EP0946180A4 - Method for stimulating bone formation - Google Patents
Method for stimulating bone formationInfo
- Publication number
- EP0946180A4 EP0946180A4 EP97945563A EP97945563A EP0946180A4 EP 0946180 A4 EP0946180 A4 EP 0946180A4 EP 97945563 A EP97945563 A EP 97945563A EP 97945563 A EP97945563 A EP 97945563A EP 0946180 A4 EP0946180 A4 EP 0946180A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- bone formation
- stimulating bone
- stimulating
- formation
- bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2776496P | 1996-10-07 | 1996-10-07 | |
US27764P | 1996-10-07 | ||
PCT/US1997/018178 WO1998015278A1 (en) | 1996-10-07 | 1997-10-07 | Method for stimulating bone formation |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0946180A1 EP0946180A1 (en) | 1999-10-06 |
EP0946180A4 true EP0946180A4 (en) | 2003-07-23 |
Family
ID=21839659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP97945563A Withdrawn EP0946180A4 (en) | 1996-10-07 | 1997-10-07 | Method for stimulating bone formation |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0946180A4 (en) |
JP (1) | JP2001501951A (en) |
WO (1) | WO1998015278A1 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6008214A (en) * | 1994-08-22 | 1999-12-28 | Smithkline Beecham Corporation | Bicyclic compounds |
US6008213A (en) * | 1995-06-29 | 1999-12-28 | Smithkline Beecham Corporation | Integrin receptor antagonists |
PE122699A1 (en) * | 1997-09-19 | 2000-02-12 | Smithkline Beecham Corp | VITRONECTIN RECEPTOR ANTAGONISTS |
US6576643B2 (en) | 1997-09-19 | 2003-06-10 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
CA2303846A1 (en) * | 1997-09-24 | 1999-04-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonist |
UA71586C2 (en) | 1998-12-04 | 2004-12-15 | Smithkline Beecham Corp | A vitronectin receptor antagonist |
AUPP794898A0 (en) * | 1998-12-24 | 1999-01-28 | Garvan Institute Of Medical Research | Transgenic animal |
WO2000046215A1 (en) * | 1999-02-03 | 2000-08-10 | Merck & Co., Inc. | Benzazepine derivatives as alpha-v integrin receptor antagonists |
WO2001007036A1 (en) | 1999-07-21 | 2001-02-01 | American Home Products Corporation | BICYCLIC ANTAGONISTS SELECTIVE FOR THE αvβ3 INTEGRIN |
ATE510557T1 (en) | 2001-04-24 | 2011-06-15 | Merck Patent Gmbh | COMBINATION THERAPY WITH ANTIANGIOGENIC AGENTS AND TNFALPHA |
JP4750360B2 (en) | 2001-10-22 | 2011-08-17 | ザ スクリプス リサーチ インスティチュート | Antibody targeting compounds |
NZ533994A (en) | 2002-01-11 | 2006-10-27 | Sankyo Co | Amino alcohol derivative or phosphonic acid derivative and medicinal compostion containing these |
JP2005272453A (en) | 2004-02-24 | 2005-10-06 | Sankyo Co Ltd | Amino alcohol compound |
UA87854C2 (en) | 2004-06-07 | 2009-08-25 | Мерк Энд Ко., Инк. | N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators |
KR20080089489A (en) | 2006-01-18 | 2008-10-06 | 메르크 파텐트 게엠베하 | Specific therapy using integrin ligands for treating cancer |
EP2441464B1 (en) | 2007-01-18 | 2014-04-09 | Merck Patent GmbH | Integrin ligands for use in treating colon cancer |
WO2009063990A1 (en) | 2007-11-16 | 2009-05-22 | Ube Industries, Ltd. | Benzazepinone compound |
EP2395992A2 (en) | 2009-02-10 | 2011-12-21 | The Scripps Research Institute | Chemically programmed vaccination |
KR20120104491A (en) | 2009-05-25 | 2012-09-21 | 메르크 파텐트 게엠베하 | Continuous administration of cilengitide in cancer treatments |
EP2878339A1 (en) | 2013-12-02 | 2015-06-03 | Siena Biotech S.p.A. | SIP3 antagonists |
CN103772273A (en) * | 2014-03-04 | 2014-05-07 | 定陶县友帮化工有限公司 | Synthetic method of 2-BOC-amino-3-hydroxyl-5-chloropyridine |
CN103772272A (en) * | 2014-03-04 | 2014-05-07 | 定陶县友帮化工有限公司 | Synthetic method of 2-BOC-amido-3-hydroxy-5-bromopyridine |
CN103880739A (en) * | 2014-03-12 | 2014-06-25 | 定陶县友帮化工有限公司 | Synthetic method for 2-BOC-amino-3-hydroxypyridine |
