JP7359751B2 - 極低温保管のための方法 - Google Patents
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Description
本出願は、2017年3月14日に出願された米国仮特許出願番号第62/471,343号に基づく優先権を主張しており、その全体の内容は、参考として本明細書中に援用される。
細胞療法は、治療目的を達成するために、細胞をレシピエントに投与する技法である。任意の所与のレシピエントについて、投与される細胞は、別の人物を起源とするものであってもよく、またはレシピエント自身を起源とするものであってもよい。後者の事例は、自家細胞療法と称される場合があり、すなわち、細胞が収集されたレシピエントへと細胞を戻して投与することである。自家細胞療法の利点としては、細胞を収集したドナーが、レシピエントであるため、レシピエントの身体が、投与された細胞を拒絶する可能性が低減されることを挙げることができる。
以下の詳細な説明および例は、本開示のある特定の実施形態を例示する。当業者であれば、本開示の多数の変化形および修正形が存在し、本開示の範囲内に含まれることを認識するであろう。したがって、ある特定の実施形態の説明は、制限として解釈されるものではない。
抗CD19 CARを発現するCD4+細胞およびCD8+細胞の治療用組成物を生成するためのプロセス
研究の設計
アフェレーシス材料の極低温保存は、細胞の表現型に、意味がある影響を及ぼさない
CD4+T細胞および/またはCD8+T細胞の集団の単離に対する極低温保存の影響
単離ステップおよび凍結ステップの後の細胞の表現型および生存性の評価
活性化、形質導入、および増大の間の細胞生存性および細胞収率の評価
極低温保存した組成物の製剤化の間の細胞生存性、細胞収率、および細胞活性の評価
例示的な実施形態
さらなる例示的な実施形態I
さらなる例示的な実施形態II
さらなる例示的な実施形態III
Claims (25)
- 下記(a)工程を含む操作T細胞の組成物を産生するための方法:
(a)極低温で保管した解凍T細胞に、組換え受容体を導入し、それによって、操作T細胞の組成物を生成する工程、ここで、前記操作T細胞は、ドナーの疾患または状態を処置するためであり、前記T細胞は以下の工程を含む方法によって極低温で保管されていた:
(i)ドナーに由来する生物学的試料から得られた濃縮T細胞の集団を、3v/v%~9v/v%のジメチルスルホキシド(DMSO)および1w/v%~5w/v%のヒト血清アルブミン(HSA)を含む極低温保存媒体中に懸濁して、約10x10 6 個の細胞/mLと約150x10 6 個の細胞/mLとの間の密度の懸濁組成物を形成すること、ここで、濃縮T細胞の集団が、少なくとも80%T細胞を含む;
(ii)前記T細胞を含む懸濁組成物を、チャンバが1分間につき1℃を上回る速度で冷却される少なくとも1つのステップを含む、段階的な凍結プロファイルを使用するチャンバを含む、制御された速度の凍結装置において、極低温で凍結すること;および
(iii)極低温で凍結した細胞を保管すること。 - 下記工程を含む操作T細胞の組成物を産生するための方法:
(a)ドナーに由来する生物学的試料から得られた濃縮T細胞の集団を、3v/v%~9v/v%のジメチルスルホキシド(DMSO)および1w/v%~5w/v%のヒト血清アルブミン(HSA)を含む凍結保存媒体中に懸濁して、約10x10 6 個の細胞/mLと約150x10 6 個の細胞/mLとの間の密度の懸濁組成物を形成すること、ここで、濃縮T細胞の集団が、少なくとも80%T細胞を含む;
(b)前記T細胞を含む懸濁組成物を、前記チャンバが1分間につき1℃を上回る速度で冷却される少なくとも1つのステップを含む、段階的な凍結プロファイルを使用するチャンバを含む、制御された速度の凍結装置において、極低温で凍結すること;
(c)極低温で凍結したT細胞を保管すること;
(d)極低温で保管したT細胞を解凍すること;および
(e)解凍T細胞に、組換え受容体を導入し、それによって、操作T細胞の組成物を生成すること、ここで、前記操作T細胞は、ドナーの疾患または状態を処置するためである。 - 前記T細胞を含む生物学的試料が、前記ドナーが前記疾患もしくは状態であると診断されたか、またはそれを有するかもしくはそれを有することが疑われるとみなされた後であり、かつ前記ドナーが前記疾患または状態の1つ以上の処置を受ける前である時点で、前記ドナーから得られるものである、請求項1または2に記載の方法。
- 前記T細胞を含む生物学的試料が、前記ドナーが前記疾患または状態の処置レジメンに不応性であるとみなされたか、または前記処置レジメンの後に再発を経験した後であり、かつ前記ドナーが前記疾患または状態の後続の処置を受ける前である時点で、前記ドナーから得られる、請求項1から3のいずれか1項に記載の方法。
- 前記T細胞を含む生物学的試料が、前記ドナーが前記疾患または状態であると診断されていないか、またはそれを有することが判明していないか、またはそれを有することが疑われていない時点で、前記ドナーから得られる、請求項1から4のいずれか1項に記載の方法。
- 前記生物学的試料が、アフェレーシス試料を含み、前記生物学的試料中の前記細胞のうちの少なくとも80%、85%、90%、95%、96%、97%、98%、もしくは99%が、白血球である、請求項1から5のいずれか1項に記載の方法。
- 前記T細胞が、極低温で凍結される前に、(a)免疫親和性に基づくまたは標的特異的な選択ステップおよび/または(b)血液細胞集団、T細胞集団またはT細胞サブセット集団の濃縮ステップに供されていない、請求項1から6のいずれか1項に記載の方法。
