EA200100618A1 - Антагонист витронектинового рецептора - Google Patents

Антагонист витронектинового рецептора

Info

Publication number
EA200100618A1
EA200100618A1 EA200100618A EA200100618A EA200100618A1 EA 200100618 A1 EA200100618 A1 EA 200100618A1 EA 200100618 A EA200100618 A EA 200100618A EA 200100618 A EA200100618 A EA 200100618A EA 200100618 A1 EA200100618 A1 EA 200100618A1
Authority
EA
Eurasian Patent Office
Prior art keywords
vitronectin receptor
antagonist
compound
formula
pharmaceutically acceptable
Prior art date
Application number
EA200100618A
Other languages
English (en)
Other versions
EA003254B1 (ru
Inventor
Вилльям Х. Миллер
Питер Дж. Мэнли
Original Assignee
Смитклайн Бичам Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Смитклайн Бичам Корпорейшн filed Critical Смитклайн Бичам Корпорейшн
Publication of EA200100618A1 publication Critical patent/EA200100618A1/ru
Publication of EA003254B1 publication Critical patent/EA003254B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Inorganic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Описано соединение формулы (I), которое является антагонистом витронектинового рецептора и может использоваться для лечения остеопороза, или его фармацевтически приемлемая соль.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100618A 1998-12-04 1999-12-03 Антагонист витронектинового рецептора EA003254B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11090398P 1998-12-04 1998-12-04
PCT/US1999/028662 WO2000033838A1 (en) 1998-12-04 1999-12-03 Vitronectin receptor antagonist

Publications (2)

Publication Number Publication Date
EA200100618A1 true EA200100618A1 (ru) 2001-12-24
EA003254B1 EA003254B1 (ru) 2003-02-27

Family

ID=22335565

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100618A EA003254B1 (ru) 1998-12-04 1999-12-03 Антагонист витронектинового рецептора

Country Status (39)

Country Link
US (1) US6495560B1 (ru)
EP (1) EP1146874B1 (ru)
JP (1) JP4481504B2 (ru)
KR (1) KR100620485B1 (ru)
CN (1) CN1147300C (ru)
AP (1) AP1534A (ru)
AR (1) AR035006A1 (ru)
AT (1) ATE277043T1 (ru)
AU (1) AU754408B2 (ru)
BG (1) BG65118B1 (ru)
BR (1) BR9915879A (ru)
CA (1) CA2353415A1 (ru)
CO (1) CO5150166A1 (ru)
CZ (1) CZ20011963A3 (ru)
DE (1) DE69920518T2 (ru)
DK (1) DK1146874T3 (ru)
DZ (1) DZ2954A1 (ru)
EA (1) EA003254B1 (ru)
EG (1) EG24025A (ru)
ES (1) ES2229798T3 (ru)
HK (1) HK1042037B (ru)
HU (1) HUP0104804A3 (ru)
ID (1) ID28811A (ru)
IL (2) IL143390A0 (ru)
MA (1) MA25265A1 (ru)
NO (1) NO318895B1 (ru)
NZ (1) NZ511876A (ru)
OA (1) OA11724A (ru)
PE (1) PE20001563A1 (ru)
PL (1) PL195973B1 (ru)
PT (1) PT1146874E (ru)
SI (1) SI1146874T1 (ru)
SK (1) SK7452001A3 (ru)
TR (1) TR200101654T2 (ru)
TW (1) TW482673B (ru)
UA (1) UA71586C2 (ru)
UY (1) UY25824A1 (ru)
WO (1) WO2000033838A1 (ru)
ZA (1) ZA200104398B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001269821A1 (en) 2000-06-15 2001-12-24 Barbara Chen Cycloalkyl alkanoic acids as integrin receptor antagonists
CA2425117A1 (en) * 2000-10-24 2002-05-23 Merck & Co., Inc. Dibenzoxazepine alpha v integrin receptor antagonist
NZ539682A (en) 2001-01-29 2006-03-31 Dimensional Pharm Inc Substituted indoles and their use as integrin antagonists
US6872730B2 (en) * 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
US20040224986A1 (en) 2002-08-16 2004-11-11 Bart De Corte Piperidinyl targeting compounds that selectively bind integrins
AU2003297408A1 (en) 2002-12-20 2004-07-22 Pharmacia Corporation Thiazole compounds as integrin receptor antagonists derivatives
GB0319069D0 (en) * 2003-08-14 2003-09-17 Glaxo Group Ltd Therapeutically useful compounds
WO2006069079A2 (en) * 2004-12-21 2006-06-29 Smithkline Beecham Corporation Methods and formulations
MY156795A (en) 2010-07-14 2016-03-31 Novartis Ag Ip receptor agonist heterocyclic compounds
TW201335160A (zh) 2012-01-13 2013-09-01 Novartis Ag Ｉｐ受體激動劑之雜環化合物
JP2016507582A (ja) 2013-02-13 2016-03-10 ノバルティス アーゲー Ｉｐ受容体アゴニスト複素環式化合物
PT3050878T (pt) 2013-09-24 2021-12-02 Fujifilm Corp Novo composto contendo azoto ou seu sal, ou seu complexo de metal

