TR200101654T2 - Vitronektin resept”r antagonistleri - Google Patents

Vitronektin resept”r antagonistleri

Info

Publication number
TR200101654T2
TR200101654T2 TR2001/01654T TR200101654T TR200101654T2 TR 200101654 T2 TR200101654 T2 TR 200101654T2 TR 2001/01654 T TR2001/01654 T TR 2001/01654T TR 200101654 T TR200101654 T TR 200101654T TR 200101654 T2 TR200101654 T2 TR 200101654T2
Authority
TR
Turkey
Prior art keywords
vitronectin receptor
receptor antagonists
vitronectin
osteoporosis
describes
Prior art date
Application number
TR2001/01654T
Other languages
English (en)
Inventor
H. Miller William
J. Manley Peter
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200101654T2 publication Critical patent/TR200101654T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Bir vitronektin reseptör antagonisti olup osteoporozun tedavisinde faydal olan bir formül (I) bileçiGi veya bunun farmasötik olarak kabul edilebilir bir tuzu anlat lmaktad r.
TR2001/01654T 1998-12-04 1999-12-03 Vitronektin resept”r antagonistleri TR200101654T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11090398P 1998-12-04 1998-12-04

Publications (1)

Publication Number Publication Date
TR200101654T2 true TR200101654T2 (tr) 2002-03-21

Family

ID=22335565

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01654T TR200101654T2 (tr) 1998-12-04 1999-12-03 Vitronektin resept”r antagonistleri

Country Status (39)

Country Link
US (1) US6495560B1 (tr)
EP (1) EP1146874B1 (tr)
JP (1) JP4481504B2 (tr)
KR (1) KR100620485B1 (tr)
CN (1) CN1147300C (tr)
AP (1) AP1534A (tr)
AR (1) AR035006A1 (tr)
AT (1) ATE277043T1 (tr)
AU (1) AU754408B2 (tr)
BG (1) BG65118B1 (tr)
BR (1) BR9915879A (tr)
CA (1) CA2353415A1 (tr)
CO (1) CO5150166A1 (tr)
CZ (1) CZ20011963A3 (tr)
DE (1) DE69920518T2 (tr)
DK (1) DK1146874T3 (tr)
DZ (1) DZ2954A1 (tr)
EA (1) EA003254B1 (tr)
EG (1) EG24025A (tr)
ES (1) ES2229798T3 (tr)
HK (1) HK1042037B (tr)
HU (1) HUP0104804A3 (tr)
ID (1) ID28811A (tr)
IL (2) IL143390A0 (tr)
MA (1) MA25265A1 (tr)
NO (1) NO318895B1 (tr)
NZ (1) NZ511876A (tr)
OA (1) OA11724A (tr)
PE (1) PE20001563A1 (tr)
PL (1) PL195973B1 (tr)
PT (1) PT1146874E (tr)
SI (1) SI1146874T1 (tr)
SK (1) SK7452001A3 (tr)
TR (1) TR200101654T2 (tr)
TW (1) TW482673B (tr)
UA (1) UA71586C2 (tr)
UY (1) UY25824A1 (tr)
WO (1) WO2000033838A1 (tr)
ZA (1) ZA200104398B (tr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900232B2 (en) 2000-06-15 2005-05-31 Pharmacia Corporation Cycloalkyl alkanoic acids as integrin receptor antagonists
EP1331937B1 (en) * 2000-10-24 2006-03-15 Merck & Co., Inc. Dibenzoxazepine alpha v integrin receptor antagonist
CA2436130A1 (en) 2001-01-29 2002-08-08 3-Dimensional Pharmaceuticals, Inc. Substituted indoles and their use as integrin antagonists
US6872730B2 (en) 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
WO2004058760A1 (en) 2002-12-20 2004-07-15 Pharmacia Corporation Thiazole compounds as integrin receptor antagonists derivatives
GB0319069D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Therapeutically useful compounds
WO2006069079A2 (en) * 2004-12-21 2006-06-29 Smithkline Beecham Corporation Methods and formulations
EP2593452B1 (en) 2010-07-14 2017-01-18 Novartis AG Ip receptor agonist heterocyclic compounds
CN104053659B (zh) 2012-01-13 2016-11-09 诺华股份有限公司 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类
EP2956455B1 (en) 2013-02-13 2017-05-17 Novartis AG Ip receptor agonist heterocyclic compounds
PT3050878T (pt) 2013-09-24 2021-12-02 Fujifilm Corp Novo composto contendo azoto ou seu sal, ou seu complexo de metal

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687154B1 (fr) * 1992-02-07 1995-05-12 Rhone Poulenc Rorer Sa Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
PT910563E (pt) * 1995-06-29 2003-09-30 Smithkline Beecham Corp Antagonistas de receptores de integrina
AU4109297A (en) * 1996-09-27 1998-04-17 Merkler, H. Tank for liquids, particularly for chemically aggressive liquids
WO1998015278A1 (en) 1996-10-07 1998-04-16 Smithkline Beecham Corporation Method for stimulating bone formation
UY24949A1 (es) 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos

Also Published As

Publication number Publication date
AP1534A (en) 2006-01-09
DK1146874T3 (da) 2005-01-31
ID28811A (id) 2001-07-05
PL195973B1 (pl) 2007-11-30
UA71586C2 (en) 2004-12-15
PT1146874E (pt) 2005-02-28
IL143390A (en) 2006-07-05
AU1750200A (en) 2000-06-26
EP1146874B1 (en) 2004-09-22
DE69920518T2 (de) 2005-09-22
UY25824A1 (es) 2001-07-31
KR20010080669A (ko) 2001-08-22
EA003254B1 (ru) 2003-02-27
ZA200104398B (en) 2002-05-29
ES2229798T3 (es) 2005-04-16
OA11724A (en) 2005-01-26
US6495560B1 (en) 2002-12-17
NO20012732D0 (no) 2001-06-01
DE69920518D1 (de) 2004-10-28
SI1146874T1 (en) 2005-04-30
HK1042037B (zh) 2005-07-29
NO318895B1 (no) 2005-05-18
JP4481504B2 (ja) 2010-06-16
PL348702A1 (en) 2002-06-03
JP2003523931A (ja) 2003-08-12
CO5150166A1 (es) 2002-04-29
AR035006A1 (es) 2004-04-14
TW482673B (en) 2002-04-11
EG24025A (en) 2008-03-26
HUP0104804A2 (hu) 2002-05-29
EA200100618A1 (ru) 2001-12-24
BR9915879A (pt) 2002-02-13
EP1146874A4 (en) 2002-06-05
CN1147300C (zh) 2004-04-28
MA25265A1 (fr) 2001-10-01
IL143390A0 (en) 2002-04-21
AU754408B2 (en) 2002-11-14
CA2353415A1 (en) 2000-06-15
DZ2954A1 (fr) 2004-06-20
SK7452001A3 (en) 2001-12-03
EP1146874A1 (en) 2001-10-24
BG65118B1 (bg) 2007-03-30
KR100620485B1 (ko) 2006-09-13
HK1042037A1 (en) 2002-08-02
HUP0104804A3 (en) 2002-12-28
NO20012732L (no) 2001-08-01
CN1334730A (zh) 2002-02-06
NZ511876A (en) 2004-02-27
BG105651A (en) 2002-02-28
WO2000033838A1 (en) 2000-06-15
PE20001563A1 (es) 2001-02-09
CZ20011963A3 (cs) 2001-11-14
ATE277043T1 (de) 2004-10-15

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