- 前記T細胞が、極低温で凍結される前に、(a)免疫親和性に基づくまたは標的特異的な選択ステップおよび/または(b)血液細胞集団、T細胞集団またはT細胞サブセット集団の濃縮ステップに供されている、請求項1から6のいずれか1項に記載の方法。
- 前記血液細胞集団、T細胞集団またはT細胞サブセット集団が、CD4+細胞もしくはそのサブセットおよび/またはCD8+細胞もしくはそのサブセットを含み、CD4+細胞またはそのサブセットの選択または濃縮が、CD8+細胞またはそのサブセットの選択または濃縮とは別個にまたはそれと組み合わせてのいずれかで行われる、請求項8に記載の方法。
- 前記血液細胞集団、T細胞集団またはT細胞サブセット集団が、メモリー細胞、セントラルメモリーT(TCM)細胞、エフェクターメモリー細胞(TEM)、ステムセントラルメモリー(TSCM)細胞、エフェクターT(TE)細胞、エフェクターメモリーRA T(TEMRA)細胞、ナイーブT(TN)細胞、および/または調節性T(TREG)細胞を含む、請求項8または9に記載の方法。
- 前記T細胞が、少なくとも約1.5x107個の細胞/mLの密度で懸濁される、請求項1から10のいずれか1項に記載の方法。
- 前記極低温保存媒体が、約7.5%のDMSOを含む、請求項1から11のいずれか1項に記載の方法。
- 前記T細胞の保管が、-80℃を下回る温度においてである、請求項1から12のいずれか1項に記載の方法。
- 段階的な凍結プロファイルが、極低温で凍結したT細胞を保管する前に、-80℃を上回るかまたは-20℃を下回る温度まで前記チャンバを冷却することを含む、請求項1から13のいずれか1項に記載の方法。
- 段階的な凍結プロファイルが、一連の複数の冷却および加熱プロファイルを含む、請求項1から14のいずれか1項に記載の方法。
- 段階的な凍結プロファイルが、下記ステップを含む、請求項1から15のいずれか1項に記載の方法:
(a)4.0℃での保持ステップ;
(b)T細胞の組成物を含有するチャンバを、-6℃の温度に達するまで1分間につき1.2℃の冷却ステップ;
(c)T細胞の組成物を含有するチャンバを、-65℃の温度に達するまで1分間につき25℃の冷却ステップ;
(d)T細胞の組成物を含有するチャンバを、-30℃の温度に達するまで1分間につき15℃の加熱ステップ;
(e)T細胞の組成物を含有するチャンバを、-40℃の温度に達するまで1分間につき1℃の冷却ステップ;
(f)T細胞の組成物を含有するチャンバを、-90℃の温度に達するまで1分間につき10℃の冷却ステップ;および
(g)-90℃での保持ステップ。 - 極低温で凍結されたT細胞の保管が、液体窒素の気相に入れた容器においてである、請求項1から16のいずれか1項に記載の方法。
- 前記T細胞が、以下を上回るかまたは以下に等しい期間:12時間、24時間、36時間、48時間、1週間、2週間、3週間、もしくは4週間、1カ月間、2カ月間、3カ月間、4カ月間、5カ月間、6カ月間、7カ月間、8カ月間、9カ月間、10カ月間、11カ月間、1年間、2年間、3年間、4年間、5年間、6年間、7年間、8年間、9年間、10年間、11年間、12年間、13年間、14年間、15年間、16年間、17年間、18年間、19年間、20年間、25年間、30年間、35年間、または40年間、極低温で保管されていた、請求項1から17のいずれか1項に方法。
- 前記T細胞が、ある期間極低温で保管された後、生存細胞もしくは生存T細胞またはそれらのサブタイプもしくはサブセットの割合が、少なくとも約15%、20%、25%、30%、35%、40%、45%、50%、55%、60%、65%、70%、75%、80%、85%、もしくは90%である、請求項1~18のいずれか1項に記載の方法。
- 前記疾患もしくは状態が、がん、炎症性疾患もしくは状態、自己免疫性疾患もしくは状態、または感染性疾患もしくは状態である、請求項1~19のいずれか1項に記載の方法。
- 極低温保管の前に、前記T細胞を、1つまたは複数の表現型マーカーについて、前記細胞の表面発現を評価することによって、分析することをさらに含む、請求項1~20のいずれか1項に記載の方法。
- 組換え受容体が、T細胞受容体(TCR)、またはキメラ受容体を含む、請求項1~21のいずれか1項に記載の方法。
- 組換え受容体がキメラ抗原受容体(CAR)を含む、請求項1~21のいずれか1項に記載の方法。
- 前記T細胞を、極低温で凍結する前または凍結した後のいずれかで、保管施設に輸送することをさらに含み、 前記保管施設が、中央または共通のリポジトリの保管施設である、請求項1~23のいずれか1項に記載の方法。
- 前記T細胞または生物学的試料が、処理、極低温保存、および/または保管の間、前記細胞を分類するために、1つまたは複数のコードまたは識別子で印を付けた容器に入れられ、 前記1つまたは複数のコードまたは識別子が、文字識別子、バーコード、QRコード(登録商標)、RFID、またはトランスポンダを含み、前記1つまたは複数のコードまたは識別子が、ドナー、試料、バイアル、容器、疾患、および/または保管施設のうちの1つまたは複数の識別に対応するか、またはそれを示す、請求項1~24のいずれか1項に記載の方法。
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AU2017362418B2 (en) | 2016-11-17 | 2024-05-02 | Iovance Biotherapeutics, Inc. | Remnant tumor infiltrating lymphocytes and methods of preparing and using the same |
