MA52289A - Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisations - Google Patents
Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisationsInfo
- Publication number
- MA52289A MA52289A MA052289A MA52289A MA52289A MA 52289 A MA52289 A MA 52289A MA 052289 A MA052289 A MA 052289A MA 52289 A MA52289 A MA 52289A MA 52289 A MA52289 A MA 52289A
- Authority
- MA
- Morocco
- Prior art keywords
- heterodimerus
- fusion proteins
- fusion
- proteins
- Prior art date
Links
- 102100020789 Interleukin-15 receptor subunit alpha Human genes 0.000 title 1
- 101710107699 Interleukin-15 receptor subunit alpha Proteins 0.000 title 1
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2086—IL-13 to IL-16
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/289—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD45
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862659563P | 2018-04-18 | 2018-04-18 | |
US201862684143P | 2018-06-12 | 2018-06-12 | |
US201862724396P | 2018-08-29 | 2018-08-29 | |
US201862756800P | 2018-11-07 | 2018-11-07 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA52289A true MA52289A (fr) | 2021-02-24 |
Family
ID=68239907
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA052289A MA52289A (fr) | 2018-04-18 | 2019-04-18 | Protéines de fusion fc hétérodimères il-15/il-15ra et leurs utilisations |
Country Status (12)
Country | Link |
---|---|
US (2) | US20190365861A1 (fr) |
EP (1) | EP3781596A1 (fr) |
KR (1) | KR20210003170A (fr) |
CN (1) | CN112105645A (fr) |
AU (1) | AU2019255744A1 (fr) |
CA (1) | CA3097625A1 (fr) |
IL (2) | IL310398A (fr) |
MA (1) | MA52289A (fr) |
MX (1) | MX2020010912A (fr) |
SG (1) | SG11202010159RA (fr) |
TW (1) | TW202011984A (fr) |
WO (1) | WO2019204592A1 (fr) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20191034A1 (es) | 2016-10-14 | 2019-08-05 | Xencor Inc | Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15r y fragmentos de anticuerpo pd-1 |
EP3548071A4 (fr) * | 2016-11-30 | 2020-07-15 | OncoMed Pharmaceuticals, Inc. | Méthodes de traitement du cancer comprenant des agents de liaison à tigit |
AU2019256539A1 (en) | 2018-04-18 | 2020-11-26 | Xencor, Inc. | PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof |
EP3781598A1 (fr) | 2018-04-18 | 2021-02-24 | Xencor, Inc. | Protéines de fusion hétérodimères ciblant tim-3 contenant des protéines de fusion fc d'il-15/il-15ra et domaines de liaison à l'antigène de tim-3 |
CN113423734A (zh) | 2018-10-12 | 2021-09-21 | Xencor股份有限公司 | 靶向PD-1的IL-15/IL-15RαFC融合蛋白及其在联合疗法中的应用 |
EP3897853A1 (fr) | 2018-12-20 | 2021-10-27 | Xencor, Inc. | Protéines de fusion fc hétérodimères ciblées contenant les il-15/il-15ra et des domaines de liaison à l'antigène nkg2d |
TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
WO2021092719A1 (fr) * | 2019-11-11 | 2021-05-20 | 王盛典 | Protéine de fusion ciblant des lymphocytes t spécifiques d'un antigène pour induire leur différenciation en cellules souches de mémoire |
JP2023502712A (ja) * | 2019-11-21 | 2023-01-25 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | 抗pd-1/il-15免疫サイトカインによる新しいpd-1標的免疫療法 |
US20230048046A1 (en) * | 2019-12-13 | 2023-02-16 | Cugene Inc | Novel interleukin-15 (il-15) fusion proteins and uses thereof |
CA3164353A1 (fr) * | 2019-12-13 | 2021-06-17 | Cugene Inc. | Medicaments bioactivables a base de cytokine et procedes d'utilisations associes |
WO2021142476A1 (fr) * | 2020-01-12 | 2021-07-15 | Dragonfly Therapeutics, Inc. | Polypeptides à chaîne unique |
JP2023511439A (ja) * | 2020-01-28 | 2023-03-17 | ジェネンテック, インコーポレイテッド | がんの治療のためのil15/il15rアルファヘテロ二量体fc融合タンパク質 |