RU2016146826A (en) | 2014-05-30 | 2018-07-04 | Пфайзер Инк. | CARBONITRIL DERIVATIVES AS SELECTIVE ANDROGEN RECEPTOR MODULATORS |
WO2023275715A1 (en) | 2021-06-30 | 2023-01-05 | Pfizer Inc. | Metabolites of selective androgen receptor modulators |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169837A (en) * | 1991-03-28 | 1992-12-08 | Allelix Biopharmaceuticals Inc. | Isolated osteogenic factor |
EP0528587A1 (en) * | 1991-08-09 | 1993-02-24 | Merck & Co. Inc. | Inhibiting osteoclast-mediated bone resorption using substituted phenyl derivatives |
US5240961A (en) * | 1992-07-02 | 1993-08-31 | Shug Austin L | Method of treating reduced insulin-like growth factor and bone loss associated with aging |
EP0557663A1 (en) * | 1992-02-27 | 1993-09-01 | Delmas, Pierre, Dr. | Assessment of bone fragility and prediction of osteoporotic fracture risk using a quantitative determination of circulating under-carboxylated osteocalcin |
WO1996000574A1 (en) * | 1994-06-29 | 1996-01-11 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3812119A (en) * | 1969-11-21 | 1974-05-21 | Ciba Geigy Corp | Dibenzocycloheptenes |
US5686116A (en) * | 1990-01-12 | 1997-11-11 | New York Society For The Relief Of The Ruptured And Crippled, Maintaining The Hospital For Special Surgery | Methods of enhancing repair, healing and augmentation of bone implants |
JP2935541B2 (en) * | 1990-06-28 | 1999-08-16 | サントリー株式会社 | Fused heterocyclic compound |
JPH0792165A (en) * | 1993-09-21 | 1995-04-07 | Hoechst Japan Ltd | Diagnostic agent for osteoporosis |
CN1156995A (en) * | 1994-06-29 | 1997-08-13 | 史密丝克莱恩比彻姆公司 | Vitronectin receptor antagonists |
US6008214A (en) * | 1994-08-22 | 1999-12-28 | Smithkline Beecham Corporation | Bicyclic compounds |
WO1996026190A1 (en) * | 1995-02-22 | 1996-08-29 | Smithkline Beecham Corporation | Integrin receptor antagonists |
-
1997
- 1997-10-07 WO PCT/US1997/018178 patent/WO1998015278A1/en not_active Application Discontinuation
- 1997-10-07 EP EP97945563A patent/EP0946180A4/en not_active Withdrawn
- 1997-10-07 JP JP10517727A patent/JP2001501951A/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5169837A (en) * | 1991-03-28 | 1992-12-08 | Allelix Biopharmaceuticals Inc. | Isolated osteogenic factor |
EP0528587A1 (en) * | 1991-08-09 | 1993-02-24 | Merck & Co. Inc. | Inhibiting osteoclast-mediated bone resorption using substituted phenyl derivatives |
EP0557663A1 (en) * | 1992-02-27 | 1993-09-01 | Delmas, Pierre, Dr. | Assessment of bone fragility and prediction of osteoporotic fracture risk using a quantitative determination of circulating under-carboxylated osteocalcin |
US5240961A (en) * | 1992-07-02 | 1993-08-31 | Shug Austin L | Method of treating reduced insulin-like growth factor and bone loss associated with aging |
WO1996000574A1 (en) * | 1994-06-29 | 1996-01-11 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
Non-Patent Citations (1)
Title |
---|
See also references of WO9815278A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP0946180A1 (en) | 1999-10-06 |
JP2001501951A (en) | 2001-02-13 |
WO1998015278A1 (en) | 1998-04-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
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17P | Request for examination filed |
Effective date: 19990409 |
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AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): BE CH DE ES FR GB IT LI NL |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 20030605 |
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17Q | First examination report despatched |
Effective date: 20030901 |
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STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
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18D | Application deemed to be withdrawn |
Effective date: 20040113 |
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