US11357841B2 (en) | 2017-01-06 | 2022-06-14 | Iovance Biotherapeutics, Inc. | Expansion of tumor infiltrating lymphocytes with potassium channel agonists and therapeutic uses thereof |
EP3595683A1 (en) | 2017-03-15 | 2020-01-22 | Orca Biosystems, Inc. | Compositions and methods for hematopoietic stem cell transplants |
US11254913B1 (en) | 2017-03-29 | 2022-02-22 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes and uses of same in immunotherapy |
JOP20190224A1 (ar) | 2017-03-29 | 2019-09-26 | Iovance Biotherapeutics Inc | عمليات من أجل إنتاج الخلايا اللمفاوية المرتشحة للأورام واستخداماتها في العلاج المناعي |
MA50571A (fr) | 2017-11-10 | 2020-09-16 | Juno Therapeutics Inc | Réservoirs cryogéniques à système fermé |
US20200384025A1 (en) | 2017-12-08 | 2020-12-10 | Juno Therapeutics, Inc. | Process for producing a composition of engineered t cells |
MX2020005906A (es) | 2017-12-08 | 2020-10-22 | Juno Therapeutics Inc | Marcadores fenotipicos para terapia celular y metodos relacionados. |
AU2019218792A1 (en) | 2018-02-08 | 2020-09-03 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for allogenic hematopoietic stem cell transplantation |
US20210208137A1 (en) * | 2018-05-23 | 2021-07-08 | University Of Florida Research Foundation, Inc. | Paramagnetic immunobeads for the isolation of human adipose-derived stem cells |
MX2021001523A (es) | 2018-08-09 | 2021-05-27 | Juno Therapeutics Inc | Procesos para generar células modificadas y composiciones de las mismas. |
WO2020089343A1 (en) | 2018-10-31 | 2020-05-07 | Juno Therapeutics Gmbh | Methods for selection and stimulation of cells and apparatus for same |
BR112021008738A2 (pt) | 2018-11-06 | 2021-11-03 | Juno Therapeutics Inc | Processo para produzir células t geneticamente construídas |
CN110352951A (zh) * | 2018-11-15 | 2019-10-22 | 崔磊 | 一种无血清无dmso组织工程骨冻存液及其制备和冻存方法 |
CN114600172A (zh) | 2019-08-30 | 2022-06-07 | 朱诺治疗学股份有限公司 | 用于将细胞分类的机器学习方法 |
CN114929360A (zh) | 2019-10-30 | 2022-08-19 | 朱诺治疗学有限公司 | 细胞选择和/或刺激装置及使用方法 |
WO2021150560A1 (en) * | 2020-01-21 | 2021-07-29 | Millennium Pharmaceuticals, Inc. | Compositions and methods of cryopreserving cells |
CA3170153A1 (en) | 2020-02-12 | 2021-08-19 | Juno Therapeutics, Inc. | Bcma-directed chimeric antigen receptor t cell compositions and methods and uses thereof |
CN115835873A (zh) | 2020-05-13 | 2023-03-21 | 朱诺治疗学股份有限公司 | 用于产生表达重组受体的供体分批细胞的方法 |
GB202007905D0 (en) * | 2020-05-27 | 2020-07-08 | Univ Edinburgh | Cryopressing macrophages |
CN114762497B (zh) * | 2021-01-11 | 2023-08-11 | 京东方再生医学科技有限公司 | 细胞冻存液及细胞冻存方法 |
