BR9915879A - Antagonista de receptor de vitronectina - Google Patents

Antagonista de receptor de vitronectina

Info

Publication number
BR9915879A
BR9915879A BR9915879-5A BR9915879A BR9915879A BR 9915879 A BR9915879 A BR 9915879A BR 9915879 A BR9915879 A BR 9915879A BR 9915879 A BR9915879 A BR 9915879A
Authority
BR
Brazil
Prior art keywords
receptor antagonist
vitronectin receptor
vitronectin
useful
compound
Prior art date
Application number
BR9915879-5A
Other languages
English (en)
Inventor
William H Miller
Peter J Manley
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR9915879A publication Critical patent/BR9915879A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

"ANTAGONISTA DE RECEPTOR DE VITRONECTINA". Trata-se de um composto de fórmula (I) que é um antagonista de receptor de vitronectina, sendo útil no tratamento de osteoporose ou um sal farmaceuticamente aceitável do mesmo.
BR9915879-5A 1998-12-04 1999-12-03 Antagonista de receptor de vitronectina BR9915879A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11090398P 1998-12-04 1998-12-04
PCT/US1999/028662 WO2000033838A1 (en) 1998-12-04 1999-12-03 Vitronectin receptor antagonist

Publications (1)

Publication Number Publication Date
BR9915879A true BR9915879A (pt) 2002-02-13

Family

ID=22335565

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915879-5A BR9915879A (pt) 1998-12-04 1999-12-03 Antagonista de receptor de vitronectina

Country Status (39)

Country Link
US (1) US6495560B1 (pt)
EP (1) EP1146874B1 (pt)
JP (1) JP4481504B2 (pt)
KR (1) KR100620485B1 (pt)
CN (1) CN1147300C (pt)
AP (1) AP1534A (pt)
AR (1) AR035006A1 (pt)
AT (1) ATE277043T1 (pt)
AU (1) AU754408B2 (pt)
BG (1) BG65118B1 (pt)
BR (1) BR9915879A (pt)
CA (1) CA2353415A1 (pt)
CO (1) CO5150166A1 (pt)
CZ (1) CZ20011963A3 (pt)
DE (1) DE69920518T2 (pt)
DK (1) DK1146874T3 (pt)
DZ (1) DZ2954A1 (pt)
EA (1) EA003254B1 (pt)
EG (1) EG24025A (pt)
ES (1) ES2229798T3 (pt)
HK (1) HK1042037B (pt)
HU (1) HUP0104804A3 (pt)
ID (1) ID28811A (pt)
IL (2) IL143390A0 (pt)
MA (1) MA25265A1 (pt)
NO (1) NO318895B1 (pt)
NZ (1) NZ511876A (pt)
OA (1) OA11724A (pt)
PE (1) PE20001563A1 (pt)
PL (1) PL195973B1 (pt)
PT (1) PT1146874E (pt)
SI (1) SI1146874T1 (pt)
SK (1) SK7452001A3 (pt)
TR (1) TR200101654T2 (pt)
TW (1) TW482673B (pt)
UA (1) UA71586C2 (pt)
UY (1) UY25824A1 (pt)
WO (1) WO2000033838A1 (pt)
ZA (1) ZA200104398B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY26780A1 (es) 2000-06-15 2002-01-31 Pharmacia Corp Cicloalquil avb3 antagonistas
DE60118025T2 (de) * 2000-10-24 2006-11-23 Merck & Co., Inc. Dibenzoxazepin-alpha-v-integrin-rezeptorantagonist
CA2436130A1 (en) 2001-01-29 2002-08-08 3-Dimensional Pharmaceuticals, Inc. Substituted indoles and their use as integrin antagonists
US6872730B2 (en) 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
BR0316876A (pt) 2002-12-20 2005-10-25 Pharmacia Corp Compostos de tiazol e composição farmacêutica compreendendo o mesmo
GB0319069D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Therapeutically useful compounds
EP1841406A4 (en) * 2004-12-21 2008-06-25 Smithkline Beecham Corp METHOD AND FORMULATIONS
UA109786C2 (xx) 2010-07-14 2015-10-12 Гетероциклічні сполуки як агоністи ір-рецептора
AR089698A1 (es) 2012-01-13 2014-09-10 Novartis Ag Compuestos heterociclicos antagonistas del receptor ip
ES2637719T3 (es) 2013-02-13 2017-10-16 Novartis Ag Compuestos heterocíclicos agonistas del receptor IP
JP6215335B2 (ja) 2013-09-24 2017-10-18 富士フイルム株式会社 新規な含窒素化合物もしくはその塩またはそれらと金属との錯体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687154B1 (fr) 1992-02-07 1995-05-12 Rhone Poulenc Rorer Sa Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
ATE238996T1 (de) 1995-06-29 2003-05-15 Smithkline Beecham Corp Integrin-rezeptor-antagonisten
AU4109297A (en) * 1996-09-27 1998-04-17 Merkler, H. Tank for liquids, particularly for chemically aggressive liquids
EP0946180A4 (en) 1996-10-07 2003-07-23 Smithkline Beecham Corp METHODS FOR STIMULATING BONE FORMATION
UY24949A1 (es) 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos

