BR0108866A - Antagonistas de receptor de il-8 - Google Patents

Antagonistas de receptor de il-8

Info

Publication number
BR0108866A
BR0108866A BR0108866-1A BR0108866A BR0108866A BR 0108866 A BR0108866 A BR 0108866A BR 0108866 A BR0108866 A BR 0108866A BR 0108866 A BR0108866 A BR 0108866A
Authority
BR
Brazil
Prior art keywords
receptor antagonists
squarates
dianilino
chemokine
interleukin
Prior art date
Application number
BR0108866-1A
Other languages
English (en)
Inventor
Michael R Palovich
Joseph Weinstock
Katherine L Widdowson
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of BR0108866A publication Critical patent/BR0108866A/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Otolaryngology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)

Abstract

"ANTAGONISTAS DE RECEPTOR DE IL-8". Esta invenção refere-se ao novo uso de dianilino esquaratos no tratamento de estados de doença mediados mediados por quimiocina, interleucina-8 (IL-8).
BR0108866-1A 2000-03-01 2001-03-01 Antagonistas de receptor de il-8 BR0108866A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18618300P 2000-03-01 2000-03-01
PCT/US2001/006564 WO2001064208A1 (en) 2000-03-01 2001-03-01 Il-8 receptor antagonists

Publications (1)

Publication Number Publication Date
BR0108866A true BR0108866A (pt) 2004-02-25

Family

ID=22683958

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0108866-1A BR0108866A (pt) 2000-03-01 2001-03-01 Antagonistas de receptor de il-8

Country Status (28)

Country Link
EP (1) EP1261328B1 (pt)
JP (1) JP2003525242A (pt)
KR (1) KR20020080460A (pt)
CN (1) CN1416339A (pt)
AP (1) AP2002002605A0 (pt)
AR (1) AR033803A1 (pt)
AT (1) ATE299698T1 (pt)
AU (1) AU2001239970A1 (pt)
BG (1) BG107014A (pt)
BR (1) BR0108866A (pt)
CA (1) CA2401659A1 (pt)
CZ (1) CZ20022932A3 (pt)
DE (1) DE60112051T2 (pt)
DZ (1) DZ3309A1 (pt)
EA (1) EA200200933A1 (pt)
ES (1) ES2245976T3 (pt)
HU (1) HUP0300599A3 (pt)
IL (1) IL151429A0 (pt)
MA (1) MA25657A1 (pt)
MX (1) MXPA02008589A (pt)
NO (1) NO20024133L (pt)
OA (1) OA12184A (pt)
PE (1) PE20011190A1 (pt)
PL (1) PL358540A1 (pt)
SK (1) SK12352002A3 (pt)
UY (1) UY26601A1 (pt)
WO (1) WO2001064208A1 (pt)
ZA (1) ZA200206988B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011868A (es) * 2000-05-30 2003-04-10 Smithkline Beecham Corp Antagonistas de receptor de interleucina 8.
US20040132694A1 (en) * 2001-01-16 2004-07-08 Palovich Michael R. Il-8 receptor antagonists
EP1355875A1 (en) * 2001-02-02 2003-10-29 Schering Corporation 3,4-di-substituted cyclobutene-1, 2-diones as cxc chemokine receptor antagonists
US20040106794A1 (en) 2001-04-16 2004-06-03 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
US7132445B2 (en) 2001-04-16 2006-11-07 Schering Corporation 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands
NZ543869A (en) * 2001-04-16 2007-09-28 Schering Corp 3,4-di-substituted cyclobutene-1,2-diones as cxc-chemokine repcetor ligands
CN1599734A (zh) 2001-10-12 2005-03-23 先灵公司 作为cxc趋化因子受体拮抗剂的3,4－二取代的马来酰亚胺化合物
US6878709B2 (en) 2002-01-04 2005-04-12 Schering Corporation 3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists
CA2479126C (en) * 2002-03-18 2011-11-15 Schering Corporation Combination treatments for chemokine-mediated diseases
DE60326080D1 (en) * 2002-10-09 2009-03-19 Schering Corp Thiadiazoldioxide und thiadiazoloxide als cxc- und cc-chemokinrezeptor liganden
TW200528450A (en) 2003-12-19 2005-09-01 Schering Corp Thiadiazoles as cxc-and cc-chemokine receptor ligands
US7671212B2 (en) 2003-12-22 2010-03-02 Schering Corporation Isothiazole dioxides as CXC- and CC-chemokine receptor ligands
DE602006017849D1 (de) 2005-06-29 2010-12-09 Schering Corp 5,6-disubstituierte oxadiazolopyrazine und thiadiazolopyrazine als liganden des cxc-chemokinrezeptors
MX2008000366A (es) 2005-06-29 2008-03-07 Schering Corp Oxadiazoles di-sustituidos como ligandos del receptor cxc-quimiocina.
TWI734715B (zh) 2015-11-19 2021-08-01 美商卡默森屈有限公司 趨化因子受體調節劑
TWI724056B (zh) 2015-11-19 2021-04-11 美商卡默森屈有限公司 Ｃｘｃｒ２抑制劑
CA3087701A1 (en) 2018-01-08 2019-07-11 Chemocentryx, Inc. Methods of treating generalized pustular psoriasis with an antagonist of ccr6 or cxcr2
CN112851635B (zh) * 2019-11-28 2022-09-16 中国医学科学院药物研究所 环状砜类化合物及其制备方法、用途和药物组合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780483A (en) * 1995-02-17 1998-07-14 Smithkline Beecham Corporation IL-8 receptor antagonists

Also Published As

Publication number Publication date
BG107014A (bg) 2003-05-30
IL151429A0 (en) 2003-04-10
HUP0300599A2 (hu) 2003-07-28
AU2001239970A1 (en) 2001-09-12
NO20024133D0 (no) 2002-08-30
ATE299698T1 (de) 2005-08-15
AP2002002605A0 (en) 2002-09-30
UY26601A1 (es) 2001-08-27
DZ3309A1 (en) 2001-09-07
EA200200933A1 (ru) 2003-02-27
EP1261328A1 (en) 2002-12-04
KR20020080460A (ko) 2002-10-23
CN1416339A (zh) 2003-05-07
WO2001064208A1 (en) 2001-09-07
EP1261328A4 (en) 2003-05-28
CZ20022932A3 (cs) 2003-05-14
MXPA02008589A (es) 2003-02-24
JP2003525242A (ja) 2003-08-26
AR033803A1 (es) 2004-01-07
ZA200206988B (en) 2003-10-16
CA2401659A1 (en) 2001-09-07
DE60112051D1 (de) 2005-08-25
OA12184A (en) 2006-05-09
NO20024133L (no) 2002-10-31
PE20011190A1 (es) 2002-01-06
MA25657A1 (fr) 2002-12-31
EP1261328B1 (en) 2005-07-20
PL358540A1 (en) 2004-08-09
ES2245976T3 (es) 2006-02-01
HUP0300599A3 (en) 2003-09-29
DE60112051T2 (de) 2006-04-27
SK12352002A3 (sk) 2003-02-04

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