CN117916256A (zh) | 2021-05-06 | 2024-04-19 | 朱诺治疗学有限公司 | 用于刺激和转导t细胞的方法 |
CN113207871A (zh) * | 2021-05-20 | 2021-08-06 | 新乡医学院 | 一种用于体外保存t记忆性干细胞的储存液及其应用 |
WO2023201369A1 (en) | 2022-04-15 | 2023-10-19 | Iovance Biotherapeutics, Inc. | Til expansion processes using specific cytokine combinations and/or akti treatment |
WO2023230581A1 (en) | 2022-05-25 | 2023-11-30 | Celgene Corporation | Methods of manufacturing t cell therapies |
US20240285762A1 (en) | 2023-02-28 | 2024-08-29 | Juno Therapeutics, Inc. | Cell therapy for treating systemic autoimmune diseases |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004000119A (ja) | 2002-04-09 | 2004-01-08 | Olympus Corp | 細胞培養システム、培養細胞照合装置および細胞培養装置 |
JP2005332046A (ja) | 2004-05-18 | 2005-12-02 | Hitachi Plant Eng & Constr Co Ltd | 細胞管理システム及び細胞管理方法 |
JP2014526887A (ja) | 2011-08-01 | 2014-10-09 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 造血幹細胞移植の成功率を改善する方法 |
WO2016057651A1 (en) | 2014-10-09 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
WO2016069283A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in cart cells and uses thereof |
Family Cites Families (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4452773A (en) | 1982-04-05 | 1984-06-05 | Canadian Patents And Development Limited | Magnetic iron-dextran microspheres |
US4795698A (en) | 1985-10-04 | 1989-01-03 | Immunicon Corporation | Magnetic-polymer particles |
US5219740A (en) | 1987-02-13 | 1993-06-15 | Fred Hutchinson Cancer Research Center | Retroviral gene transfer into diploid fibroblasts for gene therapy |
AU4746590A (en) | 1988-12-28 | 1990-08-01 | Stefan Miltenyi | Methods and materials for high gradient magnetic separation of biological materials |
US5200084A (en) | 1990-09-26 | 1993-04-06 | Immunicon Corporation | Apparatus and methods for magnetic separation |
WO1996013593A2 (en) | 1994-10-26 | 1996-05-09 | Procept, Inc. | Soluble single chain t cell receptors |
WO1996018105A1 (en) | 1994-12-06 | 1996-06-13 | The President And Fellows Of Harvard College | Single chain t-cell receptor |
DE19608753C1 (de) | 1996-03-06 | 1997-06-26 | Medigene Gmbh | Transduktionssystem und seine Verwendung |
WO1997034634A1 (en) | 1996-03-20 | 1997-09-25 | Sloan-Kettering Institute For Cancer Research | Single chain fv constructs of anti-ganglioside gd2 antibodies |
CA2305630C (en) | 1997-10-02 | 2012-11-06 | Sunol Molecular Corporation | Soluble single-chain t-cell receptor proteins |
JP2002515243A (ja) | 1998-05-19 | 2002-05-28 | アヴィデックス リミテッド | 多価t細胞受容体複合体 |
WO2000014257A1 (en) | 1998-09-04 | 2000-03-16 | Sloan-Kettering Institute For Cancer Research | Fusion receptors specific for prostate-specific membrane antigen and uses thereof |
AU2472400A (en) | 1998-10-20 | 2000-05-08 | City Of Hope | CD20-specific redirected T cells and their use in cellular immunotherapy of CD20+ malignancies |
CA2410510A1 (en) | 2000-06-02 | 2001-12-13 | Memorial Sloan-Kettering Cancer Center | Artificial antigen presenting cells and methods of use thereof |
ATE338124T1 (de) | 2000-11-07 | 2006-09-15 | Hope City | Cd19-spezifische umgezielte immunzellen |
US7070995B2 (en) | 2001-04-11 | 2006-07-04 | City Of Hope | CE7-specific redirected immune cells |
US20090257994A1 (en) | 2001-04-30 | 2009-10-15 | City Of Hope | Chimeric immunoreceptor useful in treating human cancers |
US7329731B2 (en) | 2001-08-31 | 2008-02-12 | Medigene Limited | Soluble T cell receptor |
US7446190B2 (en) | 2002-05-28 | 2008-11-04 | Sloan-Kettering Institute For Cancer Research | Nucleic acids encoding chimeric T cell receptors |
US7569664B2 (en) | 2002-10-09 | 2009-08-04 | Immunocore Limited | Single chain recombinant T cell receptors |
US20050129671A1 (en) | 2003-03-11 | 2005-06-16 | City Of Hope | Mammalian antigen-presenting T cells and bi-specific T cells |
DE602005022595D1 (de) | 2004-06-29 | 2010-09-09 | Immunocore Ltd | Einen modifizierten t-zellen-rezeptor exprimierende zellen |
US8222027B2 (en) | 2006-06-20 | 2012-07-17 | Cook General Biotechnolgy, LLC | Systems and methods for cryopreservation of cells |
US8709797B2 (en) | 2006-06-20 | 2014-04-29 | Cook General Biotechnology Llc | Systems and methods for cryopreservation of cells |
DK2537416T3 (en) | 2007-03-30 | 2015-01-05 | Sloan Kettering Inst Cancer | Constitutive expression of costimulatory ligands ON adoptively transferred T-LYMPHOCYTES |
JP5456689B2 (ja) | 2007-12-07 | 2014-04-02 | ミルテンイ バイオテック ゲーエムベーハー | 試料を少なくとも2つの成分に分離する遠心分離機 |
US8479118B2 (en) | 2007-12-10 | 2013-07-02 | Microsoft Corporation | Switching search providers within a browser search box |
US20120164718A1 (en) | 2008-05-06 | 2012-06-28 | Innovative Micro Technology | Removable/disposable apparatus for MEMS particle sorting device |
JP5173594B2 (ja) | 2008-05-27 | 2013-04-03 | キヤノン株式会社 | 管理装置、画像形成装置及びそれらの処理方法 |
EP3006459B1 (en) | 2008-08-26 | 2021-10-06 | City of Hope | Method and compositions for enhanced anti-tumor effector functioning of t cells |
