MX2017002900A - Terapia genica de globina para el tratamiento de hemoglobinopatias. - Google Patents
Terapia genica de globina para el tratamiento de hemoglobinopatias.Info
- Publication number
- MX2017002900A MX2017002900A MX2017002900A MX2017002900A MX2017002900A MX 2017002900 A MX2017002900 A MX 2017002900A MX 2017002900 A MX2017002900 A MX 2017002900A MX 2017002900 A MX2017002900 A MX 2017002900A MX 2017002900 A MX2017002900 A MX 2017002900A
- Authority
- MX
- Mexico
- Prior art keywords
- gene therapy
- global gene
- treating
- treating hemoglobinopathies
- vectors
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0066—Manipulation of the nucleic acid to modify its expression pattern, e.g. enhance its duration of expression, achieved by the presence of particular introns in the delivered nucleic acid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
- C12N2740/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
- C12N2740/15041—Use of virus, viral particle or viral elements as a vector
- C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/40—Vector systems having a special element relevant for transcription being an insulator
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/46—Vector systems having a special element relevant for transcription elements influencing chromatin structure, e.g. scaffold/matrix attachment region, methylation free island
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La materia en cuestión descrita en la presente invención proporciona cartuchos de expresión que permiten la expresi6n de un gen de globina o una parte funcional de los mismos, vectores que lo comprenden y células transducidas con dichos cartuchos y vectores de expresión; la materia objeto de la presente descripción proporciona además métodos para tratar una hemoglobinopatía en un sujeto que comprende administrar una cantidad eficaz de tales células transducidas al sujeto.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462045997P | 2014-09-04 | 2014-09-04 | |
PCT/US2015/048698 WO2016037138A1 (en) | 2014-09-04 | 2015-09-04 | Global gene therapy for treating hemoglobinopathies |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017002900A true MX2017002900A (es) | 2017-10-24 |
Family
ID=55440425
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017002900A MX2017002900A (es) | 2014-09-04 | 2015-09-04 | Terapia genica de globina para el tratamiento de hemoglobinopatias. |
Country Status (11)
Country | Link |
---|---|
US (2) | US11717579B2 (es) |
EP (2) | EP3620521B1 (es) |
JP (3) | JP6710680B2 (es) |
KR (2) | KR102500531B1 (es) |
CN (3) | CN114457076A (es) |
AU (2) | AU2015311681B2 (es) |
BR (1) | BR112017004349A2 (es) |
CA (1) | CA2960209C (es) |
ES (1) | ES2746529T3 (es) |
MX (1) | MX2017002900A (es) |
WO (1) | WO2016037138A1 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US10590433B2 (en) | 2014-03-14 | 2020-03-17 | University Of Washington | Genomic insulator elements and uses thereof |
AU2017370640A1 (en) | 2016-12-05 | 2019-07-18 | The Regents Of The University Of California | Optimized lentiviral vector for stem cell gene therapy of hemoglobinopathies |
TW201839136A (zh) | 2017-02-06 | 2018-11-01 | 瑞士商諾華公司 | 治療血色素異常症之組合物及方法 |
CA3057862A1 (en) * | 2017-03-29 | 2018-10-04 | Bluebird Bio, Inc. | Vectors and compositions for treating hemoglobinopathies |
US20200190536A1 (en) * | 2017-06-02 | 2020-06-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Recombinant lentiviral vector for stem cell-based gene therapy of sickle cell disorder |
AU2018378683A1 (en) * | 2017-12-06 | 2020-07-02 | Memorial Sloan-Kettering Cancer Center | Globin gene therapy for treating hemoglobinopathies |
WO2019213011A1 (en) * | 2018-04-30 | 2019-11-07 | The Children's Hospital Of Philadelphia | Compositions and methods for hemoglobin production |
WO2020112870A1 (en) * | 2018-11-28 | 2020-06-04 | Forty Seven, Inc. | Genetically modified hspcs resistant to ablation regime |
EP3924376A4 (en) * | 2019-02-14 | 2022-12-14 | The Regents Of The University Of California | OPTIMIZED LENTIVIRAL VECTOR COMPRISING MINIMUM ENABLING SEQUENCE ELEMENTS FOR HEMOGLOBINOPATHY STEM CELL GENE THERAPY |
WO2020176712A1 (en) * | 2019-02-28 | 2020-09-03 | The Regents Of The University Of California | Augmentations to lentiviral vectors (cclc-mgata/ank-core lcr-beta-as3-fb) to increase expression |
CN110042124A (zh) * | 2019-04-25 | 2019-07-23 | 国家卫生健康委科学技术研究所 | 基因组碱基编辑增加人红细胞中胎儿血红蛋白水平的试剂盒及应用 |
CN109999053B (zh) * | 2019-04-26 | 2021-03-23 | 周德旺 | 曲氟尿苷或曲氟尿苷替匹嘧啶组合物的医药用途 |
CN110106203B (zh) * | 2019-05-24 | 2023-08-11 | 中国医学科学院血液病医院(血液学研究所) | 一种新型hbb过表达载体及其设计方法和应用 |
CN110699381A (zh) * | 2019-09-17 | 2020-01-17 | 合肥瑞灵生物科技有限公司 | 地中海贫血病基因治疗载体构建方法及其用途 |
US20220411822A1 (en) * | 2020-01-22 | 2022-12-29 | Altius Institute For Biomedical Sciences | Novel Erythroid Specific Enhancers and Uses Thereof |
JP7031690B2 (ja) * | 2020-01-27 | 2022-03-08 | 株式会社三洋物産 | 遊技機 |
WO2022212720A1 (en) * | 2021-03-31 | 2022-10-06 | Sigilon Therapeutics, Inc. | Genetically modified human cell lines and uses thereof |
CN113106098B (zh) * | 2021-04-21 | 2022-04-01 | 贵州医科大学 | 一种在红系细胞中特异表达人β珠蛋白的重组序列及其应用 |
CN113564248A (zh) * | 2021-09-26 | 2021-10-29 | 北京贝瑞和康生物技术有限公司 | 同时检测hba1/2、hbb和hbd基因位点多种突变的方法和试剂盒 |
CN114457119B (zh) * | 2022-04-11 | 2022-08-12 | 中吉智药(南京)生物技术有限公司 | 慢病毒载体在制备治疗β-地中海贫血药物中的应用 |
CN116271106B (zh) * | 2023-05-24 | 2023-08-11 | 中吉智药(南京)生物技术有限公司 | 慢病毒载体LentilAlpha在制备治疗α-地中海贫血药物中的应用 |
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US7541179B2 (en) * | 2001-06-29 | 2009-06-02 | Memorial Sloan-Kettering Cancer Center | Vector encoding human globin gene and use thereof in treatment of hemoglobinopathies |
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US20080069805A1 (en) * | 2005-05-18 | 2008-03-20 | Williams Bruce M | Use of stem cells to cure genetic diseases in humans cure for sickle cell anemia |
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WO2010113037A1 (en) | 2009-04-03 | 2010-10-07 | Centre National De La Recherche Scientifique | Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements |
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WO2014043131A1 (en) * | 2012-09-14 | 2014-03-20 | The Regents Of The University Of California | Lentiviral vector for stem cell gene therapy of sickle cell disease |
CA2938419A1 (en) * | 2014-01-30 | 2015-08-06 | Children's Hospital Medical Center | An improved fetal hemoglobin for genetic correction of sickle cell disease |
US10590433B2 (en) * | 2014-03-14 | 2020-03-17 | University Of Washington | Genomic insulator elements and uses thereof |
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2015
- 2015-09-04 WO PCT/US2015/048698 patent/WO2016037138A1/en active Application Filing
- 2015-09-04 ES ES15837740T patent/ES2746529T3/es active Active
- 2015-09-04 KR KR1020177008935A patent/KR102500531B1/ko active IP Right Grant
- 2015-09-04 CA CA2960209A patent/CA2960209C/en active Active
- 2015-09-04 KR KR1020237005064A patent/KR20230030002A/ko not_active Application Discontinuation
- 2015-09-04 AU AU2015311681A patent/AU2015311681B2/en active Active
- 2015-09-04 CN CN202210122741.1A patent/CN114457076A/zh active Pending
- 2015-09-04 CN CN202210122739.4A patent/CN114480393A/zh active Pending
- 2015-09-04 CN CN201580060160.8A patent/CN107208093B/zh active Active
- 2015-09-04 EP EP19185730.9A patent/EP3620521B1/en active Active
- 2015-09-04 BR BR112017004349A patent/BR112017004349A2/pt not_active Application Discontinuation
- 2015-09-04 MX MX2017002900A patent/MX2017002900A/es unknown
- 2015-09-04 JP JP2017512966A patent/JP6710680B2/ja active Active
- 2015-09-04 EP EP15837740.8A patent/EP3189143B1/en active Active
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2017
- 2017-03-03 US US15/449,416 patent/US11717579B2/en active Active
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2020
- 2020-03-03 JP JP2020035649A patent/JP7158427B2/ja active Active
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2021
- 2021-12-21 AU AU2021290257A patent/AU2021290257A1/en active Pending
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2022
- 2022-06-01 JP JP2022089526A patent/JP2022107736A/ja active Pending
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2023
- 2023-01-26 US US18/160,083 patent/US20240066148A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP3620521A1 (en) | 2020-03-11 |
KR20230030002A (ko) | 2023-03-03 |
AU2015311681A1 (en) | 2017-04-13 |
WO2016037138A8 (en) | 2017-03-16 |
JP2022107736A (ja) | 2022-07-22 |
AU2015311681A8 (en) | 2019-08-08 |
AU2015311681B2 (en) | 2021-09-23 |
JP6710680B2 (ja) | 2020-06-17 |
JP2020079327A (ja) | 2020-05-28 |
ES2746529T3 (es) | 2020-03-06 |
EP3189143A1 (en) | 2017-07-12 |
CN107208093B (zh) | 2022-03-01 |
JP7158427B2 (ja) | 2022-10-21 |
US20240066148A1 (en) | 2024-02-29 |
CN114480393A (zh) | 2022-05-13 |
JP2017532023A (ja) | 2017-11-02 |
KR102500531B1 (ko) | 2023-02-17 |
CA2960209A1 (en) | 2016-03-10 |
AU2021290257A1 (en) | 2022-01-27 |
KR20170044752A (ko) | 2017-04-25 |
BR112017004349A2 (pt) | 2017-12-05 |
CA2960209C (en) | 2023-08-29 |
CN114457076A (zh) | 2022-05-10 |
WO2016037138A1 (en) | 2016-03-10 |
CN107208093A (zh) | 2017-09-26 |
US11717579B2 (en) | 2023-08-08 |
US20170173185A1 (en) | 2017-06-22 |
EP3189143B1 (en) | 2019-08-07 |
EP3620521B1 (en) | 2024-05-29 |
EP3189143A4 (en) | 2018-03-21 |
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