BRPI0412327A - derivados de pirimidina-2,4-diona como antagonistas de receptor de hormÈnio liberador de gonadotropina - Google Patents
derivados de pirimidina-2,4-diona como antagonistas de receptor de hormÈnio liberador de gonadotropinaInfo
- Publication number
- BRPI0412327A BRPI0412327A BRPI0412327-1A BRPI0412327A BRPI0412327A BR PI0412327 A BRPI0412327 A BR PI0412327A BR PI0412327 A BRPI0412327 A BR PI0412327A BR PI0412327 A BRPI0412327 A BR PI0412327A
- Authority
- BR
- Brazil
- Prior art keywords
- sub
- receptor antagonists
- releasing hormone
- pyrimidine
- hormone receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Anesthesiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
"DERIVADOS DE PIRIMIDINA-2,4-DIONA COMO ANTAGONISTAS DE RECEPTOR DE HORMÈNIO LIBERADOR DE GONADOTROPINA". São descritos antagonistas de receptor de GnRH, os quais têm utilidade no tratamento de uma variedade de condições relacionadas a hormónios sexuais, tanto em homens como em mulheres. Os compostos dessa invenção têm a fórmula estrutural (I) , em que R~ 1a~, R~ 1b~, R~ 2a~, R~ 2b~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, R~ 7~ e X são como definidos aqui, incluindo estereoisómeros, pró-drogas e sais farmaceuticamente aceitáveis destes. São também descritas composições contendo um composto dessa invenção em combinação com um veículo farmaceuticamente aceitável, bem como métodos relacionados ao uso das mesmas para antagonizar hormónio liberador de gonadotropina em um paciente que necessite destes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US48543603P | 2003-07-07 | 2003-07-07 | |
PCT/US2004/021569 WO2005007164A1 (en) | 2003-07-07 | 2004-07-06 | Pyrimidine-2,4-dione derivatives as gonadotropin-releasing hormone receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0412327A true BRPI0412327A (pt) | 2006-09-05 |
Family
ID=34079122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0412327-1A BRPI0412327A (pt) | 2003-07-07 | 2004-07-06 | derivados de pirimidina-2,4-diona como antagonistas de receptor de hormÈnio liberador de gonadotropina |
Country Status (14)
Country | Link |
---|---|
US (2) | US7071200B2 (pt) |
EP (1) | EP1660091B1 (pt) |
JP (2) | JP4658044B2 (pt) |
KR (1) | KR20060052790A (pt) |
CN (2) | CN101229165A (pt) |
AT (1) | ATE428427T1 (pt) |
AU (1) | AU2004257636B2 (pt) |
BR (1) | BRPI0412327A (pt) |
CA (1) | CA2531507C (pt) |
DE (1) | DE602004020638D1 (pt) |
EA (1) | EA200600188A1 (pt) |
IL (1) | IL172834A0 (pt) |
MX (1) | MXPA06000300A (pt) |
WO (1) | WO2005007164A1 (pt) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001055119A2 (en) * | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
ES2314448T3 (es) * | 2003-07-07 | 2009-03-16 | Neurocrine Biosciences, Inc. | Derivados de pirimidina-2,4-diona como antagonistas del receptor de la hormona de liberacion de la gonadotropina. |
US7015226B2 (en) * | 2003-07-07 | 2006-03-21 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
CN102079743B (zh) * | 2004-03-15 | 2020-08-25 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
EP1866290B1 (en) | 2005-03-24 | 2013-05-01 | Janssen Pharmaceutica N.V. | Prokineticin 1 receptor antagonists |
JP2008537548A (ja) * | 2005-03-24 | 2008-09-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | プロキネチシン1受容体 |
KR100837785B1 (ko) * | 2007-01-17 | 2008-06-13 | 한국화학연구원 | 1,2,4-티아다이아졸리딘-3,5-다이온 화합물을 포함하는염증관련 질환의 치료 및 예방을 위한 약제학적 조성물 |
CL2008000986A1 (es) | 2007-04-06 | 2008-10-17 | Neurocrine Biosciences Inc | COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV |
PA8775801A1 (es) | 2007-04-06 | 2009-05-15 | Neurocrine Biosciences Inc | Antagonista del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos |
US8765948B2 (en) | 2007-11-07 | 2014-07-01 | Neurocrine Biosciences, Inc. | Processes for the preparation of uracil derivatives |
ES2549502T3 (es) * | 2009-11-20 | 2015-10-28 | Sk Chemicals Co., Ltd. | Antagonistas de receptores de gonadoliberina, método de fabricación de los mismos, y composición farmacéutica que los contienen |
TW201130854A (en) | 2009-12-22 | 2011-09-16 | Bayer Schering Pharma Ag | Pyridinone derivatives and pharmaceutical compositions thereof |
WO2012175514A1 (en) | 2011-06-21 | 2012-12-27 | Bayer Intellectual Property Gmbh | Pyridinone derivatives and pharmaceutical compositions thereof |
CN107935863A (zh) * | 2017-11-30 | 2018-04-20 | 厦门海乐景生化有限公司 | Elagolix的关键原料化合物C的合成方法 |
WO2019115019A1 (en) * | 2017-12-11 | 2019-06-20 | Synthon B.V. | Process for preparing elagolix |
IL310267A (en) | 2018-07-23 | 2024-03-01 | Abbvie Inc | Sodium Alagolix Compositions and Processes |
US20220242831A1 (en) * | 2019-05-24 | 2022-08-04 | Dr. Reddy's Laboratories Limited | Improved process for the preparation of elagolix and its intermediates |
ES2802815B2 (es) | 2019-07-12 | 2022-03-14 | Moehs Iberica Sl | Sal clorhidrato de 3-[2(r)-amino-2-feniletil]-5-(2-fluoro-3-metoxifenil)-1-[2-fluoro-6-(trifluorometil)bencil]-6-metil-1h-pirimidin-2,4(1h,3h)-diona (i) en forma solida, procedimiento para su preparacion y uso de la misma en la sintesis de elagolix |
CN112300081A (zh) * | 2019-07-31 | 2021-02-02 | 上海度德医药科技有限公司 | 噁拉戈利的中间体及其制备方法和应用 |
CN112694445B (zh) * | 2019-10-22 | 2023-07-28 | 成都倍特药业股份有限公司 | 一种噁拉戈利钠中间体的纯化方法 |
ES2822398B2 (es) | 2019-10-30 | 2022-03-02 | Moehs Iberica Sl | 3-((R)-2-(Amino-2-feniletil)-1-(2-fluoro-6-trifluorometilbencil)-5-yodo-6-metil-1H-pirimidin-2,4-diona o una sal de la misma, procedimiento para su preparación y su uso en la síntesis de elagolix |
CN110938038A (zh) * | 2019-11-14 | 2020-03-31 | 上海星酶生物科技有限公司 | 一种c13h10f4n2o2的制备工艺 |
CN111333586A (zh) * | 2020-02-19 | 2020-06-26 | 诚达药业股份有限公司 | 一种含有6-甲基尿嘧啶结构化合物的制备方法 |
CN111333587B (zh) * | 2020-04-11 | 2023-04-07 | 东莞市东阳光新药研发有限公司 | 取代的嘧啶-2,4(1h,3h)-二酮衍生物及其用途 |
CN113527213B (zh) * | 2020-04-20 | 2023-01-03 | 上海英诺富成生物科技有限公司 | 促性激素释放激素受体拮抗剂及其用途 |
CN111574461A (zh) * | 2020-05-29 | 2020-08-25 | 奥锐特药业股份有限公司 | 一种噁拉戈利中间体的成盐纯化方法及获得的噁拉戈利中间体精品 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2213510A1 (en) | 1995-06-01 | 1996-12-05 | Takeda Chemical Industries, Ltd. | Diazepinones, their production and use |
US5859014A (en) * | 1995-06-09 | 1999-01-12 | Syntex (U.S.A.) Inc. | Pyrimidinedione, pyrimidinetrione, triazinedione and tetrahydroquinazolinedione derivatives as α1 -adrenergic receptor antagonists |
WO1997014697A1 (en) | 1995-10-19 | 1997-04-24 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives as gonadotropin releasing hormone antagonists |
CA2229201A1 (en) | 1995-10-19 | 1997-04-24 | Satoshi Sasaki | Quinoline derivatives, their production and use |
WO1997021704A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU707277B2 (en) | 1995-12-14 | 1999-07-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
WO1997021435A1 (en) | 1995-12-14 | 1997-06-19 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
KR19990072124A (ko) | 1995-12-14 | 1999-09-27 | 애쉬톤 왈레이스 티 | 고나도트로핀 방출 호르몬의 길항제 |
WO1998055119A1 (en) | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
CA2291647A1 (en) | 1997-06-05 | 1998-12-10 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU729752B2 (en) | 1997-06-05 | 2001-02-08 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
EP0986385A4 (en) | 1997-06-05 | 2001-05-16 | Merck & Co Inc | GONADOLIBERINE ANTAGONISTS |
US6313301B1 (en) | 1997-08-13 | 2001-11-06 | Takeda Chemical Industries, Ltd. | Thienopyridine derivatives, their intermediates and production thereof |