EP2486049A1 (en) | 2009-10-06 | 2012-08-15 | The Board Of Trustees Of The UniversityOf Illinois | Human single-chain t cell receptors |
TR201904484T4 (tr) | 2009-11-03 | 2019-05-21 | Hope City | Transdüse T hücre seçimine yönelik kesik epiderimal büyüme faktörü reseptörü (EGFRt). |
DK2649086T3 (en) | 2010-12-09 | 2017-09-18 | Univ Pennsylvania | USING CHEMICAL ANTIGEN RECEPTOR-MODIFIED T-CELLS TO TREAT CANCER |
CN106074601A (zh) | 2011-03-23 | 2016-11-09 | 弗雷德哈钦森癌症研究中心 | 用于细胞免疫治疗的方法和组合物 |
US8398282B2 (en) | 2011-05-12 | 2013-03-19 | Delphi Technologies, Inc. | Vehicle front lighting assembly and systems having a variable tint electrowetting element |
CA2855358C (en) | 2011-11-11 | 2021-03-16 | Fred Hutchinson Cancer Research Center | Cyclin a1-targeted t-cell immunotherapy for cancer |
US9447194B2 (en) | 2012-02-13 | 2016-09-20 | Seattle Children's Hospital | Bispecific chimeric antigen receptors and encoding polynucleotides thereof |
WO2013126726A1 (en) | 2012-02-22 | 2013-08-29 | The Trustees Of The University Of Pennsylvania | Double transgenic t cells comprising a car and a tcr and their methods of use |
KR102276888B1 (ko) | 2012-05-03 | 2021-07-14 | 프레드 헛친슨 켄서 리서치 센터 | 증강된 친화성 t 세포 수용체 및 이의 제조 방법 |
CN102758259B (zh) * | 2012-07-30 | 2013-08-21 | 济南赛尔生物科技有限公司 | 一种人外周血免疫细胞库的构建方法 |
SG10201701339RA (en) | 2012-08-20 | 2017-03-30 | Seattle Children S Hospital Dba Seattle Children S Res Inst | Method and compositions for cellular immunotherapy |
NZ746914A (en) | 2012-10-02 | 2020-03-27 | Memorial Sloan Kettering Cancer Center | Compositions and methods for immunotherapy |
DE112012007250T5 (de) | 2012-12-20 | 2015-10-08 | Mitsubishi Electric Corp. | Fahrzeuginterne Vorrichtung und Programm |
TWI654206B (zh) | 2013-03-16 | 2019-03-21 | 諾華公司 | 使用人類化抗-cd19嵌合抗原受體治療癌症 |
US9108442B2 (en) | 2013-08-20 | 2015-08-18 | Ricoh Company, Ltd. | Image forming apparatus |
KR20200032763A (ko) * | 2014-02-04 | 2020-03-26 | 카이트 파마 인코포레이티드 | B 세포 악성종양 및 다른 암을 치료하는데 유용한 자가 t 세포 및 그의 조성물의 생산 방법 |
MX2016013149A (es) | 2014-04-10 | 2017-04-27 | Seattle Children's Hospital (Dba Seattle Children's Res Institute) | Produccion de celulas t modificadas, mediante transposon bella durmiente, acoplada con seleccion por metotrexato. |
KR102447958B1 (ko) | 2014-04-23 | 2022-09-27 | 주노 쎄러퓨티크스 인코퍼레이티드 | 입양 치료용 면역 세포 집단의 단리, 배양 및 유전자 조작 방법 |
TWI805109B (zh) | 2014-08-28 | 2023-06-11 | 美商奇諾治療有限公司 | 對cd19具專一性之抗體及嵌合抗原受體 |
CN104357383A (zh) * | 2014-10-11 | 2015-02-18 | 张炳强 | 人脂肪间充质干细胞制备方法及其在制备疾病药物的应用 |
