DE60215637D1 - Tri- und tetraaza-acenaphthylen-derivate als crf-rezeptor-antagonisten - Google Patents

Tri- und tetraaza-acenaphthylen-derivate als crf-rezeptor-antagonisten

Info

Publication number
DE60215637D1
DE60215637D1 DE60215637T DE60215637T DE60215637D1 DE 60215637 D1 DE60215637 D1 DE 60215637D1 DE 60215637 T DE60215637 T DE 60215637T DE 60215637 T DE60215637 T DE 60215637T DE 60215637 D1 DE60215637 D1 DE 60215637D1
Authority
DE
Germany
Prior art keywords
sub
crf receptor
receptor antagonists
tetraaza
tri
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60215637T
Other languages
English (en)
Other versions
DE60215637T2 (de
Inventor
Fabio Romano Di
Gabriella Gentile
Mustapha Haddach
Yves St-Denis
John Patrick Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurocrine Biosciences Inc
SB Pharmco Puerto Rico Inc
Original Assignee
Neurocrine Biosciences Inc
SB Pharmco Puerto Rico Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc, SB Pharmco Puerto Rico Inc filed Critical Neurocrine Biosciences Inc
Application granted granted Critical
Publication of DE60215637D1 publication Critical patent/DE60215637D1/de
Publication of DE60215637T2 publication Critical patent/DE60215637T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DE60215637T 2001-05-21 2002-05-21 Tri- und tetraaza-acenaphthylen-derivate als crf-rezeptor-antagonisten Expired - Fee Related DE60215637T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29266001P 2001-05-21 2001-05-21
US292660P 2001-05-21
PCT/GB2002/002377 WO2002094826A1 (en) 2001-05-21 2002-05-21 Tri-and tetraaza-acenaphthylen derivatives as crf receptor antagonists

Publications (2)

Publication Number Publication Date
DE60215637D1 true DE60215637D1 (de) 2006-12-07
DE60215637T2 DE60215637T2 (de) 2007-08-23

Family

ID=23125629

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60215637T Expired - Fee Related DE60215637T2 (de) 2001-05-21 2002-05-21 Tri- und tetraaza-acenaphthylen-derivate als crf-rezeptor-antagonisten

Country Status (21)

Country Link
US (1) US7446108B2 (de)
EP (1) EP1392689B1 (de)
JP (1) JP2004530702A (de)
KR (1) KR20040018260A (de)
CN (1) CN1529705A (de)
AT (1) ATE343578T1 (de)
AU (1) AU2002257939B2 (de)
BR (1) BR0209947A (de)
CA (1) CA2450535A1 (de)
CO (1) CO5540310A2 (de)
CZ (1) CZ20033165A3 (de)
DE (1) DE60215637T2 (de)
ES (1) ES2274972T3 (de)
HU (1) HUP0400854A2 (de)
IL (1) IL158806A0 (de)
MX (1) MXPA03010635A (de)
NO (1) NO20035148D0 (de)
NZ (1) NZ529471A (de)
PL (1) PL367771A1 (de)
WO (1) WO2002094826A1 (de)
ZA (1) ZA200308810B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
GB0308208D0 (en) 2003-04-09 2003-05-14 Glaxo Group Ltd Chemical compounds
JP4766393B2 (ja) * 2004-01-06 2011-09-07 大正製薬株式会社 トリアザ−シクロペンタ［ｃｄ］インデン誘導体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
US7879802B2 (en) 2007-06-04 2011-02-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP3239170B1 (de) 2008-06-04 2019-03-20 Synergy Pharmaceuticals Inc. Für die behandlung von gastrointestinalen erkrankungen, entzündungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
EP3241839B1 (de) 2008-07-16 2019-09-04 Bausch Health Ireland Limited Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase
US8343983B2 (en) 2009-03-31 2013-01-01 Arqule, Inc. Substituted pyrazolo-pyrimidine compounds
DK2440558T3 (en) 2009-06-08 2015-07-06 Takeda Pharmaceutical Dihydropyrrolnaphthyridinon-relations as inhibitors of jak
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04211063A (ja) * 1990-03-05 1992-08-03 Takeda Chem Ind Ltd 縮合三環性複素環化合物、その製造法、用途及び中間体
ZA973884B (en) * 1996-05-23 1998-11-06 Du Pont Merck Pharma Tetrahydropteridines and pyridylpiperazines for treatment of neurological disorders
CZ68199A3 (cs) 1996-08-28 1999-11-17 Pfizer Inc. 6,5-Heterobicyklické deriváty, farmaceutická kompozice na jejich bázi a způsob léčení chorob
EP1129091B1 (de) 1998-11-12 2002-10-02 Neurocrine Biosciences, Inc. Crf rezeptor-antagonisten und darauf bezogene methoden
GB0117395D0 (en) 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
NO20035148D0 (no) 2003-11-19
ZA200308810B (en) 2004-11-30
DE60215637T2 (de) 2007-08-23
PL367771A1 (en) 2005-03-07
KR20040018260A (ko) 2004-03-02
IL158806A0 (en) 2004-05-12
WO2002094826A1 (en) 2002-11-28
JP2004530702A (ja) 2004-10-07
AU2002257939B2 (en) 2006-08-24
ATE343578T1 (de) 2006-11-15
MXPA03010635A (es) 2004-12-06
HUP0400854A2 (hu) 2004-08-30
US20040198726A1 (en) 2004-10-07
CO5540310A2 (es) 2005-07-29
CZ20033165A3 (cs) 2004-10-13
CN1529705A (zh) 2004-09-15
EP1392689B1 (de) 2006-10-25
BR0209947A (pt) 2004-04-27
EP1392689A1 (de) 2004-03-03
US7446108B2 (en) 2008-11-04
CA2450535A1 (en) 2002-11-28
ES2274972T3 (es) 2007-06-01
NZ529471A (en) 2005-12-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee