MX2019000205A - Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno. - Google Patents

Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno.

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Publication number
MX2019000205A
MX2019000205A MX2019000205A MX2019000205A MX2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A MX 2019000205 A MX2019000205 A MX 2019000205A
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Mexico
Prior art keywords
exogenous rna
compositions
methods related
cell systems
therapeutic cell
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MX2019000205A
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English (en)
Inventor
J Deans Robert
Mata-Fink Jordi
Harandi Omid
Khanwalkar Urjeet
Hariharan Sneha
Kahvejian Avak
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Rubius Therapeutics Inc
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Publication date
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Publication of MX2019000205A publication Critical patent/MX2019000205A/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0641—Erythrocytes
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/922—Ribonucleases (RNAses); Deoxyribonucleases (DNAses)

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Abstract

La invención incluye composiciones y métodos relacionados con células eritroides que comprenden ARN exógeno que codifica una proteína. El ARN exógeno puede comprender una región no traducida heteróloga que comprende un elemento regulador. Como alternativa o en combinación, el ARN exógeno puede comprender modificaciones químicas.
MX2019000205A 2016-07-07 2017-07-07 Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno. MX2019000205A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662359416P 2016-07-07 2016-07-07
PCT/US2017/041155 WO2018009838A1 (en) 2016-07-07 2017-07-07 Compositions and methods related to therapeutic cell systems expressing exogenous rna

Publications (1)

Publication Number Publication Date
MX2019000205A true MX2019000205A (es) 2019-09-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019000205A MX2019000205A (es) 2016-07-07 2017-07-07 Composiciones y metodos relacionados con sistemas celulares terapeuticos que expresan arn exogeno.

Country Status (10)

Country Link
US (1) US20190161730A1 (es)
EP (1) EP3481943A1 (es)
JP (2) JP2019520829A (es)
KR (1) KR20190026819A (es)
CN (1) CN109526226A (es)
AU (1) AU2017293931A1 (es)
BR (1) BR112019000195A2 (es)
CA (1) CA3029906A1 (es)
MX (1) MX2019000205A (es)
WO (1) WO2018009838A1 (es)

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