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687154B1 (fr) 1992-02-07 1995-05-12 Rhone Poulenc Rorer Sa Nouveau derive de l'isoindolinone, sa preparation et les compositions pharmaceutiques qui le contiennent.
ATE238996T1 (de) * 1995-06-29 2003-05-15 Smithkline Beecham Corp Integrin-rezeptor-antagonisten
WO1998013278A1 (de) * 1996-09-27 1998-04-02 Merkler, H. Tank für flüssigkeiten, insbesondere für chemisch aggressive flüssigkeiten
JP2001501951A (ja) 1996-10-07 2001-02-13 スミスクライン・ビーチャム・コーポレイション 骨形成刺激方法
UY24949A1 (es) 1997-04-08 2001-04-30 Smithkline Beecham Corp Compuestos calcilíticos

Also Published As

Publication number Publication date
CA2353415A1 (en) 2000-06-15
ES2229798T3 (es) 2005-04-16
DE69920518D1 (de) 2004-10-28
SI1146874T1 (en) 2005-04-30
HK1042037A1 (en) 2002-08-02
EP1146874B1 (en) 2004-09-22
PL195973B1 (pl) 2007-11-30
NO20012732L (no) 2001-08-01
IL143390A0 (en) 2002-04-21
BR9915879A (pt) 2002-02-13
PL348702A1 (en) 2002-06-03
KR100620485B1 (ko) 2006-09-13
PT1146874E (pt) 2005-02-28
DE69920518T2 (de) 2005-09-22
US6495560B1 (en) 2002-12-17
NZ511876A (en) 2004-02-27
AU1750200A (en) 2000-06-26
KR20010080669A (ko) 2001-08-22
EP1146874A4 (en) 2002-06-05
HUP0104804A3 (en) 2002-12-28
IL143390A (en) 2006-07-05
UY25824A1 (es) 2001-07-31
AR035006A1 (es) 2004-04-14
HK1042037B (zh) 2005-07-29
CN1334730A (zh) 2002-02-06
ATE277043T1 (de) 2004-10-15
EA003254B1 (ru) 2003-02-27
ID28811A (id) 2001-07-05
SK7452001A3 (en) 2001-12-03
EG24025A (en) 2008-03-26
WO2000033838A1 (en) 2000-06-15
AU754408B2 (en) 2002-11-14
DZ2954A1 (fr) 2004-06-20
JP4481504B2 (ja) 2010-06-16
CN1147300C (zh) 2004-04-28
MA25265A1 (fr) 2001-10-01
OA11724A (en) 2005-01-26
NO20012732D0 (no) 2001-06-01
CZ20011963A3 (cs) 2001-11-14
ZA200104398B (en) 2002-05-29
BG65118B1 (bg) 2007-03-30
CO5150166A1 (es) 2002-04-29
HUP0104804A2 (hu) 2002-05-29
JP2003523931A (ja) 2003-08-12
EP1146874A1 (en) 2001-10-24
NO318895B1 (no) 2005-05-18
TR200101654T2 (tr) 2002-03-21
PE20001563A1 (es) 2001-02-09
UA71586C2 (en) 2004-12-15
AP1534A (en) 2006-01-09
DK1146874T3 (da) 2005-01-31
TW482673B (en) 2002-04-11
BG105651A (en) 2002-02-28

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU