BR0010985A - Antagonistas de receptor de il-8 - Google Patents
Antagonistas de receptor de il-8Info
- Publication number
- BR0010985A BR0010985A BR0010985-1A BR0010985A BR0010985A BR 0010985 A BR0010985 A BR 0010985A BR 0010985 A BR0010985 A BR 0010985A BR 0010985 A BR0010985 A BR 0010985A
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonists
- chemokine
- interleukin
- formula
- treatment
- Prior art date
Links
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 102000010681 interleukin-8 receptors Human genes 0.000 title 1
- 108010038415 interleukin-8 receptors Proteins 0.000 title 1
- 102000004890 Interleukin-8 Human genes 0.000 abstract 3
- 108090001007 Interleukin-8 Proteins 0.000 abstract 3
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 abstract 3
- 229940096397 interleukin-8 Drugs 0.000 abstract 3
- 102000019034 Chemokines Human genes 0.000 abstract 1
- 108010012236 Chemokines Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Physical Education & Sports Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"ANTAGONISTAS DE RECEPTOR DE IL-8". Esta invenção refere-se a novos compostos de Fórmula (I), composições farmacêuticas e seu uso no tratamento de estados de doença mediados pela quimiocina, interleucina-8 (IL-8).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13967499P | 1999-06-16 | 1999-06-16 | |
PCT/US2000/016813 WO2000076516A1 (en) | 1999-06-16 | 2000-06-16 | Il-8 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0010985A true BR0010985A (pt) | 2002-03-26 |
Family
ID=22487784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0010985-1A BR0010985A (pt) | 1999-06-16 | 2000-06-16 | Antagonistas de receptor de il-8 |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP1191934A4 (pt) |
JP (1) | JP2003501471A (pt) |
KR (1) | KR20020009635A (pt) |
CN (1) | CN1494424A (pt) |
AR (1) | AR029368A1 (pt) |
AU (1) | AU766086B2 (pt) |
BR (1) | BR0010985A (pt) |
CA (1) | CA2377397A1 (pt) |
CZ (1) | CZ20014490A3 (pt) |
EC (2) | ECSP003525A (pt) |
HK (1) | HK1044716A1 (pt) |
HU (1) | HUP0202019A3 (pt) |
IL (1) | IL146214A0 (pt) |
MX (1) | MXPA01013287A (pt) |
NO (1) | NO20016065D0 (pt) |
NZ (1) | NZ515232A (pt) |
PE (1) | PE20010319A1 (pt) |
PL (1) | PL352218A1 (pt) |
TR (1) | TR200103690T2 (pt) |
UY (1) | UY26209A1 (pt) |
WO (1) | WO2000076516A1 (pt) |
ZA (1) | ZA200110203B (pt) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6642215B2 (en) * | 2001-05-24 | 2003-11-04 | Leo Pharma A/S | Method of modulating NF-kB activity |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0344425B1 (en) * | 1988-03-30 | 1993-12-08 | Warner-Lambert Company | N-[[(2,6-disubstituted)phenyl]-N'- arylalkyl] ureas as antihypercholesterolemic and antiatherosclerotic agents |
US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
AR008290A1 (es) * | 1996-08-15 | 1999-12-29 | Smithkline Beecham Corp | Nuevos compuestos que contienen guanidina utiles como antagonistas de los receptores de il-8, composiciones farmaceuticas que los contienenprocedimiento para la preparacion de dichos compuestos y procedimiento para la preparacion de intermediarios. |
-
2000
- 2000-06-12 EC EC2000003525A patent/ECSP003525A/es unknown
- 2000-06-14 UY UY26209A patent/UY26209A1/es not_active Application Discontinuation
- 2000-06-14 PE PE2000000589A patent/PE20010319A1/es not_active Application Discontinuation
- 2000-06-14 AR ARP000102925A patent/AR029368A1/es not_active Application Discontinuation
- 2000-06-16 BR BR0010985-1A patent/BR0010985A/pt not_active IP Right Cessation
- 2000-06-16 CZ CZ20014490A patent/CZ20014490A3/cs unknown
- 2000-06-16 JP JP2001502849A patent/JP2003501471A/ja not_active Withdrawn
- 2000-06-16 NZ NZ515232A patent/NZ515232A/xx unknown
- 2000-06-16 CN CNA008089205A patent/CN1494424A/zh active Pending
- 2000-06-16 HU HU0202019A patent/HUP0202019A3/hu unknown
- 2000-06-16 TR TR2001/03690T patent/TR200103690T2/xx unknown
- 2000-06-16 IL IL14621400A patent/IL146214A0/xx unknown
- 2000-06-16 WO PCT/US2000/016813 patent/WO2000076516A1/en not_active Application Discontinuation
- 2000-06-16 EP EP00942933A patent/EP1191934A4/en not_active Withdrawn
- 2000-06-16 CA CA002377397A patent/CA2377397A1/en not_active Abandoned
- 2000-06-16 KR KR1020017016140A patent/KR20020009635A/ko not_active Application Discontinuation
- 2000-06-16 AU AU57482/00A patent/AU766086B2/en not_active Ceased
- 2000-06-16 MX MXPA01013287A patent/MXPA01013287A/es unknown
- 2000-06-16 PL PL00352218A patent/PL352218A1/xx not_active Application Discontinuation
- 2000-08-14 EC EC2000003528A patent/ECSP003528A/es unknown
- 2000-12-12 ZA ZA200110203A patent/ZA200110203B/xx unknown
-
2001
- 2001-12-12 NO NO20016065A patent/NO20016065D0/no not_active Application Discontinuation
-
2002
- 2002-08-27 HK HK02106332.2A patent/HK1044716A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
WO2000076516A1 (en) | 2000-12-21 |
PL352218A1 (en) | 2003-08-11 |
AU766086B2 (en) | 2003-10-09 |
HUP0202019A2 (en) | 2002-10-28 |
TR200103690T2 (tr) | 2002-05-21 |
AR029368A1 (es) | 2003-06-25 |
AU5748200A (en) | 2001-01-02 |
PE20010319A1 (es) | 2001-05-24 |
HK1044716A1 (zh) | 2002-11-01 |
UY26209A1 (es) | 2000-12-29 |
NZ515232A (en) | 2004-02-27 |
CN1494424A (zh) | 2004-05-05 |
EP1191934A1 (en) | 2002-04-03 |
HUP0202019A3 (en) | 2003-03-28 |
ZA200110203B (en) | 2002-09-11 |
NO20016065L (no) | 2001-12-12 |
EP1191934A4 (en) | 2004-02-04 |
ECSP003525A (es) | 2002-01-25 |
CA2377397A1 (en) | 2000-12-21 |
IL146214A0 (en) | 2002-07-25 |
NO20016065D0 (no) | 2001-12-12 |
CZ20014490A3 (cs) | 2002-07-17 |
MXPA01013287A (es) | 2002-06-04 |
ECSP003528A (es) | 2002-01-25 |
JP2003501471A (ja) | 2003-01-14 |
KR20020009635A (ko) | 2002-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8O E 9O ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009. |