 Univ California Conjugates and applications of synthetic tlr agonists
WO2015036044A1 (en) * 2013-09-13 2015-03-19 Telormedix Sa Cationic lipid vehicles for delivery of tlr7 agonists for specific targeting of human cd14+ monocytes in whole blood
US20150366962A1 (en) * 2014-06-20 2015-12-24 The Regents Of The University Of California Synthetic tlr4 and tlr7 ligands as vaccine adjuvants
JP7062599B2 (ja) * 2016-05-06 2022-05-06 イグジキュア オペレーティング カンパニー 強力な抗腫瘍活性を有するｔｌｒ９を標的化する球状核酸
WO2019012107A1 (en) * 2017-07-13 2019-01-17 Danmarks Tekniske Universitet CATIONIC LIPOSOMES

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KR20220066887A (ko) 2022-05-24
US20220354789A1 (en) 2022-11-10
MX2022003398A (es) 2022-04-19
IL291361A (en) 2022-05-01
CN114514015A (zh) 2022-05-17
EP4031142A1 (en) 2022-07-27
AU2020349613A1 (en) 2022-03-31
JP2022548733A (ja) 2022-11-21
WO2021053163A1 (en) 2021-03-25
CA3150972A1 (en) 2021-03-25

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