WO2021253360A1 (fr) * | 2020-06-18 | 2021-12-23 | Proviva Therapeutics (Hong Kong) Limited | Procytokines pouvant être activées |
CN113321736B (zh) * | 2020-12-30 | 2024-01-09 | 苏州复融生物技术有限公司 | 一种长效化白介素15融合蛋白及其制备方法和应用 |
CA3206844A1 (fr) * | 2021-02-05 | 2022-08-11 | John Li | Proteines de fusion il-51 et leurs procedes de production et d'utilisation |
BR112023027312A2 (pt) * | 2021-06-23 | 2024-03-12 | Cytune Pharma | Imunocitocina |
KR20240042442A (ko) * | 2021-07-28 | 2024-04-02 | 제넨테크, 인크. | 혈액암 치료를 위한 IL15/IL15R 알파 이종이량체 Fc-융합 단백질 |
WO2023015198A1 (fr) * | 2021-08-04 | 2023-02-09 | Genentech, Inc. | Protéines de fusion hétérodimères avec fc et il15/il15r alpha servant à faire proliférer des lymphocytes nk dans le traitement de tumeurs solides |
WO2023160721A1 (fr) * | 2022-02-28 | 2023-08-31 | Wuxi Biologics (Shanghai) Co., Ltd. | Complexes polypeptidiques hétérodimères comprenant des variants d'il-15 et leurs utilisations |
WO2023239228A1 (fr) * | 2022-06-10 | 2023-12-14 | 메디맵바이오 주식회사 | Protéine de fusion comprenant un anticorps anti-tigit, l'interleukine-15 et le domaine alpha sushi du récepteur de l'interleukine-15 et son utilisation |
WO2024011179A1 (fr) * | 2022-07-07 | 2024-01-11 | Genentech, Inc. | Combinaisons de protéines de fusion fc hétérodimères il15/il15r alpha et d'anticorps bispécifiques fcrh5xcd3 pour le traitement de cancers du sang |
CN115806627A (zh) * | 2022-08-03 | 2023-03-17 | 深圳市先康达生命科学有限公司 | 一种自分泌IL-15与anti-LAG3结合的融合蛋白及其应用 |
WO2024064200A2 (fr) * | 2022-09-20 | 2024-03-28 | The Texas A&M University System | Compositions contenant la darpin et méthodes associées |
CN116554356B (zh) * | 2023-05-16 | 2024-01-23 | 武汉大学 | 一种hyperIL-15与sCD4及Fc的融合蛋白及其应用 |
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US9244059B2 (en) | 2007-04-30 | 2016-01-26 | Immutep Parc Club Orsay | Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease |
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-
2019
- 2019-04-18 AU AU2019255744A patent/AU2019255744A1/en active Pending
- 2019-04-18 MX MX2020010912A patent/MX2020010912A/es unknown
- 2019-04-18 WO PCT/US2019/028107 patent/WO2019204592A1/fr unknown
- 2019-04-18 SG SG11202010159RA patent/SG11202010159RA/en unknown
- 2019-04-18 TW TW108113628A patent/TW202011984A/zh unknown
- 2019-04-18 EP EP19722385.2A patent/EP3781596A1/fr active Pending
- 2019-04-18 KR KR1020207033076A patent/KR20210003170A/ko not_active Application Discontinuation
- 2019-04-18 IL IL310398A patent/IL310398A/en unknown
- 2019-04-18 CN CN201980028232.9A patent/CN112105645A/zh active Pending
- 2019-04-18 MA MA052289A patent/MA52289A/fr unknown
- 2019-04-18 CA CA3097625A patent/CA3097625A1/fr active Pending
- 2019-04-18 US US16/388,174 patent/US20190365861A1/en not_active Abandoned
-
2020
- 2020-10-15 IL IL278090A patent/IL278090B2/en unknown
-
2021
- 2021-03-22 US US17/209,047 patent/US20220040264A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2019204592A8 (fr) | 2020-11-05 |
IL278090A (en) | 2020-11-30 |
CA3097625A1 (fr) | 2019-10-24 |
IL278090B2 (en) | 2024-07-01 |
WO2019204592A1 (fr) | 2019-10-24 |
TW202011984A (zh) | 2020-04-01 |
IL278090B1 (en) | 2024-03-01 |
CN112105645A (zh) | 2020-12-18 |
AU2019255744A1 (en) | 2020-11-26 |
US20190365861A1 (en) | 2019-12-05 |
MX2020010912A (es) | 2021-01-29 |
JP2021522175A (ja) | 2021-08-30 |
US20220040264A1 (en) | 2022-02-10 |
IL310398A (en) | 2024-03-01 |
SG11202010159RA (en) | 2020-11-27 |
EP3781596A1 (fr) | 2021-02-24 |
AU2019255744A8 (en) | 2021-04-22 |
KR20210003170A (ko) | 2021-01-11 |
WO2019204592A9 (fr) | 2019-12-12 |
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