TR200102178T2 - CRF reseptör antagonistleri ve bunlarla ilgili yöntemler. - Google Patents

CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.

Info

Publication number
TR200102178T2
TR200102178T2 TR2001/02178T TR200102178T TR200102178T2 TR 200102178 T2 TR200102178 T2 TR 200102178T2 TR 2001/02178 T TR2001/02178 T TR 2001/02178T TR 200102178 T TR200102178 T TR 200102178T TR 200102178 T2 TR200102178 T2 TR 200102178T2
Authority
TR
Turkey
Prior art keywords
receptor antagonists
related methods
crf receptor
compounds
treatment
Prior art date
Application number
TR2001/02178T
Other languages
English (en)
Inventor
Haddach Mustapha
Guo Zhiqiang
R. Mccarthy James
Original Assignee
Neurocrine Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences, Inc. filed Critical Neurocrine Biosciences, Inc.
Publication of TR200102178T2 publication Critical patent/TR200102178T2/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Sicak kanli bir hayvanda felç gibi asiri CRF salgilanmasina neden olan rahatsizliklarin tedavisi dahil, çesitli rahatsizliklarin tedavisinde kullanilan CRF reseptörü antagonistleri tarif edilmektedir. Bu bulusun bilesikleri (I) yapisina sahiptir ve bunlarin stereoizomerleri ve farmasötik olarak uygun tuzlari dahildir, burada n, m, R, R1, R2, X ve Ar burada tanimlandigi gibidir.
TR2001/02178T 1998-11-12 1999-11-12 CRF reseptör antagonistleri ve bunlarla ilgili yöntemler. TR200102178T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19095898A 1998-11-12 1998-11-12
US40074499A 1999-09-21 1999-09-21

Publications (1)

Publication Number Publication Date
TR200102178T2 true TR200102178T2 (tr) 2002-01-21

Family

ID=26886600

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02178T TR200102178T2 (tr) 1998-11-12 1999-11-12 CRF reseptör antagonistleri ve bunlarla ilgili yöntemler.

Country Status (19)

Country Link
US (3) US6348466B1 (tr)
EP (1) EP1129096B1 (tr)
JP (1) JP2002529469A (tr)
KR (1) KR20010080402A (tr)
CN (1) CN1178941C (tr)
AT (1) ATE240958T1 (tr)
AU (1) AU755997B2 (tr)
BR (1) BR9915129A (tr)
CA (1) CA2349904A1 (tr)
DE (1) DE69908173T2 (tr)
DK (1) DK1129096T3 (tr)
ES (1) ES2196898T3 (tr)
HK (1) HK1038925B (tr)
IL (1) IL143105A0 (tr)
NO (1) NO20012228L (tr)
NZ (1) NZ511267A (tr)
PT (1) PT1129096E (tr)
TR (1) TR200102178T2 (tr)
WO (1) WO2000027850A2 (tr)

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EP1282624B1 (en) 2000-05-18 2004-03-03 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods relating thereto
EP1282622B1 (en) 2000-05-18 2003-09-17 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods relating thereto
CA2427656A1 (en) 2000-11-03 2002-05-23 Neurocrine Biosciences, Inc. Crf receptor antagonists and methods relating thereto
KR100843281B1 (ko) 2000-12-28 2008-07-09 오노 야꾸힝 고교 가부시키가이샤 삼환식 복소환 유도체 화합물 및 그 화합물을 유효성분으로 하는 의약
EP1345938A1 (en) 2000-12-28 2003-09-24 Neurocrine Biosciences, Inc. Tricyclic crf receptor antagonists
JP2004528342A (ja) * 2001-04-30 2004-09-16 グラクソ　グループ　リミテッド Ｃｒｆ受容体アンタゴニスト
US7273871B2 (en) 2001-07-17 2007-09-25 Sb Pharmco Puerto Rico Inc. Phenyl-5,6,6A,7,8,9-hexahydro-4H-1,4,9-triaza-phenalene derivatives as CRF antagonists
GB0117395D0 (en) * 2001-07-17 2001-09-05 Glaxo Group Ltd Chemical compounds
NZ544301A (en) 2003-06-25 2008-08-29 Ono Pharmaceutical Co Methanesulfonic acid salt of pyrazolopyrimidine compound, crystal thereof, and process for producing the same
US20060024661A1 (en) * 2003-07-30 2006-02-02 The Regents Of The University Of California Modulation of CRF potentiation of NMDA receptor currents via CRF receptor 2
US20070293508A1 (en) * 2003-12-22 2007-12-20 Sb Pharmco Puerto Rico Inc And Neurocrine Biosciences, Inc. Crf Receptor Antagonists and Methods Relating Thereto
AU2005250056A1 (en) 2004-06-03 2005-12-15 Athlomics Pty Ltd Agents and methods for diagnosing stress
WO2006031322A2 (en) * 2004-08-09 2006-03-23 Research Development Foundation Determination of the 3d-structure of an extracellular domain of a b1 g-protein coupled receptor by nmr analysis
WO2007050087A1 (en) 2004-08-25 2007-05-03 Ardea Biosciences, Inc. N[S(4-aryl-triazol-3-yl)α -mercaptoacetyl]-p-amino benozoic acids AS HIV REVERSE TRANSCRIPTASE INHIBITORS
IN2014CN03762A (tr) 2004-08-25 2015-09-25 Ardea Biosciences Inc
CA2607021C (en) 2005-05-05 2013-10-29 Ardea Biosciences, Inc. Diaryl-purines, -azapurines and -deazapurines as non-nucleoside reverse transcriptase inhibitors for treatment of hiv
EP2132211A4 (en) 2006-11-09 2011-12-07 Ardea Biosciences Inc 4-CYANPHENYLAMINO-SUBSTITUTED BICYCLIC AND HETEROCYCLIC COMPOUNDS AS AN HIV HEMMER
EA018193B3 (ru) 2007-11-27 2014-07-30 Ардеа Биосайнсиз Инк. Соединения и фармацевтические композиции для снижения уровня мочевой кислоты
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Also Published As

Publication number Publication date
JP2002529469A (ja) 2002-09-10
BR9915129A (pt) 2001-08-07
DE69908173D1 (de) 2003-06-26
WO2000027850A3 (en) 2000-08-03
HK1038925A1 (en) 2002-04-04
CN1178941C (zh) 2004-12-08
DE69908173T2 (de) 2004-08-19
IL143105A0 (en) 2002-04-21
US6348466B1 (en) 2002-02-19
US20020143008A1 (en) 2002-10-03
ATE240958T1 (de) 2003-06-15
NO20012228D0 (no) 2001-05-04
AU755997B2 (en) 2003-01-02
CN1326458A (zh) 2001-12-12
DK1129096T3 (da) 2003-09-15
NO20012228L (no) 2001-05-04
EP1129096A2 (en) 2001-09-05
ES2196898T3 (es) 2003-12-16
PT1129096E (pt) 2003-09-30
HK1038925B (zh) 2003-12-05
WO2000027850A2 (en) 2000-05-18
AU1819900A (en) 2000-05-29
EP1129096B1 (en) 2003-05-21
NZ511267A (en) 2002-12-20
US6723721B2 (en) 2004-04-20
KR20010080402A (ko) 2001-08-22
CA2349904A1 (en) 2000-05-18
US20040229879A1 (en) 2004-11-18

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