EA200200619A1 - Непептидильные ингибиторы vla-4-зависимого связывания клеток, применяемые при лечении воспалительных, аутоимунных и респираторных заболеваний - Google Patents

Непептидильные ингибиторы vla-4-зависимого связывания клеток, применяемые при лечении воспалительных, аутоимунных и респираторных заболеваний

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Publication number
EA200200619A1
EA200200619A1 EA200200619A EA200200619A EA200200619A1 EA 200200619 A1 EA200200619 A1 EA 200200619A1 EA 200200619 A EA200200619 A EA 200200619A EA 200200619 A EA200200619 A EA 200200619A EA 200200619 A1 EA200200619 A1 EA 200200619A1
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EA
Eurasian Patent Office
Prior art keywords
vla
inflammatory
inhibitors
treatment
respiratory diseases
Prior art date
Application number
EA200200619A
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English (en)
Other versions
EA004673B1 (ru
Inventor
Луис Стэнли Чупак
Аллен Якоб Дюплантье
Ван Фанг Лау
Энтони Джон Миличи
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Пфайзер Продактс Инк.
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Publication of EA200200619A1 publication Critical patent/EA200200619A1/ru
Publication of EA004673B1 publication Critical patent/EA004673B1/ru

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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/03—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C311/06—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atoms of the sulfonamide groups bound to hydrogen atoms or to acyclic carbon atoms to acyclic carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
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    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Abstract

Описаны непептидные соединения, характеризующиеся тем, что указанные соединения представляют собой ингибиторы VLA-4, применяемые при лечении воспалительных, аутоиммунных и респираторных заболеваний, а также тем, что указанные соединения включают соединение формулы (1.0.0) и его фармацевтически приемлемые соли и другие пролекарственные производные.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200200619A 1999-12-28 2000-12-15 Непептидильные ингибиторы vla-4-зависимого связывания клеток, применяемые при лечении воспалительных, аутоимунных и респираторных заболеваний EA004673B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17326099P 1999-12-28 1999-12-28
PCT/IB2000/001893 WO2001051487A1 (en) 1999-12-28 2000-12-15 Non-peptidyl inhibitors of vla-4 dependent cell binding useful in treating inflammatory, autoimmune, and respiratory diseases

Publications (2)

Publication Number Publication Date
EA200200619A1 true EA200200619A1 (ru) 2002-10-31
EA004673B1 EA004673B1 (ru) 2004-06-24

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EA200200619A EA004673B1 (ru) 1999-12-28 2000-12-15 Непептидильные ингибиторы vla-4-зависимого связывания клеток, применяемые при лечении воспалительных, аутоимунных и респираторных заболеваний

Country Status (35)

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US (4) US20020049236A1 (ru)
EP (1) EP1244656A1 (ru)
JP (1) JP2003519697A (ru)
KR (1) KR20020067050A (ru)
CN (1) CN1413210A (ru)
AP (1) AP2002002565A0 (ru)
AR (1) AR029216A1 (ru)
AU (1) AU2018301A (ru)
BG (1) BG106867A (ru)
BR (1) BR0016818A (ru)
CA (1) CA2396087A1 (ru)
CO (1) CO5261616A1 (ru)
CR (1) CR6682A (ru)
CZ (1) CZ20022072A3 (ru)
EA (1) EA004673B1 (ru)
EE (1) EE200200372A (ru)
GT (1) GT200000226A (ru)
HU (1) HUP0203897A3 (ru)
IL (1) IL149758A0 (ru)
IS (1) IS6382A (ru)
MA (1) MA26861A1 (ru)
NO (1) NO20023085D0 (ru)
NZ (1) NZ518886A (ru)
OA (1) OA12126A (ru)
PA (1) PA8509301A1 (ru)
PE (1) PE20010987A1 (ru)
PL (1) PL357109A1 (ru)
SK (1) SK8692002A3 (ru)
SV (1) SV2002000246A (ru)
TN (1) TNSN00256A1 (ru)
TR (1) TR200201668T2 (ru)
UY (1) UY26512A1 (ru)
WO (1) WO2001051487A1 (ru)
YU (1) YU41202A (ru)
ZA (1) ZA200205142B (ru)

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UY26512A1 (es) 2001-07-31
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AU2018301A (en) 2001-07-24
HUP0203897A3 (en) 2005-06-28
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US6903128B2 (en) 2005-06-07
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