MX2018014911A - Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. - Google Patents
Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas.Info
- Publication number
- MX2018014911A MX2018014911A MX2018014911A MX2018014911A MX2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A MX 2018014911 A MX2018014911 A MX 2018014911A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- therapy
- cell
- treating
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 7
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 238000011467 adoptive cell therapy Methods 0.000 title abstract 2
- 230000036210 malignancy Effects 0.000 title abstract 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 abstract 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000004083 survival effect Effects 0.000 abstract 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 abstract 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 229960004397 cyclophosphamide Drugs 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
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- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se proporcionan métodos de terapia de célula adoptiva que implica la administración de dosis de células para tratar afecciones malignas de células B. Las células que expresan en general receptores recombinantes tal como receptores de antígeno quiméricos (CARs). En algunas modalidades, los métodos son para tratar sujetos con leucemia linfocítica crónica (CLL). En algunas modalidades, los métodos son para tratar sujetos con linfoma no de Hodgkin (NHL). En algunas modalidades, los métodos implican la administración previa de una terapia reductora de linfocitos, tal como administración previa de fludarabina y/u otro agente quimioterapéutico reductor de linfocitos, por ejemplo ciclofosfamida. En algunas modalidades, las características de los métodos incluyen un incremento en la remisión completa, supervivencia total y/o supervivencia sin progresión de sujetos tratados de acuerdo con los métodos proporcionados.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662346547P | 2016-06-06 | 2016-06-06 | |
| US201662417292P | 2016-11-03 | 2016-11-03 | |
| US201662429737P | 2016-12-03 | 2016-12-03 | |
| PCT/US2017/036231 WO2017214207A2 (en) | 2016-06-06 | 2017-06-06 | Methods for the treatment of b cell malignancies using adoptive cell therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018014911A true MX2018014911A (es) | 2019-08-12 |
Family
ID=59227902
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018014911A MX2018014911A (es) | 2016-06-06 | 2017-06-06 | Metodos para el tratamiento de afecciones malignas de celulas t usando terapia de celulas adoptivas. |
| MX2024000151A MX2024000151A (es) | 2016-06-06 | 2018-11-30 | Composiciones y usos de las mismas para el tratamiento de afecciones malignas de celulas t usando terapias de celulas adoptivas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2024000151A MX2024000151A (es) | 2016-06-06 | 2018-11-30 | Composiciones y usos de las mismas para el tratamiento de afecciones malignas de celulas t usando terapias de celulas adoptivas. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200016199A1 (es) |
| EP (1) | EP3463437A2 (es) |
| JP (3) | JP7139318B2 (es) |
| KR (3) | KR20240036704A (es) |
| CN (1) | CN109562151A (es) |
| AU (1) | AU2017277396B2 (es) |
| BR (1) | BR112018074406A2 (es) |
| CA (1) | CA3024725A1 (es) |
| MA (1) | MA45341A (es) |
| MX (2) | MX2018014911A (es) |
| WO (1) | WO2017214207A2 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106610A (zh) | 2014-10-20 | 2017-08-29 | 朱诺治疗学股份有限公司 | 用于过继细胞治疗中的给药的组合物和方法 |