AU767440B2 (en) | 1999-05-14 | 2003-11-13 | Neurocrine Biosciences, Inc. | Imidazo- and pyrrolo(1,2-A)pyrimid-4-ones as gonadotropin-releasing hormone receptor antagonists |
US20020065309A1 (en) | 1999-08-04 | 2002-05-30 | Ge Peng | Novel Bicyclic and tricyclic pyrrolidine derivatives as GnRH antagonists |
CA2386942A1 (en) | 1999-10-15 | 2001-04-26 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
WO2001055119A2 (en) * | 2000-01-25 | 2001-08-02 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
SE0100566D0 (sv) | 2001-02-20 | 2001-02-20 | Astrazeneca Ab | Compounds |
US6939883B2 (en) | 2001-08-02 | 2005-09-06 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
AU2002321878A1 (en) | 2001-08-02 | 2003-02-17 | Neurocrine Biosciences, Inc. | Pyridinone and pyridazinone derivatives as gonadotropin-releasing hormone receptor antagonists |
US6740656B2 (en) | 2001-08-02 | 2004-05-25 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
AU2002324586B2 (en) | 2001-08-02 | 2008-04-24 | Neurocrine Biosciences, Inc. | 1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists |
MXPA04000986A (es) | 2001-08-02 | 2005-02-17 | Neurocrine Biosciences Inc | 1,2,3-triazin-3,5-dionas sustituidas como antagonistas del receptor de hormona de liberacion de gonadotropina (gnrh). |
US7015226B2 (en) | 2003-07-07 | 2006-03-21 | Neurocrine Biosciences, Inc. | Gonadotropin-releasing hormone receptor antagonists and methods relating thereto |
ES2314448T3 (es) | 2003-07-07 | 2009-03-16 | Neurocrine Biosciences, Inc. | Derivados de pirimidina-2,4-diona como antagonistas del receptor de la hormona de liberacion de la gonadotropina. |
-
2004
- 2004-07-06 AU AU2004257636A patent/AU2004257636B2/en not_active Ceased
- 2004-07-06 EA EA200600188A patent/EA200600188A1/ru unknown
- 2004-07-06 CN CNA2008100027460A patent/CN101229165A/zh active Pending
- 2004-07-06 JP JP2006518838A patent/JP4658044B2/ja active Active
- 2004-07-06 US US10/885,511 patent/US7071200B2/en active Active
- 2004-07-06 BR BRPI0412327-1A patent/BRPI0412327A/pt not_active IP Right Cessation
- 2004-07-06 MX MXPA06000300A patent/MXPA06000300A/es active IP Right Grant
- 2004-07-06 CA CA2531507A patent/CA2531507C/en not_active Expired - Fee Related
- 2004-07-06 CN CNB2004800196064A patent/CN100376246C/zh not_active Expired - Fee Related
- 2004-07-06 DE DE602004020638T patent/DE602004020638D1/de not_active Expired - Fee Related
- 2004-07-06 WO PCT/US2004/021569 patent/WO2005007164A1/en active Application Filing
- 2004-07-06 EP EP04777596A patent/EP1660091B1/en active Active
- 2004-07-06 KR KR1020067000435A patent/KR20060052790A/ko not_active Application Discontinuation
- 2004-07-06 AT AT04777596T patent/ATE428427T1/de not_active IP Right Cessation
-
2005
- 2005-12-26 IL IL172834A patent/IL172834A0/en unknown
-
2006
- 2006-06-02 US US11/446,583 patent/US7329669B2/en active Active
-
2010
- 2010-11-29 JP JP2010265832A patent/JP2011088903A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
AU2004257636B2 (en) | 2011-01-06 |
JP4658044B2 (ja) | 2011-03-23 |
ATE428427T1 (de) | 2009-05-15 |
US20050043338A1 (en) | 2005-02-24 |
JP2007521308A (ja) | 2007-08-02 |
JP2011088903A (ja) | 2011-05-06 |
US7071200B2 (en) | 2006-07-04 |
DE602004020638D1 (de) | 2009-05-28 |
CN1826119A (zh) | 2006-08-30 |
CN100376246C (zh) | 2008-03-26 |
EP1660091A1 (en) | 2006-05-31 |
EA200600188A1 (ru) | 2006-08-25 |
US20070015778A1 (en) | 2007-01-18 |
CA2531507C (en) | 2013-10-01 |
CA2531507A1 (en) | 2005-01-27 |
IL172834A0 (en) | 2006-06-11 |
EP1660091B1 (en) | 2009-04-15 |
US7329669B2 (en) | 2008-02-12 |
CN101229165A (zh) | 2008-07-30 |
AU2004257636A1 (en) | 2005-01-27 |
MXPA06000300A (es) | 2006-03-28 |
WO2005007164A1 (en) | 2005-01-27 |
KR20060052790A (ko) | 2006-05-19 |
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