MX2022011154A - Composicion farmaceutica para el tratamiento de cancer que comprende proteina de fusion que se compone de proteina il-2 y proteina cd80 y farmaco anticancerigeno. - Google Patents

Composicion farmaceutica para el tratamiento de cancer que comprende proteina de fusion que se compone de proteina il-2 y proteina cd80 y farmaco anticancerigeno.

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Publication number
MX2022011154A
MX2022011154A MX2022011154A MX2022011154A MX2022011154A MX 2022011154 A MX2022011154 A MX 2022011154A MX 2022011154 A MX2022011154 A MX 2022011154A MX 2022011154 A MX2022011154 A MX 2022011154A MX 2022011154 A MX2022011154 A MX 2022011154A
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Mexico
Prior art keywords
protein
anticancer drug
fusion protein
pharmaceutical composition
cancer treatment
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Application number
MX2022011154A
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English (en)
Inventor
Su Youn Nam
Myung Ho Jang
Young Jun Koh
Original Assignee
Gi Innovation Inc
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Publication date
Application filed by Gi Innovation Inc filed Critical Gi Innovation Inc
Publication of MX2022011154A publication Critical patent/MX2022011154A/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K33/24—Heavy metals; Compounds thereof
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774—Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • A—HUMAN NECESSITIES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/70532—B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
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    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Biochemistry (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Microbiology (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

La presente invención provee una composición farmacéutica para el tratamiento del cáncer que comprende, como ingredientes activos, una proteína de fusión que se compone de una proteína IL-2 y una proteína CD80, y un agente anticancerígeno. Una proteína de fusión que comprende un fragmento de CD80, una inmunoglobulina Fc y una variante de IL-2, que es una modalidad de la presente invención, puede activar células inmunitarias como las células asesinas naturales y, al mismo tiempo, puede controlar la actividad reguladora de las células inmunitarias de las células T reguladoras. Además, cuando se administra un agente anticanceroso en combinación con la proteína de fusión, se puede inhibir eficazmente el cáncer. Por lo tanto, una composición farmacéutica que comprende, como ingredientes activos, una proteína de fusión que comprende una proteína IL-2 y una proteína CD80, y un agente anticancerígeno puede aumentar la actividad inmunitaria en el cuerpo y puede utilizarse eficazmente no solo para el cáncer sino también para una enfermedad infecciosa, y por lo tanto tiene un alto potencial industrial.
MX2022011154A 2020-03-18 2021-03-18 Composicion farmaceutica para el tratamiento de cancer que comprende proteina de fusion que se compone de proteina il-2 y proteina cd80 y farmaco anticancerigeno. MX2022011154A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20200033233 2020-03-18
KR20210020708 2021-02-16
PCT/KR2021/003375 WO2021187922A1 (ko) 2020-03-18 2021-03-18 Il-2 단백질 및 cd80 단백질을 포함하는 융합단백질 및 항암제를 포함하는 암 치료용 약학 조성물

Publications (1)

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MX2022011154A true MX2022011154A (es) 2022-10-13

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MX2022011154A MX2022011154A (es) 2020-03-18 2021-03-18 Composicion farmaceutica para el tratamiento de cancer que comprende proteina de fusion que se compone de proteina il-2 y proteina cd80 y farmaco anticancerigeno.

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US (1) US11857601B2 (es)
EP (1) EP4140495A4 (es)
JP (1) JP2023517534A (es)
KR (2) KR102440962B1 (es)
CN (1) CN115297881A (es)
AU (1) AU2021239772A1 (es)
BR (1) BR112022018631A2 (es)
CA (1) CA3175457A1 (es)
CL (1) CL2022002503A1 (es)
IL (1) IL296437A (es)
MX (1) MX2022011154A (es)
TW (1) TW202200191A (es)
WO (1) WO2021187922A1 (es)
ZA (1) ZA202210024B (es)

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KR102461837B1 (ko) * 2022-01-13 2022-11-01 ㈜지아이이노베이션 Cd80 세포외도메인 및 항 lag3 항체 단편을 포함하는 융합 단백질 및 이의 용도
WO2023153880A1 (ko) * 2022-02-11 2023-08-17 주식회사 카나프테라퓨틱스 Il-12 및 항-fap 항체를 포함하는 융합단백질 및 항암제를 포함하는 암 치료용 약학 조성물

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CA3175457A1 (en) 2021-09-23
US11857601B2 (en) 2024-01-02
US20230190876A1 (en) 2023-06-22
CL2022002503A1 (es) 2023-05-26
ZA202210024B (en) 2024-01-31
JP2023517534A (ja) 2023-04-26
KR102440962B9 (ko) 2022-12-05
KR102440962B1 (ko) 2022-09-07
KR20220126679A (ko) 2022-09-16
BR112022018631A2 (pt) 2022-11-08
TW202200191A (zh) 2022-01-01
EP4140495A1 (en) 2023-03-01
WO2021187922A1 (ko) 2021-09-23
CN115297881A (zh) 2022-11-04
KR20210117220A (ko) 2021-09-28
IL296437A (en) 2022-11-01
EP4140495A4 (en) 2024-05-01
AU2021239772A1 (en) 2022-09-15

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