| EP3245231B1 (en) | 2015-01-16 | 2020-08-12 | Juno Therapeutics, Inc. | Antibodies and chimeric antigen receptors specific for ror1 |
| ES2903228T3 (es) | 2016-02-02 | 2022-03-31 | Hutchinson Fred Cancer Res | Anticuerpos anti-ROR1 y usos de los mismos |
| CN110139669A (zh) * | 2016-11-03 | 2019-08-16 | 朱诺治疗学股份有限公司 | T细胞疗法和btk抑制剂的组合疗法 |
| MX2019006288A (es) | 2016-12-03 | 2020-10-01 | Juno Therapeutics Inc | Metodos y composiciones para el uso de celulas t terapeuticas en combinacion con inhibidores de quinasa. |
| JP7359751B2 (ja) | 2017-03-14 | 2023-10-11 | ジュノー セラピューティクス インコーポレイテッド | 極低温保管のための方法 |
| WO2018223101A1 (en) | 2017-06-02 | 2018-12-06 | Juno Therapeutics, Inc. | Articles of manufacture and methods for treatment using adoptive cell therapy |
| KR20200096758A (ko) | 2017-10-18 | 2020-08-13 | 인트렉손 코포레이션 | 스페이서를 포함하는 폴리펩타이드 조성물 |
| US12031975B2 (en) | 2017-11-01 | 2024-07-09 | Juno Therapeutics, Inc. | Methods of assessing or monitoring a response to a cell therapy |
| US11851679B2 (en) | 2017-11-01 | 2023-12-26 | Juno Therapeutics, Inc. | Method of assessing activity of recombinant antigen receptors |
| WO2019200347A1 (en) * | 2018-04-13 | 2019-10-17 | Fred Hutchinson Cancer Research Center | Methods for adoptive cell therapy targeting ror1 |
| CA3098497A1 (en) * | 2018-05-03 | 2019-11-07 | Juno Therapeutics, Inc. | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
| EP3873539A4 (en) * | 2018-10-31 | 2023-01-18 | The Children's Hospital of Philadelphia | T LYMPHOCYTES FROM LYMPHATIC FLUID FOR DIAGNOSTIC AND THERAPEUTIC USE |
| PT3886875T (pt) * | 2018-11-30 | 2024-06-27 | Juno Therapeutics Inc | Métodos para tratamento utilizando terapia celular adotiva |
| FI3886894T3 (fi) * | 2018-11-30 | 2024-05-24 | Juno Therapeutics Inc | Menetelmiä annosteluun ja b-solumaligniteettien hoitoon adoptiivisessa soluterapiassa |
| KR20210137085A (ko) | 2019-03-05 | 2021-11-17 | 엔카르타, 인크. | Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도 |
| AU2020307667A1 (en) * | 2019-06-27 | 2022-01-20 | Crispr Therapeutics Ag | Use of chimeric antigen receptor T cells and NK cell inhibitors for treating cancer |
| BR112022010310A2 (pt) * | 2019-12-06 | 2022-08-16 | Juno Therapeutics Inc | Métodos relacionados com a toxicidade e resposta associada com terapia celular para tratamento de malignidades de célula b |
| US20230071910A1 (en) * | 2020-01-24 | 2023-03-09 | Juno Therapeutics, Inc. | Methods for dosing and treatment of follicular lymphoma and marginal zone lymphoma in adoptive cell therapy |
| CN115768443A (zh) * | 2020-02-12 | 2023-03-07 | 朱诺治疗学股份有限公司 | Cd19定向嵌合抗原受体t细胞组合物和方法及其用途 |
| EP4153616A4 (en) * | 2020-05-18 | 2024-08-21 | Robert Sackstein | COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY DISORDERS |
| EP4161563A1 (en) * | 2020-06-05 | 2023-04-12 | Tessa Therapeutics Ltd. | Treatment of cd30-positive cancer |
| WO2021260657A1 (en) * | 2020-06-26 | 2021-12-30 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| WO2022084862A1 (en) * | 2020-10-20 | 2022-04-28 | Crispr Therapeutics Ag | Allogeneic cell therapy of b cell malignancies using genetically engineered t cells targeting cd19 |
| RU2758126C1 (ru) * | 2021-04-02 | 2021-10-26 | федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации | Способ прогнозирования развития рецидива диффузной В-крупноклеточной лимфомы |
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| MA45341A (fr) | 2019-04-10 |
| JP2023184646A (ja) | 2023-12-28 |
| AU2017277396B2 (en) | 2024-08-01 |
| KR20240036704A (ko) | 2024-03-20 |
| WO2017214207A8 (en) | 2018-11-29 |
| JP7139318B2 (ja) | 2022-09-20 |
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