Also Published As

Publication number Publication date
CN1334730A (zh) 2002-02-06
EA003254B1 (ru) 2003-02-27
HUP0104804A2 (hu) 2002-05-29
WO2000033838A1 (en) 2000-06-15
EP1146874B1 (en) 2004-09-22
DZ2954A1 (fr) 2004-06-20
HK1042037A1 (en) 2002-08-02
AP1534A (en) 2006-01-09
UY25824A1 (es) 2001-07-31
ES2229798T3 (es) 2005-04-16
ZA200104398B (en) 2002-05-29
TW482673B (en) 2002-04-11
KR100620485B1 (ko) 2006-09-13
AU754408B2 (en) 2002-11-14
CO5150166A1 (es) 2002-04-29
IL143390A0 (en) 2002-04-21
CN1147300C (zh) 2004-04-28
EA200100618A1 (ru) 2001-12-24
OA11724A (en) 2005-01-26
ATE277043T1 (de) 2004-10-15
HUP0104804A3 (en) 2002-12-28
BG65118B1 (bg) 2007-03-30
TR200101654T2 (tr) 2002-03-21
SK7452001A3 (en) 2001-12-03
KR20010080669A (ko) 2001-08-22
DE69920518D1 (de) 2004-10-28
PE20001563A1 (es) 2001-02-09
NO20012732D0 (no) 2001-06-01
NO20012732L (no) 2001-08-01
JP4481504B2 (ja) 2010-06-16
PT1146874E (pt) 2005-02-28
PL348702A1 (en) 2002-06-03
CZ20011963A3 (cs) 2001-11-14
IL143390A (en) 2006-07-05
HK1042037B (zh) 2005-07-29
NZ511876A (en) 2004-02-27
UA71586C2 (en) 2004-12-15
DK1146874T3 (da) 2005-01-31
AU1750200A (en) 2000-06-26
JP2003523931A (ja) 2003-08-12
PL195973B1 (pl) 2007-11-30
AR035006A1 (es) 2004-04-14
MA25265A1 (fr) 2001-10-01
EP1146874A1 (en) 2001-10-24
CA2353415A1 (en) 2000-06-15
BG105651A (en) 2002-02-28
EG24025A (en) 2008-03-26
DE69920518T2 (de) 2005-09-22
NO318895B1 (no) 2005-05-18
US6495560B1 (en) 2002-12-17
EP1146874A4 (en) 2002-06-05
SI1146874T1 (en) 2005-04-30
ID28811A (id) 2001-07-05

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO ESTABELICIDO PELOS ARTIGOS 8O E 13 DA LPI ( LEI 9279/96)