EA201170375A1 - Антагонисты pd-1 и способы их применения - Google Patents

Антагонисты pd-1 и способы их применения

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Publication number
EA201170375A1
EA201170375A1 EA201170375A EA201170375A EA201170375A1 EA 201170375 A1 EA201170375 A1 EA 201170375A1 EA 201170375 A EA201170375 A EA 201170375A EA 201170375 A EA201170375 A EA 201170375A EA 201170375 A1 EA201170375 A1 EA 201170375A1
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Eurasian Patent Office
Prior art keywords
receptor
cell
methods
bind
antagonists
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EA201170375A
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English (en)
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Соломон Лангерманн
Линда Лю
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Эмплиммьюн, Инк.
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Application filed by Эмплиммьюн, Инк. filed Critical Эмплиммьюн, Инк.
Publication of EA201170375A1 publication Critical patent/EA201170375A1/ru

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Abstract

Настоящее изобретение относится к композициям для усиления и/или продления активации Т-клеток (то есть для увеличения антигенспецифической пролиферации Т-клеток, увеличения продуцирования цитокинов Т-клетками, стимуляции дифференцировки и эффекторных функций Т-клеток и/или способствования выживанию Т-клеток) или преодоления истощения и/или анергии Т-клеток и к способам их применения. Приемлемые композиции включают антагонисты рецепторов PD-1, которые связываются с эндогенным рецептором PD-1 и блокируют указанный рецептор, не запуская при этом передачу ингибирующих сигналов из PD-1, или связываются с лигандами рецептора PD-1 и блокируют указанные лиганды, препятствуя их взаимодействию с рецепторами PD-1. Настоящее изобретение относится к способам применения антагонистов рецепторов PD-1 для усиления иммунных реакций у нуждающихся субъектов.
EA201170375A 2008-08-25 2009-08-25 Антагонисты pd-1 и способы их применения EA201170375A1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US9170508P 2008-08-25 2008-08-25
US9150208P 2008-08-25 2008-08-25
US9170908P 2008-08-25 2008-08-25
US9169408P 2008-08-25 2008-08-25
US14254809P 2009-01-05 2009-01-05
US16565209P 2009-04-01 2009-04-01
PCT/US2009/054971 WO2010027828A2 (en) 2008-08-25 2009-08-25 Pd-1 antagonists and methods of use thereof

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EA201170375A1 true EA201170375A1 (ru) 2012-03-30

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US (4) US20110159023A1 (ru)
EP (4) EP2324055A2 (ru)
JP (4) JP2012500652A (ru)
KR (1) KR20110074850A (ru)
CN (2) CN102203125A (ru)
AU (1) AU2009288289B2 (ru)
BR (1) BRPI0917891A2 (ru)
CA (1) CA2735006A1 (ru)
EA (1) EA201170375A1 (ru)
IL (1) IL211299A (ru)
MX (1) MX2011002250A (ru)
WO (3) WO2010027828A2 (ru)
ZA (1) ZA201101119B (ru)

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