BR0108867A - Antagonistas de receptor il-8 - Google Patents

Antagonistas de receptor il-8

Info

Publication number
BR0108867A
BR0108867A BR0108867-0A BR0108867A BR0108867A BR 0108867 A BR0108867 A BR 0108867A BR 0108867 A BR0108867 A BR 0108867A BR 0108867 A BR0108867 A BR 0108867A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
chemokine
interleukin
compositions
useful
Prior art date
Application number
BR0108867-0A
Other languages
English (en)
Inventor
Michael Robert Palovich
Katherine Louisa Widdowson
Hong Nie
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0108867A publication Critical patent/BR0108867A/pt

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/64—X and Y being nitrogen atoms, e.g. N-sulfonylguanidine
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Abstract

"ANTAGONISTAS RECEPTORES DE IL-8". Esta invenção refere-se a novos compostos de Fórmula (I), e composições destes, úteis no tratamento de estados de doenças mediadas pela quimiocina, Interleucina-8 (IL-8).
BR0108867-0A 2000-03-24 2001-03-23 Antagonistas de receptor il-8 BR0108867A (pt)

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US19213200P 2000-03-24 2000-03-24
PCT/US2001/009216 WO2001072960A2 (en) 2000-03-24 2001-03-23 Il-8 receptor antagonists

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BR0108867A true BR0108867A (pt) 2005-02-09

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PL (1) PL205103B1 (pt)
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AR029361A1 (es) * 1999-05-28 2003-06-25 Smithkline Beecham Corp Compuestos de guanidina ciclicas antagonistas de los receptores de la il- 8, composicion farmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
CA2565519A1 (en) 2004-05-12 2005-12-01 Schering Corporation Cxcr1 and cxcr2 chemokine antagonists
WO2006043950A1 (en) * 2004-10-20 2006-04-27 Smithkline Beecham Corporation Il-8 receptor antagonists
EP2009992B1 (en) * 2006-04-21 2012-06-27 GlaxoSmithKline LLC Il-8 receptor antagonists
EP2010180A4 (en) * 2006-04-21 2010-10-13 Glaxosmithkline Llc IL-8 RECEPTOR ANTAGONISTS
CL2007001829A1 (es) * 2006-06-23 2008-01-25 Smithkline Beecham Corp P-toluensulfonato de n-[4-cloro-2-hidroxi-3-(piperazina-1-sulfonil)fenil]-n-(2-cloro-3-fluorofenil)urea;procedimiento de preparacion;composicion farmaceutica;combinacion farmaceutica;y uso en el tratamiento de una enfermedad mediada por la quiimioquina il-8, tales como asma y epoc.
US20090131329A1 (en) * 2007-09-14 2009-05-21 Edmund John Miller Treatment for allograft rejection
US9676721B2 (en) 2010-09-03 2017-06-13 Forma Tm, Llc Compounds and compositions for the inhibition of NAMPT
US8648070B2 (en) 2010-12-17 2014-02-11 Boehringer Ingelheim International Gmbh Bicyclic ring system substituted sulfonamide functionalised phenols as medicaments
PL2848612T3 (pl) * 2012-05-08 2017-12-29 Ishihara Sangyo Kaisha, Ltd. Sposób wytwarzania podstawionej pochodnej kwasu benzoesowego
US20230046077A1 (en) 2019-02-07 2023-02-16 Bayer Aktiengesellschaft 3-amino-2-[2-(acylamino)pyridin-4-yl]-1,5,6,7-tetrahydro-4h-pyrrolo[3,2-c]pyridin-4-one as csnk1 inhibitors

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WO1996025157A1 (en) * 1995-02-17 1996-08-22 Smithkline Beecham Corporation Il-8 receptor antagonists
AR008290A1 (es) * 1996-08-15 1999-12-29 Smithkline Beecham Corp Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios.
ZA200102033B (en) 1998-09-23 2001-09-12 Tularik Inc Arylsulfonanilide ureas.
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8

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AR031101A1 (es) 2003-09-10
AU2001249354A1 (en) 2001-10-08
CA2403787A1 (en) 2001-10-04
OA12235A (en) 2003-11-06
SK13682002A3 (sk) 2003-06-03
HK1053789A1 (zh) 2003-11-07
EP1272175A2 (en) 2003-01-08
HUP0302614A2 (hu) 2003-11-28
ATE464893T1 (de) 2010-05-15
HUP0302614A3 (en) 2005-05-30
DE60141896D1 (de) 2010-06-02
PL205103B1 (pl) 2010-03-31
ZA200207576B (en) 2004-04-08
MA25739A1 (fr) 2003-04-01
ES2344587T3 (es) 2010-09-01
BG107035A (bg) 2003-04-30
KR20040014901A (ko) 2004-02-18
EP1272175B1 (en) 2010-04-21
JP2004508287A (ja) 2004-03-18
US6680317B2 (en) 2004-01-20
UY26627A1 (es) 2001-09-28
AP1548A (en) 2006-01-16
EP1272175A4 (en) 2005-08-31
WO2001072960A3 (en) 2002-02-21
EA200201019A1 (ru) 2003-12-25
CN1452483A (zh) 2003-10-29
MY128154A (en) 2007-01-31
PL366315A1 (en) 2005-01-24
NO20024554D0 (no) 2002-09-23
CZ20023192A3 (cs) 2003-02-12
DZ3333A1 (fr) 2001-10-04
IL151210A0 (en) 2003-04-10
US20030216375A1 (en) 2003-11-20
AP2002002599A0 (en) 2002-09-30
MXPA02009355A (es) 2003-02-12
PE20020839A1 (es) 2002-12-04
WO2001072960A2 (en) 2001-10-04

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