MX2018014911A - Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. - Google Patents
Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas.Info
- Publication number
- MX2018014911A MX2018014911A MX2018014911A MX2018014911A MX2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- therapy
- cell
- treating
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000011467 adoptive cell therapy Methods 0.000 title abstract 2
- 230000036210 malignancy Effects 0.000 title abstract 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000004083 survival effect Effects 0.000 abstract 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan métodos de terapia de célula adoptiva que implica la administración de dosis de células para tratar afecciones malignas de células B. Las células que expresan en general receptores recombinantes tal como receptores de antígeno quiméricos (CARs). En algunas modalidades, los métodos son para tratar sujetos con leucemia linfocítica crónica (CLL). En algunas modalidades, los métodos son para tratar sujetos con linfoma no de Hodgkin (NHL). En algunas modalidades, los métodos implican la administración previa de una terapia reductora de linfocitos, tal como administración previa de fludarabina y/u otro agente quimioterapéutico reductor de linfocitos, por ejemplo ciclofosfamida. En algunas modalidades, las características de los métodos incluyen un incremento en la remisión completa, supervivencia total y/o supervivencia sin progresión de sujetos tratados de acuerdo con los métodos proporcionados.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662346547P | 2016-06-06 | 2016-06-06 | |
US201662417292P | 2016-11-03 | 2016-11-03 | |
US201662429737P | 2016-12-03 | 2016-12-03 | |
PCT/US2017/036231 WO2017214207A2 (en) | 2016-06-06 | 2017-06-06 | Methods for the treatment of b cell malignancies using adoptive cell therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018014911A true MX2018014911A (es) | 2019-08-12 |
Family
ID=59227902
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018014911A MX2018014911A (es) | 2016-06-06 | 2017-06-06 | Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20200016199A1 (es) |
EP (1) | EP3463437A2 (es) |
JP (3) | JP7139318B2 (es) |
KR (3) | KR102540751B1 (es) |
CN (1) | CN109562151A (es) |
AU (1) | AU2017277396A1 (es) |
BR (1) | BR112018074406A2 (es) |
CA (1) | CA3024725A1 (es) |
MA (1) | MA45341A (es) |
MX (1) | MX2018014911A (es) |
WO (1) | WO2017214207A2 (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
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SG10202104804PA (en) | 2014-10-20 | 2021-06-29 | Juno Therapeutics Inc | Methods and compositions for dosing in adoptive cell therapy |
TWI718118B (zh) | 2015-01-16 | 2021-02-11 | 美商奇諾治療有限公司 | 針對ror1之特異性抗體及嵌合抗原受體 |
AU2017213844A1 (en) | 2016-02-02 | 2018-08-02 | Fred Hutchinson Cancer Center | Anti-ROR1 antibodies and uses thereof |
JP2019532997A (ja) * | 2016-11-03 | 2019-11-14 | ジュノー セラピューティクス インコーポレイテッド | T細胞療法とbtk阻害剤との併用療法 |
EP3548046A2 (en) | 2016-12-03 | 2019-10-09 | Juno Therapeutics, Inc. | Methods and compositions for use of therapeutic t cells in combination with kinase inhibitors |
AU2018234640B2 (en) | 2017-03-14 | 2024-03-14 | Juno Therapeutics, Inc. | Methods for cryogenic storage |
CN111225675B (zh) | 2017-06-02 | 2024-05-03 | 朱诺治疗学股份有限公司 | 使用过继细胞疗法治疗的制品和方法 |
CN111511391A (zh) | 2017-10-18 | 2020-08-07 | 英特拉克森公司 | 包含间隔区的多肽组合物 |
US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
WO2019200347A1 (en) * | 2018-04-13 | 2019-10-17 | Fred Hutchinson Cancer Research Center | Methods for adoptive cell therapy targeting ror1 |
MX2020011527A (es) * | 2018-05-03 | 2021-02-26 | Juno Therapeutics Inc | Terapia de combinación de una terapia de células t-receptor de antígeno quimérico (car) y un inhibidor de cinasa. |
US20210401887A1 (en) * | 2018-10-31 | 2021-12-30 | The Children's Hospital Of Philadelphia | T cells from lymphatic fluid for diagnostic and therapeutic use |
MX2021006244A (es) * | 2018-11-30 | 2021-09-10 | Juno Therapeutics Inc | Metodos de dosificacion y tratamiento de canceres de celulas b en terapia celular adoptiva. |
KR20210117260A (ko) * | 2018-11-30 | 2021-09-28 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 세포 요법을 사용한 치료방법 |
WO2020180882A1 (en) | 2019-03-05 | 2020-09-10 | Nkarta, Inc. | Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy |
MA56388A (fr) * | 2019-06-27 | 2022-05-04 | Crispr Therapeutics Ag | Utilisation de lymphocytes t récepteurs d'antigènes chimériques et d'inhibiteurs de cellules nk pour le traitement du cancer |
EP4070097A1 (en) * | 2019-12-06 | 2022-10-12 | Juno Therapeutics, Inc. | Methods related to toxicity and response associated with cell therapy for treating b cell malignancies |
US20230071910A1 (en) * | 2020-01-24 | 2023-03-09 | Juno Therapeutics, Inc. | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
CN115768443A (zh) * | 2020-02-12 | 2023-03-07 | 朱诺治疗学股份有限公司 | Cd19定向嵌合抗原受体t细胞组合物和方法及其用途 |
EP4153616A2 (en) * | 2020-05-18 | 2023-03-29 | Robert Sackstein | Compositions and methods for treatment of inflammatory disorders |
EP4161563A1 (en) * | 2020-06-05 | 2023-04-12 | Tessa Therapeutics Ltd. | Treatment of cd30-positive cancer |
US20220023344A1 (en) * | 2020-06-26 | 2022-01-27 | Crispr Therapeutics Ag | Allogeneic cell therapy of acute lymphoblastic leukemia using genetically engineered t cells targeting cd19 |
AU2021366431A1 (en) * | 2020-10-20 | 2023-05-18 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
RU2758126C1 (ru) * | 2021-04-02 | 2021-10-26 | федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации | Способ прогнозирования развития рецидива диффузной В-крупноклеточной лимфомы |
WO2022254337A1 (en) * | 2021-06-01 | 2022-12-08 | Novartis Ag | Cd19 and cd22 chimeric antigen receptors and uses thereof |
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- 2017-06-06 KR KR1020197000351A patent/KR102540751B1/ko not_active Application Discontinuation
- 2017-06-06 MX MX2018014911A patent/MX2018014911A/es unknown
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WO2017214207A3 (en) | 2018-01-18 |
JP2019517589A (ja) | 2019-06-24 |
KR20240036704A (ko) | 2024-03-20 |
CN109562151A (zh) | 2019-04-02 |
US20200016199A1 (en) | 2020-01-16 |
KR20190026740A (ko) | 2019-03-13 |
KR102540751B1 (ko) | 2023-06-09 |
KR102644950B1 (ko) | 2024-03-11 |
MA45341A (fr) | 2019-04-10 |
JP2022033929A (ja) | 2022-03-02 |
EP3463437A2 (en) | 2019-04-10 |
AU2017277396A1 (en) | 2018-11-29 |
BR112018074406A2 (pt) | 2019-03-06 |
WO2017214207A8 (en) | 2018-11-29 |
JP2023184646A (ja) | 2023-12-28 |
WO2017214207A2 (en) | 2017-12-14 |
KR20230085947A (ko) | 2023-06-14 |
JP7139318B2 (ja) | 2022-09-20 |
CA3024725A1 (en) | 2017-12-14 |
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