IL293714A (en) | 2014-10-20 | 2022-08-01 | Juno Therapeutics Inc | Methods and preparations for dosing in stress cell therapy |
AU2015343121B2 (en) | 2014-11-05 | 2020-06-18 | Juno Therapeutics, Inc. | Methods for transduction and cell processing |
WO2016090190A1 (en) | 2014-12-03 | 2016-06-09 | Juno Therapeutics, Inc. | Methods and compositions for adoptive cell therapy |
MX2017009254A (es) | 2015-01-16 | 2017-10-12 | Juno Therapeutics Inc | Anticuerpos y receptores de antigeno quimerico especificos para ror1. |
CN105685017B (zh) * | 2016-04-18 | 2019-02-12 | 东莞市保莱生物科技有限公司 | 一种免疫细胞的储存方法及细胞冻存液 |
MA45341A (fr) | 2016-06-06 | 2019-04-10 | Hutchinson Fred Cancer Res | Procédés de traitement de malignités de lymphocytes b au moyen d'une thérapie cellulaire adoptive |
-
2018
- 2018-03-14 WO PCT/US2018/022522 patent/WO2018170188A2/en unknown
- 2018-03-14 US US16/493,828 patent/US20200077644A1/en active Pending
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-
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- 2019-09-12 IL IL269307A patent/IL269307B/en unknown
-
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- 2023-09-27 JP JP2023165221A patent/JP2024053541A/ja active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004000119A (ja) | 2002-04-09 | 2004-01-08 | Olympus Corp | 細胞培養システム、培養細胞照合装置および細胞培養装置 |
JP2005332046A (ja) | 2004-05-18 | 2005-12-02 | Hitachi Plant Eng & Constr Co Ltd | 細胞管理システム及び細胞管理方法 |
JP2014526887A (ja) | 2011-08-01 | 2014-10-09 | アルナイラム ファーマシューティカルズ, インコーポレイテッド | 造血幹細胞移植の成功率を改善する方法 |
WO2016057651A1 (en) | 2014-10-09 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
WO2016069283A1 (en) | 2014-10-31 | 2016-05-06 | The Trustees Of The University Of Pennsylvania | Altering gene expression in cart cells and uses thereof |
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MX2019010906A (es) | 2020-02-12 |
WO2018170188A3 (en) | 2018-10-25 |
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EP3595440A2 (en) | 2020-01-22 |
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WO2018170188A2 (en) | 2018-09-20 |
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JP2020513854A (ja) | 2020-05-21 |
AU2018234640C1 (en) | 2024-09-19 |
BR112019019005A2 (pt) | 2020-04-14 |
EA201992155A1 (ru) | 2020-03-16 |
KR20200010186A (ko) | 2020-01-30 |
IL292352A (en) | 2022-06-01 |
US20200077644A1 (en) | 2020-03-12 |
SG11201908271WA (en) | 2019-10-30 |
IL269307A (en) | 2019-11-28 |
IL269307B (en) | 2022-06-01 |
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